MD, PhDAnne-MarieMalfaitAnne-Marie Malfait41.87352120000000-87.66713820000000349023Malfait, Anne-Marie312) 942-3073My ORCID is 0000-0003-1428-0384.
My Scopus ID is 7003614501.
My NIH COMMONS name is AMMALFAIT.312-942-2925Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifierbibo:suffixNamename suffixAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:faxNumberfaxvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 34047230509413Miller RE, Malfait AMBest practice & research. Clinical rheumatologyOsteoarthritis pain: What are we learning from animal models? Best Pract Res Clin Rheumatol. 2017 10; 31(5):676-687.Best Pract Res Clin Rheumatol2018-04-26T00:00:002018Osteoarthritis pain: What are we learning from animal models?Authorship 35221530891933Chua JR, Jamal S, Riad M, Castrejon I, Malfait AM, Block JA, Pincus TArthritis & rheumatology (Hoboken, N.J.)Disease Burden in Osteoarthritis Is Similar to That of Rheumatoid Arthritis at Initial Rheumatology Visit and Significantly Greater Six Months Later. Arthritis Rheumatol. 2019 08; 71(8):1276-1284.Arthritis Rheumatol2019-07-03T00:00:002019Disease Burden in Osteoarthritis Is Similar to That of Rheumatoid Arthritis at Initial Rheumatology Visit and Significantly Greater Six Months Later.Authorship 35649331145219Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup LPainNerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 10; 160(10):2210-2220.Pain2019-10-01T00:00:002019Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety.D018771Disorders421210.880129ArthralgiaAuthorship 247413Authorship 17518Authorship 10053Authorship 24971Authorship 14233Authorship 24687Authorship 13262Authorship 9435Authorship 20241Authorship 18425Authorship 13721Authorship 6834Authorship 24737Authorship 17281Authorship 20331Authorship 107311Authorship 18807Authorship 16591Authorship 10427Authorship 6789Authorship 6742Authorship 8518Authorship 22173Authorship 131110Authorship 101115Authorship 13145Authorship 155711Authorship 15546Authorship 20134Authorship 10266Authorship 111011Authorship 1194123185004Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, Malfait AMProceedings of the National Academy of Sciences of the United States of AmericaCCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20602-7.Proc Natl Acad Sci U S A2012-11-26T00:00:002012CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.21370305Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MDProtein science : a publication of the Protein SocietyStructure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci. 2011 Apr; 20(4):735-44.Protein Sci2011-04-01T00:00:002011Structure analysis reveals the flexibility of the ADAMTS-5 active site.17311924Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J, Zack MD, Arner EC, Viswanathan M, Abujoub A, Muruganandam A, Sexton DJ, Bassill GJ, Sato AK, Malfait AM, Tortorella MDThe Journal of biological chemistryIdentification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. J Biol Chem. 2007 Apr 13; 282(15):11101-9.J Biol Chem2007-02-20T00:00:002007Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.19714641Zack MD, Malfait AM, Skepner AP, Yates MP, Griggs DW, Hall T, Hills RL, Alston JT, Nemirovskiy OV, Radabaugh MR, Leone JW, Arner EC, Tortorella MDArthritis and rheumatismADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271). Arthritis Rheum. 2009 Sep; 60(9):2704-13.Arthritis Rheum2009-09-01T00:00:002009ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).26233284Miller RE, Tran PB, Obeidat AM, Raghu P, Ishihara S, Miller RJ, Malfait AMCurrent osteoporosis reportsThe Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain. Curr Osteoporos Rep. 2015 Oct; 13(5):318-26.Curr Osteoporos Rep2015-10-01T00:00:002015The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain.17991750Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli AThe Journal of biological chemistryHigh resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2). J Biol Chem. 2008 Jan 18; 283(3):1501-1507.J Biol Chem2007-11-08T00:00:002007High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).14715656Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AMThe Journal of biological chemistryAlpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004 Apr 23; 279(17):17554-61.J Biol Chem2004-01-07T00:00:002004Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.19601837Tortorella MD, Malfait F, Barve RA, Shieh HS, Malfait AMCurrent pharmaceutical designA review of the ADAMTS family, pharmaceutical targets of the future. Curr Pharm Des. 2009; 15(20):2359-74.Curr Pharm Des2009-01-01T00:00:002009A review of the ADAMTS family, pharmaceutical targets of the future.26245312Miller RE, Belmadani A, Ishihara S, Tran PB, Ren D, Miller RJ, Malfait AMArthritis & rheumatology (Hoboken, N.J.)Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4. Arthritis Rheumatol. 