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This is a "connection" page, showing publications co-authored by Joshua Jacobs and Nadim Hallab.
Joshua Jacobs
Connection Strength
8.540
Nadim Hallab
  1. Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris. Front Endocrinol (Lausanne). 2017; 8:5.
    View in: PubMed
    Score: 0.607
  2. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res. 2013 Feb; 31(2):173-82.
    View in: PubMed
    Score: 0.448
  3. In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation. J Biomed Mater Res A. 2010 Feb; 92(2):667-82.
    View in: PubMed
    Score: 0.374
  4. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009; 67(2):182-8.
    View in: PubMed
    Score: 0.347
  5. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res. 2008 Feb 13; 3:6.
    View in: PubMed
    Score: 0.327
  6. Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity? J Bone Joint Surg Am. 2006 Jun; 88(6):1171-2.
    View in: PubMed
    Score: 0.290
  7. Effects of soluble metals on human peri-implant cells. J Biomed Mater Res A. 2005 Jul 01; 74(1):124-40.
    View in: PubMed
    Score: 0.272
  8. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res. 2005 Mar; 23(2):384-91.
    View in: PubMed
    Score: 0.266
  9. Immune responses correlate with serum-metal in metal-on-metal hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):88-93.
    View in: PubMed
    Score: 0.262
  10. Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements. J Orthop Res. 2004 Mar; 22(2):250-9.
    View in: PubMed
    Score: 0.248
  11. Establishing clinically meaningful ranges of metal hypersensitivity in orthopaedic patients using COVID-19 vaccine-induced adaptive immune responses from fully vaccinated adults. J Orthop. 2024 Feb; 48:89-95.
    View in: PubMed
    Score: 0.244
  12. Spinal implant debris-induced osteolysis. Spine (Phila Pa 1976). 2003 Oct 15; 28(20):S125-38.
    View in: PubMed
    Score: 0.242
  13. Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation. J Biomed Mater Res A. 2003 Jun 01; 65(3):311-8.
    View in: PubMed
    Score: 0.236
  14. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002 Jun 05; 60(3):420-33.
    View in: PubMed
    Score: 0.220
  15. Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation. J Biomed Mater Res. 2001 Sep 05; 56(3):427-36.
    View in: PubMed
    Score: 0.209
  16. COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively. J Orthop Surg Res. 2021 Jun 30; 16(1):415.
    View in: PubMed
    Score: 0.206
  17. Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner. PLoS One. 2021; 16(5):e0251885.
    View in: PubMed
    Score: 0.205
  18. Metal sensitivity in patients with orthopaedic implants. J Bone Joint Surg Am. 2001 Mar; 83(3):428-36.
    View in: PubMed
    Score: 0.202
  19. Evaluation of metallic and polymeric biomaterial surface energy and surface roughness characteristics for directed cell adhesion. Tissue Eng. 2001 Feb; 7(1):55-71.
    View in: PubMed
    Score: 0.201
  20. A triple assay technique for the evaluation of metal-induced, delayed-type hypersensitivity responses in patients with or receiving total joint arthroplasty. J Biomed Mater Res. 2000 Sep; 53(5):480-9.
    View in: PubMed
    Score: 0.195
  21. Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity? Clin Orthop Relat Res. 2020 04; 478(4):752-766.
    View in: PubMed
    Score: 0.189
  22. Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336.
    View in: PubMed
    Score: 0.174
  23. CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model. Open Orthop J. 2018; 12:115-124.
    View in: PubMed
    Score: 0.165
  24. Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences. J Bone Joint Surg Am. 2017 Apr 19; 99(8):621-628.
    View in: PubMed
    Score: 0.154
  25. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation. PLoS One. 2016; 11(7):e0160141.
    View in: PubMed
    Score: 0.147
  26. TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles. J Orthop Res. 2017 05; 35(5):1007-1017.
    View in: PubMed
    Score: 0.147
  27. The pathology of orthopedic implant failure is mediated by innate immune system cytokines. Mediators Inflamm. 2014; 2014:185150.
