PhDMeghanMoranMeghan Moran349793Moran, MeghanMy Scopus ID is 40762104000.
Research Areas:
I am a bone biologist interested in the molecular interactions between the gut, gut microbiome and bone as a mechanistic pathway to delaying or mitigating arthroplasty failure due to peri-implant particle-induced osteolysis. Osteolysis is inflammatory bone loss, in this case, stimulated by wear particles from the implant. The gut may provide a point of intervention in the inflammatory response to an orthopedic implant and the gut microbiome may act as a biomarker for implant health. My research may lead to a reduced need for invasive revision surgery, which is currently the treatment for failed implants. Previously, I focused on bone regeneration genetics to identify poor bone repair post-injury.
My Faculty Profile at Rush University Medical Center:
https://www.rushu.rush.edu/faculty/meghan-moran-phd
My Laboratory:
https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-meghan-moran-phd
My NCBI Bibliography:
https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40498281/?sort=date&direction=descending
My Scopus:
https://www.scopus.com/authid/detail.uri?authorId=56604656200
https://www.scopus.com/authid/detail.uri?authorId=40762104000
Education:
PhD, Kent State University/Northeast Ohio Medical UniversityAssistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifierbibo:suffixNamename suffixAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD015212Disorders19880.891432Inflammatory Bowel DiseasesD055106Procedures403010.893773Genome-Wide Association Study31825107Wilson BM, Moran MM, Meagher MJ, Ross RD, Mashiatulla M, Virdi AS, Sumner DRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyEarly changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening. J Orthop Res. 2020 06; 38(6):1216-1227.J Orthop Res2019-12-25T00:00:002019Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening.Authorship 381322true1ProfessorProfessortrue1ProfessorProfessorBrianColeBrian Cole41.87352120000000-87.66713820000000349060Cole, BrianProfessorCraigDella ValleCraig Della Valle41.87352120000000-87.66713820000000349062Della Valle, CraigProfessorAnnaPlaasAnna Plaas41.87352120000000-87.66713820000000349608Plaas, AnnaProfessorAmarjitVirdiAmarjit Virdi349707Virdi, AmarjitProfessorD010014DisordersPhysiology321490.888926Osteolysis6Assistant Professor4ProfessorD015519Concepts & IdeasPhenomena351340.908853Bone DensityFrankKoFrank C. Ko350085Ko, FrankAssistant Professor25808034Moran MM, Virdi AS, Sena K, Mazzone SR, McNulty MA, Sumner DRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyIntramembranous bone regeneration differs among common inbred mouse strains following marrow ablation. J Orthop Res. 2015 Sep; 33(9):1374-81.J Orthop Res2015-04-24T00:00:002015Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation.27648259Moran MM, Sena K, McNulty MA, Sumner DR, Virdi ASBoneKEy reportsIntramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models. Bonekey Rep. 2016; 5:837.Bonekey Rep2016-09-07T00:00:002016Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models.Authorship 41518132931052Moran MM, Wilson BM, Li J, Engen PA, Naqib A, Green SJ, Virdi AS, Plaas A, Forsyth CB, Keshavarzian A, Sumner DRFASEB journal : official publication of the Federation of American Societies for Experimental BiologyThe gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats. FASEB J. 2020 11; 34(11):14302-14317.FASEB J2020-09-15T00:00:002020The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats.Neurological SciencesOrthopedic SurgeryAnatomy and Cell BiologyRush University, Rush Medical CollegeDavidBennettDavid A. Bennett41.87328300000000-87.66936330000000349004Bennett, DavidProfessorAliKeshavarzianAli Keshavarzian41.87386750000000-87.67102690000000349021Keshavarzian, AliProfessorDale (Rick)SumnerDale (Rick) Sumner41.87328300000000-87.66936330000000349028Sumner, Dale (Rick)0000-0001-9575-3862Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant ProfessorAuthorship 443301Authorship 44423234735461Moran MM, Wessman P, Rolfson O, Bohl DD, K?rrholm J, Keshavarzian A, Sumner DRPloS oneThe risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study. PLoS One. 2021; 16(11):e0257310.PLoS One2021-11-04T00:00:002021The risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study.34811780Ko FC, Moran MM, Ross RD, Sumner DRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyActivation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice. J Orthop Res. 2022 08; 40(8):1834-1843.J Orthop Res2021-11-22T00:00:002021Activation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice.Internal Medicine, Division of Digestive Diseases and Nutrition1111selected publications1.294070.035551368research areas1.654690.1957147coauthor of37.20472.9822160similar totrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorInternal Medicine, Division of RheumatologyAuthorship 274901Authorship 274912Authorship 274921Authorship 274931Authorship 28284128548682Moran MM, Wilson BM, Ross RD, Virdi AS, Sumner DRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyArthrotomy-based preclinical models of particle-induced osteolysis: A systematic review. J Orthop Res. 2017 12; 35(12):2595-2605.J Orthop Res2017-06-28T00:00:002017Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review.28471533Mashiatulla M, Moran MM, Chan D, Li J, Freedman JD, Snyder BD, Grinstaff MW, Plaas A, Sumner DRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyMurine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced ?CT. J Orthop Res. 2017 12; 35(12):2740-2748.J Orthop Res2017-05-23T00:00:002017Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced ?CT.21901843Moran MM, Nummela S, Thewissen JGAnatomical record (Hoboken, N.J. : 2007)Development of the skull of the pantropical spotted dolphin (Stenella attenuata). Anat Rec (Hoboken). 2011 Oct; 294(10):1743-56.Anat Rec (Hoboken)2011-09-08T00:00:002011Development of the skull of the pantropical spotted dolphin (Stenella attenuata).Authorship 470351Authorship 48078237052843Plaas AHK, Moran MM, Sandy JD, Hascall VCAdvances in experimental medicine and biologyAggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now. Adv Exp Med Biol. 2023; 1402:3-29.Adv Exp Med Biol2023-01-01T00:00:002023Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now.36028119Moran MM, Ko FC, Mesner LD, Calabrese GM, Al-Barghouthi BM, Farber CR, Sumner DRBoneIntramembranous bone regeneration in diversity outbred mice is heritable. Bone. 2022 11; 164:116524.Bone2022-08-24T00:00:002022Intramembranous bone regeneration in diversity outbred mice is heritable.D001861Physiology20680.943111Bone Regeneration