Xian-MingChenXian-Ming Chen350097Chen, Xian-MingXian-Ming Chen, MD, is a faculty member in the Department of Microbial Pathogens and Immunity. He received graduate training in China and conducted a Sasakawa Scholarship fellowship in Japan and a second research fellowship at Mayo Clinic. His research interests focus on the regulatory role for ncRNAs in mucosal innate defense and in host-pathogen interactions. Specifically, his research group studies the expression of ncRNA genes and their role in regulation of immune responses of innate immune cells and epithelial cells in the gastrointestinal tract; interactions between gastrointestinal epithelial cells and Cryptosporidium (a long-recognized cause of chronic and life-threatening enteric disease in HIV-AIDS patients and one of the most common pathogens responsible for moderate-to-severe diarrhea in young children worldwide); and the ncRNA signatures that may link mucosal inflammation to the tumorigenesis and other infectious diseases. He served on several NIH study sections and international grant review panels.
My Scopus ID is 35271047800.
Research Areas:
Innate immunity and inflammation, host-pathogen interactions, infectious diseases.
My Faculty Profile at Rush University Medical Center:
https://www.rushu.rush.edu/faculty/xian-ming-chen-md
My Laboratory:
https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-xian-ming-chen-md
My NCBI Bibliography:
https://pubmed.ncbi.nlm.nih.gov/?term=Xian-Ming+Chen&sort=date
My Scopus:
https://www.scopus.com/authid/detail.uri?authorId=35271047800
Education:
MD, Xianning Medical College, China
MS, Shanxi Medical University, China
Research Fellow, Mayo Clinic College of Medicine
Research Fellow, Kurume University School of Medicine, Japan
BS, Xianning Medical College, Hubei Medical University (Wuhan University School of Basic Medical Sciences), ChinaProfessorFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersontrue1ProfessorProfessorD001343Physiology14300.964266AutophagyD065150Physiology550.993421Cellular ReprogrammingKalipadaPahanKalipada Pahan349039Pahan, KalipadaProfessorD015972Physiology451000.94637Gene Expression Regulation, NeoplasticCarlMakiCarl Maki349531Maki, CarlProfessorLenaAl-HarthiLena Al-Harthi41.87386750000000-87.67102690000000349563Al-Harthi, Lena0000-0003-3915-3904ProfessorD006867Chemicals & Drugs450.997509Hydrolases4ProfessorChicago60612ILtrue1ProfessorProfessor117selected publications0.2415630.0097093469research areas5.202840.30504760similar toAuthorship 404875Authorship 407335Authorship 408166Authorship 408488Authorship 408542Authorship 408842Authorship 40903526481520Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Chen L, Jin P, Wu GY, Chen GCell stem cellSmall Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 2015 Dec 03; 17(6):735-747.Cell Stem Cell2015-10-17T00:00:002015Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.23795230Zhu H, Wang Y, Wang Y, Zhao S, Zhao M, Gui L, Xu W, Chen XA, Wang Y, Peng SThe journal of physical chemistry. C, Nanomaterials and interfacesFolded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56. J Phys Chem C Nanomater Interfaces. 2013 May 16; 117(19):10070-10078.J Phys Chem C Nanomater Interfaces2013-05-16T00:00:002013Folded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56.25043190Chang GS, Chen XA, Park B, Rhee HS, Li P, Han KH, Mishra T, Chan-Salis KY, Li Y, Hardison RC, Wang Y, Pugh BFCell reportsA comprehensive and high-resolution genome-wide response of p53 to stress. Cell Rep. 2014 Jul 24; 8(2):514-27.Cell Rep2014-07-17T00:00:002014A comprehensive and high-resolution genome-wide response of p53 to stress.25612620Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, Wang YMolecular cancer therapeuticsATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015 Apr; 14(4):877-88.Mol Cancer Ther2015-01-22T00:00:002015ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.22184127Cichon J, Sun C, Chen B, Jiang M, Chen XA, Sun Y, Wang Y, Chen GThe Journal of biological chemistryCofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons. J Biol Chem. 2012 Feb 03; 287(6):3919-29.J Biol Chem2011-12-19T00:00:002011Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons.22605338Wang Y, Li P, Wang S, Hu J, Chen XA, Wu J, Fisher M, Oshaben K, Zhao N, Gu Y, Wang D, Chen G, Wang YThe Journal of biological chemistryAnticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27; 287(31):25941-53.J Biol Chem2012-05-17T00:00:002012Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.23060885Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang YFrontiers in immunologyPAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol. 2012; 3:307.Front Immunol2012-10-04T00:00:002012PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures.Neurological SciencesAnatomy and Cell BiologyRush University, Rush Medical CollegeDavidBennettDavid A. Bennett41.87328300000000-87.66936330000000349004Bennett, DavidProfessorJeffreyKordowerJeffrey Kordower41.87386750000000-87.67102690000000349008Kordower, JeffreyProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorMicrobial Pathogens and ImmunityD016159Chemicals & Drugs25890.913956Tumor Suppressor Protein p53