Perez, Ricardo
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last name: Perez
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research areas: Proto-Oncogene Proteins c-akt
research areas: Tumor Suppressor Protein p53
research areas: Imidazoles
research areas: Piperazines
research areas: Insulin Receptor Substrate Proteins
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Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a.
PubMed Identifier: 30289354
author list: Duan L, Perez RE, Maki CG
published in: Cancer biology & therapy
information resource reference: Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer Biol Ther. 2019; 20(3):252-260.
journal title abbreviation: Cancer Biol Ther
publication date: 2018-10-05T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
PubMed Identifier: 30967636
author list: Duan L, Perez RE, Chastain PD, Mathew MT, Bijukumar DR, Maki CG
published in: Oncogene
information resource reference: JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells. Oncogene. 2019 07; 38(28):5643-5657.
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publication date: 2019-04-09T00:00:00
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The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.
PubMed Identifier: 31036564
author list: Duan L, Perez RE, Lai X, Chen L, Maki CG
published in: The Journal of biological chemistry
information resource reference: The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells. J Biol Chem. 2019 06 07; 294(23):9186-9197.
journal title abbreviation: J Biol Chem
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Imidazoles
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Gitelis, Steven
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Duan, Lei
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Jones, Robin
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Maki, Carl
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Borgia, Jeffrey
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Professor
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The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
PubMed Identifier: 24936056
author list: Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG
published in: The Journal of biological chemistry
information resource reference: The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. J Biol Chem. 2014 Aug 01; 289(31):21694-705.
journal title abbreviation: J Biol Chem
publication date: 2014-06-16T00:00:00
year: 2014
type: Academic Article
type: Article
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Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.
PubMed Identifier: 25482935
author list: Duan L, Perez RE, Hansen M, Gitelis S, Maki CG
published in: Cancer biology & therapy
information resource reference: Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer Biol Ther. 2014; 15(12):1600-12.
journal title abbreviation: Cancer Biol Ther
publication date: 2014-01-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

p53-regulated autophagy is controlled by glycolysis and determines cell fate.
PubMed Identifier: 26337205
author list: Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG
published in: Oncotarget
information resource reference: p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. 2015 Sep 15; 6(27):23135-56.
journal title abbreviation: Oncotarget
publication date: 2015-09-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Modeling the Etiology of p53-mutated Cancer Cells.
PubMed Identifier: 27022024
author list: Perez RE, Shen H, Duan L, Kim RH, Kim T, Park NH, Maki CG
published in: The Journal of biological chemistry
information resource reference: Modeling the Etiology of p53-mutated Cancer Cells. J Biol Chem. 2016 May 06; 291(19):10131-47.
journal title abbreviation: J Biol Chem
publication date: 2016-03-28T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
PubMed Identifier: 27050276
author list: Davaadelger B, Duan L, Perez RE, Gitelis S, Maki CG
published in: Oncotarget
information resource reference: Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor. Oncotarget. 2016 May 10; 7(19):27511-26.
journal title abbreviation: Oncotarget
publication date: 2016-05-10T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 55639
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: Two 4N cell-cycle arrests contribute to cisplatin-resistance.

Authorship 55647
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author rank in publication: 1
linked author: Perez, Ricardo
linked information resource: Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.

Authorship 55657
type: Authorship
author rank in publication: 1
linked author: Perez, Ricardo
linked information resource: Modeling the Etiology of p53-mutated Cancer Cells.

Authorship 55658
type: Authorship
author rank in publication: 3
linked author: Perez, Ricardo
linked information resource: Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.

Authorship 55665
type: Authorship
author rank in publication: 3
linked author: Perez, Ricardo
linked information resource: Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer.

Authorship 55666
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a.

Authorship 55690
type: Authorship
author rank in publication: 4
linked author: Perez, Ricardo
linked information resource: Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells.

Authorship 55707
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.

Authorship 55712
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.

Authorship 55723
type: Authorship
author rank in publication: 4
linked author: Perez, Ricardo
linked information resource: The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.

Authorship 55729
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.

Authorship 55749
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: p53-regulated autophagy is controlled by glycolysis and determines cell fate.

Authorship 55777
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.

Authorship 55783
type: Authorship
author rank in publication: 4
linked author: Perez, Ricardo
linked information resource: Corrigendum to 'Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells'.

Authorship 55784
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: https://profiles.rush.edu/profile/4358939

Authorship 55788
type: Authorship
author rank in publication: 3
linked author: Perez, Ricardo
linked information resource: Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer.

Authorship 55792
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: Author Correction: RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.

Authorship 55794
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.

Authorship 55807
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.

Authorship 55810
type: Authorship
author rank in publication: 2
linked author: Perez, Ricardo
linked information resource: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.

