PhDJeffreyBorgiaJeffrey A. Borgia349549Borgia, JeffreyA.Director, Rush University Cancer Center Biorepository.
Director, Rush Biomarker Development Core.
My Scopus ID is 6602993443.
My NIH COMMONS name is JBORGIA.
Research Areas:
My research is primarily focused on the development of novel diagnostic tests based on ‘Omic’-level profiling of patient specimens and/or mechanistic insights for pathophysiology. As the Director of the Rush Cancer Center Biorepository, I oversee the collection and annotation of patient specimens to support translational research projects and clinical trials that are ongoing in the Rush University Cancer Center. My role as the Director of the Rush Biomarker Development Core permits me to facilitate the administration of ‘state of the art’ services aimed at the discovery and development of novel biomarkers aimed at altering treatment decisions in the clinics, ranging from early cancer detection to personalized treatment selection for patients. Platforms supported include quantitative mass spectrometry and custom Luminex immunoassays that, combined with accompanying laboratory automation and skilled personnel, generate very high-throughput biomarker discovery, assay development (with analytical validation), and routine specimen processing.
In response to the global Covid-19 pandemic my laboratory has developed a novel multiplex serological test that has been submitted for FDA approval under the Emergency Use Authorization. This assay quantitatively evaluates an immune response to the SARS-CoV-2 virus, including antibodies associated with viral neutralization. Further, my lab has partnered with Dr. Jeffrey Schneider and Dr. João Mamede to provide a functional assessment of SARS-CoV-2 neutralization through an ‘in house’ developed pseudovirus neutralization assay.
My Faculty Profile at Rush University Medical Center:
https://www.rushu.rush.edu/faculty/jeffrey-borgia-phd
My Laboratory:
https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-jeffrey-borgia-phd
My NCBI Bibliography:
https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40797756/?sort=date&direction=descending
My Scopus:
https://www.scopus.com/authid/detail.uri?authorId=6602993443
Education:
PhD, University of Minnesota, Twin Cities
BS, Eckerd CollegeAssociate Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifierbibo:suffixNamename suffixAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 35165630941741Burkart M, Schieber M, Basu S, Shah P, Venugopal P, Borgia JA, Gordon L, Karmali RBritish journal of haematologyEvaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma. Br J Haematol. 2019 07; 186(1):45-53.Br J Haematol2019-04-02T00:00:002019Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma.25991908Li Y, Rouhi O, Chen H, Ramirez R, Borgia JA, Deng YCancer informaticsRNA-Seq and Network Analysis Revealed Interacting Pathways in TGF-?-Treated Lung Cancer Cell Lines. Cancer Inform. 2014; 13(Suppl 5):129-40.Cancer Inform2015-04-01T00:00:002015RNA-Seq and Network Analysis Revealed Interacting Pathways in TGF-?-Treated Lung Cancer Cell Lines.25312225Kubasiak JC, Seder CW, Pithadia R, Basu S, Fhied C, Phillips WW, Daly S, Shersher DD, Yoder MA, Chmielewski G, Edell ES, Maldonado F, Liptay MJ, Borgia JAThe Journal of thoracic and cardiovascular surgeryValue of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 2015 Mar; 149(3):727-34.e1-3; discussion 734.J Thorac Cardiovasc Surg2014-09-19T00:00:002014Value of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer.26958084Chen H, Liu H, Zou H, Chen R, Dou Y, Sheng S, Dai S, Ai J, Melson J, Kittles RA, Pirooznia M, Liptay MJ, Borgia JA, Deng YJournal of CancerEvaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers. J Cancer. 