PhDEduardoRiosEduardo Rios41.87432800000000-87.67059170000000349616Rios, EduardoMy Scopus ID is 7101859118.
My NIH COMMONS name ERIOS1.
Research Areas:
Signals that control contraction in skeletal and cardiac muscle.
My Faculty Profile at Rush University Medical Center:
https://www.rushu.rush.edu/faculty/eduardo-rios-lic
My Laboratory:
https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-eduardo-r%C3%ADos-phd
My Google Scholar:
https://scholar.google.com/citations?user=OcmHHfQAAAAJ&hl
My NCBI Bibliography:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Eduardo+Rios
My Scopus:
https://www.scopus.com/authid/detail.uri?authorId=7101859118
Education:
School of Medicine, Uruguay National University
School of Engineering, Montevideo, Uruguay
School of Sciences, Montevideo, UruguayProfessorprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifierbibo:suffixNamename suffixAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD002155Chemicals & Drugs10390.963243Calsequestrin30728215R?os E, Gillespie D, Franzini-Armstrong CThe Journal of general physiologyThe binding interactions that maintain excitation-contraction coupling junctions in skeletal muscle. J Gen Physiol. 2019 04 01; 151(4):593-605.J Gen Physiol2019-02-06T00:00:002019The binding interactions that maintain excitation-contraction coupling junctions in skeletal muscle.NIAMS/Nat'l Institutes of Health USA20061996M.E.R.I.T.Rush University2013Mentor of the yearAuthorship 358461Authorship 358476Authorship 358481Authorship 358491Authorship 358501Authorship 358516Authorship 358521Authorship 358535Authorship 358549Authorship 358556Authorship 358568Authorship 358571Authorship 358584Authorship 358593Authorship 358606Authorship 358614Authorship 358622Authorship 358634Authorship 358643Authorship 358651Authorship 358662Authorship 358672Authorship 358684Authorship 358692Authorship 358705Authorship 358713Authorship 358721Authorship 358734Authorship 358741Authorship 358759Authorship 358762Authorship 358774Authorship 358784Authorship 358794Authorship 358801Authorship 358814Authorship 358821Authorship 358835Authorship 358845Authorship 358851Authorship 358864Authorship 358874Authorship 358882Authorship 35889230579404Figueroa L, Kraeva N, Manno C, Toro S, R?os E, Riazi SBritish journal of anaesthesiaAbnormal calcium signalling and the caffeine-halothane contracture test. Br J Anaesth. 2019 Jan; 122(1):32-41.Br J Anaesth2018-09-20T00:00:002018Abnormal calcium signalling and the caffeine-halothane contracture test.29514865R?os EThe Journal of general physiologyCalcium-induced release of calcium in muscle: 50 years of work and the emerging consensus. J Gen Physiol. 2018 04 02; 150(4):521-537.J Gen Physiol2018-03-07T00:00:002018Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus.16933025R?os E, Launikonis BS, Royer L, Brum G, Zhou JJournal of muscle research and cell motilityThe elusive role of store depletion in the control of intracellular calcium release. J Muscle Res Cell Motil. 2006; 27(5-7):337-50.J Muscle Res Cell Motil2006-08-25T00:00:002006The elusive role of store depletion in the control of intracellular calcium release.15878940R?os EThe Journal of physiologyThe Ca2+ spark of mammalian muscle. Physiology or pathology? J Physiol. 2005 Jun 15; 565(Pt 3):705.J Physiol2005-05-05T00:00:002005The Ca2+ spark of mammalian muscle. Physiology or pathology?12835473Zhou J, Brum G, Gonzalez A, Launikonis BS, Stern MD, Rios EThe Journal of general physiologyCa2+ sparks and embers of mammalian muscle. Properties of the sources. J Gen Physiol. 2003 Jul; 122(1):95-114.J Gen Physiol2003-07-01T00:00:002003Ca2+ sparks and embers of mammalian muscle. Properties of the sources.11159393R?os E, Shirokova N, Kirsch WG, Pizarro G, Stern MD, Cheng H, Gonz?lez ABiophysical journalA preferred amplitude of calcium sparks in skeletal muscle. Biophys J. 2001 Jan; 80(1):169-83.Biophys J2001-01-01T00:00:002001A preferred amplitude of calcium sparks in skeletal muscle.11060121Brum G, Gonz?lez A, Rengifo J, Shirokova N, R?os EThe Journal of physiologyFast imaging in two dimensions resolves extensive sources of Ca2+ sparks in frog skeletal muscle. J Physiol. 2000 Nov 01; 528(Pt 3):419-33.J Physiol2000-11-01T00:00:002000Fast imaging in two dimensions resolves extensive sources of Ca2+ sparks in frog skeletal muscle.10759554Gonz?lez A, Kirsch WG, Shirokova N, Pizarro G, Brum G, Pessah IN, Stern MD, Cheng H, R?os EProceedings of the National Academy of Sciences of the United States of AmericaInvolvement of multiple intracellular release channels in calcium sparks of skeletal muscle. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4380-5.Proc Natl Acad Sci U S A2000-04-11T00:00:002000Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle.10653893Gonz?lez A, Kirsch WG, Shirokova N, Pizarro G, Stern MD, R?os EThe Journal of general physiologyThe spark and its ember: separately gated local components of Ca(2+) release in skeletal muscle. J Gen Physiol. 2000 Feb; 115(2):139-58.J Gen Physiol2000-02-01T00:00:002000The spark and its ember: separately gated local components of Ca(2+) release in skeletal muscle.10581317Shirokova N, Shirokov R, Rossi D, Gonz?lez A, Kirsch WG, Garc?a J, Sorrentino V, R?os EThe Journal of physiologySpatially segregated control of Ca2+ release in developing skeletal muscle of mice. J Physiol. 1999 Dec 01; 521 Pt 2:483-95.J Physiol1999-12-01T00:00:001999Spatially segregated control of Ca2+ release in developing skeletal muscle of mice.10398690R?os E, Stern MD, Gonz?lez A, Pizarro G, Shirokova NThe Journal of general physiologyCalcium release flux underlying Ca2+ sparks of frog skeletal muscle. J Gen Physiol. 1999 Jul; 114(1):31-48.J Gen Physiol1999-07-01T00:00:001999Calcium release flux underlying Ca2+ sparks of frog skeletal muscle.10051514Shirokova N, Gonz?lez A, Kirsch WG, R?os E, Pizarro G, Stern MD, Cheng HThe Journal of general physiologyCalcium sparks: release packets of uncertain origin and fundamental role. J Gen Physiol. 1999 Mar; 113(3):377-84.J Gen Physiol1999-03-01T00:00:001999Calcium sparks: release packets of uncertain origin and fundamental role.9763628Shirokova N, Garc?a J, R?os EThe Journal of physiologyLocal calcium release in mammalian skeletal muscle. J Physiol. 1998 Oct 15; 512 ( Pt 2):377-84.J Physiol1998-10-15T00:00:001998Local calcium release in mammalian skeletal muscle.9738021Zhou J, Cribbs L, Yi J, Shirokov R, Perez-Reyes E, R?os EThe Journal of biological chemistryMolecular cloning and functional expression of a skeletal muscle dihydropyridine receptor from Rana catesbeiana. J Biol Chem. 1998 Sep 25; 273(39):25503-9.J Biol Chem1998-09-25T00:00:001998Molecular cloning and functional expression of a skeletal muscle dihydropyridine receptor from Rana catesbeiana.9607938Shirokov R, Ferreira G, Yi J, R?os EThe Journal of general physiologyInactivation of gating currents of L-type calcium channels. Specific role of the alpha 2 delta subunit. J Gen Physiol. 1998 Jun; 111(6):807-23.J Gen Physiol1998-06-01T00:00:001998Inactivation of gating currents of L-type calcium channels. Specific role of the alpha 2 delta subunit.9234193Shirokova N, R?os EThe Journal of physiologySmall event Ca2+ release: a probable precursor of Ca2+ sparks in frog skeletal muscle. J Physiol. 1997 Jul 01; 502 ( Pt 1):3-11.J Physiol1997-07-01T00:00:001997Small event Ca2+ release: a probable precursor of Ca2+ sparks in frog skeletal muscle.9192301Pizarro G, Shirokova N, Tsugorka A, R?os EThe Journal of physiology'Quantal' calcium release operated by membrane voltage in frog skeletal muscle. J Physiol. 1997 Jun 01; 501 ( Pt 2):289-303.J Physiol1997-06-01T00:00:001997'Quantal' calcium release operated by membrane voltage in frog skeletal muscle.9101404Ferreira G, Yi J, R?os E, Shirokov RThe Journal of general physiologyIon-dependent inactivation of barium current through L-type calcium channels. J Gen Physiol. 1997 Apr; 109(4):449-61.J Gen Physiol1997-04-01T00:00:001997Ion-dependent inactivation of barium current through L-type calcium channels.9241413R?os E, Stern MDAnnual review of biophysics and biomolecular structureCalcium in close quarters: microdomain feedback in excitation-contraction coupling and other cell biological phenomena. Annu Rev Biophys Biomol Struct. 1997; 26:47-82.Annu Rev Biophys Biomol Struct1997-01-01T00:00:001997Calcium in close quarters: microdomain feedback in excitation-contraction coupling and other cell biological phenomena.8782100Shirokova N, R?os EThe Journal of physiologyCaffeine enhances intramembranous charge movement in frog skeletal muscle by increasing cytoplasmic Ca2+ concentration. J Physiol. 1996 Jun 01; 493 ( Pt 2):341-56.J Physiol1996-06-01T00:00:001996Caffeine enhances intramembranous charge movement in frog skeletal muscle by increasing cytoplasmic Ca2+ concentration.8782099Shirokova N, R?os EThe Journal of physiologyActivation of Ca2+ release by caffeine and voltage in frog skeletal muscle. J Physiol. 