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Transcription Factor 4

"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.

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This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
Bar chart showing 4 publications over 2 distinct years, with a maximum of 3 publications in 2011
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