2015 Nov; 67(11):2933-43.Arthritis Rheumatol2015-11-01T00:00:002015Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4.14744861Wang P, Tortorella M, England K, Malfait AM, Thomas G, Arner EC, Pei DThe Journal of biological chemistryProprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem. 2004 Apr 09; 279(15):15434-40.J Biol Chem2004-01-26T00:00:002004Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.23973146Malfait AM, Little CB, McDougall JJOsteoarthritis and cartilageA commentary on modelling osteoarthritis pain in small animals. Osteoarthritis Cartilage. 2013 Sep; 21(9):1316-26.Osteoarthritis Cartilage2013-09-01T00:00:002013A commentary on modelling osteoarthritis pain in small animals.22492243Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, Glant TT, Malfait AM, Crow MK, Spear GT, Finnegan A, Scanzello CRArthritis and rheumatismSynovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012 Jul; 64(7):2268-77.Arthritis Rheum2012-07-01T00:00:002012Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.17646410Blair WS, Cao J, Jackson L, Jimenez J, Peng Q, Wu H, Isaacson J, Butler SL, Chu A, Graham J, Malfait AM, Tortorella M, Patick AKAntimicrobial agents and chemotherapyIdentification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing. Antimicrob Agents Chemother. 2007 Oct; 51(10):3554-61.Antimicrob Agents Chemother2007-07-23T00:00:002007Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.21337391Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas AJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyKnockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res. 2011 Apr; 29(4):516-22.J Orthop Res2010-10-26T00:00:002010Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.22018974Malfait AMPainModelling pain in post-traumatic osteoarthritis of the knee. Pain. 2012 Feb; 153(2):257-258.Pain2011-10-22T00:00:002011Modelling pain in post-traumatic osteoarthritis of the knee.24045707Malfait AM, Schnitzer TJNature reviews. RheumatologyTowards a mechanism-based approach to pain management in osteoarthritis. Nat Rev Rheumatol. 2013 Nov; 9(11):654-64.Nat Rev Rheumatol2013-09-17T00:00:002013Towards a mechanism-based approach to pain management in osteoarthritis.17487981Wittwer AJ, Hills RL, Keith RH, Munie GE, Arner EC, Anglin CP, Malfait AM, Tortorella MDBiochemistrySubstrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1). Biochemistry. 2007 May 29; 46(21):6393-401.Biochemistry2007-05-08T00:00:002007Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).25066335Miller RE, Miller RJ, Malfait AMCytokineOsteoarthritis joint pain: the cytokine connection. Cytokine. 2014 Dec; 70(2):185-93.Cytokine2014-07-24T00:00:002014Osteoarthritis joint pain: the cytokine connection.16948117Zack MD, Arner EC, Anglin CP, Alston JT, Malfait AM, Tortorella MDArthritis and rheumatismIdentification of fibronectin neoepitopes present in human osteoarthritic cartilage. Arthritis Rheum. 2006 Sep; 54(9):2912-22.Arthritis Rheum2006-09-01T00:00:002006Identification of fibronectin neoepitopes present in human osteoarthritic cartilage.18671934Malfait AM, Arner EC, Song RH, Alston JT, Markosyan S, Staten N, Yang Z, Griggs DW, Tortorella MDArchives of biochemistry and biophysicsProprotein convertase activation of aggrecanases in cartilage in situ. Arch Biochem Biophys. 2008 Oct 01; 478(1):43-51.Arch Biochem Biophys2008-07-19T00:00:002008Proprotein convertase activation of aggrecanases in cartilage in situ.22996566Morgen M, Tung D, Boras B, Miller W, Malfait AM, Tortorella MPharmaceutical researchNanoparticles for improved local retention after intra-articular injection into the knee joint. Pharm Res. 2013 Jan; 30(1):257-68.Pharm Res2012-09-21T00:00:002012Nanoparticles for improved local retention after intra-articular injection into the knee joint.22440827Malfait AM, Seymour AB, Gao F, Tortorella MD, Le Graverand-Gastineau MP, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JSAnnals of the rheumatic diseasesA role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Ann Rheum Dis. 2012 Jun; 71(6):1042-8.Ann Rheum Dis2012-03-22T00:00:002012A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.17265492Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DWArthritis and rheumatismAggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum. 2007 Feb; 56(2):575-85.Arthritis Rheum2007-02-01T00:00:002007Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.23926636Miller RE, Lu Y, Tortorella MD, Malfait AMCurrent rheumatology reportsGenetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep. 2013 Aug; 15(8):350.Curr Rheumatol Rep2013-08-01T00:00:002013Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets.20447377Byun S, Tortorella MD, Malfait AM, Fok K, Frank EH, Grodzinsky AJArchives of biochemistry and biophysicsTransport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Arch Biochem Biophys. 2010 Jul; 499(1-2):32-9.Arch Biochem Biophys2010-05-04T00:00:002010Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions.14673981Tortorella MD, Malfait AMArthritis and rheumatismThe usual suspects: verdict not guilty? Arthritis Rheum. 