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De novo design of potent and selective mimics of IL-2 and IL-15.
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De novo design of potent and selective mimics of IL-2 and IL-15.
De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 2019 01; 565(7738):186-191.
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PubMed
subject areas
Amino Acid Sequence
Animals
Binding Sites
Colonic Neoplasms
Computer Simulation
Crystallography, X-Ray
Disease Models, Animal
Drug Design
Humans
Interleukin-15
Interleukin-2
Interleukin-2 Receptor alpha Subunit
Melanoma
Mice
Models, Molecular
Molecular Mimicry
Protein Stability
Receptors, Interleukin-2
Signal Transduction
authors with profiles
Stephanie J. Crowley