    View in: PubMed
    Score: 0.126
  28. Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences. J Long Term Eff Med Implants. 2014; 24(1):77-88.
    View in: PubMed
    Score: 0.123
  29. Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2013 Oct; 42(10):E84-7.
    View in: PubMed
    Score: 0.121
  30. Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42.
    View in: PubMed
    Score: 0.118
  31. Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure. PLoS One. 2013; 8(6):e67127.
    View in: PubMed
    Score: 0.118
  32. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am. 2013 Mar 20; 95(6):512-8.
    View in: PubMed
    Score: 0.116
  33. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Orthopedics. 2012 May; 35(5):386-91.
    View in: PubMed
    Score: 0.109
  34. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res A. 2010 Jun 15; 93(4):1312-21.
    View in: PubMed
    Score: 0.096
  35. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54.
    View in: PubMed
    Score: 0.090
  36. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009 Feb; 17(2):69-76.
    View in: PubMed
    Score: 0.087
  37. Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+. J Biomed Mater Res A. 2008 Sep 15; 86(4):905-13.
    View in: PubMed
    Score: 0.085
  38. Wear particles. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:99-102.
    View in: PubMed
    Score: 0.072
  39. The biology of alternative bearing surfaces in total joint arthroplasty. Instr Course Lect. 2005; 54:481-93.
    View in: PubMed
    Score: 0.066
  40. Can metal levels be used to monitor metal-on-metal hip arthroplasties? J Arthroplasty. 2004 Dec; 19(8 Suppl 3):59-65.
    View in: PubMed
    Score: 0.065
  41. Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res. 2003 Dec; (417):139-47.
    View in: PubMed
    Score: 0.061
  42. The potential role of the osteoblast in the development of periprosthetic osteolysis: review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth factors. J Arthroplasty. 2001 Dec; 16(8 Suppl 1):95-100.
    View in: PubMed
    Score: 0.053
  43. Osteolysis: basic science. Clin Orthop Relat Res. 2001 Dec; (393):71-7.
    View in: PubMed
    Score: 0.053
  44. Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels - An in-vitro study. J Mech Behav Biomed Mater. 2021 06; 118:104443.
    View in: PubMed
    Score: 0.051
  45. Hypersensitivity to metallic biomaterials: a review of leukocyte migration inhibition assays. Biomaterials. 2000 Jul; 21(13):1301-14.
    View in: PubMed
    Score: 0.048
  46. Systemic metal-protein binding associated with total joint replacement arthroplasty. J Biomed Mater Res. 2000 Mar 05; 49(3):353-61.
    View in: PubMed
    Score: 0.047
  47. Metal release and excretion from cementless titanium alloy total knee replacements. Clin Orthop Relat Res. 1999 Jan; (358):173-80.
    View in: PubMed
    Score: 0.043
  48. Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study. J Bone Joint Surg Am. 1998 Oct; 80(10):1447-58.
    View in: PubMed
    Score: 0.043
  49. In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH. Med Eng Phys. 2018 02; 52:1-9.
    View in: PubMed
    Score: 0.040
  50. Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation. J Mech Behav Biomed Mater. 2016 09; 62:570-587.
    View in: PubMed
    Score: 0.036
  51. Fretting-corrosion in Hip Implant Modular Junctions: New Experimental Set-up and Initial Outcome. Tribol Int. 2015 Nov 01; 91:235-245.
    View in: PubMed
    Score: 0.035
  52. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010 Aug; 468(8):2017-23.
    View in: PubMed
    Score: 0.024
  53. Stem diameter and rotational stability in revision total hip arthroplasty: a biomechanical analysis. J Orthop Surg Res. 2006 Oct 02; 1:5.
    View in: PubMed
    Score: 0.019
  54. The combination of pamidronate and calcitriol reverses particle- and TNF-alpha-induced altered functions of bone-marrow-derived stromal cells with osteoblastic phenotype. J Bone Joint Surg Br. 2004 Jul; 86(5):759-70.
    View in: PubMed
    Score: 0.016
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.