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Vineet Gupta

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Nephrology
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-0102
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    Collapse Overview 
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    Other Appointments:
    Vice Chair for Research and Innovation
    Director, Drug Discovery Center

    My ORCID is 0000-0001-6987-2550.
    My Scopus ID is 14064902400.
    My NIH COMMONS name is GUPTAV.

    Education:
    PhD, University of Rochester

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Williams MD, Gupta V, Chan EY, Olaitan O. Perspectives on Donor-Derived Cell-Free DNA in Kidney Transplant Recipients with Systemic Lupus Erythematosus. Prog Transplant. 2023 06; 33(2):182-183. PMID: 36974516.
      Citations:    
    2. Pandey S, Gupta VK, Lavania SP. Role of epigenetics in pancreatic ductal adenocarcinoma. Epigenomics. 2023 01; 15(2):89-110. PMID: 36647796.
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    3. Li X, Venkatesh I, Villanueva V, Wei H, Geraghty T, Rajagopalan A, Helmuth RW, Altintas MM, Faridi HM, Gupta V. Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease. Front Med (Lausanne). 2022; 9:897188. PMID: 36059820.
      Citations:    
    4. Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, Reiser J, Sever S. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022 05 03; 13(1):2422. PMID: 35504916.
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    5. Modi S, Giri B, Gupta VK, Lavania S, Sethi V, Sharma NS, Pandey S, Vickers S, Dudeja V, Saluja AK. Minnelide synergizes with conventional chemotherapy by targeting both cancer and associated stroma components in pancreatic cancer. Cancer Lett. 2022 07 01; 537:215591. PMID: 35398530.
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    6. Villanueva V, Li X, Jimenez V, Faridi HM, Gupta V. CD11b agonists offer a novel approach for treating lupus nephritis. Transl Res. 2022 07; 245:41-54. PMID: 35288363.
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    7. Kesh K, Mendez R, Mateo-Victoriano B, Garrido VT, Durden B, Gupta VK, Oliveras Reyes A, Merchant N, Datta J, Banerjee S, Banerjee S. Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC. Gut Microbes. 2022 Jan-Dec; 14(1):2096328. PMID: 35816618.
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    8. Lavania S, Gupta VK, Saluja A. The Rise of Aptamers: Promising Avenues in the Treatment of Solid Tumors. Gastroenterology. 2021 09; 161(3):804-806. PMID: 34174244.
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    9. Rajagopalan A, Venkatesh I, Aslam R, Kirchenbuechler D, Khanna S, Cimbaluk D, Kordower JH, Gupta V. SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues. Cell Rep Methods. 2021 06 21; 1(2). PMID: 34766102.
      Citations:    
    10. Gupta VK, Sharma NS, Durden B, Garrido VT, Kesh K, Edwards D, Wang D, Myer C, Mateo-Victoriano B, Kollala SS, Ban Y, Gao Z, Bhattacharya SK, Saluja A, Singh PK, Banerjee S. Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer. Cancer Res. 2021 08 01; 81(15):4001-4013. PMID: 33990397.
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    11. Reddy SN, Nair NP, Tate JE, Thiyagarajan V, Giri S, Praharaj I, Mohan VR, Babji S, Gupte MD, Arora R, Bidari S, Senthamizh S, Mekala S, Goru KB, Reddy B, Pamu P, Gorthi RP, Badur M, Mohan V, Sathpathy S, Mohanty H, Dash M, Mohakud NK, Ray RK, Mohanty P, Gathwala G, Chawla S, Gupta M, Gupta R, Goyal S, Sharma P, Mathew MA, Jacob TJK, Sundaram B, Purushothaman GKC, Dorairaj P, Jagannatham M, Murugiah K, Boopathy H, Maniam R, Gurusamy R, Kumaravel S, Shenoy A, Jain H, Goswami JK, Wakhlu A, Gupta V, Vinayagamurthy G, Parashar UD, Kang G. Intussusception after Rotavirus Vaccine Introduction in India. N Engl J Med. 2020 11 12; 383(20):1932-1940. PMID: 33176083.
