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David Bennett to Genome-Wide Association Study

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This is a "connection" page, showing publications David Bennett has written about Genome-Wide Association Study.
David Bennett
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7.576
Genome-Wide Association Study
  1. Dissecting the human leptomeninges at single-cell resolution. Nat Commun. 2023 11 03; 14(1):7036.
    View in: PubMed
    Score: 0.203
  2. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021 12; 600(7890):675-679.
    View in: PubMed
    Score: 0.178
  3. Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants. PLoS Genet. 2021 11; 17(11):e1009918.
    View in: PubMed
    Score: 0.178
  4. Brain proteome-wide association study implicates novel proteins in depression pathogenesis. Nat Neurosci. 2021 06; 24(6):810-817.
    View in: PubMed
    Score: 0.170
  5. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet. 2021 03; 53(3):294-303.
    View in: PubMed
    Score: 0.168
  6. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021 01 28; 12(1):654.
    View in: PubMed
    Score: 0.168
  7. Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218. Transl Psychiatry. 2020 08 24; 10(1):297.
    View in: PubMed
    Score: 0.163
  8. Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease. Neurobiol Aging. 2020 09; 93:61-68.
    View in: PubMed
    Score: 0.159
  9. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019 11; 51(11):1624-1636.
    View in: PubMed
    Score: 0.154
  10. Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults. Transl Psychiatry. 2019 10 03; 9(1):241.
    View in: PubMed
    Score: 0.153
  11. Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019 09 01; 142(9):2581-2589.
    View in: PubMed
    Score: 0.152
  12. Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med. 2018 04; 80(3):242-251.
    View in: PubMed
    Score: 0.138
  13. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 07 19; 8(1):80.
    View in: PubMed
    Score: 0.131
  14. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.
    View in: PubMed
    Score: 0.127
  15. Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Mol Psychiatry. 2017 07; 22(7):1069-1078.
    View in: PubMed
    Score: 0.125
  16. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 12; 19(12):1569-1582.
    View in: PubMed
    Score: 0.124
  17. Relation of genomic variants for Alzheimer disease dementia to common neuropathologies. Neurology. 2016 Aug 02; 87(5):489-96.
    View in: PubMed
    Score: 0.122
  18. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 10; 15(5):792-800.
    View in: PubMed
    Score: 0.122
  19. Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 2016 05 26; 533(7604):539-42.
    View in: PubMed
    Score: 0.121
  20. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016 06; 48(6):624-33.
    View in: PubMed
    Score: 0.121
  21. Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology. Alzheimers Dement. 2016 09; 12(9):942-951.
    View in: PubMed
    Score: 0.120
  22. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 2015 Oct; 11(10):e1005378.
    View in: PubMed
    Score: 0.116
  23. Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies. Int J Biochem Cell Biol. 2015 Oct; 67:58-64.
    View in: PubMed
    Score: 0.113
  24. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiol Aging. 2015 Apr; 36(4):1765.e7-1765.e16.
    View in: PubMed
    Score: 0.110
  25. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.
    View in: PubMed
    Score: 0.109
  26. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet. 2014 Sep; 10(9):e1004606.
    View in: PubMed
    Score: 0.108
  27. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014 Sep; 17(9):1156-63.
    View in: PubMed
    Score: 0.107
  28. Epigenomics of Alzheimer's disease. Transl Res. 2015 Jan; 165(1):200-20.
    View in: PubMed
    Score: 0.105
  29. Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol. 2014 Apr; 71(4):429-35.
    View in: PubMed
    Score: 0.105
  30. Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease. Biochem Pharmacol. 2014 Apr 15; 88(4):617-30.
    View in: PubMed
    Score: 0.104
  31. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec; 45(12):1452-8.
    View in: PubMed
    Score: 0.102
  32. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol. 2013 Sep 01; 70(9):1150-7.
    View in: PubMed
    Score: 0.100
  33. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013 Jun 21; 340(6139):1467-71.
    View in: PubMed
    Score: 0.099
  34. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10; 309(14):1483-92.
    View in: PubMed
    Score: 0.098
  35. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 2013 Apr 24; 78(2):256-68.
    View in: PubMed
    Score: 0.098
  36. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell. 2013 Jan 31; 152(3):642-54.
    View in: PubMed
    Score: 0.096
  37. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013 Apr 01; 73(7):667-78.
    View in: PubMed
    Score: 0.096
  38. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging. 2012 May; 33(5):1017.e1-15.
    View in: PubMed
    Score: 0.089
  39. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet. 2011 Feb; 7(2):e1001308.
