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David Bennett to Genetic Predisposition to Disease

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This is a "connection" page, showing publications David Bennett has written about Genetic Predisposition to Disease.
David Bennett
Connection Strength
9.780
Genetic Predisposition to Disease
  1. Deconstructing and targeting the genomic architecture of human neurodegeneration. Nat Neurosci. 2018 10; 21(10):1310-1317.
    View in: PubMed
    Score: 0.528
  2. APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PLoS One. 2017; 12(7):e0180356.
    View in: PubMed
    Score: 0.485
  3. Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline. Alzheimers Dement. 2017 Dec; 13(12):1380-1388.
    View in: PubMed
    Score: 0.483
  4. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol. 2013 Sep 01; 70(9):1150-7.
    View in: PubMed
    Score: 0.372
  5. An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome. JAMA Neurol. 2013 Jun; 70(6):719-26.
    View in: PubMed
    Score: 0.365
  6. High CRP with "normal" cognition: a resilient phenotype in old age. Neurology. 2012 Sep 11; 79(11):1078-9.
    View in: PubMed
    Score: 0.346
  7. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. 2010; 34(1):43-9.
    View in: PubMed
    Score: 0.285
  8. Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology. 2009 Apr 28; 72(17):1495-503.
    View in: PubMed
    Score: 0.275
  9. The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke. 2005 May; 36(5):954-9.
    View in: PubMed
    Score: 0.207
  10. Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants. PLoS Genet. 2021 11; 17(11):e1009918.
    View in: PubMed
    Score: 0.164
  11. Brain proteome-wide association study implicates novel proteins in depression pathogenesis. Nat Neurosci. 2021 06; 24(6):810-817.
    View in: PubMed
    Score: 0.157
  12. PLD3 is a neuronal lysosomal phospholipase D associated with ?-amyloid plaques and cognitive function in Alzheimer's disease. PLoS Genet. 2021 04; 17(4):e1009406.
    View in: PubMed
    Score: 0.157
  13. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021 01 28; 12(1):654.
    View in: PubMed
    Score: 0.155
  14. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113.
    View in: PubMed
    Score: 0.154
  15. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667.
    View in: PubMed
    Score: 0.145
  16. APOE e4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. Neurobiol Aging. 2020 03; 87:18-25.
    View in: PubMed
    Score: 0.143
  17. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):327-330.
    View in: PubMed
    Score: 0.142
  18. Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019 09 01; 142(9):2581-2589.
    View in: PubMed
    Score: 0.141
  19. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell. 2019 08; 18(4):e12964.
    View in: PubMed
    Score: 0.138
  20. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430.
    View in: PubMed
    Score: 0.136
  21. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226.
    View in: PubMed
    Score: 0.133
  22. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement. 2019 02; 15(2):258-266.
    View in: PubMed
    Score: 0.132
  23. APOE e2e4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults. Neurology. 2018 06 12; 90(24):e2127-e2134.
    View in: PubMed
    Score: 0.129
  24. A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease. Genetics. 2018 05; 209(1):51-64.
    View in: PubMed
    Score: 0.127
  25. A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants. Sci Transl Med. 2017 Dec 20; 9(421).
    View in: PubMed
    Score: 0.125
  26. Genetic influence of plasma homocysteine on Alzheimer's disease. Neurobiol Aging. 2018 02; 62:243.e7-243.e14.
    View in: PubMed
    Score: 0.124
  27. Polygenic risk scores in familial Alzheimer disease. Neurology. 2017 Mar 21; 88(12):1180-1186.
    View in: PubMed
    Score: 0.118
  28. TOMM40'523 variant and cognitive decline in older persons with APOE e3/3 genotype. Neurology. 2017 Feb 14; 88(7):661-668.
    View in: PubMed
    Score: 0.117
  29. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2017 09 01; 82(5):322-329.
    View in: PubMed
    Score: 0.117
  30. Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. Mol Neurobiol. 2017 Dec; 54(10):8021-8032.
    View in: PubMed
    Score: 0.116
  31. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 12; 19(12):1569-1582.
    View in: PubMed
    Score: 0.115
  32. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016 11; 19(11):1442-1453.
    View in: PubMed
    Score: 0.115
  33. The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism. Acta Neuropathol. 2016 10; 132(4):503-14.
    View in: PubMed
    Score: 0.114
  34. The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults. PLoS One. 2016; 11(7):e0157452.
    View in: PubMed
    Score: 0.114
  35. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 2016 Feb 01; 7:10495.
    View in: PubMed
    Score: 0.110
  36. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 2015 Oct; 11(10):e1005378.
    View in: PubMed
    Score: 0.107
  37. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci. 2015 Nov; 18(11):1556-8.
    View in: PubMed
    Score: 0.107
  38. Genetic variants associated with susceptibility to psychosis in?late-onset Alzheimer's disease families. Neurobiol Aging. 2015 Nov; 36(11):3116.e9-3116.e16.
    View in: PubMed
    Score: 0.106
  39. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement. 2016 Mar; 12(3):233-43.
    View in: PubMed
    Score: 0.105
  40. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015 Feb; 20(2):183-92.
    View in: PubMed
    Score: 0.103
  41. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.
    View in: PubMed
    Score: 0.101
  42. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimers Dement. 2014 Nov; 10(6):609-618.e11.
    View in: PubMed
    Score: 0.099
  43. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014 Sep; 17(9):1156-63.
    View in: PubMed
    Score: 0.099
  44. Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol. 2014 Apr; 71(4):429-35.
    View in: PubMed
    Score: 0.097
  45. The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan. Mol Psychiatry. 2014 Oct; 19(10):1125-32.
    View in: PubMed
    Score: 0.094
  46. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec; 45(12):1452-8.
