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Xavier M. Keutgen

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentSurgery
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    My Scopus ID is 24605276200.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Keutgen XM, Li H, Memeh K, Conn Busch J, Williams J, Lan L, Sarne D, Finnerty B, Angelos P, Fahey TJ, Giger ML. A machine-learning algorithm for distinguishing malignant from benign indeterminate thyroid nodules using ultrasound radiomic features. J Med Imaging (Bellingham). 2022 May; 9(3):034501. PMID: 35692282.
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    2. Lakiza O, Lutze J, Vogle A, Williams J, Abukdheir A, Miller P, Liao C', Pitroda SP, Martinez C, Olivas A, Setia N, Kron SJ, Weichselbaum RR, Keutgen XM. Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors. Endocr Relat Cancer. 2022 03 21; 29(4):225-239. PMID: 35171113.
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    3. Keutgen XM. First Differentiate and Then Operate (Or Not) : Editorial on "Surgical Treatment of Patients with Poorly Differentiated Pancreatic Neuroendocrine Carcinoma: An NCDB Analysis". Ann Surg Oncol. 2022 06; 29(6):3371-3372. PMID: 35230582.
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    4. Sharma AE, Olivas A, Parilla M, Yassan L, Wang H, Zhang SS, Weber C, Keutgen XM, Hart J, Krausz T, Setia N. Epigenetic Dysregulation of 5-hydroxymethylcytosine in Well-Differentiated Pancreatic Neuroendocrine Tumors. Appl Immunohistochem Mol Morphol. 2022 02 01; 30(2):e11-e15. PMID: 34711739.
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    5. Laks S, van Leeuwaarde R, Patel D, Keutgen XM, Hammel P, Nilubol N, Links TP, Halfdanarson TR, Daniels AB, Tirosh A. Management recommendations for pancreatic manifestations of von Hippel-Lindau disease. Cancer. 2022 02 01; 128(3):435-446. PMID: 34735022.
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    6. Keutgen XM, Ornell KJ, Vogle A, Lakiza O, Williams J, Miller P, Mistretta KS, Setia N, Weichselbaum RR, Coburn JM. Sunitinib-Loaded Chondroitin Sulfate Hydrogels as a Novel Drug-Delivery Mechanism for the Treatment of Pancreatic Neuroendocrine Tumors. Ann Surg Oncol. 2021 Dec; 28(13):8532-8543. PMID: 34091777.
      View in: PubMed
    7. Memeh K, Ruhle B, Alsafran S, Vaghaiwalla T, Kaplan E, Angelos P, Keutgen XM. Total Thyroidectomy vs Thyroid Lobectomy for Localized Papillary Thyroid Cancer in Children: A Propensity-Matched Survival Analysis. J Am Coll Surg. 2021 07; 233(1):39-49. PMID: 33887483.
      View in: PubMed
    8. Chatani PD, Aversa JG, McDonald JD, Khan TM, Keutgen XM, Nilubol N. Preoperative serum chromogranin-a is predictive of survival in locoregional jejuno-ileal small bowel neuroendocrine tumors. Surgery. 2021 07; 170(1):106-113. PMID: 33814188.
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    9. Dolezal JM, Trzcinska A, Liao CY, Kochanny S, Blair E, Agrawal N, Keutgen XM, Angelos P, Cipriani NA, Pearson AT. Deep learning prediction of BRAF-RAS gene expression signature identifies noninvasive follicular thyroid neoplasms with papillary-like nuclear features. Mod Pathol. 2021 05; 34(5):862-874. PMID: 33299111.
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    10. Tierney JF, Vogle A, Finnerty B, Zarnegar R, Ghai R, Gattuso P, Fahey TJ, Keutgen XM. Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma. J Surg Res. 2020 12; 256:90-95. PMID: 32683062.