2016; 7(5):490-9.J Cancer2016-02-05T00:00:002016Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers.21945224Shersher DD, Vercillo MS, Fhied C, Basu S, Rouhi O, Mahon B, Coon JS, Warren WH, Faber LP, Hong E, Bonomi P, Liptay MJ, Borgia JAThe Annals of thoracic surgeryBiomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. Ann Thorac Surg. 2011 Nov; 92(5):1805-11; discussion 1811.Ann Thorac Surg2011-09-25T00:00:002011Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer.20859284Farlow EC, Vercillo MS, Coon JS, Basu S, Kim AW, Faber LP, Warren WH, Bonomi P, Liptay MJ, Borgia JABritish journal of cancerA multi-analyte serum test for the detection of non-small cell lung cancer. Br J Cancer. 2010 Oct 12; 103(8):1221-8.Br J Cancer2010-09-21T00:00:002010A multi-analyte serum test for the detection of non-small cell lung cancer.23201823Daly S, Rinewalt D, Fhied C, Basu S, Mahon B, Liptay MJ, Hong E, Chmielewski G, Yoder MA, Shah PN, Edell ES, Maldonado F, Bungum AO, Borgia JAJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerDevelopment and validation of a plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules. J Thorac Oncol. 2013 Jan; 8(1):31-6.J Thorac Oncol2013-01-01T00:00:002013Development and validation of a plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules.19190517Borgia JA, Basu S, Faber LP, Kim AW, Coon JS, Kaiser-Walters KA, Fhied C, Thomas S, Rouhi O, Warren WH, Bonomi P, Liptay MJJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerEstablishment of a multi-analyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer. J Thorac Oncol. 2009 Mar; 4(3):338-47.J Thorac Oncol2009-03-01T00:00:002009Establishment of a multi-analyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer.20824709Patel K, Farlow EC, Kim AW, Lee BS, Basu S, Coon JS, DeCresce D, Thimothy L, Walters KA, Fhied C, Chang C, Chen SH, Faber LP, Bonomi P, Liptay MJ, Borgia JAInternational journal of cancerEnhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers. Int J Cancer. 2011 Jul 01; 129(1):133-42.Int J Cancer2010-11-09T00:00:002010Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers.27157918Medairos RA, Clark J, Holoubek S, Kubasiak JC, Pithadia R, Hamid F, Chmielewski GW, Warren WH, Basu S, Borgia JA, Liptay MJ, Seder CWThe Journal of thoracic and cardiovascular surgeryMetformin exposure is associated with improved progression-free survival in diabetic patients after resection for early-stage non-small cell lung cancer. J Thorac Cardiovasc Surg. 2016 Jul; 152(1):55-61.e1.J Thorac Cardiovasc Surg2016-04-14T00:00:002016Metformin exposure is associated with improved progression-free survival in diabetic patients after resection for early-stage non-small cell lung cancer.25301368Daly S, Kubasiak JC, Rinewalt D, Pithadia R, Basu S, Fhied C, Lobato GC, Seder CW, Hong E, Warren WH, Chmielewski G, Liptay MJ, Bonomi P, Borgia JAThe Annals of thoracic surgeryCirculating angiogenesis biomarkers are associated with disease progression in lung adenocarcinoma. Ann Thorac Surg. 2014 Dec; 98(6):1968-75; discussion 1975.Ann Thorac Surg2014-10-07T00:00:002014Circulating angiogenesis biomarkers are associated with disease progression in lung adenocarcinoma.22982029Rinewalt D, Shersher DD, Daly S, Fhied C, Basu S, Mahon B, Hong E, Chmielewski G, Liptay MJ, Borgia JAThe Journal of thoracic and cardiovascular surgeryDevelopment of a serum biomarker panel predicting recurrence in stage I non-small cell lung cancer patients. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1344-50; discussion 1350-1.J Thorac Cardiovasc Surg2012-09-13T00:00:002012Development of a serum biomarker panel predicting recurrence in stage I non-small cell lung cancer patients.20570928Farlow EC, Patel K, Basu S, Lee BS, Kim AW, Coon JS, Faber LP, Bonomi P, Liptay MJ, Borgia JAClinical cancer research : an official journal of the American Association for Cancer ResearchDevelopment of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer. Clin Cancer Res. 2010 Jul 01; 16(13):3452-62.Clin Cancer Res2010-06-22T00:00:002010Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer.26138771Seder CW, Kubasiak JC, Pithadia R, Basu S, Fhied C, Tarhoni I, Davila E, Alnajjar H, Chmielewski GW, Warren WH, Liptay MJ, Borgia JAThe Annals of thoracic surgeryAngiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules. Ann Thorac Surg. 2015 Aug; 100(2):429-36.Ann Thorac Surg2015-06-30T00:00:002015Angiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules.Authorship 364172131273063Becker JH, Gao Y, Soucheray M, Pulido I, Kikuchi E, Rodr?guez ML, Gandhi R, Lafuente-Sanchis A, Aup? M, Alc?cer Fern?ndez-Coronado J, Mart?n-Martorell P, Cremades A, Galbis-Caravajal JM, Alc?cer J, Christensen CL, Simms P, Hess A, Asahina H, Kahle MP, Al-Shahrour F, Borgia JA, Lahoz A, Insa A, Juan O, J?nne PA, Wong KK, Carretero J, Shimamura TCancer researchCXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC. Cancer Res. 2019 09 01; 79(17):4439-4452.Cancer Res2019-07-04T00:00:002019CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC.Authorship 36848231471841Fidler MJ, Borgia JA, Bonomi PD, Shah PAnnals of surgical oncologyPrognostic Significance of Skeletal Muscle Loss During Early Postoperative Period in Elderly Patients with Esophageal Cancer. Ann Surg Oncol. 2019 Nov; 26(12):3807-3808.Ann Surg Oncol2019-08-30T00:00:002019Prognostic Significance of Skeletal Muscle Loss During Early Postoperative Period in Elderly Patients with Esophageal Cancer.Authorship 37386431652685Bonomi P, Fidler MJ, Shah P, Borgia JCancersTheoretical and Practical Implications of Treating Cachexia in Advanced Lung Cancer Patients. Cancers (Basel). 2019 Oct 23; 11(11).Cancers (Basel)2019-10-23T00:00:002019Theoretical and Practical Implications of Treating Cachexia in Advanced Lung Cancer Patients.PhilipBonomiPhilip Bonomi349183Bonomi, PhilipProfessorChicago60612IL1169selected publications7.535180.0135458315research areas3.440390.02482231coauthor of255.34211.525260similar toMartaBatusMarta Batus349586Batus, MartaAssociate ProfessorMary JoFidlerMary Jo Fidler349589Fidler, Mary JoAssociate ProfessorChristopherSederChristopher Seder349647Seder, ChristopherAssistant Professor6Assistant Professor5Associate Professor4ProfessorD055613Disorders590.982361Multiple Pulmonary Nodulestrue1ProfessorProfessor21447156Chubinskaya S, Otten L, Soeder S, Borgia JA, Aigner T, Rueger DC, Loeser RFArthritis research & therapyRegulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther. 2011 Mar 29; 13(2):R55.Arthritis Res Ther2011-03-29T00:00:002011Regulation of chondrocyte gene expression by osteogenic protein-1.22423264Fidler MJ, Shersher DD, Borgia JA, Bonomi PTherapeutic advances in medical oncologyTargeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls. Ther Adv Med Oncol. 2012 Mar; 4(2):51-60.Ther Adv Med Oncol2012-03-01T00:00:002012Targeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls.23866081Sutton P, Borgia JA, Bonomi P, Plate JMMolecular cancerLyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. Mol Cancer. 2013 Jul 16; 12:76.Mol Cancer2013-07-16T00:00:002013Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.27629044Jeganathan N, Predescu D, Zhang J, Sha F, Bardita C, Patel M, Wood S, Borgia JA, Balk RA, Predescu SMolecular cancerRac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. Mol Cancer. 2016 09 14; 15(1):59.Mol Cancer2016-09-14T00:00:002016Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis.Authorship 401242132747363Pulido I, Ollosi S, Aparisi S, Becker JH, Aliena-Valero A, Benet M, Rodr?guez ML, L?pez A, Tamayo-Torres E, Chuli?