23794526Caicedo MS, Samelko L, McAllister K, Jacobs JJ, Hallab NJJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyAlloys; Inflammasomes; Lysosomes; MacrophagesCarrier Proteins; Caspase 1; Cathepsin B; Cells, Cultured; Chromium; Cobalt; Humans; In Vitro Techniques; Interleukin-1beta; Macrophage Activation; Molybdenum; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Particle Size; Phagocytosis; RNA, Small Interfering; Surface PropertiesIncreasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42.J Orthop Res2013-06-21T00:00:002013Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms.Faculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD002352Chemicals & Drugs54980.945354Carrier ProteinsD008264Anatomy481290.915941MacrophagesD053583Chemicals & Drugs28550.974053Interleukin-1betaD066298Concepts & IdeasProcedures762140.960601In Vitro TechniquesD010587Physiology21550.979598PhagocytosisAuthorship 198240.473990.1184982authors10.2521has subject areaD000497Chemicals & Drugs181020.951104Alloystrue1ProfessorProfessorNadimHallabNadim Hallab41.87352120000000-87.66713820000000349072Hallab, NadimProfessorD008982Chemicals & Drugs8220.988434Molybdenum4ProfessorAuthorship 71585D002401Chemicals & Drugs440.998795Cathepsin Btrue1ProfessorProfessorD058847Chemicals & Drugs9150.986926InflammasomesD002857Chemicals & Drugs18920.940471ChromiumD002478Anatomy1316880.866181Cells, CulturedD003035Chemicals & Drugs201160.92206CobaltD009000Anatomy331170.93677MonocytesD013499Phenomena311440.964709Surface PropertiesOrthopedic SurgeryRush University, Rush Medical CollegeJoshuaJacobsJoshua J. Jacobs41.87352120000000-87.66713820000000349020Jacobs, Joshua0000-0003-3902-7334ProfessorD034741Chemicals & Drugs33650.972885RNA, Small InterferingD020170Chemicals & Drugs7140.990668Caspase 1D006801Living Beings644293510.211905HumansD010316Concepts & Ideas22780.979947Particle SizeD0000711995110.987396NLR Family, Pyrin Domain-Containing 3 ProteinD008262Physiology12130.994276Macrophage ActivationD008247Anatomy16240.981081Lysosomes