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    11. Memeh K, Ruhle B, Vaghaiwalla T, Kaplan E, Keutgen X, Angelos P. Thyroidectomy for euthyroid patients with Hashimoto thyroiditis and persisting symptoms: A cost-effectiveness analysis. Surgery. 2021 Jan; 169(1):7-13. PMID: 32460999.
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    12. Vaghaiwalla T, Ruhle B, Memeh K, Angelos P, Kaplan E, Liao CY, Polite B, Keutgen X. Response rates in metastatic neuroendocrine tumors receiving peptide receptor radionuclide therapy and implications for future treatment strategies. Surgery. 2021 01; 169(1):162-167. PMID: 32446596.
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    13. Vaghaiwalla T, Keutgen XM. Surgical Management of Pancreatic Neuroendocrine Tumors. Surg Oncol Clin N Am. 2020 Apr; 29(2):243-252. PMID: 32151358.
      View in: PubMed
    14. Skertich NJ, Tierney JF, Chivukula SV, Babazadeh NT, Hertl M, Poirier J, Keutgen XM. Risk factors associated with positive resection margins in patients with adrenocortical carcinoma. Am J Surg. 2020 10; 220(4):932-937. PMID: 32111342.
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    15. Babazadeh NT, Schlund DJ, Cornelius T, Singh JS, Tierney JF, Chen M, Keutgen XM. Should 68Ga-DOTATATE PET/CT be Performed Routinely in Patients with Neuroendocrine Tumors Before Surgical Resection? World J Surg. 2020 02; 44(2):604-611. PMID: 31576440.
      View in: PubMed
    16. Howe JR, Merchant NB, Conrad C, Keutgen XM, Hallet J, Drebin JA, Minter RM, Lairmore TC, Tseng JF, Zeh HJ, Libutti SK, Singh G, Lee JE, Hope TA, Kim MK, Menda Y, Halfdanarson TR, Chan JA, Pommier RF. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2020 01; 49(1):1-33. PMID: 31856076.
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    17. Tierney JF, Chivukula SV, Poirier J, Pappas SG, Schadde E, Hertl M, Kebebew E, Keutgen X. National Treatment Practice for Adrenocortical Carcinoma: Have They Changed and Have We Made Any Progress? J Clin Endocrinol Metab. 2019 12 01; 104(12):5948-5956. PMID: 31361313.
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    18. Chivukula SV, Tierney JF, Hertl M, Poirier J, Keutgen XM. Operative resection in early stage pancreatic neuroendocrine tumors in the United States: Are we over- or undertreating patients? Surgery. 2020 01; 167(1):180-186. PMID: 31537303.
      View in: PubMed
    19. Xie H, Liu J, Yadav S, Keutgen XM, Hobday TJ, Strosberg JR, Halfdanarson TR. The Role of Perioperative Systemic Therapy in Localized Pancreatic Neuroendocrine Neoplasms. Neuroendocrinology. 2020; 110(3-4):234-245. PMID: 31121586.
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    20. Tirosh A, Killian JK, Zhu YJ, Petersen D, Walling J, Mor-Cohen R, Neychev V, Stevenson H, Keutgen XM, Patel D, Nilubol N, Meltzer P, Kebebew E. ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. Endocr Pract. 2019 Jun; 25(6):580-588. PMID: 30865533.
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    21. Tierney JF, Poirier J, Chivukula S, Pappas SG, Hertl M, Schadde E, Keutgen X. Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases. Int J Endocrinol. 2019; 2019:9871319. PMID: 30992703.
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    22. Kalil JA, Poirier J, Becker B, Van Dam R, Keutgen X, Schadde E. Laparoscopic Parenchymal-Sparing Hepatectomy: the New Maximally Minimal Invasive Surgery of the Liver-a Systematic Review and Meta-Analysis. J Gastrointest Surg. 2019 04; 23(4):860-869. PMID: 30756316.
