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An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.

Danilov SM, Gordon K, Nesterovitch AB, L├╝nsdorf H, Chen Z, Castellon M, Popova IA, Kalinin S, Mendonca E, Petukhov PA, Schwartz DE, Minshall RD, Sturrock ED. An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding. PLoS One. 2011; 6(10):e25952.

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