2003 Dec; 48(12):3304-7.Arthritis Rheum2003-12-01T00:00:002003The usual suspects: verdict not guilty?16289022Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AMArchives of biochemistry and biophysicsADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms. Arch Biochem Biophys. 2005 Dec 01; 444(1):34-44.Arch Biochem Biophys2005-10-26T00:00:002005ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.26364707Malfait AM, Little CBArthritis research & therapyOn the predictive utility of animal models of osteoarthritis. Arthritis Res Ther. 2015 Sep 14; 17:225.Arthritis Res Ther2015-09-14T00:00:002015On the predictive utility of animal models of osteoarthritis.20036347Malfait AM, Ritchie J, Gil AS, Austin JS, Hartke J, Qin W, Tortorella MD, Mogil JSOsteoarthritis and cartilageADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010 Apr; 18(4):572-80.Osteoarthritis Cartilage2009-12-21T00:00:002009ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.26259032Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu QNature medicinePCSK6-mediated corin activation is essential for normal blood pressure. Nat Med. 2015 Sep; 21(9):1048-53.Nat Med2015-08-10T00:00:002015PCSK6-mediated corin activation is essential for normal blood pressure.17391681Hall T, Fok KF, Liu MM, Zobel JF, Marino MH, Malfait AM, Tortorella MD, Tomasselli AGJournal of chromatography. AA high performance liquid chromatography assay for monitoring proprotein convertase activity. J Chromatogr A. 2007 Apr 27; 1148(1):46-54.J Chromatogr A2007-03-07T00:00:002007A high performance liquid chromatography assay for monitoring proprotein convertase activity.19586907Tortorella MD, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Munie G, Williams JM, Caspers N, Wittwer AJ, Malfait AM, Shieh HSThe Journal of biological chemistryStructural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J Biol Chem. 2009 Sep 04; 284(36):24185-91.J Biol Chem2009-07-08T00:00:002009Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.D001169Disorders161250.901195Arthritis, ExperimentalAuthorship 367964Authorship 372771Authorship 372831Authorship 37329331351964Obeidat AM, Miller RE, Miller RJ, Malfait AMOsteoarthritis and cartilageThe nociceptive innervation of the normal and osteoarthritic mouse knee. Osteoarthritis Cartilage. 2019 11; 27(11):1669-1679.Osteoarthritis Cartilage2019-07-25T00:00:002019The nociceptive innervation of the normal and osteoarthritic mouse knee.31612243Miller RE, Scanzello CR, Malfait AMSeminars in immunopathologyAn emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis. Semin Immunopathol. 2019 09; 41(5):583-594.Semin Immunopathol2019-10-14T00:00:002019An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis.31621567Malfait AM, Pincus TClinical and experimental rheumatologyNew concepts in osteoarthritis. Clin Exp Rheumatol. 2019 Sep-Oct; 37 Suppl 120(5):2.Clin Exp Rheumatol2019-10-14T00:00:002019New concepts in osteoarthritis.31621572Malfait AM, Tortorella MDClinical and experimental rheumatologyThe "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic. Clin Exp Rheumatol. 2019 Sep-Oct; 37 Suppl 120(5):130-134.Clin Exp Rheumatol2019-10-15T00:00:002019The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic.KalipadaPahanKalipada Pahan349039Pahan, KalipadaProfessorAuthorship 38064231862470Miller RJ, Malfait AM, Miller REOsteoarthritis and cartilageThe innate immune response as a mediator of osteoarthritis pain. Osteoarthritis Cartilage. 2020 05; 28(5):562-571.Osteoarthritis Cartilage2019-12-17T00:00:002019The innate immune response as a mediator of osteoarthritis pain.true1ProfessorProfessortrue1ProfessorProfessorMarkCohenMark Cohen41.87352120000000-87.66713820000000349059Cohen, MarkProfessorBrianColeBrian Cole41.87352120000000-87.66713820000000349060Cole, BrianProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessorPediatricsRobinPourzalRobin Pourzal41.87352120000000-87.66713820000000349087Pourzal, RobinAssistant ProfessorNikhilVermaNikhil Verma41.87352120000000-87.66713820000000349096Verma, NikhilProfessorMarkusWimmerMarkus A. Wimmer41.87352120000000-87.66713820000000349100Wimmer, Markus0000-0001-6169-3873ProfessorNajiaShakoorNajia Shakoor41.87352120000000-87.66713820000000349137Shakoor, NajiaProfessorAuthorship 38297131926266Malfait AM, Miller REOsteoarthritis and cartilageWhy we should study osteoarthritis pain in experimental models in both sexes. Osteoarthritis Cartilage. 2020 04; 28(4):397-399.Osteoarthritis Cartilage2020-01-09T00:00:002020Why we should study osteoarthritis pain in experimental models in both sexes.true1Assistant ProfessorAssistant ProfessorRachelMillerRachel Miller349450Miller, RachelAssociate ProfessorTheodorePincusTheodore Pincus349493Pincus, TheodoreProfessorJoelBlockJoel Block349607Block, JoelProfessorLaiWangLai Wang349713Wang, LaiAssistant Professor6Assistant Professor5Associate Professor4ProfessorAuthorship 38376831982564Miller RE, Tran PB, Ishihara S, Syx D, Ren D, Miller RJ, Valdes AM, Malfait AMOsteoarthritis and cartilageMicroarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis. Osteoarthritis Cartilage. 