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    23. Skertich NJ, Gerard J, Poirier J, Hertl M, Pappas SG, Schadde E, Keutgen XM. Do All Abdominal Neuroendocrine Tumors Require Extended Postoperative VTE Prophylaxis? A NSQIP Analysis. J Gastrointest Surg. 2019 04; 23(4):788-793. PMID: 30671795.
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    24. Tirosh A, Mukherjee S, Lack J, Gara SK, Wang S, Quezado MM, Keutgen XM, Wu X, Cam M, Kumar S, Patel D, Nilubol N, Tyagi MV, Kebebew E. Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors. Cancer. 2019 04 15; 125(8):1247-1257. PMID: 30620390.
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    25. Tierney JF, Kosche C, Schadde E, Ali A, Virmani S, Pappas SG, Poirier J, Keutgen XM. 68Gallium-DOTATATE positron emission tomography-computed tomography (PET CT) changes management in a majority of patients with neuroendocrine tumors. Surgery. 2019 01; 165(1):178-185. PMID: 30415869.
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    26. Tierney JF, Vogle A, Poirier J, Min IM, Finnerty B, Zarnegar R, Pappas SG, Scognamiglio T, Ghai R, Gattuso P, Fahey TJ, Keutgen XM. Expression of programmed death ligand 1 and 2 in adrenocortical cancer tissues: An exploratory study. Surgery. 2019 01; 165(1):196-201. PMID: 30413322.
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    27. Tierney JF, Chivukula SV, Wang X, Pappas SG, Schadde E, Hertl M, Poirier J, Keutgen XM. Resection of primary tumor may prolong survival in metastatic gastroenteropancreatic neuroendocrine tumors. Surgery. 2019 03; 165(3):644-651. PMID: 30366604.
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    28. Keutgen XM, Schadde E, Pommier RF, Halfdanarson TR, Howe JR, Kebebew E. Metastatic neuroendocrine tumors of the gastrointestinal tract and pancreas: A surgeon's plea to centering attention on the liver. Semin Oncol. 2018 08; 45(4):232-235. PMID: 30318110.
      View in: PubMed
    29. Tirosh A, El Lakis M, Green P, Nockel P, Patel D, Nilubol N, Gara SK, Keutgen XM, Linehan WM, Kebebew E. In silico VHL Gene Mutation Analysis and Prognosis of Pancreatic Neuroendocrine Tumors in von Hippel-Lindau Disease. J Clin Endocrinol Metab. 2018 04 01; 103(4):1631-1638. PMID: 29294023.
      View in: PubMed
    30. Shell J, Keutgen XM, Millo C, Nilubol N, Patel D, Sadowski S, Boufraqech M, Yang L, Merkel R, Atallah C, Herscovitch P, Kebebew E. 68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor. Int J Endocr Oncol. 2018 Feb; 5(1):IJE04. PMID: 30112163.
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    31. Keutgen XM, Kumar S, Gara SK, Boufraqech M, Agarwal S, Hruban RH, Nilubol N, Quezado M, Finney R, Cam M, Kebebew E. Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Cancer. 2018 02 01; 124(3):636-647. PMID: 29149451.
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    32. Tirosh A, Papadakis GZ, Millo C, Hammoud D, Sadowski SM, Herscovitch P, Pacak K, Marx SJ, Yang L, Nockel P, Shell J, Green P, Keutgen XM, Patel D, Nilubol N, Kebebew E. Prognostic Utility of Total 68Ga-DOTATATE-Avid Tumor Volume in Patients With Neuroendocrine Tumors. Gastroenterology. 2018 03; 154(4):998-1008.e1. PMID: 29155309.
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    33. Deal R, Frederiks C, Williams L, Olthof PB, Dirscherl K, Keutgen X, Chan E, Deziel D, Hertl M, Schadde E. Rapid Liver Hypertrophy After Portal Vein Occlusion Correlates with the Degree of Collateralization Between Lobes-a Study in Pigs. J Gastrointest Surg. 2018 02; 22(2):203-213. PMID: 28766271.