1996 Jun 01; 493 ( Pt 2):317-39.J Physiol1996-06-01T00:00:001996Activation of Ca2+ release by caffeine and voltage in frog skeletal muscle.8741727Shirokova N, Garc?a J, Pizarro G, R?os EThe Journal of general physiologyCa2+ release from the sarcoplasmic reticulum compared in amphibian and mammalian skeletal muscle. J Gen Physiol. 1996 Jan; 107(1):1-18.J Gen Physiol1996-01-01T00:00:001996Ca2+ release from the sarcoplasmic reticulum compared in amphibian and mammalian skeletal muscle.7473205Shirokova N, Gonz?lez A, Ma J, Shirokov R, R?os EThe Journal of physiologyProperties and roles of an intramembranous charge mobilized at high voltages in frog skeletal muscle. J Physiol. 1995 Jul 15; 486 ( Pt 2):385-400.J Physiol1995-07-15T00:00:001995Properties and roles of an intramembranous charge mobilized at high voltages in frog skeletal muscle.7528782Shirokova N, Pizarro G, R?os EThe Journal of general physiologyA damped oscillation in the intramembranous charge movement and calcium release flux of frog skeletal muscle fibers. J Gen Physiol. 1994 Sep; 104(3):449-76.J Gen Physiol1994-09-01T00:00:001994A damped oscillation in the intramembranous charge movement and calcium release flux of frog skeletal muscle fibers.7919026R?os EBiophysical journalReining in calcium release. Biophys J. 1994 Jul; 67(1):7-9.Biophys J1994-07-01T00:00:001994Reining in calcium release.8133239Shirokov R, Levis R, Shirokova N, R?os EThe Journal of general physiologyCa(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor. J Gen Physiol. 1993 Dec; 102(6):1005-30.J Gen Physiol1993-12-01T00:00:001993Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor.8245819R?os E, Karhanek M, Ma J, Gonz?lez AThe Journal of general physiologyAn allosteric model of the molecular interactions of excitation-contraction coupling in skeletal muscle. J Gen Physiol. 1993 Sep; 102(3):449-81.J Gen Physiol1993-09-01T00:00:001993An allosteric model of the molecular interactions of excitation-contraction coupling in skeletal muscle.8245818Ma J, Anderson K, Shirokov R, Levis R, Gonz?lez A, Karhanek M, Hosey MM, Meissner G, R?os EThe Journal of general physiologyEffects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle. J Gen Physiol. 1993 Sep; 102(3):423-48.J Gen Physiol1993-09-01T00:00:001993Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle.8245817Gonz?lez A, R?os EThe Journal of general physiologyPerchlorate enhances transmission in skeletal muscle excitation-contraction coupling. J Gen Physiol. 1993 Sep; 102(3):373-421.J Gen Physiol1993-09-01T00:00:001993Perchlorate enhances transmission in skeletal muscle excitation-contraction coupling.1297844Pizarro G, Csernoch L, Uribe I, R?os EThe Journal of physiologyDifferential effects of tetracaine on two kinetic components of calcium release in frog skeletal muscle fibres. J Physiol. 1992 Nov; 457:525-38.J Physiol1992-11-01T00:00:001992Differential effects of tetracaine on two kinetic components of calcium release in frog skeletal muscle fibres.1330033Ma J, Guti?rrez LM, Hosey MM, R?os EBiophysical journalDihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 3. Effects of phosphorylation by protein kinase C. Biophys J. 1992 Sep; 63(3):639-47.Biophys J1992-09-01T00:00:001992Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 3. Effects of phosphorylation by protein kinase C.1322450Shirokov R, Levis R, Shirokova N, R?os EThe Journal of general physiologyTwo classes of gating current from L-type Ca channels in guinea pig ventricular myocytes. J Gen Physiol. 1992 Jun; 99(6):863-95.J Gen Physiol1992-06-01T00:00:001992Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes.1562172R?os E, Pizarro G, Stefani EAnnual review of physiologyCharge movement and the nature of signal transduction in skeletal muscle excitation-contraction coupling. Annu Rev Physiol. 1992; 54:109-33.Annu Rev Physiol1992-01-01T00:00:001992Charge movement and the nature of signal transduction in skeletal muscle excitation-contraction coupling.1660319Ma J, Mundi?a-Weilenmann C, Hosey MM, R?os EBiophysical journalDihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 1. Kinetics and voltage dependence of gating. Biophys J. 1991 Oct; 60(4):890-901.Biophys J1991-10-01T00:00:001991Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. 