2020 05; 28(5):581-592.Osteoarthritis Cartilage2020-01-23T00:00:002020Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis.1611 W. Harrison St.Chicago60612ILtrue1ProfessorProfessorD020370Disorders573810.69573Osteoarthritis, KneeAuthorship 39223132311372Malfait AM, Miller RE, Block JAPharmacology & therapeuticsTargeting neurotrophic factors: Novel approaches to musculoskeletal pain. Pharmacol Ther. 2020 07; 211:107553.Pharmacol Ther2020-04-18T00:00:002020Targeting neurotrophic factors: Novel approaches to musculoskeletal pain.Authorship 39572932483055Syx D, Miller RE, Obeidat AM, Tran PB, Vroman R, Malfait Z, Miller RJ, Malfait F, Malfait AMPainPain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome. Pain. 2020 10; 161(10):2274-2283.Pain2020-10-01T00:00:002020Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome.Neurological SciencesOrthopedic SurgeryRush University, Rush Medical CollegeJoshuaJacobsJoshua J. Jacobs41.87352120000000-87.66713820000000349020Jacobs, Joshua0000-0003-3902-7334Professor11112selected publications13.81210.00544352419research areas11.18260.027699612coauthor of302.25216.864960similar toAuthorship 415626Authorship 415875Authorship 41918133781488Malfait AM, Miller RE, Miller RJRheumatic diseases clinics of North AmericaBasic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives. Rheum Dis Clin North Am. 2021 05; 47(2):165-180.Rheum Dis Clin North Am2021-05-01T00:00:002021Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives.33827672Ishihara S, Obeidat AM, Wokosin DL, Ren D, Miller RJ, Malfait AM, Miller REArthritis research & therapyThe role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice. Arthritis Res Ther. 2021 04 07; 23(1):103.Arthritis Res Ther2021-04-07T00:00:002021The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice.33981927Geraghty T, Winter DR, Miller RJ, Miller RE, Malfait AMPain reportsNeuroimmune interactions and osteoarthritis pain: focus on macrophages. Pain Rep. 2021; 6(1):e892.Pain Rep2021-03-09T00:00:002021Neuroimmune interactions and osteoarthritis pain: focus on macrophages.Authorship 43264834232927George DS, Hackelberg S, Jayaraj ND, Ren D, Edassery SL, Rathwell CA, Miller RE, Malfait AM, Savas JN, Miller RJ, Menichella DMPainMitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics. Pain. 2022 03 01; 163(3):560-578.Pain2022-03-01T00:00:002022Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics.Authorship 448667Authorship 450412Authorship 451882Authorship 454062Authorship 45455334628019Miller RE, Malfait AMOsteoarthritis and cartilageCan we prevent chronic osteoarthritis pain? A view from the bench. Osteoarthritis Cartilage. 2021 12; 29(12):1635-1637.Osteoarthritis Cartilage2021-10-08T00:00:002021Can we prevent chronic osteoarthritis pain? A view from the bench.34712265Vroman R, Malfait AM, Miller RE, Malfait F, Syx DFrontiers in geneticsAnimal Models of Ehlers-Danlos Syndromes: Phenotype, Pathogenesis, and Translational Potential. Front Genet. 2021; 12:726474.Front Genet2021-10-12T00:00:002021Animal Models of Ehlers-Danlos Syndromes: Phenotype, Pathogenesis, and Translational Potential.34797601Malfait F, Colman M, Vroman R, De Wandele I, Rombaut L, Miller RE, Malfait AM, Syx DAmerican journal of medical genetics. Part C, Seminars in medical geneticsPain in the Ehlers-Danlos syndromes: Mechanisms, models, and challenges. Am J Med Genet C Semin Med Genet. 2021 12; 187(4):429-445.Am J Med Genet C Semin Med Genet2021-11-19T00:00:002021Pain in the Ehlers-Danlos syndromes: Mechanisms, models, and challenges.35410677Wood MJ, Miller RE, Malfait AMClinics in geriatric medicineThe Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain. Clin Geriatr Med. 2022 05; 38(2):221-238.Clin Geriatr Med2022-05-01T00:00:002022The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain.35691475Hunter DJ, Malfait AMOsteoarthritis and cartilageDoubling down on osteoarthritis: statement from the incoming editors-in-chief. Osteoarthritis Cartilage. 2022 08; 30(8):1013-1014.Osteoarthritis Cartilage2022-06-09T00:00:002022Doubling down on osteoarthritis: statement from the incoming editors-in-chief.true1ProfessorProfessortrue1ProfessorProfessorAuthorship 224253Authorship 225323Authorship 225463Authorship 226123Authorship 226233Authorship 230971Authorship 232055Authorship 232102Authorship 232482Authorship 233062Authorship 235571Authorship 237201Authorship 238831Authorship 239085Authorship 239981Authorship 242762Authorship 245342Authorship 245831Authorship 2463412Authorship 246935Authorship 2522112Authorship 253815Authorship 254251Authorship 258395Authorship 258703Authorship 259491Authorship 259616Authorship 265602Authorship 266132Authorship 2685171954699Verbruggen G, Veys EM, Malfait AM, De Clercq L, Van den Bosch F, de Vlam KClinical and experimental rheumatologyInfluence of human recombinant interleukin-1 beta on human articular cartilage. Mitotic activity and proteoglycan metabolism. Clin Exp Rheumatol. 