A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Descriptor ID	D003123
MeSH Number(s)	C04.588.274.476.411.307.190 C04.700.250 C06.301.371.411.307.190 C06.405.249.411.307.190 C06.405.469.158.356.190 C06.405.469.491.307.190 C16.320.700.250 C18.452.284.255
Concept/Terms	Colorectal Neoplasms, Hereditary Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer Hereditary Nonpolyposis Lynch Syndrome I Lynch Cancer Family Syndrome I Lynch Syndrome Syndrome, Lynch Colon Cancer, Familial Nonpolyposis Hereditary Nonpolyposis Colon Cancer

Below are MeSH descriptors whose meaning is more general than "Colorectal Neoplasms, Hereditary Nonpolyposis".

Below are MeSH descriptors whose meaning is related to "Colorectal Neoplasms, Hereditary Nonpolyposis".

Below are MeSH descriptors whose meaning is more specific than "Colorectal Neoplasms, Hereditary Nonpolyposis".