Proto-Oncogene Proteins c-akt
MeSH DescriptorUI: D051057
MeSH semantic group name: Chemicals & Drugs
number of authors: 30
number of publications: 62
uniqueness weight: 0.943118
type: Concept

Two 4N cell-cycle arrests contribute to cisplatin-resistance.
PubMed Identifier: 23560058
author list: Shen H, Perez RE, Davaadelger B, Maki CG
published in: PloS one
information resource reference: Two 4N cell-cycle arrests contribute to cisplatin-resistance. PLoS One. 2013; 8(4):e59848.
journal title abbreviation: PLoS One
publication date: 2013-04-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.
PubMed Identifier: 33044914
author list: Perez RE, Calhoun S, Shim D, Levenson VV, Duan L, Maki CG
published in: Cancer biology & therapy
information resource reference: Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 11 01; 21(11):1033-1040.
journal title abbreviation: Cancer Biol Ther
publication date: 2020-10-12T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Internal Medicine
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Rush Alzheimer's Disease Center
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Anatomy and Cell Biology
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Rush University, Rush Medical College
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Bennett, David
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Mulshine, James
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Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells.
PubMed Identifier: 33755174
author list: Duan L, Calhoun S, Shim D, Perez RE, Blatter LA, Maki CG
published in: Journal of molecular cell biology
information resource reference: Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells. J Mol Cell Biol. 2021 09 11; 13(6):433-444.
journal title abbreviation: J Mol Cell Biol
publication date: 2021-09-11T00:00:00
year: 2021
type: Academic Article
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type: Document
type: Information Resource

Piperazines
MeSH DescriptorUI: D010879
MeSH semantic group name: Chemicals & Drugs
number of authors: 32
number of publications: 86
uniqueness weight: 0.927254
type: Concept

Professor
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Associate Professor
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Corrigendum to 'Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells'.
PubMed Identifier: 35092683
author list: Duan L, Calhoun S, Shim D, Perez RE, Blatter LA, Maki CG
published in: Journal of molecular cell biology
information resource reference: Corrigendum to 'Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells'. J Mol Cell Biol. 2022 Jan 29; 13(12):922.
journal title abbreviation: J Mol Cell Biol
publication date: 2022-01-29T00:00:00
year: 2022
type: Academic Article
type: Article
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type: Information Resource

RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.
PubMed Identifier: 35058503
author list: Duan L, Perez RE, Calhoun S, Maki CG
published in: Scientific reports
information resource reference: RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC. Sci Rep. 2022 01 20; 12(1):1049.
journal title abbreviation: Sci Rep
publication date: 2022-01-20T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

https://profiles.rush.edu/profile/4358939
PubMed Identifier: 35100078
author list: Duan L, Perez RE, Calhoun S, Maki CG
published in: Cancer biology & therapy
information resource reference: Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15. Cancer Biol Ther. 2022 12 31; 23(1):65-75.
journal title abbreviation: Cancer Biol Ther
publication date: 2022-12-31T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15.

Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer.
PubMed Identifier: 35159006
author list: Duan L, Calhoun S, Perez RE, Macias V, Mir F, Pergande MR, Gattuso P, Borgia JA, Maki CG
published in: Cancers
information resource reference: Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer. Cancers (Basel). 2022 Jan 31; 14(3).
journal title abbreviation: Cancers (Basel)
publication date: 2022-01-31T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Author Correction: RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.
PubMed Identifier: 35296774
author list: Duan L, Perez RE, Calhoun S, Maki CG
published in: Scientific reports
information resource reference: Author Correction: RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC. Sci Rep. 2022 Mar 16; 12(1):4525.
journal title abbreviation: Sci Rep
publication date: 2022-03-16T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor
is primary position: true
position in department: Pathology
position in division: https://profiles.rush.edu/profile/29646
sort order: 1
type: Position
HR job title: Professor
position in organization: Rush University, Rush Medical College

The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.
PubMed Identifier: 28696156
author list: Davaadelger B, Perez RE, Zhou Y, Duan L, Gitelis S, Maki CG
published in: Cancer biology & therapy
information resource reference: The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer Biol Ther. 2017 Nov 02; 18(11):895-903.
journal title abbreviation: Cancer Biol Ther
publication date: 2017-07-11T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.
PubMed Identifier: 29190376
author list: Duan L, Perez RE, Chen L, Blatter LA, Maki CG
published in: Journal of molecular cell biology
information resource reference: p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. J Mol Cell Biol. 2018 08 01; 10(4):331-340.
journal title abbreviation: J Mol Cell Biol
publication date: 2018-08-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer.
PubMed Identifier: 36332175
author list: Duan L, Calhoun SJ, Perez RE, Macias V, Mir F, Gattuso P, Maki CG
published in: Cancer biology & therapy
information resource reference: Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer. Cancer Biol Ther. 2022 Dec 31; 23(1):1-10.
journal title abbreviation: Cancer Biol Ther
publication date: 2022-12-31T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
PubMed Identifier: 29394130
author list: Zhou Y, Perez RE, Duan L, Maki CG
published in: Cancer biology & therapy
information resource reference: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. Cancer Biol Ther. 2018 06 03; 19(6):465-474.
journal title abbreviation: Cancer Biol Ther
publication date: 2018-03-13T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Tumor Suppressor Protein p53
MeSH DescriptorUI: D016159
MeSH semantic group name: Chemicals & Drugs
number of authors: 21
number of publications: 86
uniqueness weight: 0.921208
type: Concept

Insulin Receptor Substrate Proteins
MeSH DescriptorUI: D055504
MeSH semantic group name: Chemicals & Drugs
number of authors: 11
number of publications: 17
uniqueness weight: 0.980404
type: Concept

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type: URLLink
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link anchor text: Laboratory at RUSH University Medical Center

https://profiles.rush.edu/profile/8648459
type: URLLink
label: https://pubmed.ncbi.nlm.nih.gov/
link anchor text: My NCBI Bibliography

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type: URLLink
label: https://www.scopus.com/authid/detail.uri
link anchor text: My Scopus