1. Kinetics and voltage dependence of gating.2057528R?os E, Pizarro GPhysiological reviewsVoltage sensor of excitation-contraction coupling in skeletal muscle. Physiol Rev. 1991 Jul; 71(3):849-908.Physiol Rev1991-07-01T00:00:001991Voltage sensor of excitation-contraction coupling in skeletal muscle.1713947Csernoch L, Pizarro G, Uribe I, Rodr?guez M, R?os EThe Journal of general physiologyInterfering with calcium release suppresses I gamma, the "hump" component of intramembranous charge movement in skeletal muscle. J Gen Physiol. 1991 May; 97(5):845-84.J Gen Physiol1991-05-01T00:00:001991Interfering with calcium release suppresses I gamma, the "hump" component of intramembranous charge movement in skeletal muscle.1650812Pizarro G, Csernoch L, Uribe I, Rodr?guez M, R?os EThe Journal of general physiologyThe relationship between Q gamma and Ca release from the sarcoplasmic reticulum in skeletal muscle. J Gen Physiol. 1991 May; 97(5):913-47.J Gen Physiol1991-05-01T00:00:001991The relationship between Q gamma and Ca release from the sarcoplasmic reticulum in skeletal muscle.1648106R?os E, Ma JJ, Gonz?lez AJournal of muscle research and cell motilityThe mechanical hypothesis of excitation-contraction (EC) coupling in skeletal muscle. J Muscle Res Cell Motil. 1991 Apr; 12(2):127-35.J Muscle Res Cell Motil1991-04-01T00:00:001991The mechanical hypothesis of excitation-contraction (EC) coupling in skeletal muscle.2481710Pizarro G, Fitts R, Uribe I, R?os EThe Journal of general physiologyThe voltage sensor of excitation-contraction coupling in skeletal muscle. Ion dependence and selectivity. J Gen Physiol. 1989 Sep; 94(3):405-28.J Gen Physiol1989-09-01T00:00:001989The voltage sensor of excitation-contraction coupling in skeletal muscle. Ion dependence and selectivity.3260626Brum G, Fitts R, Pizarro G, R?os EThe Journal of physiologyVoltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling. J Physiol. 1988 Apr; 398:475-505.J Physiol1988-04-01T00:00:001988Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling.2455801Brum G, R?os E, St?fani EThe Journal of physiologyEffects of extracellular calcium on calcium movements of excitation-contraction coupling in frog skeletal muscle fibres. J Physiol. 1988 Apr; 398:441-73.J Physiol1988-04-01T00:00:001988Effects of extracellular calcium on calcium movements of excitation-contraction coupling in frog skeletal muscle fibres.3116215Brum G, Rios EThe Journal of physiologyIntramembrane charge movement in frog skeletal muscle fibres. Properties of charge 2. J Physiol. 1987 Jun; 387:489-517.J Physiol1987-06-01T00:00:001987Intramembrane charge movement in frog skeletal muscle fibres. Properties of charge 2.D002118Chemicals & Drugs644990.726648CalciumD020013Physiology191780.833562Calcium Signaling8InstructorBobEisenbergBob Eisenberg41.87432800000000-87.67059170000000349256Eisenberg, Bob0000-0002-4860-5434ProfessorDirkGillespieDirk Gillespie41.87432800000000-87.67059170000000349292Gillespie, DirkProfessor1750 West Harrison StChicago60612ILLotharBlatterLothar Blatter41.87432800000000-87.67059170000000349611Blatter, LotharProfessorMichaelFillMichael Fill41.87432800000000-87.67059170000000349613Fill, MichaelProfessor11101selected publications11.44830.00515423289research areas4.624020.04401598coauthor of410.9118.2248960similar toTomShannonTom Shannon41.87432800000000-87.67059170000000349656Shannon, TomAssociate ProfessorJohnTangJohn Tang41.87432800000000-87.67059170000000349692Tang, John0000-0003-0104-8324Assistant Professor6Assistant Professor5Associate Professor4Professor18664579Musset B, Morgan D, Cherny VV, MacGlashan DW, Thomas LL, R?os E, DeCoursey TEProceedings of the National Academy of Sciences of the United States of AmericaA pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):11020-5.Proc Natl Acad Sci U S A2008-07-29T00:00:002008A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils.19805063Morgan D, Capasso M, Musset B, Cherny VV, R?os E, Dyer MJ, DeCoursey TEProceedings of the National Academy of Sciences of the United States of AmericaVoltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):18022-7.Proc Natl Acad Sci U S A2009-10-05T00:00:002009Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis.Authorship 39143832364497Tammineni ER, Kraeva N, Figueroa L, Manno C, Ibarra CA, Klip A, Riazi S, Rios EeLifeIntracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes. Elife. 2020 05 04; 9.Elife2020-05-04T00:00:002020Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes.Authorship 40336532861507Ibarra Moreno CA, Kraeva N, Zvaritch E, Figueroa L, Rios E, Biesecker L, Van Petegem F, Hopkins PM, Riazi SBritish journal of anaesthesiaA multi-dimensional analysis of genotype-phenotype discordance in malignant hyperthermia susceptibility. Br J Anaesth. 