The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins.

The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins. J Biol Chem. 2004 Jul 30; 279(31):32524-33.

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subject areas

Animals
Binding, Competitive
Cell Line
Chemokine CXCL10
Chemokines, CXC
COS Cells
Cyclic AMP
DNA
DNA, Complementary
Dose-Response Relationship, Drug
GTP-Binding Protein alpha Subunits, G12-G13
GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Protein alpha Subunits, Gq-G11
Herpesvirus 2, Saimiriine
Humans
Inhibitory Concentration 50
Interleukin-8
Ligands
Luciferases
NF-kappa B
Open Reading Frames
Phosphatidylinositols
Phylogeny
Protein Binding
Receptors, Chemokine
Signal Transduction
Transcription Factors
Transcription, Genetic
Transfection
Up-Regulation