"Dideoxynucleosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
| Descriptor ID |
D015224
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| MeSH Number(s) |
D13.570.230.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dideoxynucleosides".
Below are MeSH descriptors whose meaning is more specific than "Dideoxynucleosides".
This graph shows the total number of publications written about "Dideoxynucleosides" by people in this website by year, and whether "Dideoxynucleosides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dideoxynucleosides" by people in Profiles.
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Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study. AIDS. 2010 Jul 17; 24(11):1657-65.
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Immune responses to abacavir in antigen-presenting cells from hypersensitive patients. AIDS. 2007 Jun 19; 21(10):1233-44.
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Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. MedGenMed. 2005 Jun 02; 7(2):70.
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Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease. AIDS Res Hum Retroviruses. 2002 Jan 20; 18(2):95-102.
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Abacavir expanded access program for adult patients infected with human immunodeficiency virus type 1. Clin Infect Dis. 2002 Feb 15; 34(4):535-42.
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Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase. AIDS. 2000 Dec 01; 14(17):2635-42.
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Efficacy and safety of the combination of efavirenz and abacavir in HIV-infected patients failing antiretroviral therapy. AIDS. 2000 Jul 07; 14(10):1470-1.