-Peris L, Garc?a-Ca?averas JC, Soucheray M, Dalheim AV, Salom JB, Qiu W, Kaja S, Fern?ndez-Coronado JA, Alandes S, Alc?cer J, Al-Shahrour F, Borgia JA, Juan O, Nishimura MI, Lahoz A, Carretero J, Shimamura TCancer researchEndothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma. Cancer Res. 2020 10 01; 80(19):4224-4232.Cancer Res2020-08-03T00:00:002020Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma.Authorship 108366Authorship 1124810Authorship 113333Authorship 124227Authorship 127303Authorship 127573Authorship 129788Authorship 138218Authorship 1391314Authorship 145643Authorship 1507514Authorship 1580314Authorship 1631913Authorship 168934Authorship 169625Authorship 170105Authorship 170963Authorship 171342Authorship 1759510Authorship 1804112Authorship 1838413Authorship 1852510Authorship 187212Authorship 188975Authorship 1903616Authorship 192232Authorship 193134Authorship 20070115292257Baronas-Lowell D, Lauer-Fields JL, Borgia JA, Sferrazza GF, Al-Ghoul M, Minond D, Fields GBThe Journal of biological chemistryDifferential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen. J Biol Chem. 2004 Oct 15; 279(42):43503-13.J Biol Chem2004-08-02T00:00:002004Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.18633940Lee BS, Jayathilaka GD, Huang JS, Decresce D, Borgia JA, Zhou X, Gupta SElectrophoresisModification of the immobilized metal affinity electrophoresis using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Electrophoresis. 2008 Aug; 29(15):3160-3.Electrophoresis2008-08-01T00:00:002008Modification of the immobilized metal affinity electrophoresis using sodium dodecyl sulfate polyacrylamide gel electrophoresis.20812336Kim JS, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJArthritis and rheumatismInsulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010 Dec; 62(12):3706-15.Arthritis Rheum2010-12-01T00:00:002010Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells.21163304Overk CR, Borgia JA, Mufson EJJournal of neuroscience methodsA novel approach for long-term oral drug administration in animal research. J Neurosci Methods. 2011 Feb 15; 195(2):194-9.J Neurosci Methods2010-12-14T00:00:002010A novel approach for long-term oral drug administration in animal research.22784619Land WH, Qiao X, Margolis DE, Ford WS, Paquette CT, Perez-Rogers JF, Borgia JA, Yang JY, Deng YBMC systems biologyKernelized partial least squares for feature reduction and classification of gene microarray data. BMC Syst Biol. 2011; 5 Suppl 3:S13.BMC Syst Biol2011-12-23T00:00:002011Kernelized partial least squares for feature reduction and classification of gene microarray data.23237500Frankenberger C, Borgia JA, Edirisinghe PD, Oegema TRConnective tissue researchIncomplete elongation of the chondroitin sulfate linkage region on aggrecan and response to interleukin-1?. Connect Tissue Res. 2013; 54(2):123-31.Connect Tissue Res2013-01-18T00:00:002013Incomplete elongation of the chondroitin sulfate linkage region on aggrecan and response to interleukin-1?.24047464Gaynes JS, Micic C, Gaynes BI, Borgia JACurrent eye researchQuantitation of in vitro a-1 adrenergic receptor antagonist binding capacity to biologic melanin using tandem mass spectrometry. Curr Eye Res. 2013 Dec; 38(12):1214-20.Curr Eye Res2013-09-18T00:00:002013Quantitation of in vitro a-1 adrenergic receptor antagonist binding capacity to biologic melanin using tandem mass spectrometry.24657702Fhied C, Kanangat S, Borgia JAJournal of immunological methodsDevelopment of a bead-based immunoassay to routinely measure vimentin autoantibodies in the clinical setting. J Immunol Methods. 2014 May; 407:9-14.J Immunol Methods2014-03-20T00:00:002014Development of a bead-based immunoassay to routinely measure vimentin autoantibodies in the clinical setting.25433571Karmali R, Dalovisio A, Borgia JA, Venugopal P, Kim BW, Grant-Szymanski K, Hari P, Lazarus HBlood reviewsAll in the family: Clueing into the link between metabolic syndrome and hematologic malignancies. Blood Rev. 2015 Mar; 29(2):71-80.Blood Rev2014-09-28T00:00:002014All in the family: Clueing into the link between metabolic syndrome and hematologic malignancies.25735964Karmali R, Larson ML, Shammo JM, Basu S, Christopherson K, Borgia JA, Venugopal PLeukemia & lymphomaImpact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemia. Leuk Lymphoma. 