1991 Sep-Oct; 9(5):481-8.Clin Exp Rheumatol1991-09-01T00:00:001991Influence of human recombinant interleukin-1 beta on human articular cartilage. Mitotic activity and proteoglycan metabolism.2335050Verbruggen G, Veys EM, Malfait AM, Schatteman L, Wieme N, Nimmegeers J, Gerin MG, Broddelez CClinical rheumatologyProteoglycan metabolism in isolated chondrocytes from human cartilage. Influence of niflumic acid. Clin Rheumatol. 1990 Mar; 9(1):32-41.Clin Rheumatol1990-03-01T00:00:001990Proteoglycan metabolism in isolated chondrocytes from human cartilage. Influence of niflumic acid.2402599Verbruggen G, Veys EM, Malfait AM, Schatteman L, Wieme N, Nimmegeers J, Gerin MG, Broddelez CScandinavian journal of rheumatologyProteoglycan metabolism in tissue-cultured human articular cartilage. Influence of niflumic acid. Scand J Rheumatol. 1990; 19(4):257-68.Scand J Rheumatol1990-01-01T00:00:001990Proteoglycan metabolism in tissue-cultured human articular cartilage. Influence of niflumic acid.2706816Verbruggen G, Veys EM, Malfait AM, Schatteman L, Wieme N, Heynen G, Vanhoutte V, Broddelez CClinical and experimental rheumatologyProteoglycan metabolism in isolated chondrocytes from human cartilage and in short-term tissue-cultured human articular cartilage. Clin Exp Rheumatol. 1989 Jan-Feb; 7(1):13-7.Clin Exp Rheumatol1989-01-01T00:00:001989Proteoglycan metabolism in isolated chondrocytes from human cartilage and in short-term tissue-cultured human articular cartilage.2724253Verbruggen G, Veys EM, Malfait AM, Cochez P, Schatteman L, Wieme N, Heynen G, Broddelez CThe Journal of rheumatologyProteoglycan metabolism in tissue cultured human articular cartilage. Influence of piroxicam. J Rheumatol. 1989 Mar; 16(3):355-62.J Rheumatol1989-03-01T00:00:001989Proteoglycan metabolism in tissue cultured human articular cartilage. Influence of piroxicam.7881628Malfait AM, Verbruggen G, Almqvist KF, Broddelez C, Veys EMIn vitro cellular & developmental biology. AnimalCoculture of human articular chondrocytes with peripheral blood mononuclear cells as a model to study cytokine-mediated interactions between inflammatory cells and target cells in the rheumatoid joint. In Vitro Cell Dev Biol Anim. 1994 Nov; 30A(11):747-52.In Vitro Cell Dev Biol Anim1994-11-01T00:00:001994Coculture of human articular chondrocytes with peripheral blood mononuclear cells as a model to study cytokine-mediated interactions between inflammatory cells and target cells in the rheumatoid joint.8314729Cornelissen M, Dewulf M, Verbruggen G, Hellebuyck P, Malfait AM, De Ridder L, Veys EMIn vitro cellular & developmental biology. AnimalSize distribution of native aggrecan aggregates of human articular chondrocytes in agarose. 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Agents Actions Suppl. 1993; 39:267-72.Agents Actions Suppl1993-01-01T00:00:001993Development of immortalized human articular cartilage cell lines.8689460Verbruggen G, Malfait AM, Dewulf M, Broddelez C, Veys EMOsteoarthritis and cartilageStandardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture. Osteoarthritis Cartilage. 1995 Dec; 3(4):249-59.Osteoarthritis Cartilage1995-12-01T00:00:001995Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture.9486407Malfait AM, Butler DM, Presky DH, Maini RN, Brennan FM, Feldmann MClinical and experimental immunologyBlockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin Exp Immunol. 1998 Feb; 111(2):377-83.Clin Exp Immunol1998-02-01T00:00:001998Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.10229875Malfait AM, Malik AS, Marinova-Mutafchieva L, Butler DM, Maini RN, Feldmann MJournal of immunology (Baltimore, Md. : 1950)The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action. J Immunol. 1999 May 15; 162(10):6278-83.J Immunol1999-05-15T00:00:001999The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.10920191Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, Feldmann MProceedings of the National Academy of Sciences of the United States of AmericaThe nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9561-6.Proc Natl Acad Sci U S A2000-08-15T00:00:002000The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.11053102Feldmann M, Miotla J, Paleolog E, Williams R, Malfait AM, Taylor P, Brennan FM, Maini RNAnnals of the rheumatic diseasesFuture prospects for anti-cytokine treatment. Ann Rheum Dis. 2000 Nov; 59 Suppl 1:i119-22.Ann Rheum Dis2000-11-01T00:00:002000Future prospects for anti-cytokine treatment.11352257Malfait AM, Williams RO, Malik AS, Maini RN, Feldmann MArthritis and rheumatismChronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies. Arthritis Rheum. 2001 May; 44(5):1215-24.Arthritis Rheum2001-05-01T00:00:002001Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.15030516Sumariwalla PF, Malfait AM, Feldmann MClinical and experimental immunologyP-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor. Clin Exp Immunol. 2004 Apr; 136(1):67-75.Clin Exp Immunol2004-04-01T00:00:002004P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.18289053Tortorella MD, Malfait AMCurrent pharmaceutical biotechnologyWill the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis. Curr Pharm Biotechnol. 