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    34. Tirosh A, Papadakis GZ, Millo C, Sadowski SM, Herscovitch P, Pacak K, Marx SJ, Yang L, Nockel P, Shell J, Green P, Keutgen XM, Patel D, Nilubol N, Kebebew E. Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total 68Ga-DOTATATE-Avid tumor volume measurements. Eur J Endocrinol. 2017 May; 176(5):575-582. PMID: 28289088.
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    35. Babic B, Keutgen X, Nockel P, Miettinen M, Millo C, Herscovitch P, Patel D, Nilubol N, Cochran C, Gorden P, Kebebew E. Insulinoma Due to Multiple Pancreatic Microadenoma Localized by Multimodal Imaging. J Clin Endocrinol Metab. 2016 10; 101(10):3559-3563. PMID: 27504852.
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    36. Keutgen XM, Nilubol N, Agarwal S, Welch J, Cochran C, Marx SJ, Weinstein LS, Simonds WF, Kebebew E. Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism. Ann Surg Oncol. 2016 12; 23(Suppl 5):701-707. PMID: 27464610.
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    37. Nockel P, Millo C, Keutgen X, Klubo-Gwiezdzinska J, Shell J, Patel D, Nilubol N, Herscovitch P, Sadowski SM, Kebebew E. The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography. Thyroid. 2016 06; 26(6):831-5. PMID: 27094616.
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    38. Keutgen XM, Hammel P, Choyke PL, Libutti SK, Jonasch E, Kebebew E. Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease. Nat Rev Clin Oncol. 2016 09; 13(9):537-49. PMID: 27030075.
      View in: PubMed
    39. Keutgen XM, Nilubol N, Kebebew E. Malignant-functioning neuroendocrine tumors of the pancreas: A survival analysis. Surgery. 2016 May; 159(5):1382-9. PMID: 26704781.
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    40. Keutgen XM, Nilubol N, Glanville J, Sadowski SM, Liewehr DJ, Venzon DJ, Steinberg SM, Kebebew E. Resection of primary tumor site is associated with prolonged survival in metastatic nonfunctioning pancreatic neuroendocrine tumors. Surgery. 2016 Jan; 159(1):311-8. PMID: 26453135.
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    41. Sadowski SM, Millo C, Neychev V, Aufforth R, Keutgen X, Glanville J, Alimchandani M, Nilubol N, Herscovitch P, Quezado M, Kebebew E. Feasibility of Radio-Guided Surgery with 68Gallium-DOTATATE in Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumors. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S676-82. PMID: 26350374.
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    42. Keutgen XM, Sadowski SM, Kebebew E. Management of anaplastic thyroid cancer. Gland Surg. 2015 Feb; 4(1):44-51. PMID: 25713779.
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    43. Erler P, Keutgen XM, Crowley MJ, Zetoune T, Kundel A, Kleiman D, Beninato T, Scognamiglio T, Elemento O, Zarnegar R, Fahey TJ. Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer. Surgery. 2014 Dec; 156(6):1342-50; discussion 1350. PMID: 25456905.
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    44. Keutgen XM, Petrowsky H. Procurement for visceral organ transplantation: where to cannulate and how to perfuse? Curr Opin Organ Transplant. 2014 Apr; 19(2):92-9. PMID: 24565959.
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    45. Keutgen XM, Filicori F, Fahey TJ. Molecular diagnosis for indeterminate thyroid nodules on fine needle aspiration: advances and limitations. Expert Rev Mol Diagn. 2013 Jul; 13(6):613-23. PMID: 23895130.
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    46. Filicori F, Stock C, Schweitzer AD, Keutgen XM, Lagratta MD, Zarnegar R, Fahey TJ. Three-dimensional CT volumetry predicts outcome of laparoscopic splenectomy for splenomegaly: retrospective clinical study. World J Surg. 2013 Jan; 37(1):52-8. PMID: 23079780.