2020 12; 125(6):995-1001.Br J Anaesth2020-08-27T00:00:002020A multi-dimensional analysis of genotype-phenotype discordance in malignant hyperthermia susceptibility.D018482Anatomy843490.785785Muscle, SkeletalAuthorship 109954D012519Anatomy142160.862664Sarcoplasmic ReticulumAuthorship 20072212829480Brum G, Piriz N, DeArmas R, Rios E, Stern M, Pizarro GBiophysical journalDifferential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscle. Biophys J. 2003 Jul; 85(1):245-54.Biophys J2003-07-01T00:00:002003Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscle.12975450Kettlun C, Gonz?lez A, R?os E, Fill MThe Journal of general physiologyUnitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions. J Gen Physiol. 2003 Oct; 122(4):407-17.J Gen Physiol2003-09-15T00:00:002003Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions.22310315Figueroa L, Shkryl VM, Zhou J, Manno C, Momotake A, Brum G, Blatter LA, Ellis-Davies GC, R?os EThe Journal of physiologySynthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. J Physiol. 2012 Mar 15; 590(6):1389-411.J Physiol2012-02-06T00:00:002012Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle.22330954Shkryl VM, Blatter LA, R?os EThe Journal of general physiologyProperties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle. J Gen Physiol. 2012 Mar; 139(3):189-207.J Gen Physiol2012-02-13T00:00:002012Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle.23409040Figueroa L, Shkryl VM, Blatter LA, R?os EPloS oneUsing two dyes with the same fluorophore to monitor cellular calcium concentration in an extended range. PLoS One. 2013; 8(2):e55778.PLoS One2013-02-07T00:00:002013Using two dyes with the same fluorophore to monitor cellular calcium concentration in an extended range.2553859Bean BP, Rios EThe Journal of general physiologyNonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating. J Gen Physiol. 1989 Jul; 94(1):65-93.J Gen Physiol1989-07-01T00:00:001989Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating.7569901Tsugorka A, R?os E, Blatter LAScience (New York, N.Y.)Imaging elementary events of calcium release in skeletal muscle cells. Science. 1995 Sep 22; 269(5231):1723-6.Science1995-09-22T00:00:001995Imaging elementary events of calcium release in skeletal muscle cells.Rush University, Rush Medical Collegetrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant ProfessorAuthorship 45631535796671Manno C, Tammineni E, Figueroa L, Oropeza-Almaz?n Y, Rios EThe Journal of general physiologyA novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes. J Gen Physiol. 2022 09 05; 154(9).J Gen Physiol2022-07-07T00:00:002022A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes.CarlosMannoCarlos Manno41.87432800000000-87.67059170000000349854Manno, CarlosAssistant ProfessorCarolinaFigueroaCarolina Figueroa41.87432800000000-87.67059170000000349855Figueroa, CarolinaAssistant Professor20713548Royer L, Sztretye M, Manno C, Pouvreau S, Zhou J, Knollmann BC, Protasi F, Allen PD, R?os EThe Journal of general physiologyParadoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle. J Gen Physiol. 2010 Sep; 136(3):325-38.J Gen Physiol2010-08-16T00:00:002010Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle.23148320Manno C, Sztretye M, Figueroa L, Allen PD, R?os EThe Journal of physiologyDynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle. J Physiol. 2013 Jan 15; 591(2):423-42.J Physiol2012-11-12T00:00:002012Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle.23440278Manno C, Figueroa L, Fitts R, R?os EThe Journal of general physiologyConfocal imaging of transmembrane voltage by SEER of di-8-ANEPPS. J Gen Physiol. 2013 Mar; 141(3):371-87.J Gen Physiol2013-03-01T00:00:002013Confocal imaging of transmembrane voltage by SEER of di-8-ANEPPS.23798496Manno C, Figueroa L, Royer L, Pouvreau S, Lee CS, Volpe P, Nori A, Zhou J, Meissner G, Hamilton SL, R?os EThe Journal of physiologyAltered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol. 2013 Sep 15; 591(18):4439-57.J Physiol2013-06-24T00:00:002013Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.25712015Manno C, R?os EThe Journal of general physiologyA better method to measure total calcium in biological samples yields immediate payoffs. J Gen Physiol. 