2015; 56(11):3135-42.Leuk Lymphoma2015-05-14T00:00:002015Impact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemia.25847239Avasarala S, Van Scoyk M, Karuppusamy Rathinam MK, Zerayesus S, Zhao X, Zhang W, Pergande MR, Borgia JA, DeGregori J, Port JD, Winn RA, Bikkavilli RKThe Journal of biological chemistryPRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem. 2015 May 22; 290(21):13479-89.J Biol Chem2015-04-06T00:00:002015PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.11994000Malkar NB, Lauer-Fields JL, Borgia JA, Fields GBBiochemistryModulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives. Biochemistry. 2002 May 14; 41(19):6054-64.Biochemistry2002-05-14T00:00:002002Modulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives.Authorship 406267Authorship 40917633233515Barengolts E, Akbar A, Layden BT, Eisenberg Y, Priyadarshini M, Borgia JA, Fhied CL, Salim M, Dugas LRBiomedicinesPredictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance. Biomedicines. 2020 Nov 20; 8(11).Biomedicines2020-11-20T00:00:002020Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance.33434603Tarhoni I, Wakefield CJ, Kollipara R, Fidler MJ, Batus M, Bonomi P, Borgia JAJournal of immunological methodsRelationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition. J Immunol Methods. 2021 03; 490:112956.J Immunol Methods2021-01-09T00:00:002021Relationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition.Internal MedicineNeurological SciencesAnatomy and Cell BiologyRush University, Rush Medical CollegeMichaelLiptayMichael Liptay41.87340050000000-87.67011710000000349003Liptay, MichaelProfessorDavidBennettDavid A. Bennett41.87328300000000-87.66936330000000349004Bennett, DavidProfessorJamesMulshineJames L. Mulshine41.87328300000000-87.66936330000000349025Mulshine, James0000-0002-4648-9177ProfessorAuthorship 416807Authorship 42550733717559Wakefield CJ, Hamati F, Karush JM, Arndt AT, Geissen N, Liptay MJ, Borgia JA, Basu S, Seder CWJournal of thoracic diseaseSarcopenia after induction therapy is associated with reduced survival in patients undergoing esophagectomy for locally-advanced esophageal cancer. J Thorac Dis. 2021 Feb; 13(2):861-869.J Thorac Dis2021-02-01T00:00:002021Sarcopenia after induction therapy is associated with reduced survival in patients undergoing esophagectomy for locally-advanced esophageal cancer.33804721Yun NK, Rouhani SJ, Bestvina CM, Ritz EM, Gilmore BA, Tarhoni I, Borgia JA, Batus M, Bonomi PD, Fidler MJCancersNeutrophil-to-Lymphocyte Ratio Is a Predictive Biomarker in Patients with Epidermal Growth Factor Receptor (EGFR) Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Tyrosine Kinase Inhibitor (TKI) Therapy. Cancers (Basel). 2021 Mar 20; 13(6).Cancers (Basel)2021-03-20T00:00:002021Neutrophil-to-Lymphocyte Ratio Is a Predictive Biomarker in Patients with Epidermal Growth Factor Receptor (EGFR) Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Tyrosine Kinase Inhibitor (TKI) Therapy.D001323Chemicals & Drugs38990.938356AutoantibodiesD002289Disorders253160.769548Carcinoma, Non-Small-Cell LungAuthorship 4309227Authorship 43434534320344Larsen BM, Kannan M, Langer LF, Leibowitz BD, Bentaieb A, Cancino A, Dolgalev I, Drummond BE, Dry JR, Ho CS, Khullar G, Krantz BA, Mapes B, McKinnon KE, Metti J, Perera JF, Rand TA, Sanchez-Freire V, Shaxted JM, Stein MM, Streit MA, Tan YC, Zhang Y, Zhao E, Venkataraman J, Stumpe MC, Borgia JA, Masood A, Catenacci DVT, Mathews JV, Gursel DB, Wei JJ, Welling TH, Simeone DM, White KP, Khan AA, Igartua C, Salahudeen AACell reportsA pan-cancer organoid platform for precision medicine. Cell Rep. 2021 07 27; 36(4):109429.Cell Rep2021-07-27T00:00:002021A pan-cancer organoid platform for precision medicine.34386763Skertich NJ, Chu F, Tarhoni