D050760Chemicals & DrugsD12.644.360.225.600D12.776.167.187.600D12.776.476.225.600D12.776.624.776.355.600470.992677Cyclin-Dependent Kinase Inhibitor p27Faculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson30322885Draney C, Austin MC, Leifer AH, Smith CJ, Kener KB, Aitken TJ, Hess KH, Haines AC, Lett E, Hernandez-Carretero A, Fueger PT, Arlotto M, Tessem JSThe Biochemical journalHDAC1 overexpression enhances ?-cell proliferation by down-regulating Cdkn1b/p27. Biochem J. 2018 12 19; 475(24):3997-4010.Biochem J2018-12-19T00:00:002018HDAC1 overexpression enhances ?-cell proliferation by down-regulating Cdkn1b/p27.true1ProfessorProfessorStevenGitelisSteven Gitelis41.87352120000000-87.66713820000000349068Gitelis, StevenProfessorAbdeAbukhdeirAbde Abukhdeir349143Abukhdeir, AbdeAssistant ProfessorLeiDuanLei Duan349250Duan, LeiAssistant ProfessorCarlMakiCarl Maki349531Maki, CarlProfessor6Assistant Professor4Professor10443844Venkatesan TK, Kuropkat C, Caldarelli DD, Panje WR, Hutchinson JC, Chen S, Coon JSThe LaryngoscopePrognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx. Laryngoscope. 1999 Aug; 109(8):1329-33.Laryngoscope1999-08-01T00:00:001999Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx.18590585Abukhdeir AM, Park BHExpert reviews in molecular medicineP21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med. 2008 Jul 01; 10:e19.Expert Rev Mol Med2008-07-01T00:00:002008P21 and p27: roles in carcinogenesis and drug resistance.25482935Duan L, Perez RE, Hansen M, Gitelis S, Maki CGCancer biology & therapyIncreasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer Biol Ther. 2014; 15(12):1600-12.Cancer Biol Ther2014-01-01T00:00:002014Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.27050276Davaadelger B, Duan L, Perez RE, Gitelis S, Maki CGOncotargetCrosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor. Oncotarget. 2016 May 10; 7(19):27511-26.Oncotarget2016-05-10T00:00:002016Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.0.6967470.1741874research area of0.6937160.04524865subject area forInternal MedicineOrthopedic SurgeryAnatomy and Cell BiologyRush University, Rush Medical Collegetrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor