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Thomas Nielsen

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentOtolaryngology
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    My Scopus ID is 57192118614.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Qvortrup K, Hultqvist LD, Nilsson M, Jakobsen TH, Jansen CU, Uhd J, Andersen JB, Nielsen TE, Givskov M, Tolker-Nielsen T. Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation. Front Chem. 2019; 7:742. PMID: 31737611.
      View in: PubMed
    2. Wu P, Givskov M, Nielsen TE. Reactivity and Synthetic Applications of Multicomponent Petasis Reactions. Chem Rev. 2019 Oct 23; 119(20):11245-11290. PMID: 31454230.
      View in: PubMed
    3. Wu P, Nielsen TE. Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. Drug Discov Today Technol. 2018 Nov; 29:27-33. PMID: 30471670.
      View in: PubMed
    4. Mikkelsen RJT, Grier KE, Mortensen KT, Nielsen TE, Qvortrup K. Photolabile Linkers for Solid-Phase Synthesis. ACS Comb Sci. 2018 07 09; 20(7):377-399. PMID: 29863839.
      View in: PubMed
    5. Komnatnyy VV, Nielsen TE, Qvortrup K. Bead-based screening in chemical biology and drug discovery. Chem Commun (Camb). 2018 Jun 19; 54(50):6759-6771. PMID: 29888365.
      View in: PubMed
    6. Petersen J, Christensen KE, Nielsen MT, Mortensen KT, Komnatnyy VV, Nielsen TE, Qvortrup K. Oxidative Modification of Tryptophan-Containing Peptides. ACS Comb Sci. 2018 06 11; 20(6):344-349. PMID: 29719155.
      View in: PubMed
    7. Bang CG, Jensen JF, O'Hanlon Cohrt E, Olsen LB, Siyum SG, Mortensen KT, Skovgaard T, Berthelsen J, Yang L, Givskov M, Qvortrup K, Nielsen TE. A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. ACS Comb Sci. 2017 10 09; 19(10):657-669. PMID: 28746804.
      View in: PubMed
    8. Jakobsen TH, Warming AN, Vejborg RM, Moscoso JA, Stegger M, Lorenzen F, Rybtke M, Andersen JB, Petersen R, Andersen PS, Nielsen TE, Tolker-Nielsen T, Filloux A, Ingmer H, Givskov M. A broad range quorum sensing inhibitor working through sRNA inhibition. Sci Rep. 2017 08 29; 7(1):9857. PMID: 28851971.
      View in: PubMed
    9. Ishoey M, Petersen RG, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions. Chem Commun (Camb). 2017 Aug 22; 53(68):9410-9413. PMID: 28714998.
      View in: PubMed
    10. Qvortrup K, Petersen RG, Dohn AO, Møller KB, Nielsen TE. Solvent-Controlled Chemoselectivity in the Photolytic Release of Hydroxamic Acids and Carboxamides from Solid Support. Org Lett. 2017 06 16; 19(12):3263-3266. PMID: 28570068.
      View in: PubMed
    11. Wu P, Nielsen TE. Scaffold Diversity from N-Acyliminium Ions. Chem Rev. 2017 Jun 28; 117(12):7811-7856. PMID: 28493667.
      View in: PubMed
    12. Qvortrup K, Jensen JF, Sørensen MS, Kouskoumvekaki I, Petersen RK, Taboureau O, Kristiansen K, Nielsen TE. Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPAR? partial agonists. PLoS One. 2017; 12(2):e0162642. PMID: 28245241.
      View in: PubMed
    13. Hansen CL, Ohm RG, Olsen LB, Ascic E, Tanner D, Nielsen TE. Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions. Org Lett. 2016 12 02; 18(23):5990-5993. PMID: 27934390.
      View in: PubMed
    14. O'Toole TR, Ghai R, Nielsen T. Painless, Nonhealing Submental Ulcer. JAMA Otolaryngol Head Neck Surg. 2016 09 01; 142(9):913-4. PMID: 27149053.
      View in: PubMed
    15. Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T. The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation. Microbiology. 2016 10; 162(10):1797-1807. PMID: 27526691.
      View in: PubMed
    16. Wu P, Petersen MÅ, Cohrt AE, Petersen R, Morgentin R, Lemoine H, Roche C, Willaume A, Clausen MH, Nielsen TE. A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. Org Biomol Chem. 2016 Aug 07; 14(29):6947-50. PMID: 27356738.
      View in: PubMed
    17. Qvortrup K, Nielsen TE. In-Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors. Angew Chem Int Ed Engl. 2016 Mar 24; 55(14):4472-5. PMID: 26945672.
      View in: PubMed
    18. Wu P, Clausen MH, Nielsen TE. Allosteric small-molecule kinase inhibitors. Pharmacol Ther. 2015 Dec; 156:59-68. PMID: 26478442.
      View in: PubMed
    19. Wu P, Nielsen TE, Clausen MH. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discov Today. 2016 Jan; 21(1):5-10. PMID: 26210956.
      View in: PubMed
    20. Flagstad T, Petersen MT, Nielsen TE. A Four-Component Reaction for the Synthesis of Dioxadiazaborocines. Angew Chem Int Ed Engl. 2015 Jul 13; 54(29):8395-7. PMID: 26068978.
      View in: PubMed
    21. Wu P, Nielsen TE, Clausen MH. FDA-approved small-molecule kinase inhibitors. Trends Pharmacol Sci. 2015 Jul; 36(7):422-39. PMID: 25975227.
      View in: PubMed
    22. Petersen R, Cohrt AE, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence. Bioorg Med Chem. 2015 Jun 01; 23(11):2646-9. PMID: 25703308.
      View in: PubMed
    23. Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JW, Le Quement ST, Tolker-Nielsen T, Givskov M, Nielsen TE. Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. Bioorg Med Chem. 2015 Apr 01; 23(7):1638-50. PMID: 25716005.
      View in: PubMed
    24. Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, Clausen MH. Synthesis of 1,4,5 trisubstituted ?-lactams via a 3-component cascade reaction. Bioorg Med Chem. 2015 Jun 01; 23(11):2695-8. PMID: 25684425.
      View in: PubMed
    25. Flagstad T, Hansen MR, Le Quement ST, Givskov M, Nielsen TE. Combining the Petasis 3-component reaction with multiple modes of cyclization: a build/couple/pair strategy for the synthesis of densely functionalized small molecules. ACS Comb Sci. 2015 Jan 12; 17(1):19-23. PMID: 25469710.
      View in: PubMed
    26. Petersen R, Le Quement ST, Nielsen TE. Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. Angew Chem Int Ed Engl. 2014 Oct 27; 53(44):11778-82. PMID: 25214457.
      View in: PubMed
    27. Qvortrup K, Komnatnyy VV, Nielsen TE. A photolabile linker for the solid-phase synthesis of peptide hydrazides and heterocycles. Org Lett. 2014 Sep 19; 16(18):4782-5. PMID: 25166929.
      View in: PubMed
    28. Ishoey M, Nielsen TE. Synthesis of heterocycles through transition-metal-catalyzed isomerization reactions. Chemistry. 2014 Jul 14; 20(29):8832-40. PMID: 24924616.
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    29. Dandekar V, Morgan T, Turian J, Fidler MJ, Showel J, Nielsen T, Coleman J, Diaz A, Sher DJ. Patterns-of-failure after helical tomotherapy-based chemoradiotherapy for head and neck cancer: implications for CTV margin, elective nodal dose and bilateral parotid sparing. Oral Oncol. 2014 May; 50(5):520-6. PMID: 24613544.
      View in: PubMed
    30. Ascic E, Ohm RG, Petersen R, Hansen MR, Hansen CL, Madsen D, Tanner D, Nielsen TE. Synthesis of oxacyclic scaffolds via dual ruthenium hydride/Brønsted acid-catalyzed isomerization/cyclization of allylic ethers. Chemistry. 2014 Mar 17; 20(12):3297-300. PMID: 24616060.
      View in: PubMed
    31. Cohrt AE, Nielsen TE. Solid-phase synthesis of peptide thioureas and thiazole-containing macrocycles through Ru-catalyzed ring-closing metathesis. ACS Comb Sci. 2014 Feb 10; 16(2):71-7. PMID: 24377264.
      View in: PubMed
    32. Hansen MR, Le Quement ST, Jakobsen TH, Skovstrup S, Taboureau O, Tolker-Nielsen T, Givskov M, Nielsen TE. Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators. Chembiochem. 2014 Feb 10; 15(3):460-5. PMID: 24436223.
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    33. Komnatnyy VV, Chiang WC, Tolker-Nielsen T, Givskov M, Nielsen TE. Bacteria-triggered release of antimicrobial agents. Angew Chem Int Ed Engl. 2014 Jan 07; 53(2):439-41. PMID: 24288347.
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    34. Hansen CL, Clausen JW, Ohm RG, Ascic E, Le Quement ST, Tanner D, Nielsen TE. Ruthenium hydride/Brønsted acid-catalyzed tandem isomerization/N-acyliminium cyclization sequence for the synthesis of tetrahydro-ß-carbolines. J Org Chem. 2013 Dec 20; 78(24):12545-65. PMID: 24180610.
      View in: PubMed
    35. Christensen LD, van Gennip M, Rybtke MT, Wu H, Chiang WC, Alhede M, Høiby N, Nielsen TE, Givskov M, Tolker-Nielsen T. Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria. Infect Immun. 2013 Aug; 81(8):2705-13. PMID: 23690403.
      View in: PubMed
    36. Petersen MT, Nielsen TE. Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein. Org Lett. 2013 Apr 19; 15(8):1986-9. PMID: 23550830.
      View in: PubMed
    37. Kouskoumvekaki I, Petersen RK, Fratev F, Taboureau O, Nielsen TE, Oprea TI, Sonne SB, Flindt EN, Jónsdóttir SÓ, Kristiansen K. Discovery of a novel selective PPAR? ligand with partial agonist binding properties by integrated in silico/in vitro work flow. J Chem Inf Model. 2013 Apr 22; 53(4):923-37. PMID: 23432662.
      View in: PubMed
    38. Skovstrup S, Le Quement ST, Hansen T, Jakobsen TH, Harmsen M, Tolker-Nielsen T, Nielsen TE, Givskov M, Taboureau O. Identification of LasR ligands through a virtual screening approach. ChemMedChem. 2013 Jan; 8(1):157-63. PMID: 23203920.
      View in: PubMed
    39. Komnatnyy VV, Givskov M, Nielsen TE. Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence. Chemistry. 2012 Dec 21; 18(52):16793-800. PMID: 23132763.
      View in: PubMed
    40. Rybtke MT, Borlee BR, Murakami K, Irie Y, Hentzer M, Nielsen TE, Givskov M, Parsek MR, Tolker-Nielsen T. Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Aug; 78(15):5060-9. PMID: 22582064.
      View in: PubMed
    41. Ascic E, Le Quement ST, Ishoey M, Daugaard M, Nielsen TE. Build/couple/pair strategy combining the Petasis 3-component reaction with Ru-catalyzed ring-closing metathesis and isomerization. ACS Comb Sci. 2012 Apr 09; 14(4):253-7. PMID: 22356899.
      View in: PubMed
    42. Ascic E, Hansen CL, Le Quement ST, Nielsen TE. Synthesis of tetrahydro-ß-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet-Spengler theme. Chem Commun (Camb). 2012 Apr 04; 48(27):3345-7. PMID: 22367559.
      View in: PubMed
    43. Le Quement ST, Flagstad T, Mikkelsen RJ, Hansen MR, Givskov MC, Nielsen TE. Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones. Org Lett. 2012 Jan 20; 14(2):640-3. PMID: 22233295.
      View in: PubMed
    44. Ascic E, Jensen JF, Nielsen TE. Synthesis of heterocycles through a ruthenium-catalyzed tandem ring-closing metathesis/isomerization/N-acyliminium cyclization sequence. Angew Chem Int Ed Engl. 2011 May 23; 50(22):5188-91. PMID: 21520365.
      View in: PubMed
    45. Qvortrup K, Nielsen TE. A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles. Chem Commun (Camb). 2011 Mar 21; 47(11):3278-80. PMID: 21286634.
      View in: PubMed
    46. Qvortrup K, Taveras KM, Thastrup O, Nielsen TE. Chemical synthesis on SU-8. Chem Commun (Camb). 2011 Jan 28; 47(4):1309-11. PMID: 21063592.
      View in: PubMed
    47. Cohrt AE, Jensen JF, Nielsen TE. Traceless azido linker for the solid-phase synthesis of NH-1,2,3-triazoles via Cu-catalyzed azide-alkyne cycloaddition reactions. Org Lett. 2010 Dec 03; 12(23):5414-7. PMID: 21049916.
      View in: PubMed
    48. Le Quement ST, Petersen R, Meldal M, Nielsen TE. N-acyliminium intermediates in solid-phase synthesis. Biopolymers. 2010; 94(2):242-56. PMID: 20225296.
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    49. Nielsen TE, Meldal M. Solid-phase synthesis of complex and pharmacologically interesting heterocycles. Curr Opin Drug Discov Devel. 2009 Nov; 12(6):798-810. PMID: 19894191.
      View in: PubMed
    50. Nielsen TE, Schreiber SL. Towards the optimal screening collection: a synthesis strategy. Angew Chem Int Ed Engl. 2008; 47(1):48-56. PMID: 18080276.
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    51. Ahlquist M, Nielsen TE, Le Quement S, Tanner D, Norrby PO. An experimental and theoretical study of the mechanism of stannylcupration of alpha,beta-acetylenic ketones and esters. Chemistry. 2006 Mar 20; 12(10):2866-73. PMID: 16425170.
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    52. Juhl M, Nielsen TE, Le Quement S, Tanner D. Synthesis of the zoanthamine ABC ring system: some surprises from intramolecular Diels-Alder reactions. J Org Chem. 2006 Jan 06; 71(1):265-80. PMID: 16388646.
      View in: PubMed
    53. Nielsen TE, Le Quement S, Meldal M. Solid-phase synthesis of bicyclic dipeptide mimetics by intramolecular cyclization of alcohols, thiols, amines, and amides with N-acyliminium intermediates. Org Lett. 2005 Aug 18; 7(17):3601-4. PMID: 16092829.
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    54. Nielsen TE, Diness F, Meldal M. The Pictet-Spengler reaction in solid-phase combinatorial chemistry. Curr Opin Drug Discov Devel. 2003 Nov; 6(6):801-14. PMID: 14758752.
      View in: PubMed
    55. Nielsen TE, Cubillo De Dios MA, Tanner D. Highly stereoselective addition of stannylcuprates to alkynones. J Org Chem. 2002 Oct 18; 67(21):7309-13. PMID: 12375959.
      View in: PubMed
    56. Nielsen TE, Tanner D. Stereoselective synthesis of (E)-beta-tributylstannyl-alpha,beta-unsaturated ketones: construction of a key intermediate for the total synthesis of zoanthamine. J Org Chem. 2002 Sep 06; 67(18):6366-71. PMID: 12201755.
      View in: PubMed
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