IA, Szajek S, Borgia JA, Madonna MBSurgery open scienceExpression of programmed death ligand 1 in drug-resistant osteosarcoma: An exploratory study. Surg Open Sci. 2021 Oct; 6:10-14.Surg Open Sci2021-07-14T00:00:002021Expression of programmed death ligand 1 in drug-resistant osteosarcoma: An exploratory study.true1Associate ProfessorAssociate ProfessorAuthorship 440158Authorship 442033Authorship 449157Authorship 451358Authorship 451935Authorship 45524835155590Manshad AS, Ballout FA, Borgia JA, Reiser J, Okwuosa TMFrontiers in cardiovascular medicineSoluble Urokinase Plasminogen Activator Receptor Is Associated With Subclinical Myocardial Impairment by Speckle Tracking Echocardiography in Lung Cancer Patients. Front Cardiovasc Med. 2021; 8:659524.Front Cardiovasc Med2022-01-28T00:00:002022Soluble Urokinase Plasminogen Activator Receptor Is Associated With Subclinical Myocardial Impairment by Speckle Tracking Echocardiography in Lung Cancer Patients.35159006Duan L, Calhoun S, Perez RE, Macias V, Mir F, Pergande MR, Gattuso P, Borgia JA, Maki CGCancersProlyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer. Cancers (Basel). 2022 Jan 31; 14(3).Cancers (Basel)2022-01-31T00:00:002022Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer.35159017Skertich NJ, Chu F, Tarhoni IAM, Szajek S, Borgia JA, Madonna MBCancersExpression of Immunomodulatory Checkpoint Molecules in Drug-Resistant Neuroblastoma: An Exploratory Study. Cancers (Basel). 2022 Jan 31; 14(3).Cancers (Basel)2022-01-31T00:00:002022Expression of Immunomodulatory Checkpoint Molecules in Drug-Resistant Neuroblastoma: An Exploratory Study.35198099Pohlman AW, Moudgalya H, Jordano L, Lobato GC, Gerard D, Liptay MJ, Seder CW, Borgia JAOncotargetThe role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer. Oncotarget. 2022; 13:393-407.Oncotarget2022-02-18T00:00:002022The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer.35253789Fhied CL, Tarhoni I, Gerard D, Lewin GM, Moudgalya H, Schneider JR, Borgia JAJournal of visualized experiments : JoVEDynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19. J Vis Exp. 2022 02 16; (180).J Vis Exp2022-02-16T00:00:002022Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19.35538548Khaliq AM, Erdogan C, Kurt Z, Turgut SS, Grunvald MW, Rand T, Khare S, Borgia JA, Hayden DM, Pappas SG, Govekar HR, Kam AE, Reiser J, Turaga K, Radovich M, Zang Y, Qiu Y, Liu Y, Fishel ML, Turk A, Gupta V, Al-Sabti R, Subramanian J, Kuzel TM, Sadanandam A, Waldron L, Hussain A, Saleem M, El-Rayes B, Salahudeen AA, Masood AGenome biologyRefining colorectal cancer classification and clinical stratification through a single-cell atlas. Genome Biol. 2022 05 11; 23(1):113.Genome Biol2022-05-11T00:00:002022Refining colorectal cancer classification and clinical stratification through a single-cell atlas.Cardiovascular and Thoracic SurgeryInternal Medicine, Division of Hematology/Oncology/Cell Therapytrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant ProfessorD008175Disorders646250.65394Lung Neoplasms28209123Derman BA, Macklis JN, Azeem MS, Sayidine S, Basu S, Batus M, Esmail F, Borgia JA, Bonomi P, Fidler MJBMC cancerRelationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer. BMC Cancer. 2017 02 16; 17(1):141.BMC Cancer2017-02-16T00:00:002017Relationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer.true1ProfessorProfessorAuthorship 2744315Authorship 274444Authorship 2744513Authorship 274468Authorship 274472Authorship 274487Authorship 2744910Authorship 274501Authorship 274511Authorship 290381028938541Fidler MJ, Frankenberger C, Seto R, Lobato GC, Fhied CL, Sayidine S, Basu S, Pool M, Karmali R, Batus M, Lie WR, Hayes D, Mistry J, Bonomi P, Borgia JAOncotargetDifferential expression of circulating biomarkers of tumor phenotype and outcomes in previously treated non-small cell lung cancer patients receiving erlotinib vs. cytotoxic chemotherapy. Oncotarget. 2017 Aug 29; 8(35):58108-58121.Oncotarget2017-04-28T00:00:002017Differential expression of circulating biomarkers of tumor phenotype and outcomes in previously treated non-small cell lung cancer patients receiving erlotinib vs. cytotoxic chemotherapy.28462232Bonomi P, Batus M, Fidler MJ, Borgia JAAnnals of translational medicinePractical and theoretical implications of weight gain in advanced non-small cell lung cancer patients. Ann Transl Med. 2017 Mar; 5(6):152.Ann Transl Med2017-03-01T00:00:002017Practical and theoretical implications of weight gain in advanced non-small cell lung cancer patients.28417157Karmali R, Alrifai T, Fughhi IAM, Ng R, Chukkapalli V, Shah P, Basu S, Nathan S, Szymanski-Grant K, Gordon LI, Venugopal P, Penedo FJ, Borgia JAAnnals of hematologyImpact of cachexia on outcomes in aggressive lymphomas. Ann Hematol. 2017 Jun; 96(6):951-956.Ann Hematol2017-04-17T00:00:002017Impact of cachexia on outcomes in aggressive lymphomas.27569939Lopez-Soler RI, Borgia JA, Kanangat S, Fhied CL, Conti DJ, Constantino D, Ata A, Chan R, Wang ZTransplantation proceedingsAnti-vimentin Antibodies Present at the Time of Transplantation May Predict Early Development of Interstitial Fibrosis/Tubular Atrophy. Transplant Proc. 2016 Jul-Aug; 48(6):2023-33.Transplant Proc2016-07-01T00:00:002016Anti-vimentin Antibodies Present at the Time of Transplantation May Predict Early Development of Interstitial Fibrosis/Tubular Atrophy.25321476Gu J, Lu Y, Li F, Qiao L, Wang Q, Li N, Borgia JA, Deng Y, Lei G, Zheng QCell death & diseaseIdentification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation. Cell Death Dis. 2014 Oct 16; 5:e1469.Cell Death Dis2014-10-16T00:00:002014Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation.19499072Borgia JA, Malkar NB, Abbasi HU, Fields GBJournal of biomolecular techniques : JBTDifficulties encountered during glycopeptide syntheses. J Biomol Tech. 2001 Sep; 12(3):44-68.J Biomol Tech2001-09-01T00:00:002001Difficulties encountered during glycopeptide syntheses.10802559Borgia JA, Fields GBTrends in biotechnologyChemical synthesis of proteins. Trends Biotechnol. 2000 Jun; 18(6):243-51.Trends Biotechnol2000-06-01T00:00:002000Chemical synthesis of proteins.28964418Seder CW, Arndt AT, Jordano L, Basu S, Fhied CL, Sayidine S, Chmielewski GW, Gallo K, Liptay MJ, Borgia JAThe Annals of thoracic surgerySerum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters. Ann Thorac Surg. 2017 Nov; 104(5):1637-1643.Ann Thorac Surg2017-09-28T00:00:002017Serum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters.Authorship 4663816Authorship 471008Authorship 4679519Authorship 48357836087784Jeanblanc N, Jackson L, Gawel S, Brophy S, Vaidya S, Syed S, Davis GJ, Borgia JAClinica chimica acta; international journal of clinical chemistryDevelopment of exploratory algorithms to aid in risk of malignancy prediction of indeterminate pulmonary nodules. Clin Chim Acta. 2022 Oct 01; 535:197-202.Clin Chim Acta2022-09-07T00:00:002022Development of exploratory algorithms to aid in risk of malignancy prediction of indeterminate pulmonary nodules.36493786Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negr?o F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JRCell reportsBulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep. 2022 12 13; 41(11):111799.Cell Rep2022-11-22T00:00:002022Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response.36524067Wakefield CJ, Lund N, Coughlin J, Karush JM, Geissen N, Alex G, Liptay MJ, Borgia JA, Shah P, Seder CWJournal of thoracic diseaseThe association between thoracic sarcopenia and survival is gender specific in early-stage lung cancer. J Thorac Dis. 2022 Nov; 14(11):4256-4265.J Thorac Dis2022-11-01T00:00:002022The association between thoracic sarcopenia and survival is gender specific in early-stage lung cancer.37190187Auger C, Moudgalya H, Neely MR, Stephan JT, Tarhoni I, Gerard D, Basu S, Fhied CL, Abdelkader A, Vargas M, Hu S, Hulett T, Liptay MJ, Shah P, Seder CW, Borgia JACancersDevelopment of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules. Cancers (Basel). 