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Xun Ai

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 8891857500.
    My NIH COMMONS name is XUNAI63.

    Research Areas:
    cardiac arrhythmias, atrial fibrillation, cardiovascular diseases.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/xun-ai-md

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-xun-ai-md

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46483484/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=8891857500

    Education:
    BS/MD, Suzhou Medical College (now Soochow University), China
    MS, Medical Science, Shanghai Medical University (now Fudan University), China
    Postdoctoral training, Johns Hopkins University / University of Illinois at Chicago


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yan J, Bare DJ, Ai X. The antiarrhythmic potential of aldehyde dehydrogenase 2. Heart Rhythm. 2022 May 30. PMID: 35654310.
      View in: PubMed
    2. Brundel BJJM, Ai X, Hills MT, Kuipers MF, Lip GYH, de Groot NMS. Atrial fibrillation. Nat Rev Dis Primers. 2022 04 07; 8(1):21. PMID: 35393446.
      View in: PubMed
    3. Hamilton S, Terentyeva R, Bogdanov V, Kim TY, Perger F, Yan J, Ai X, Carnes CA, Belevych AE, George CH, Davis JP, Gyorke S, Choi BR, Terentyev D. Ero1a-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia. Circ Res. 2022 03 04; 130(5):711-724. PMID: 35086342.
      View in: PubMed
    4. Ai X, Yan J, Pogwizd SM. Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders. Cell Signal. 2021 10; 86:110070. PMID: 34217833.
      View in: PubMed
    5. Yan J, Killingsworth C, Walcott G, Zhu Y, Litovsky S, Huang J, Ai X, Pogwizd SM. Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure. J Mol Cell Cardiol. 2021 09; 158:72-81. PMID: 34048725.
      View in: PubMed
    6. Bare DJ, Yue L, Ai X. A special issue on calcium dynamics of the heart: remodeling of ion channels and regulatory pathways. Pflugers Arch. 2021 03; 473(3):313-316. PMID: 33666746.
      View in: PubMed
    7. Yang M, Yan J, Wu A, Zhao W, Qin J, Pogwizd SM, Wu X, Yuan S, Ai X. Alterations of housekeeping proteins in human aged and diseased hearts. Pflugers Arch. 2021 03; 473(3):351-362. PMID: 33638007.
      View in: PubMed
    8. Feng J, Zong P, Yan J, Yue Z, Li X, Smith C, Ai X, Yue L. Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients. Pflugers Arch. 2021 03; 473(3):521-531. PMID: 33594499.
      View in: PubMed
    9. McKee C, Bare DJ, Ai X. Stress-driven cardiac calcium mishandling via a kinase-to-kinase crosstalk. Pflugers Arch. 2021 03; 473(3):363-375. PMID: 33590296.
      View in: PubMed
    10. Yan J, Bare DJ, DeSantiago J, Zhao W, Mei Y, Chen Z, Ginsburg K, Solaro RJ, Wolska BM, Bers DM, Chen SRW, Ai X. JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca2+]SR Leak-Load Relationship. Circ Res. 2021 02 19; 128(4):455-470. PMID: 33334123.
      View in: PubMed
    11. Yang M, Barrios J, Yan J, Zhao W, Yuan S, Dong E, Ai X. Causal roles of stress kinase JNK2 in DNA methylation and binge alcohol withdrawal-evoked behavioral deficits. Pharmacol Res. 2021 02; 164:105375. PMID: 33316384.
      View in: PubMed
    12. Ai X, Brundel BJJM. Editorial: Innovative Approaches to Tackle Atrial Fibrillation: From Bench to Bedside. Front Cardiovasc Med. 2020; 7:566239. PMID: 33195456.
      View in: PubMed
    13. McCauley MD, Hong L, Sridhar A, Menon A, Perike S, Zhang M, da Silva IB, Yan J, Bonini MG, Ai X, Rehman J, Darbar D. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008296. PMID: 32654503.
      View in: PubMed
    14. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164.
      View in: PubMed
    15. Bare DJ, Yan J, Ai X. Evidence of CaMKII-Regulated Late INa in Atrial Fibrillation Patients With Sleep Apnea: One-Step Closer to Finding Plausible Therapeutic Targets for Atrial Fibrillation? Circ Res. 2020 02 28; 126(5):616-618. PMID: 32105580.
      View in: PubMed
    16. Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 04; 129:236-246. PMID: 30862451.
      View in: PubMed
    17. Liu Z, Finet JE, Wolfram JA, Anderson ME, Ai X, Donahue JK. Calcium/calmodulin-dependent protein kinase II causes atrial structural remodeling associated with atrial fibrillation and heart failure. Heart Rhythm. 2019 07; 16(7):1080-1088. PMID: 30654134.
      View in: PubMed
    18. Du H, Huang Y, Hou X, Quan X, Jiang J, Wei X, Liu Y, Li H, Wang P, Zhan M, Ai X, Lu L, Yuan S, Sun L. Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo. Eur J Pharm Sci. 2018 Oct 15; 123:546-559. PMID: 30118848.
      View in: PubMed
    19. Yan J, Thomson JK, Zhao W, Gao X, Huang F, Chen B, Liang Q, Song LS, Fill M, Ai X. Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia. J Am Coll Cardiol. 2018 04 03; 71(13):1459-1470. PMID: 29598867.
      View in: PubMed
    20. Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X. Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIId expression in the aged atrium. Cardiovasc Res. 2018 04 01; 114(5):737-746. PMID: 29360953.
