 Vascular Endothelial Growth Factor Receptor-1
"Vascular Endothelial Growth Factor Receptor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
| Descriptor ID |
D040281
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.950.100 D12.776.543.750.060.750.100 D12.776.543.750.750.400.910.100
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| Concept/Terms |
Vascular Endothelial Growth Factor Receptor-1- Vascular Endothelial Growth Factor Receptor-1
- Vascular Endothelial Growth Factor Receptor 1
- FLT1 RTK
- VEGFR-1
- Proto-Oncogene Protein flt
- Proto Oncogene Protein flt
- VEGF Receptor flt-1 Protein
- VEGF Receptor flt 1 Protein
- VEGF Receptor, FLT
- FLT VEGF Receptor
- Receptor, FLT VEGF
- FLT1 Receptor Tyrosine Kinase
- fms-Like Tyrosine Kinase
- Tyrosine Kinase, fms-Like
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Below are MeSH descriptors whose meaning is more general than "Vascular Endothelial Growth Factor Receptor-1".
Below are MeSH descriptors whose meaning is more specific than "Vascular Endothelial Growth Factor Receptor-1".
This graph shows the total number of publications written about "Vascular Endothelial Growth Factor Receptor-1" by people in this website by year, and whether "Vascular Endothelial Growth Factor Receptor-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Vascular Endothelial Growth Factor Receptor-1" by people in Profiles.
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Gordon LI, Karmali R, Kaplan JB, Popat R, Burris HA, Ferrari S, Madan S, Patel MR, Gritti G, El-Sharkawi D, Chau FI, Radford J, de Oteyza JP, Zinzani PL, Iyer SP, Townsend W, Miao H, Proscurshim I, Wang S, Katyayan S, Yuan Y, Zhu J, Stumpo K, Shou Y, Carpio C, Bosch F. Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/CB-659). Oncotarget. 2023 01 26; 14:57-70.
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Qiu S, Shi C, Anbazhagan AN, Das V, Arora V, Kc R, Li X, O-Sullivan I, van Wijnen A, Chintharlapalli S, Gott-Velis G, Richard R, Mwale F, Shibuya M, Min S, Im HJ. Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model. J Cell Physiol. 2020 06; 235(6):5305-5317.
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Butler SM, Abrassart JM, Hubbell MC, Adeoye O, Semotiuk A, Williams JM, Mata-Greenwood E, Khorram O, Pearce WJ. Contributions of VEGF to age-dependent transmural gradients in contractile protein expression in ovine carotid arteries. Am J Physiol Cell Physiol. 2011 Sep; 301(3):C653-66.
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Mehendale R, Hibbard J, Fazleabas A, Leach R. Placental angiogenesis markers sFlt-1 and PlGF: response to cigarette smoke. Am J Obstet Gynecol. 2007 Oct; 197(4):363.e1-5.
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Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003 Mar; 111(5):649-58.
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