 Caspase 1
"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
| Descriptor ID |
D020170
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
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| Concept/Terms |
Caspase 1- Caspase 1
- ICE Protease
- Interleukin-1beta Converting Enzyme
- Converting Enzyme, Interleukin-1beta
- Interleukin 1beta Converting Enzyme
- IL-1 beta-Converting Enzyme
- IL 1 beta Converting Enzyme
- beta-Converting Enzyme, IL-1
- IL1BC Enzyme
- Interleukin-1 Converting Enzyme
- Converting Enzyme, Interleukin-1
- Interleukin 1 Converting Enzyme
- CASP1 Caspase
- Caspase, CASP1
- IL-1 beta Convertase
- Convertase, IL-1 beta
- IL 1 beta Convertase
- beta Convertase, IL-1
Procaspase-1- Procaspase-1
- Procaspase 1
- Pro-Caspase-1
- Pro Caspase 1
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Below are MeSH descriptors whose meaning is more general than "Caspase 1".
Below are MeSH descriptors whose meaning is more specific than "Caspase 1".
This graph shows the total number of publications written about "Caspase 1" by people in this website by year, and whether "Caspase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 1" by people in Profiles.
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Samelko L, Caicedo M, McAllister K, Jacobs J, Hallab NJ. Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner. PLoS One. 2021; 16(5):e0251885.
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Mishra PK, Palma M, Buechel B, Moore J, Davra V, Chu N, Millman A, Hallab NJ, Kanneganti TD, Birge RB, Behrens EM, Rivera A, Beebe KS, Benevenia J, Gause WC. Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway. Nat Mater. 2019 03; 18(3):289-297.
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Samelko L, Caicedo MS, Jacobs J, Hallab NJ. Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336.
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Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF. Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis. Mediators Inflamm. 2014; 2014:195327.
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Caicedo MS, Samelko L, McAllister K, Jacobs JJ, Hallab NJ. Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42.
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Loda E, Balabanov R. Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination. Rev Neurosci. 2012 Jan 26; 23(2):145-52.
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Wang Y, Ren Z, Tao D, Tilwalli S, Goswami R, Balabanov R. STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells. Glia. 2010 Jan 15; 58(2):195-208.
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Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54.
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Tortorella MD, Malfait AM. The usual suspects: verdict not guilty? Arthritis Rheum. 2003 Dec; 48(12):3304-7.
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Zhang J, Mikecz K, Finnegan A, Glant TT. Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway. J Immunol. 2000 Sep 15; 165(6):2970-4.
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