      View in: PubMed
    21. Hou X, Du H, Quan X, Shi L, Zhang Q, Wu Y, Liu Y, Xiao J, Li Y, Lu L, Ai X, Zhan M, Yuan S, Sun L. Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway. Front Pharmacol. 2018; 9:21. PMID: 29472856.
      View in: PubMed
    22. Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 03 16; 122(6):821-835. PMID: 29352041.
      View in: PubMed
    23. Zhang R, Zhang G, Xiang B, Chen X, Tang L, Shi S, Liu Y, Ai X, Xie P, Li Z. TRAF3 negatively regulates platelet activation and thrombosis. Sci Rep. 2017 12 07; 7(1):17112. PMID: 29215030.
      View in: PubMed
    24. Yan J, Thomson JK, Zhao W, Wu X, Gao X, DeMarco D, Kong W, Tong M, Sun J, Bakhos M, Fast VG, Liang Q, Prabhu SD, Ai X. The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart. J Mol Cell Cardiol. 2018 01; 114:105-115. PMID: 29146153.
      View in: PubMed
    25. Hood AR, Ai X, Pogwizd SM. Regulation of cardiac gap junctions by protein phosphatases. J Mol Cell Cardiol. 2017 06; 107:52-57. PMID: 28478048.
      View in: PubMed
    26. Ai X, Yan J, Carrillo E, Ding W. The Stress-Response MAP Kinase Signaling in Cardiac Arrhythmias. Rev Physiol Biochem Pharmacol. 2016; 172:77-100. PMID: 27848025.
      View in: PubMed
    27. Zhang Y, Wu S, Ma J, Xia Y, Ai X, Sun J. Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway. Tissue Barriers. 2015; 3(1-2):e972849. PMID: 25838979.
      View in: PubMed
    28. Yan J, Thomson JK, Zhao W, Fast VG, Ye T, Ai X. Voltage and calcium dual channel optical mapping of cultured HL-1 atrial myocyte monolayer. J Vis Exp. 2015 Mar 23; (97). PMID: 25867896.
      View in: PubMed
    29. Ai X. SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation. Front Physiol. 2015; 6:46. PMID: 25745402.
      View in: PubMed
    30. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XHT, Chang J. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10. PMID: 25348166.
      View in: PubMed
    31. Gemel J, Levy AE, Simon AR, Bennett KB, Ai X, Akhter S, Beyer EC. Connexin40 abnormalities and atrial fibrillation in the human heart. J Mol Cell Cardiol. 2014 Nov; 76:159-68. PMID: 25200600.
      View in: PubMed
    32. Yan J, Thomson JK, Wu X, Zhao W, Pollard AE, Ai X. Novel methods of automated quantification of gap junction distribution and interstitial collagen quantity from animal and human atrial tissue sections. PLoS One. 2014; 9(8):e104357. PMID: 25105669.
      View in: PubMed
    33. Wang Y, Yang Y, Ai X. Heart failure. ScientificWorldJournal. 2014; 2014:730651. PMID: 24693244.
      View in: PubMed
    34. Zhu Y, Ai X, Oster RA, Bers DM, Pogwizd SM. Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits. Pflugers Arch. 2013 Jun; 465(6):805-18. PMID: 23242028.
      View in: PubMed
    35. Yan J, Kong W, Zhang Q, Beyer EC, Walcott G, Fast VG, Ai X. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res. 2013 Mar 01; 97(3):589-97. PMID: 23241357.
      View in: PubMed
    36. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83. PMID: 22511749.
      View in: PubMed
    37. Dong JZ, Lei C, Ai XR, Wang Y. Selenium enrichment on Cordyceps militaris link and analysis on its main active components. Appl Biochem Biotechnol. 2012 Mar; 166(5):1215-24. PMID: 22246726.
      View in: PubMed
    38. Ai X, Jiang A, Ke Y, Solaro RJ, Pogwizd SM. Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardiovasc Res. 2011 Oct 01; 92(1):106-14. PMID: 21727092.
      View in: PubMed
    39. Ai X, Zhao W, Pogwizd SM. Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes. Cardiovasc Res. 2010 Mar 01; 85(4):751-62. PMID: 19880431.
      View in: PubMed
    40. Fahrenbach JP, Ai X, Banach K. Decreased intercellular coupling improves the function of cardiac pacemakers derived from mouse embryonic stem cells. J Mol Cell Cardiol. 2008 Nov; 45(5):642-9. PMID: 18817780.
      View in: PubMed
    41. Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 06; 102(11):1389-97. PMID: 18467626.
      View in: PubMed
    42. Guo T, Ai X, Shannon TR, Pogwizd SM, Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007 Oct 12; 101(8):802-10. PMID: 17704210.
      View in: PubMed
    43. Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005 Dec 09; 97(12):1314-22. PMID: 16269653.
      View in: PubMed
    44. Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers DM. Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res. 2005 Sep 16; 97(6):558-65. PMID: 16100047.
      View in: PubMed
    45. Ai X, Pogwizd SM. Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circ Res. 2005 Jan 07; 96(1):54-63. PMID: 15576650.
      View in: PubMed
    46. Li J, Yan JG, Ai X, Hu S, Gu YD, Matloub HS, Sanger JR. Ultrastructural analysis of peripheral-nerve regeneration within a nerve conduit. J Reconstr Microsurg. 2004 Oct; 20(7):565-9. PMID: 15534784.
      View in: PubMed
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