    View in: PubMed
    Score: 0.094
  47. Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. Cerebrovasc Dis. 2013; 36(3):181-188.
    View in: PubMed
    Score: 0.094
  48. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013 Apr 01; 73(7):667-78.
    View in: PubMed
    Score: 0.089
  49. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 2012 May 08; 78(19):1464-71.
    View in: PubMed
    Score: 0.085
  50. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet. 2011 Feb; 7(2):e1001308.
    View in: PubMed
    Score: 0.078
  51. Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study. J Alzheimers Dis. 2011; 23(2):249-55.
    View in: PubMed
    Score: 0.077
  52. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet. 2010 Aug 15; 19(16):3295-301.
    View in: PubMed
    Score: 0.074
  53. Is there a link between cancer and Alzheimer disease? Neurology. 2010 Jan 12; 74(2):100-1.
    View in: PubMed
    Score: 0.072
  54. Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons. Alzheimer Dis Assoc Disord. 2009 Jan-Mar; 23(1):63-9.
    View in: PubMed
    Score: 0.067
  55. Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease. Neurosci Lett. 2005 Jun 10-17; 381(1-2):36-41.
    View in: PubMed
    Score: 0.051
  56. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. 2003 Feb; 60(2):185-9.
    View in: PubMed
    Score: 0.045
  57. Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology. 2003 Jan 28; 60(2):246-52.
    View in: PubMed
    Score: 0.045
  58. The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms. Neurobiol Dis. 2023 01; 176:105938.
    View in: PubMed
    Score: 0.044
  59. Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease. Hum Mol Genet. 2022 09 29; 31(19):3355-3366.
    View in: PubMed
    Score: 0.044
  60. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 07 29; 145(7):2541-2554.
    View in: PubMed
    Score: 0.043
  61. Adherence to MIND Diet, Genetic Susceptibility, and Incident Dementia in Three US Cohorts. Nutrients. 2022 Jul 03; 14(13).
    View in: PubMed
    Score: 0.043
  62. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021 12; 600(7890):675-679.
    View in: PubMed
    Score: 0.041
  63. Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation. Hum Genet. 2022 Jan; 141(1):127-146.
    View in: PubMed
    Score: 0.041
  64. Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia. PLoS Genet. 2021 04; 17(4):e1009482.
    View in: PubMed
    Score: 0.039
  65. Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction. Alzheimers Res Ther. 2021 03 04; 13(1):55.
    View in: PubMed
    Score: 0.039
  66. Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. Transl Psychiatry. 2021 02 26; 11(1):146.
    View in: PubMed
    Score: 0.039
  67. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet. 2021 03; 53(3):294-303.
    View in: PubMed
    Score: 0.039
  68. EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE e4 ON ALZHEIMER'S DISEASE RISK IN HUMANS. Alzheimers Dement. 2020 12; 16(Suppl 2).
    View in: PubMed
    Score: 0.038
  69. DNA methylation variability in Alzheimer's disease. Neurobiol Aging. 2019 04; 76:35-44.
    View in: PubMed
    Score: 0.034
  70. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nat Genet. 2018 11; 50(11):1584-1592.
    View in: PubMed
    Score: 0.033
  71. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018 05 29; 9(1):2098.
    View in: PubMed
    Score: 0.032
  72. Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement. 2018 12; 14(12):1580-1588.
    View in: PubMed
    Score: 0.032
  73. An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome. Nat Neurosci. 2017 Oct; 20(10):1418-1426.
    View in: PubMed
    Score: 0.031
  74. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384.
    View in: PubMed
    Score: 0.030
  75. Genetic epistasis regulates amyloid deposition in resilient aging. Alzheimers Dement. 2017 Oct; 13(10):1107-1116.
    View in: PubMed
    Score: 0.030
  76. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.
    View in: PubMed
    Score: 0.029
  77. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624.
    View in: PubMed
    Score: 0.029
  78. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimers Dement. 2017 Jun; 13(6):663-673.
    View in: PubMed
    Score: 0.029
  79. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2017 02; 13(2):119-129.
    View in: PubMed
    Score: 0.029
  80. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016 06 18; 53(3):921-32.
    View in: PubMed
    Score: 0.028
  81. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet. 2014 Sep; 10(9):e1004606.
    View in: PubMed
    Score: 0.025
  82. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). JAMA Neurol. 2014 Mar; 71(3):315-23.
    View in: PubMed
    Score: 0.024
  83. CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility. Hum Mol Genet. 2014 May 15; 23(10):2729-36.
    View in: PubMed
    Score: 0.024
  84. Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):770-8.
    View in: PubMed
    Score: 0.023
  85. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10; 309(14):1483-92.
    View in: PubMed
    Score: 0.023
  86. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8.
    View in: PubMed
    Score: 0.021
  87. Alzheimer disease susceptibility loci: evidence for a protein network under natural selection. Am J Hum Genet. 2012 Apr 06; 90(4):720-6.
    View in: PubMed
    Score: 0.021
  88. A genome-wide association study of aging. Neurobiol Aging. 2011 Nov; 32(11):2109.e15-28.
    View in: PubMed
    Score: 0.020
  89. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.
    View in: PubMed
    Score: 0.020
  90. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann Neurol. 2011 Mar; 69(3):560-9.
    View in: PubMed
    Score: 0.020
  91. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet. 2011 Feb 11; 88(2):232-8.
    View in: PubMed
    Score: 0.019
  92. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One. 2010 Jun 21; 5(6):e11244.
    View in: PubMed
    Score: 0.019
  93. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9.
    View in: PubMed
    Score: 0.018
  94. Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease. Neurobiol Aging. 2008 May; 29(5):793-4.
    View in: PubMed
    Score: 0.015
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.