22476197Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SEThe Journal of clinical investigationAlzheimer Disease; Brain; Cognition Disorders; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor IAged; Aged, 80 and over; Apolipoprotein E4; Cerebellar Cortex; Diabetes Complications; Drug Resistance; Female; Glucose; Hippocampus; Humans; Insulin; Male; Middle Aged; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Recombinant Proteins; Signal TransductionDemonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012 Apr; 122(4):1316-38.J Clin Invest2012-04-01T00:00:002012Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.Faculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000368Living Beings46094410.373134AgedD000544Disorders7819420.428697Alzheimer DiseaseAuthorship 174514Authorship 1746120.1089010.1089014authors10.2524has subject areaD048909Disorders37640.953136Diabetes ComplicationsD011994Chemicals & Drugs762510.939523Recombinant ProteinsZoeArvanitakisZoe Arvanitakis349047Arvanitakis, ZoeProfessorAuthorship 325511Pathology4ProfessorD003072Disorders8410110.585065Cognition DisordersD007333Disorders31590.954604Insulin ResistanceD008875Concepts & IdeasLiving Beings48398170.373681Middle AgedD002525Anatomy770.998278Cerebellar CortexD006624Anatomy652760.830451HippocampusD008297Physiology564156270.299065MaleD015398Physiology1374860.811992Signal TransductionD005260Physiology579162020.293532FemaleD004351Physiology34550.980868Drug ResistanceD010766Phenomena641720.95548PhosphorylationD005947Chemicals & Drugs37590.972831GlucoseNeurological SciencesRush University, Rush Medical CollegeDavidBennettDavid A. Bennett41.87328300000000-87.66936330000000349004Bennett, DavidProfessorJulieSchneiderJulie A. Schneider41.87328300000000-87.66936330000000349026Schneider, JulieProfessorD053327Chemicals & Drugs272270.862351Apolipoprotein E4D007328Chemicals & Drugs54910.926482InsulinRobertWilsonRobert S. Wilson41.87328300000000-87.66936330000000349742Wilson, RobertProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorD011499Physiology20360.985356Protein Processing, Post-TranslationalD006801Living Beings643293340.211949HumansAuthorship 3136510D001921Anatomy14916890.49271BrainD010768Chemicals & Drugs550.999205PhosphoserineD000369Living Beings33648440.492606Aged, 80 and overD055504Chemicals & Drugs9140.982422Insulin Receptor Substrate ProteinsD007334Chemicals & Drugs23540.955639Insulin-Like Growth Factor I