2015 Mar; 145(3):167-71.J Gen Physiol2015-03-01T00:00:002015A better method to measure total calcium in biological samples yields immediate payoffs.26009541R?os E, Figueroa L, Manno C, Kraeva N, Riazi SThe Journal of general physiologyThe couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle. J Gen Physiol. 2015 Jun; 145(6):459-74.J Gen Physiol2015-06-01T00:00:002015The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle.true1ProfessorProfessor28069951Manno C, Figueroa LC, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C, Rios EProceedings of the National Academy of Sciences of the United States of AmericaCalsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E638-E647.Proc Natl Acad Sci U S A2017-01-09T00:00:002017Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessorPhysiology and BiophysicsAuthorship 272581Authorship 272597Authorship 272607Authorship 272616Authorship 272632Authorship 272651Authorship 272672Authorship 272682Authorship 2726911Authorship 272702Authorship 272714Authorship 272724Authorship 272731Authorship 272745Authorship 272763Authorship 272779Authorship 272785Authorship 272798Authorship 272806Authorship 272841Authorship 272851Authorship 272866Authorship 272881Authorship 272896Authorship 272905Authorship 272911Authorship 272921Authorship 272931Authorship 272946Authorship 272951Authorship 272962Authorship 272972Authorship 272983Authorship 272995Authorship 273006Authorship 273011Authorship 273026Authorship 273037Authorship 273046Authorship 273051Authorship 273063Authorship 273072Authorship 273083Authorship 273093Authorship 273113Authorship 273121Authorship 273136Authorship 273141Authorship 27315421788611Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Allen P, Brum G, R?os EThe Journal of general physiologyMeasurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle. J Gen Physiol. 2011 Aug; 138(2):231-47.J Gen Physiol2011-08-01T00:00:002011Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle.21788610Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, R?os EThe Journal of general physiologyD4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle. J Gen Physiol. 2011 Aug; 138(2):211-29.J Gen Physiol2011-08-01T00:00:002011D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle.28798278R?os EThe Journal of general physiologyPerspectives on "Control of Ca release from within the cardiac sarcoplasmic reticulum". J Gen Physiol. 2017 09 04; 149(9):833-836.J Gen Physiol2017-08-10T00:00:002017Perspectives on "Control of Ca release from within the cardiac sarcoplasmic reticulum".28415913Palau J, Sancho E, Herrera M, S?nchez S, Mingot ME, Upegui RI, Rodr?guez Salazar MJ, de la Cruz F, Fern?ndez MC, Gonz?lez L?pez TJ, Hern?ndez JJ, R?os E, L?pez-Fern?ndez MF, Garc?a M, Hern?ndez J?, Sanz MAHematology (Amsterdam, Netherlands)Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study. Hematology. 2017 Sep; 22(8):484-492.Hematology2017-04-17T00:00:002017Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study.27649144Lewis KM, Munske GR, Byrd SS, Kang J, Cho HJ, R?os E, Kang CInternational journal of molecular sciencesCharacterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle. Int J Mol Sci. 2016 Sep 13; 17(9).Int J Mol Sci2016-09-13T00:00:002016Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle.26416891Lewis KM, Ronish LA, R?os E, Kang CThe Journal of biological chemistryCharacterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregate Myopathy. J Biol Chem. 2015 Nov 27; 290(48):28665-74.J Biol Chem2015-09-28T00:00:002015Characterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregate Myopathy.23980195Stern MD, R?os E, Maltsev VAThe Journal of general physiologyLife and death of a cardiac calcium spark. J Gen Physiol. 2013 Sep; 142(3):257-74.J Gen Physiol2013-09-01T00:00:002013Life and death of a cardiac calcium spark.23473480Santiago DJ, R?os E, Shannon TRBiophysical journalIsoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes. Biophys J. 2013 Mar 05; 104(5):976-85.Biophys J2013-03-05T00:00:002013Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes.23263920R?os EThe journal of physiological sciences : JPSOn an early demonstration of the cell boundary theorem. J Physiol Sci. 2013 Mar; 63(2):161.J Physiol Sci2012-12-22T00:00:002012On an early demonstration of the cell boundary theorem.21795684Yi J, Ma C, Li Y, Weisleder N, R?os E, Ma J, Zhou JThe Journal of biological chemistryMitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. J Biol Chem. 2011 Sep 16; 286(37):32436-43.J Biol Chem2011-07-27T00:00:002011Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling.20709761R?os EThe