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    12. Kesh K, Garrido VT, Dosch A, Durden B, Gupta VK, Sharma NS, Lyle M, Nagathihalli N, Merchant N, Saluja A, Banerjee S. Stroma secreted IL6 selects for "stem-like" population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways. Cell Death Dis. 2020 11 11; 11(11):967. PMID: 33177492.
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    13. Kesh K, Gupta VK, Durden B, Garrido V, Mateo-Victoriano B, Lavania SP, Banerjee S. Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded. Cancers (Basel). 2020 Oct 21; 12(10). PMID: 33096662.
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    14. Gupta VK, Banerjee S, Saluja AK. Learning From Gender Disparity: Role of Estrogen Receptor Activation in Coping With Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2020; 10(4):862-863. PMID: 32798451.
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    15. Geraghty T, Rajagopalan A, Aslam R, Pohlman A, Venkatesh I, Zloza A, Cimbaluk D, DeNardo DG, Gupta V. Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer. Front Oncol. 2020; 10:748. PMID: 32528880.
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    16. Sharma NS, Gupta VK, Garrido VT, Hadad R, Durden BC, Kesh K, Giri B, Ferrantella A, Dudeja V, Saluja A, Banerjee S. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2020 01 02; 130(1):451-465. PMID: 31613799.
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    17. Sharma K, Singh U, Rai M, Shukla J, Gupta V, Narayan G, Kumar S. Interleukin 6 and disease transformation in chronic myeloid leukemia: A Northeast Indian population study. J Cancer Res Ther. 2020 Jan-Mar; 16(1):30-33. PMID: 32362606.
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    18. Sharma NS, Gnamlin P, Durden B, Gupta VK, Kesh K, Garrido VT, Dudeja V, Saluja A, Banerjee S. Long non-coding RNA GAS5 acts as proliferation "brakes" in CD133+ cells responsible for tumor recurrence. Oncogenesis. 2019 Nov 18; 8(12):68. PMID: 31740660.
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    19. Giri B, Gupta VK, Yaffe B, Modi S, Roy P, Sethi V, Lavania SP, Vickers SM, Dudeja V, Banerjee S, Watts J, Saluja A. Correction to: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. J Transl Med. 2019 Sep 04; 17(1):301. PMID: 31484534.
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    20. Sharma NS, Gupta VK, Dauer P, Kesh K, Hadad R, Giri B, Chandra A, Dudeja V, Slawson C, Banerjee S, Vickers SM, Saluja A, Banerjee S. O-GlcNAc modification of Sox2 regulates self-renewal in pancreatic cancer by promoting its stability. Theranostics. 2019; 9(12):3410-3424. PMID: 31281487.
      Citations:    
    21. Giri B, Gupta VK, Yaffe B, Modi S, Roy P, Sethi V, Lavania SP, Vickers SM, Dudeja V, Banerjee S, Watts J, Saluja A. Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. J Transl Med. 2019 05 20; 17(1):163. PMID: 31109340.
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    22. Dauer P, Sharma NS, Gupta VK, Durden B, Hadad R, Banerjee S, Dudeja V, Saluja A, Banerjee S. ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness". Cell Death Dis. 2019 02 12; 10(2):132. PMID: 30755605.
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    23. Kaminski A, Gupta KH, Goldufsky JW, Lee HW, Gupta V, Shafikhani SH. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018 09 19; 8(1):14047. PMID: 30232373.
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    24. Dauer P, Sharma NS, Gupta VK, Nomura A, Dudeja V, Saluja A, Banerjee S. GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells. Mol Oncol. 2018 09; 12(9):1498-1512. PMID: 29738634.
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    25. Dauer P, Zhao X, Gupta VK, Sharma N, Kesh K, Gnamlin P, Dudeja V, Vickers SM, Banerjee S, Saluja A. Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression. Cancer Res. 2018 03 01; 78(5):1321-1333. PMID: 29259015.
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    26. Lee HW, Arif E, Altintas MM, Quick K, Maheshwari S, Plezia A, Mahmood A, Reiser J, Nihalani D, Gupta V. High-content screening assay-based discovery of paullones as novel podocyte-protective agents. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F280-F292. PMID: 29046299.
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    27. Nomura A, Gupta VK, Dauer P, Sharma NS, Dudeja V, Merchant N, Saluja AK, Banerjee S. NF?B-Mediated Invasiveness in CD133+ Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling. Mol Cancer Res. 2018 01; 16(1):162-172. PMID: 28970361.
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    28. McGinn O, Gupta VK, Dauer P, Arora N, Sharma N, Nomura A, Dudeja V, Saluja A, Banerjee S. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer. Sci Rep. 2017 08 11; 7(1):7872. PMID: 28801636.
      Citations:    
    29. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. A tripartite complex of suPAR, APOL1 risk variants and av?3 integrin on podocytes mediates chronic kidney disease. Nat Med. 2017 Aug; 23(8):945-953. PMID: 28650456.
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    30. Dauer P, Gupta VK, McGinn O, Nomura A, Sharma NS, Arora N, Giri B, Dudeja V, Saluja AK, Banerjee S. Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer. Sci Rep. 2017 05 08; 7(1):1564. PMID: 28484232.
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    31. Reiser J, Lee HW, Gupta V, Altintas MM. A High-Content Screening Technology for Quantitatively Studying Podocyte Dynamics. Adv Chronic Kidney Dis. 2017 05; 24(3):183-188. PMID: 28501082.
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    32. Gupta VK, Banerjee S. Isolation of Lipid Raft Proteins from CD133+ Cancer Stem Cells. Methods Mol Biol. 2017; 1609:25-31. PMID: 28660570.
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    33. Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106. PMID: 27941791.
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    34. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem. 2017 Jan 13; 292(2):732-747. PMID: 27913625.
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    35. Johnson CM, O'Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi MH, LeFort CT, Gupta V, Kim M, Reichner JS. Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal ?-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response. J Immunol. 2017 01 01; 198(1):318-334. PMID: 27852744.
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    36. Gupta V, Reiser J. Stop that podocyte! Am J Physiol Renal Physiol. 2017 02 01; 312(2):F373-F374. PMID: 27760773.
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    37. Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. J Am Soc Nephrol. 2017 02; 28(2):446-451. PMID: 27432739.
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    38. Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, Wu S. Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats. Am J Respir Cell Mol Biol. 2015 Dec; 53(6):793-801. PMID: 25909334.
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    39. Gupta V, Kerry VB, Goosby E, Yates R. Politics and Universal Health Coverage--The Post-2015 Global Health Agenda. N Engl J Med. 2015 Sep 24; 373(13):1189-92. PMID: 26376044.
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    40. Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J Am Soc Nephrol. 2015 Nov; 26(11):2741-52. PMID: 25858967.
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    41. Khan SQ, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A, Gupta V. A Small Molecule ?2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy. Front Med (Lausanne). 2014; 1:45. PMID: 25593918.
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    42. Gupta V, Reiser J. MicroRNAs: a macroview into focal segmental glomerulosclerosis. Am J Kidney Dis. 2015 Feb; 65(2):206-8. PMID: 25616630.
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    43. Casc?o R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF. Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis. Mediators Inflamm. 2014; 2014:195327. PMID: 24623960.
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    44. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23. PMID: 24206430.
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    45. Mills RW, McCrudden K, Gupta VK, Britton A, Al Qahtani M, Hasan RA. Intussusception caused by heterotopic pancreatic tissue in a child. Fetal Pediatr Pathol. 2011; 30(2):106-10. PMID: 21391750.
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    46. Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, Salem SM, Singhal M, Stoub D, Krastins B, Ogihara M, Zaki MJ, Gupta V. Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling. PLoS One. 2009 Oct 27; 4(10):e7627. PMID: 19859549.
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    47. Gupta V, Alonso JL, Sugimori T, Essafi M, Issafi M, Xiong JP, Arnaout MA. Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol. 2008 Feb 01; 180(3):1713-8. PMID: 18209068.
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    48. Wei C, M?ller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008 Jan; 14(1):55-63. PMID: 18084301.
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    49. Park JY, Arnaout MA, Gupta V. A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. 2007 Apr; 12(3):406-17. PMID: 17438069.
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    50. Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA. The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20. PMID: 17170130.
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    51. Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: an evidence-based review. Pediatr Crit Care Med. 2005 Mar; 6(2):204-11. PMID: 15730610.
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