2008 Feb; 9(1):16-23.Curr Pharm Biotechnol2008-02-01T00:00:002008Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.19026578Malfait AM, Tortorella M, Thompson J, Hills R, Meyer DM, Jaffee BD, Chinn K, Ghoreishi-Haack N, Markosyan S, Arner ECOsteoarthritis and cartilageIntra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation. Osteoarthritis Cartilage. 2009 May; 17(5):627-35.Osteoarthritis Cartilage2008-11-01T00:00:002008Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation.19737139Zack MD, Melton MA, Stock JL, Storer CE, Barve RA, Minnerly JC, Weiss DJ, Stejskal JA, Tortorella MD, Turk JR, Shevlin KM, Malfait AMClinical and experimental immunologyReduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8). Clin Exp Immunol. 2009 Nov; 158(2):246-56.Clin Exp Immunol2009-08-06T00:00:002009Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).20603097Dufield DR, Nemirovskiy OV, Jennings MG, Tortorella MD, Malfait AM, Mathews WRAnalytical biochemistryAn immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation. Anal Biochem. 2010 Nov 15; 406(2):113-23.Anal Biochem2010-07-23T00:00:002010An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.28380690Miller RE, Ishihara S, Bhattacharyya B, Delaney A, Menichella DM, Miller RJ, Malfait AMArthritis & rheumatology (Hoboken, N.J.)Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis. Arthritis Rheumatol. 2017 07; 69(7):1429-1439.Arthritis Rheumatol2017-06-02T00:00:002017Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis.25800415Larkin J, Lohr TA, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Genell C, Miller RE, Tran PB, Malfait AM, Maier CC, Matheny CJOsteoarthritis and cartilageTranslational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage. 2015 Aug; 23(8):1254-66.Osteoarthritis Cartilage2015-03-20T00:00:002015Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.26410555Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AMOsteoarthritis and cartilageTherapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. Osteoarthritis Cartilage. 2016 Feb; 24(2):299-306.Osteoarthritis Cartilage2015-09-26T00:00:002015Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.26707989Malfait AMOsteoarthritis and cartilageOsteoarthritis year in review 2015: biology. Osteoarthritis Cartilage. 2016 Jan; 24(1):21-6.Osteoarthritis Cartilage2016-01-01T00:00:002016Osteoarthritis year in review 2015: biology.27646532Tran PB, Miller RE, Ishihara S, Miller RJ, Malfait AMOsteoarthritis and cartilageSpinal microglial activation in a murine surgical model of knee osteoarthritis. Osteoarthritis Cartilage. 2017 05; 25(5):718-726.Osteoarthritis Cartilage2016-09-16T00:00:002016Spinal microglial activation in a murine surgical model of knee osteoarthritis.27672741Miller RE, Block JA, Malfait AMCurrent opinion in rheumatologyNerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Curr Opin Rheumatol. 2017 01; 29(1):110-118.Curr Opin Rheumatol2017-01-01T00:00:002017Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?27730452Malfait AM, Miller RJCurrent osteoporosis reportsEmerging Targets for the Management of Osteoarthritis Pain. Curr Osteoporos Rep. 2016 12; 14(6):260-268.Curr Osteoporos Rep2016-12-01T00:00:002016Emerging Targets for the Management of Osteoarthritis Pain.27746376Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, Stott B, Vincent TLOsteoarthritis and cartilageCCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy. Osteoarthritis Cartilage. 2017 03; 25(3):406-412.Osteoarthritis Cartilage2016-10-13T00:00:002016CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.28189827Miller RE, Malfait AMOsteoarthritis and cartilageCan we target CCR2 to treat osteoarthritis? The trick is in the timing! Osteoarthritis Cartilage. 2017 06; 25(6):799-801.Osteoarthritis Cartilage2017-02-09T00:00:002017Can we target CCR2 to treat osteoarthritis? The trick is in the timing!28224967Vincent T, Malfait AMOsteoarthritis and cartilageTime to be positive about negative data? Osteoarthritis Cartilage. 2017 03; 25(3):351-353.Osteoarthritis Cartilage2017-03-01T00:00:002017Time to be positive about negative data?true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorInternal Medicine, Division of RheumatologyAuthorship 277223Authorship 277238Authorship 277242Authorship 277252Authorship 277266Authorship 277272Authorship 277282Authorship 277291Authorship 277305Authorship 277315Authorship 277325Authorship 277334Authorship 290471Authorship 290502Authorship 290541Authorship 29090728934882Trevino RL, Pacione CA, Malfait AM, Chubinskaya S, Wimmer MACartilageDevelopment of a Cartilage Shear-Damage Model to Investigate the Impact of Surface Injury on Chondrocytes and Extracellular Matrix Wear. Cartilage. 