Journal of biological chemistryRyR1 expression and the cell boundary theorem. J Biol Chem. 2010 Aug 20; 285(34):le13; author reply le14.J Biol Chem2010-08-20T00:00:002010RyR1 expression and the cell boundary theorem.20483318Santiago DJ, Curran JW, Bers DM, Lederer WJ, Stern MD, R?os E, Shannon TRBiophysical journalCa sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J. 2010 May 19; 98(10):2111-20.Biophys J2010-05-19T00:00:002010Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.19937486R?os EThe journal of physiological sciences : JPSThe cell boundary theorem: a simple law of the control of cytosolic calcium concentration. J Physiol Sci. 2010 Jan; 60(1):81-4.J Physiol Sci2009-11-26T00:00:002009The cell boundary theorem: a simple law of the control of cytosolic calcium concentration.19889637Zhou J, Yi J, Fu R, Liu E, Siddique T, R?os E, Deng HXThe Journal of biological chemistryHyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis. J Biol Chem. 2010 Jan 01; 285(1):705-12.J Biol Chem2009-11-04T00:00:002009Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis.19567746R?os E, Gy?rke SThe Journal of physiologyCalsequestrin, triadin and more: the molecules that modulate calcium release in cardiac and skeletal muscle. J Physiol. 2009 Jul 01; 587(Pt 13):3069-70.J Physiol2009-07-01T00:00:002009Calsequestrin, triadin and more: the molecules that modulate calcium release in cardiac and skeletal muscle.19403601Royer L, R?os EThe Journal of physiologyDeconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle. J Physiol. 2009 Jul 01; 587(Pt 13):3101-11.J Physiol2009-04-29T00:00:002009Deconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle.18687715Royer L, Pouvreau S, R?os EThe Journal of physiologyEvolution and modulation of intracellular calcium release during long-lasting, depleting depolarization in mouse muscle. J Physiol. 2008 Oct 01; 586(19):4609-29.J Physiol2008-08-07T00:00:002008Evolution and modulation of intracellular calcium release during long-lasting, depleting depolarization in mouse muscle.18347079R?os E, Zhou J, Brum G, Launikonis BS, Stern MDThe Journal of general physiologyCalcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. J Gen Physiol. 2008 Apr; 131(4):335-48.J Gen Physiol2008-03-17T00:00:002008Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians.17569733Launikonis BS, R?os EThe Journal of physiologyStore-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. J Physiol. 2007 Aug 15; 583(Pt 1):81-97.J Physiol2007-06-14T00:00:002007Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle.17360329Pouvreau S, Royer L, Yi J, Brum G, Meissner G, R?os E, Zhou JProceedings of the National Academy of Sciences of the United States of AmericaCa(2+) sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5235-40.Proc Natl Acad Sci U S A2007-03-14T00:00:002007Ca(2+) sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle.17234966Curran J, Hinton MJ, R?os E, Bers DM, Shannon TRCirculation researchBeta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007 Feb 16; 100(3):391-8.Circ Res2007-01-18T00:00:002007Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.16769796Launikonis BS, Zhou J, Santiago D, Brum G, R?os EThe Journal of general physiologyThe changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle. J Gen Physiol. 2006 Jul; 128(1):45-54.J Gen Physiol2006-06-12T00:00:002006The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle.16473932Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, R?os EProceedings of the National Academy of Sciences of the United States of AmericaDepletion "skraps" and dynamic buffering inside the cellular calcium store. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2982-7.Proc Natl Acad Sci U S A2006-02-10T00:00:002006Depletion "skraps" and dynamic buffering inside the cellular calcium store.16469777R?os EThe Journal of physiologyCalcium signalling in muscle: a milestone for modulation studies. J Physiol. 2006 Apr 01; 572(Pt 1):1-2.J Physiol2006-02-09T00:00:002006Calcium signalling in muscle: a milestone for modulation studies.16186560Zhou J, Brum G, Gonz?lez A, Launikonis BS, Stern MD, R?os EThe Journal of general physiologyConcerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. J Gen Physiol. 