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Jeffrey Schneider

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
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    Dr. Schneider’s lab focuses on HIV antibody distribution. He has helped develop a platform to track intravenous injected fluorophore conjugated IgG in plasma, tissue, and weck-cel fluid. This methodology has led to a grant to study how the timing of antibody injection affects distal site accumulation of virus following challenge. Through a better understanding of how antibodies get to and fortify mucosal surfaces from incoming pathogens, this research has the potential to elucidate novel HIV prevention strategies with the ultimate goal of blocking initial HIV transmission. This work will help inform future passive immunization studies, such as the AMP (Antibody Mediated Prevention) trial which is currently underway and administering anti-HIV antibodies to at-risk individuals around the world. As the SARS-CoV-2 pandemic emerged, I have adapted my work with HIV antibodies to better understand the neutralizing antibody response in COVID-19 patients.

    My Scopus ID is 55465896500.

    Research Areas:
    HIV pathogenesis, broadly neutralizing antibodies, passive immunization, and COVID-19.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/jeffrey-schneider-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-jeffrey-schneider-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/jeffrey.schneider.2/bibliography/public/

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=55465896500

    Education:
    PhD, Molecular Pathogenesis and Molecular Medicine, University of Chicago
    BS, Bioengineering, University of Illinois Urbana-Champaign

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negr?o F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR. Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep. 2022 12 13; 41(11):111799. PMID: 36493786.
      Citations:    
    2. Forte E, Des Soye BJ, Melani RD, Hollas MAR, Kafader JO, Sha BE, Schneider JR, Kelleher NL. Divergent Antibody Repertoires Found for Omicron versus Wuhan SARS-CoV-2 Strains Using Ig-MS. J Proteome Res. 2022 12 02; 21(12):2987-2997. PMID: 36343328.
      Citations:    
    3. Ozer EA, Simons LM, Adewumi OM, Fowotade AA, Omoruyi EC, Adeniji JA, Olayinka OA, Dean TJ, Zayas J, Bhimalli PP, Ash MK, Maiga AI, Somboro AM, Maiga M, Godzik A, Schneider JR, Mamede JI, Taiwo BO, Hultquist JF, Lorenzo-Redondo R. Multiple expansions of globally uncommon SARS-CoV-2 lineages in Nigeria. Nat Commun. 2022 02 03; 13(1):688. PMID: 35115515.
      Citations:    
    4. Melani RD, Des Soye BJ, Kafader JO, Forte E, Hollas M, Blagojevic V, Negr?o F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, Fellers RT, Cho BK, Mattamana BB, Goo YA, Thomas PM, Ash MK, Bhimalli PP, Al-Harthi L, Sha BE, Schneider JR, Kelleher NL. Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. J Proteome Res. 2022 01 07; 21(1):274-288. PMID: 34878788.
      Citations:    
    5. Docherty B, Schneider JC. Enlisting healthcare professionals in the campaign against incendiary weapons. Burns. 2022 Mar; 48(2):485-486. PMID: 34903413.
      Citations:    
    6. Melani RD, Soye BJD, Kafader JO, Forte E, Hollas M, Blagojevic V, Negr?o F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, Fellers RT, Cho BK, Mattamana BB, Goo YA, Thomas PM, Ash MK, Bhimalli PP, Al-Harthi L, Sha BE, Schneider JR, Kelleher NL. Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. medRxiv. 2021 Jul 07. PMID: 34268518.
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    7. Ozer EA, Simons LM, Adewumi OM, Fowotade AA, Omoruyi EC, Adeniji JA, Dean TJ, Zayas J, Bhimalli PP, Ash MK, Godzik A, Schneider JR, Mamede JI, Taiwo BO, Hultquist JF, Lorenzo-Redondo R. Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria. medRxiv. 2021 Jul 02. PMID: 33880483.
      Citations:    
    8. Carias AM, Schneider JR, Madden P, Lorenzo-Redondo R, Ara?nga M, Pegu A, Cianci GC, Maric D, Villinger F, Mascola JR, Veazey RS, Hope TJ. Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues. J Immunol. 2021 07 15; 207(2):505-511. PMID: 34162723.
      Citations:    
    9. Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Ara?nga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Fought AJ, Anderson MR, Thomas Y, Schneider JR, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure. PLoS Pathog. 2021 06; 17(6):e1009632. PMID: 34061907.
      Citations:    
    10. Schneider JR, Shen X, Orlandi C, Nyanhete T, Sawant S, Carias AM, Smith AD, Kelleher NL, Veazey RS, Lewis GK, Tomaras GD, Hope TJ. A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities. J Virol. 2020 02 14; 94(5). PMID: 31776284.
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    11. Schneider JR, Carias AM, Bastian AR, Cianci GC, Kiser PF, Veazey RS, Hope TJ. Long-term direct visualization of passively transferred fluorophore-conjugated antibodies. J Immunol Methods. 2017 11; 450:66-72. PMID: 28780040.
      Citations:    
    12. Lee AF, Ryan CM, Schneider JC, Kazis LE, Li NC, Rose M, Liang MH, Wang C, Palmieri T, Meyer WJ, Pidcock FS, Reilly D, Sheridan RL, Tompkins RG. Quantifying Risk Factors for Long-Term Sleep Problems After Burn Injury in Young Adults. J Burn Care Res. 2017 Mar/Apr; 38(2):e510-e520. PMID: 27003738.
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    13. Gunn B, Schneider J, Shansab M, Bastian AR, Fahrbach K, Smith A, Mahan A, Karim M, Licht A, Zvonar I, Tedesco J, Anderson M, Chapel A, Suscovich T, Malaspina D, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter G. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunol. 2016 11; 9(6):1549-1558. PMID: 26960182.
      Citations:    
    14. Schneider JR, Lodolce JP, Boone DL. An Ubiquitin-like Motif in ASK1 Mediates its Association with and Inhibition of the Proteasome. J Biochem Pharmacol Res. 2013 Sep 01; 1(3):161-167. PMID: 24286022.
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    15. Zhao B, Bhuripanyo K, Schneider J, Zhang K, Schindelin H, Boone D, Yin J. Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display. ACS Chem Biol. 2012 Dec 21; 7(12):2027-35. PMID: 23003343.
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    16. Rhee L, Murphy SF, Kolodziej LE, Grimm WA, Weber CR, Lodolce JP, Chang JE, Bartulis SJ, Messer JS, Schneider JR, Paski S, Nero TM, Boone DL. Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2):G220-7. PMID: 22595989.
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    17. Kolodziej LE, Lodolce JP, Chang JE, Schneider JR, Grimm WA, Bartulis SJ, Zhu X, Messer JS, Murphy SF, Reddy N, Turner JR, Boone DL. TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. PLoS One. 2011; 6(10):e26352. PMID: 22031828.
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    18. Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, Schneider JR, Boone D, Eves EM, Rosner MR, Gibbs JS, Embry A, Dolan B, Das S, Hickman HD, Berglund P, Bennink JR, Yewdell JW, Pan T. Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 26; 462(7272):522-6. PMID: 19940929.
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    19. Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol. 2005 Aug 15; 175(4):2061-5. PMID: 16081771.
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