2023 Apr 12; 15(8).Cancers (Basel)2023-04-12T00:00:002023Development of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules.Authorship 300313Authorship 300516Authorship 30067729296211Yu Z, Chen H, Ai J, Zhu Y, Li Y, Borgia JA, Yang JS, Zhang J, Jiang B, Gu W, Deng YOncotargetGlobal lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer. Oncotarget. 2017 Dec 08; 8(64):107899-107906.Oncotarget2017-11-11T00:00:002017Global lipidomics identified plasma lipids as novel biomarkers for early detection of lung cancer.29288018Seder CW, Liptay MJ, Borgia JAThe Annals of thoracic surgeryReply. Ann Thorac Surg. 2018 07; 106(1):316-317.Ann Thorac Surg2017-12-26T00:00:002017Reply.29309212Tarhoni I, Fhied CL, Pool M, Liptay MJ, Bonomi P, Seder CW, Borgia JAJournal of immunoassay & immunochemistryDevelopment of bead based multiplexed immunoassay for evaluation of midkine, syndecan-1, and ANGPTL4 in patient serum. J Immunoassay Immunochem. 2018; 39(1):84-98.J Immunoassay Immunochem2018-02-02T00:00:002018Development of bead based multiplexed immunoassay for evaluation of midkine, syndecan-1, and ANGPTL4 in patient serum.Authorship 48679738025036Anderson KD, Beckmann C, Heermant S, Ko FC, Dulion B, Tarhoni I, Borgia JA, Virdi AS, Wimmer MA, Sumner DR, Ross RDJBMR plusZucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength. JBMR Plus. 2023 Nov; 7(11):e10819.JBMR Plus2023-10-11T00:00:002023Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength.Authorship 315241029558888Fidler MJ, Fhied CL, Roder J, Basu S, Sayidine S, Fughhi I, Pool M, Batus M, Bonomi P, Borgia JABMC cancerThe serum-based VeriStrat? test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients. BMC Cancer. 2018 03 20; 18(1):310.BMC Cancer2018-03-20T00:00:002018The serum-based VeriStrat? test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients.Authorship 31757829656111Kanangat S, Seder CW, Pergande MR, Lobato GC, Fhied CL, Raouf MF, Liptay MJ, Borgia JAHuman immunologyCirculating histocompatibility antigen (HLA) gene products may help differentiate benign from malignant indeterminate pulmonary lesions. Hum Immunol. 2018 Jul; 79(7):558-563.Hum Immunol2018-04-12T00:00:002018Circulating histocompatibility antigen (HLA) gene products may help differentiate benign from malignant indeterminate pulmonary lesions.Authorship 32007429383130Karmali R, Chukkapalli V, Gordon LI, Borgia JA, Ugolkov A, Mazar AP, Giles FJOncotargetGSK-3? inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents. Oncotarget. 2017 Dec 29; 8(70):114924-114934.Oncotarget2017-11-11T00:00:002017GSK-3? inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents.Authorship 3229522Authorship 324217Authorship 32502629906573Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DANeurobiology of learning and memoryStore depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Neurobiol Learn Mem. 2018 10; 154:141-157.Neurobiol Learn Mem2018-06-12T00:00:002018Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.29963143Yu Z, Chen H, Zhu Y, Ai J, Li Y, Gu W, Borgia JA, Zhang J, Jiang B, Chen W, Deng YOncology lettersGlobal lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study. Oncol Lett. 2018 Jul; 16(1):761-768.Oncol Lett2018-05-18T00:00:002018Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study.30029594Dou Y, Zhu Y, Ai J, Chen H, Liu H, Borgia JA, Li X, Yang F, Jiang B, Wang J, Deng YBMC genomicsPlasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening. BMC Genomics. 2018 Jul 20; 19(1):545.BMC Genomics2018-07-20T00:00:002018Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening.D014408Chemicals & Drugs461750.889691Biomarkers, Tumor