2005 Oct; 126(4):301-9.J Gen Physiol2005-10-01T00:00:002005Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle.16148029Zhou J, Yi J, Royer L, Launikonis BS, Gonz?lez A, Garc?a J, R?os EAmerican journal of physiology. Cell physiologyA probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C539-53.Am J Physiol Cell Physiol2005-09-07T00:00:002005A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle.15946962Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, R?os EThe Journal of physiologyConfocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. J Physiol. 2005 Sep 01; 567(Pt 2):523-43.J Physiol2005-06-09T00:00:002005Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence.15709685R?os E, Zhou JBiological researchControl of dual isoforms of Ca2+ release channels in muscle. Biol Res. 2004; 37(4):583-91.Biol Res2004-01-01T00:00:002004Control of dual isoforms of Ca2+ release channels in muscle.15452201Zhou J, Launikonis BS, R?os E, Brum GThe Journal of general physiologyRegulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling? J Gen Physiol. 2004 Oct; 124(4):409-28.J Gen Physiol2004-10-01T00:00:002004Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?15337820Pizarro G, R?os EThe Journal of general physiologyHow source content determines intracellular Ca2+ release kinetics. Simultaneous measurement of [Ca2+] transients and [H+] displacement in skeletal muscle. J Gen Physiol. 2004 Sep; 124(3):239-58.J Gen Physiol2004-09-01T00:00:002004How source content determines intracellular Ca2+ release kinetics. Simultaneous measurement of [Ca2+] transients and [H+] displacement in skeletal muscle.15004280Wang SQ, Stern MD, R?os E, Cheng HProceedings of the National Academy of Sciences of the United States of AmericaThe quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3979-84.Proc Natl Acad Sci U S A2004-03-02T00:00:002004The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells.12770874Ferreira G, R?os E, Reyes NBiophysical journalTwo components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents. Biophys J. 2003 Jun; 84(6):3662-78.Biophys J2003-06-01T00:00:002003Two components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents.12414685Rengifo J, Rosales R, González A, Cheng H, Stern MD, Ríos EBiophysical journalIntracellular Ca(2+) release as irreversible Markov process. Biophys J. 2002 Nov; 83(5):2511-21.Biophys J2002-11-01T00:00:002002Intracellular Ca(2+) release as irreversible Markov process.12080116Wang SQ, Song LS, Xu L, Meissner G, Lakatta EG, R?os E, Stern MD, Cheng HBiophysical journalThermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J. 2002 Jul; 83(1):242-51.Biophys J2002-07-01T00:00:002002Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks.11991852R?os E, Brum GFrontiers in bioscience : a journal and virtual libraryInitiation and termination of calcium sparks in skeletal muscle Front Biosci. 2002 05 01; 7:d1212-1222.Front Biosci2002-05-01T00:00:002002Initiation and termination of calcium sparks in skeletal muscle11801475Gonz?lez N, R?os E, Mart?n-Noya A, Rodr?guez JMHaematologicaThrombotic thrombocytopenic purpura and bone marrow necrosis as a complication of gastric neoplasm. Haematologica. 2002 Jan; 87(1):ECR01.Haematologica2002-01-01T00:00:002002Thrombotic thrombocytopenic purpura and bone marrow necrosis as a complication of gastric neoplasm.29021148Ferreira Gregorio J, Pequera G, Manno C, R?os E, Brum GThe Journal of general physiologyThe voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2. J Gen Physiol. 2017 Nov 06; 149(11):1041-1058.J Gen Physiol2017-10-11T00:00:002017The voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2.Authorship 478839Authorship 46839736724092Tammineni ER, Figueroa L, Manno C, Varma D, Kraeva N, Ibarra CA, Klip A, Riazi S, Rios EeLifeMuscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation. Elife. 2023 02 01; 12.Elife2023-02-01T00:00:002023Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation.36792386Figueroa L, Kraeva N, Manno C, Ibarra-Moreno CA, Tammineni ER, Riazi S, Rios EBritish journal of anaesthesiaDistinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia. Br J Anaesth. 2023 07; 131(1):47-55.Br J Anaesth2023-02-13T00:00:002023Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia.Authorship 303004https://www.rushu.rush.edu/faculty/john-tang-phdFaculty Profile at RUSH University Medical Centerhttps://www.ncbi.nlm.nih.gov/myncbi/browse/collection/51989419/?sort=date&direction=descendingMy NCBI Bibliographyhttp://orcid.org/0000-0003-0104-8324My ORCIDhttps://www.scopus.com/authid/detail.uri?authorId=7404638670My Scopustrue1InstructorInstructorDanBareDan Bare41.87432800000000-87.67059170000000350046Bare, DanInstructor