 Dideoxynucleosides
"Dideoxynucleosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
| Descriptor ID |
D015224
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| MeSH Number(s) |
D13.570.230.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dideoxynucleosides".
Below are MeSH descriptors whose meaning is more specific than "Dideoxynucleosides".
This graph shows the total number of publications written about "Dideoxynucleosides" by people in this website by year, and whether "Dideoxynucleosides" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dideoxynucleosides" by people in Profiles.
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Palella FJ, Gange SJ, Benning L, Jacobson L, Kaplan RC, Landay AL, Tracy RP, Elion R. Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study. AIDS. 2010 Jul 17; 24(11):1657-65.
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Martin AM, Almeida CA, Cameron P, Purcell AW, Nolan D, James I, McCluskey J, Phillips E, Landay A, Mallal S. Immune responses to abacavir in antigen-presenting cells from hypersensitive patients. AIDS. 2007 Jun 19; 21(10):1233-44.
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Kessler HA. Triple-nucleoside analog antiretroviral therapy: is there still a role in clinical practice? A review. MedGenMed. 2005 Jun 02; 7(2):70.
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Kessler HA, Johnson J, Follansbee S, Sension MG, Mildvan D, Sepulveda GE, Bellos NC, Hetherington SV. Abacavir expanded access program for adult patients infected with human immunodeficiency virus type 1. Clin Infect Dis. 2002 Feb 15; 34(4):535-42.
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Lederman MM, McKinnis R, Kelleher D, Cutrell A, Mellors J, Neisler M, Cooney E, Haas DW, Haubrich R, Stanford J, Horton J, Landay A, Spreen W. Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase. AIDS. 2000 Dec 01; 14(17):2635-42.
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Tenorio AR, Irlanda IE, Narkiewicz E, Smith KY, Kessler HA, Sha BE. Efficacy and safety of the combination of efavirenz and abacavir in HIV-infected patients failing antiretroviral therapy. AIDS. 2000 Jul 07; 14(10):1470-1.
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