2017 Oct; 8(4):444-455.Cartilage2016-12-12T00:00:002016Development of a Cartilage Shear-Damage Model to Investigate the Impact of Surface Injury on Chondrocytes and Extracellular Matrix Wear.28767178Sambamurthy N, Nguyen V, Smalley R, Xiao R, Hankenson K, Gan J, Miller RE, Malfait AM, Dodge GR, Scanzello CRJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyChemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. J Orthop Res. 2018 03; 36(3):864-875.J Orthop Res2017-08-29T00:00:002017Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis.10589369Williams RO, Malfait AM, Butler DM, Walmsley MJ, Feldmann M, Maini RNClinical and experimental rheumatologyCombination therapy with DMARDs and biological agents in collagen-induced arthritis. Clin Exp Rheumatol. 1999 Nov-Dec; 17(6 Suppl 18):S115-20.Clin Exp Rheumatol1999-11-01T00:00:001999Combination therapy with DMARDs and biological agents in collagen-induced arthritis.10427983Butler DM, Malfait AM, Maini RN, Brennan FM, Feldmann MEuropean journal of immunologyAnti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis. Eur J Immunol. 1999 07; 29(7):2205-12.Eur J Immunol1999-07-01T00:00:001999Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.9550429Ross SE, Williams RO, Mason LJ, Mauri C, Marinova-Mutafchieva L, Malfait AM, Maini RN, Feldmann MJournal of immunology (Baltimore, Md. : 1950)Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram. J Immunol. 1997 Dec 15; 159(12):6253-9.J Immunol1997-12-15T00:00:001997Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.9300710Butler DM, Malfait AM, Mason LJ, Warden PJ, Kollias G, Maini RN, Feldmann M, Brennan FMJournal of immunology (Baltimore, Md. : 1950)DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition. J Immunol. 1997 Sep 15; 159(6):2867-76.J Immunol1997-09-15T00:00:001997DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.7628158De Geeter F, Malfait AM, Van Hoof AClinical nuclear medicineAspergilloma of the thoracic wall. Another cold spot lesion on bone scanning. Clin Nucl Med. 1995 May; 20(5):462.Clin Nucl Med1995-05-01T00:00:001995Aspergilloma of the thoracic wall. Another cold spot lesion on bone scanning.8182643Malfait AM, Verbruggen G, Veys EM, Lambert J, De Ridder L, Cornelissen MThe Journal of rheumatologyComparative and combined effects of interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha on proteoglycan metabolism of human articular chondrocytes cultured in agarose. J Rheumatol. 1994 Feb; 21(2):314-20.J Rheumatol1994-02-01T00:00:001994Comparative and combined effects of interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha on proteoglycan metabolism of human articular chondrocytes cultured in agarose.8162636Mielants H, Veys EM, De Keyser F, Ghyselen G, Malfait AMClinical and experimental rheumatologySecond conference on spondylarthropathies and the gut. Clin Exp Rheumatol. 1994 Jan-Feb; 12(1):111-6.Clin Exp Rheumatol1994-01-01T00:00:001994Second conference on spondylarthropathies and the gut.8513590De Keyser F, Verbruggen G, Veys EM, Cuvelier C, Malfait AM, Benoit D, Elewaut D, Vermeersch J, Heirwegh AClinical immunology and immunopathologyT cell receptor V beta usage in rheumatoid nodules: marked oligoclonality among IL-2 expanded lymphocytes. Clin Immunol Immunopathol. 1993 Jul; 68(1):29-34.Clin Immunol Immunopathol1993-07-01T00:00:001993T cell receptor V beta usage in rheumatoid nodules: marked oligoclonality among IL-2 expanded lymphocytes.1484963De Keyser F, Benoit D, Elewaut D, Leroy B, Malfait AM, Verbruggen G, Veys EMProgress in histochemistry and cytochemistryT-cell receptor expression in patients with rheumatic diseases. Prog Histochem Cytochem. 1992; 26(1-4):218-22.Prog Histochem Cytochem1992-01-01T00:00:001992T-cell receptor expression in patients with rheumatic diseases.2204512Verbruggen G, Veys EM, Wieme N, Malfait AM, Gijselbrecht L, Nimmegeers J, Almquist KF, Broddelez CClinical and experimental rheumatologyThe synthesis and immobilisation of cartilage-specific proteoglycan by human chondrocytes in different concentrations of agarose. Clin Exp Rheumatol. 1990 Jul-Aug; 8(4):371-8.Clin Exp Rheumatol1990-07-01T00:00:001990The synthesis and immobilisation of cartilage-specific proteoglycan by human chondrocytes in different concentrations of agarose.28967366Malfait AMClinical and experimental rheumatologyWhy we should study pain in animal models of rheumatic diseases. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):37-39.Clin Exp Rheumatol2017-09-28T00:00:002017Why we should study pain in animal models of rheumatic diseases.28967370Miller RE, Malfait AM, Block JAClinical and experimental rheumatologyCurrent status of nerve growth factor antibodies for the treatment of osteoarthritis pain. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):85-87.Clin Exp Rheumatol2017-09-28T00:00:002017Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain.28967375Malfait AM, Pincus TClinical and experimental rheumatologyPain in rheumatic diseases. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):1.Clin Exp Rheumatol2017-09-28T00:00:002017Pain in rheumatic diseases.28992367Miller RE, Kim YS, Tran PB, Ishihara S, Dong X, Miller RJ, Malfait AMArthritis & rheumatology (Hoboken, N.J.)Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging. Arthritis Rheumatol. 2018 01; 70(1):88-97.Arthritis Rheumatol2017-12-01T00:00:002017Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging.true1Associate ProfessorAssociate ProfessorAuthorship 465819Authorship 4696210Authorship 4839910Authorship 4825311Authorship 4734118Authorship 481279Authorship 473928Authorship 464555Authorship 47779837061736Wang L, Ishihara S, Li J, Miller RE, Malfait AMArthritis research & therapyNotch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain. Arthritis Res Ther. 2023 04 15; 25(1):63.Arthritis Res Ther2023-04-15T00:00:002023Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.37380025Colman M, Syx D, De Wandele I, Rombaut L, Wille D, Malfait Z, Meeus M, Malfait AM, Van Oosterwijck J, Malfait FThe journal of painSensory Profiling in Classical Ehlers-Danlos Syndrome: A Case-Control Study Revealing Pain Characteristics, Somatosensory Changes, and Impaired Pain Modulation. J Pain. 2023 11; 24(11):2063-2078.J Pain2023-06-26T00:00:002023Sensory Profiling in Classical Ehlers-Danlos Syndrome: A Case-Control Study Revealing Pain Characteristics, Somatosensory Changes, and Impaired Pain Modulation.37904981Obeidat AM, Kim SY, Burt KG, Hu B, Li J, Ishihara S, Xiao R, Miller RE, Little C, Malfait AM, Scanzello CRbioRxiv : the preprint server for biologyRecommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis. bioRxiv. 2023 Oct 18.bioRxiv2023-10-18T00:00:002023Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis.36865307Colman M, Syx D, de Wandele I, Rombaut L, Wilie D, Malfait Z, Meeus M, Malfait AM, Van Oosterwijck J, Malfait FmedRxiv : the preprint server for health sciencesSensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation. medRxiv. 2023 Feb 26.medRxiv2023-02-26T00:00:002023Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation.37662384Bai Z, Bartelo N, Aslam M, Hale C, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese E, Smith MHmedRxiv : the preprint server for health sciencesMachine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid Arthritis. medRxiv. 2023 Aug 23.medRxiv2023-08-23T00:00:002023Machine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid Arthritis.37664243Vroman R, Hunter RS, Wood MJ, Davis OC, Malfait Z, George DS, Ren D, Tavares-Ferreira D, Price TJ, Miller RJ, Malfait AM, Malfait F, Miller RE, Syx DFrontiers in molecular neuroscienceAnalysis of matrisome expression patterns in murine and human dorsal root ganglia. Front Mol Neurosci. 2023; 16:1232447.Front Mol Neurosci2023-08-17T00:00:002023Analysis of matrisome expression patterns in murine and human dorsal root ganglia.37716404Bergman RF, Lammlin L, Junginger L, Farrell E, Goldman S, Darcy R, Rasner C, Obeidat AM, Malfait AM, Miller RE, Maerz TOsteoarthritis and cartilageSexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury. Osteoarthritis Cartilage. 2023 Sep 15.Osteoarthritis Cartilage2023-09-15T00:00:002023Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury.37096632Geraghty T, Obeidat AM, Ishihara S, Wood MJ, Li J, Lopes EBP, Scanzello CR, Griffin TM, Malfait AM, Miller REArthritis & rheumatology (Hoboken, N.J.)Age-Associated Changes in Knee Osteoarthritis, Pain-Related Behaviors, and Dorsal Root Ganglia Immunophenotyping of Male and Female Mice. Arthritis Rheumatol. 2023 10; 75(10):1770-1780.Arthritis Rheumatol2023-07-14T00:00:002023Age-Associated Changes in Knee Osteoarthritis, Pain-Related Behaviors, and Dorsal Root Ganglia Immunophenotyping of Male and Female Mice.37120427Obeidat AM, Wood MJ, Adamczyk NS, Ishihara S, Li J, Wang L, Ren D, Bennett DA, Miller RJ, Malfait AM, Miller RENature communicationsPiezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. Nat Commun. 2023 04 29; 14(1):2479.Nat Commun2023-04-29T00:00:002023Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.29361112Miller RE, Block JA, Malfait AMRheumatology (Oxford, England)What is new in pain modification in osteoarthritis? Rheumatology (Oxford). 2018 05 01; 57(suppl_4):iv99-iv107.Rheumatology (Oxford)2018-05-01T00:00:002018What is new in pain modification in osteoarthritis?Authorship 301553Authorship 30726429480410Syx D, Tran PB, Miller RE, Malfait AMCurrent rheumatology reportsPeripheral Mechanisms Contributing to Osteoarthritis Pain. Curr Rheumatol Rep. 2018 02 26; 20(2):9.Curr Rheumatol Rep2018-02-26T00:00:002018Peripheral Mechanisms Contributing to Osteoarthritis Pain.Authorship 48848738147415George DS, Jayaraj ND, Pacifico P, Ren D, Sriram N, Miller RE, Malfait AM, Miller RJ, Menichella DMPainThe Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy. Pain. 2023 Dec 22.Pain2023-12-22T00:00:002023The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.Authorship 31530829563338Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AMJCI insightAn aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6).JCI Insight2018-03-22T00:00:002018An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.D010146Disorders963910.764869PainD010003Disorders623630.707797Osteoarthritis