    View in: PubMed
    Score: 0.084
  40. Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging. 2011 Dec; 32(12):2113-22.
    View in: PubMed
    Score: 0.080
  41. Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. Neurobiol Dis. 2022 Nov; 174:105880.
    View in: PubMed
    Score: 0.047
  42. Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease. Hum Mol Genet. 2022 09 29; 31(19):3355-3366.
    View in: PubMed
    Score: 0.047
  43. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 07 29; 145(7):2541-2554.
    View in: PubMed
    Score: 0.047
  44. Adherence to MIND Diet, Genetic Susceptibility, and Incident Dementia in Three US Cohorts. Nutrients. 2022 Jul 03; 14(13).
    View in: PubMed
    Score: 0.046
  45. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 11; 18(11):2042-2054.
    View in: PubMed
    Score: 0.045
  46. Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease. Biol Psychiatry. 2022 07 01; 92(1):25-33.
    View in: PubMed
    Score: 0.045
  47. Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance. Alzheimers Dement. 2022 10; 18(10):1797-1811.
    View in: PubMed
    Score: 0.045
  48. Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation. Hum Genet. 2022 Jan; 141(1):127-146.
    View in: PubMed
    Score: 0.045
  49. A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease. Nat Commun. 2021 07 22; 12(1):4472.
    View in: PubMed
    Score: 0.043
  50. A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun. 2021 06 10; 12(1):3517.
    View in: PubMed
    Score: 0.043
  51. Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia. PLoS Genet. 2021 04; 17(4):e1009482.
    View in: PubMed
    Score: 0.042
  52. Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction. Alzheimers Res Ther. 2021 03 04; 13(1):55.
    View in: PubMed
    Score: 0.042
  53. Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. Transl Psychiatry. 2021 02 26; 11(1):146.
    View in: PubMed
    Score: 0.042
  54. Genetic control of the human brain proteome. Am J Hum Genet. 2021 03 04; 108(3):400-410.
    View in: PubMed
    Score: 0.042
  55. Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis. Nat Genet. 2021 02; 53(2):143-146.
    View in: PubMed
    Score: 0.042
  56. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113.
    View in: PubMed
    Score: 0.042
  57. Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020 12 08; 11(1):6285.
    View in: PubMed
    Score: 0.042
  58. Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics. Am J Hum Genet. 2020 10 01; 107(4):714-726.
    View in: PubMed
    Score: 0.041
  59. Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. Cell Rep. 2020 09 01; 32(9):108091.
    View in: PubMed
    Score: 0.041
  60. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020 08 01; 143(8):2561-2575.
    View in: PubMed
    Score: 0.041
  61. Sex-dependent autosomal effects on clinical progression of Alzheimer's disease. Brain. 2020 07 01; 143(7):2272-2280.
    View in: PubMed
    Score: 0.040
  62. Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways. Alzheimers Dement. 2020 08; 16(8):1134-1145.
    View in: PubMed
    Score: 0.040
  63. A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol. 2019; 2:285.
    View in: PubMed
    Score: 0.038
  64. TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits. Am J Hum Genet. 2019 08 01; 105(2):258-266.
    View in: PubMed
    Score: 0.038
  65. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell. 2019 08; 18(4):e12964.
    View in: PubMed
    Score: 0.037
  66. Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in A? and TAU proteostasis. Hum Mol Genet. 2019 03 01; 28(5):718-735.
    View in: PubMed
    Score: 0.037
  67. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430.
    View in: PubMed
    Score: 0.037
  68. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 02 01; 109(2):276-287.
    View in: PubMed
    Score: 0.037
  69. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nat Commun. 2019 01 24; 10(1):409.
    View in: PubMed
    Score: 0.037
  70. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226.
    View in: PubMed
    Score: 0.036
  71. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nat Genet. 2018 11; 50(11):1584-1592.
    View in: PubMed
    Score: 0.036
  72. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018 09 26; 9(1):3945.
    View in: PubMed
    Score: 0.036
  73. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018 12; 136(6):857-872.
    View in: PubMed
    Score: 0.035
  74. Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement. 2018 12; 14(12):1580-1588.
    View in: PubMed
    Score: 0.034
  75. A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease. Genetics. 2018 05; 209(1):51-64.
    View in: PubMed
    Score: 0.034
  76. A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants. Sci Transl Med. 2017 Dec 20; 9(421).
    View in: PubMed
    Score: 0.034
  77. An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome. Nat Neurosci. 2017 Oct; 20(10):1418-1426.
    View in: PubMed
    Score: 0.033
  78. Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017 04; 14(4):e1002287.
    View in: PubMed
    Score: 0.032
  79. Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies. Mol Psychiatry. 2018 06; 23(6):1521-1529.
    View in: PubMed
    Score: 0.032
  80. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624.
    View in: PubMed
    Score: 0.032
  81. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY). 2017 01 10; 9(1):209-246.
    View in: PubMed
    Score: 0.032
  82. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2017 09 01; 82(5):322-329.
    View in: PubMed
    Score: 0.032
  83. Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans. Mol Neurobiol. 2017 Dec; 54(10):8021-8032.
    View in: PubMed
    Score: 0.031
  84. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2017 02; 13(2):119-129.
    View in: PubMed
    Score: 0.031
  85. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016 11; 19(11):1442-1453.
    View in: PubMed
    Score: 0.031
  86. The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism. Acta Neuropathol. 2016 10; 132(4):503-14.
    View in: PubMed
    Score: 0.031
  87. Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet. 2016 10; 19(5):407-17.
    View in: PubMed
    Score: 0.031
  88. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016 06 18; 53(3):921-32.
    View in: PubMed
    Score: 0.030
  89. Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease. Mol Psychiatry. 2017 02; 22(2):287-295.
    View in: PubMed
    Score: 0.030
  90. Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med. 2016 06; 46(8):1613-23.
    View in: PubMed
    Score: 0.030
  91. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 2016 Feb 01; 7:10495.
    View in: PubMed
    Score: 0.030
  92. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. JAMA Neurol. 2015 Nov; 72(11):1313-23.
    View in: PubMed
    Score: 0.029
  93. Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults. Medicine (Baltimore). 2015 Nov; 94(47):e1892.
    View in: PubMed
    Score: 0.029
  94. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry. 2016 Feb; 21(2):189-197.
    View in: PubMed
    Score: 0.028
  95. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. 2016 Jan; 21(1):108-17.
    View in: PubMed
    Score: 0.028
  96. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015 Feb; 20(2):183-92.
    View in: PubMed
    Score: 0.028
  97. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015 Apr 15; 77(8):749-63.
    View in: PubMed
    Score: 0.027
  98. FASTKD2 is associated with memory and hippocampal structure in older adults. Mol Psychiatry. 2015 Oct; 20(10):1197-204.
    View in: PubMed
    Score: 0.027
  99. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015 Jan; 70(1):110-8.
    View in: PubMed
    Score: 0.027
  100. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimers Dement. 2014 Nov; 10(6):609-618.e11.
    View in: PubMed
    Score: 0.027
  101. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci. 2014 Sep; 17(9):1164-70.
    View in: PubMed
    Score: 0.027
  102. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 2014; 127(6):825-43.
    View in: PubMed
    Score: 0.026
  103. Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. Cerebrovasc Dis. 2013; 36(3):181-188.
    View in: PubMed
    Score: 0.025
  104. Charting a dynamic DNA methylation landscape of the human genome. Nature. 2013 Aug 22; 500(7463):477-81.
    View in: PubMed
    Score: 0.025
  105. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. Alzheimers Dement. 2014 Jan; 10(1):45-52.
    View in: PubMed
    Score: 0.024
  106. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 2012 May 08; 78(19):1464-71.
    View in: PubMed
    Score: 0.023
  107. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012 Apr 15; 44(5):545-51.
    View in: PubMed
    Score: 0.023
  108. Alzheimer disease susceptibility loci: evidence for a protein network under natural selection. Am J Hum Genet. 2012 Apr 06; 90(4):720-6.
    View in: PubMed
    Score: 0.023
  109. A coding variant in CR1 interacts with APOE-e4 to influence cognitive decline. Hum Mol Genet. 2012 May 15; 21(10):2377-88.
    View in: PubMed
    Score: 0.023
  110. Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology. 2012 Jan 31; 78(5):334-41.
    View in: PubMed
    Score: 0.022
  111. A genome-wide association study of aging. Neurobiol Aging. 2011 Nov; 32(11):2109.e15-28.
    View in: PubMed
    Score: 0.022
  112. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.
    View in: PubMed
    Score: 0.021
  113. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet. 2011 Feb 11; 88(2):232-8.
    View in: PubMed
    Score: 0.021
  114. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec; 67(12):1473-84.
    View in: PubMed
    Score: 0.020
  115. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One. 2010 Jun 21; 5(6):e11244.
    View in: PubMed
    Score: 0.020
  116. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet. 2010 Aug 15; 19(16):3295-301.
    View in: PubMed
    Score: 0.020
  117. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9.
    View in: PubMed
    Score: 0.020
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