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    47. Filicori F, Keutgen XM, Zanello M, Ercolani G, Di Saverio S, Sacchetti F, Pinna AD, Grazi GL. Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy. Hepatobiliary Pancreat Dis Int. 2012 Oct; 11(5):507-12. PMID: 23060396.
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    48. Keutgen XM, Buitrago D, Filicori F, Kundel A, Elemento O, Fahey TJ, Zarnegar R. Calcimimetics versus parathyroidectomy for treatment of primary hyperparathyroidism: retrospective chart analysis of a prospective database. Ann Surg. 2012 May; 255(5):981-5. PMID: 22470074.
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    49. Bernie AM, Schwanke T, Keutgen X, Spigland N. Reduction en masse in a 7-year-old boy: an interesting case. J Pediatr Surg. 2012 May; 47(5):E19-20. PMID: 22595604.
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    50. Keutgen XM, Filicori F, Crowley MJ, Wang Y, Scognamiglio T, Hoda R, Buitrago D, Cooper D, Zeiger MA, Zarnegar R, Elemento O, Fahey TJ. A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration. Clin Cancer Res. 2012 Apr 01; 18(7):2032-8. PMID: 22351693.
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    51. Di Saverio S, Catena F, Filicori F, Ansaloni L, Coccolini F, Keutgen XM, Giugni A, Coniglio C, Biscardi A, Cavallo P, Mengoli F, Masetti M, Cinquantini F, Gordini G, Tugnoli G. Predictive factors of morbidity and mortality in grade IV and V liver trauma undergoing perihepatic packing: single institution 14 years experience at European trauma centre. Injury. 2012 Sep; 43(9):1347-54. PMID: 22281197.
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    52. Tom?s G, Tarabichi M, Gacquer D, H?brant A, Dom G, Dumont JE, Keutgen X, Fahey TJ, Maenhaut C, Detours V. A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic. Oncogene. 2012 Oct 11; 31(41):4490-8. PMID: 22266856.
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    53. Filicori F, Keutgen XM, Buitrago D, AlDailami H, Crowley M, Fahey TJ, Zarnegar R. Risk stratification of indeterminate thyroid fine-needle aspiration biopsy specimens based on mutation analysis. Surgery. 2011 Dec; 150(6):1085-91. PMID: 22136825.
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    54. Buitrago D, Keutgen XM, Crowley M, Filicori F, Aldailami H, Hoda R, Liu YF, Hoda RS, Scognamiglio T, Jin M, Fahey TJ, Zarnegar R. Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinoma. Ann Surg Oncol. 2012 Mar; 19(3):973-80. PMID: 21879273.
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    55. Stock C, Keutgen XM, Pisapia D, Crawford C, Zarnegar R. Heterotopic pancreatic neoplasm presenting as an obstructing mass at the fourth portion of the duodenum. JOP. 2011 May 06; 12(3):241-3. PMID: 21546699.
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    56. Kato MA, Buitrago D, Moo TA, Keutgen XM, Hoda RS, Ricci JA, Christos PJ, Yang G, Fahey TJ, Zarnegar R. Predictive value of cytologic atypia in indeterminate thyroid fine-needle aspirate biopsies. Ann Surg Oncol. 2011 Oct; 18(10):2893-8. PMID: 21424883.
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    57. Zetoune T, Keutgen X, Buitrago D, Aldailami H, Shao H, Mazumdar M, Fahey TJ, Zarnegar R. Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis. Ann Surg Oncol. 2010 Dec; 17(12):3287-93. PMID: 20596784.
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    58. Keutgen XM, Filicori F, Lee SW, Zarnegar R. En bloc right hemicolectomy and pancreaticoduodenectomy for HNPCC with simultaneous mutations of MSH-2 and MSH-6. Int J Colorectal Dis. 2011 Apr; 26(4):527-9. PMID: 20556398.
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    59. Hachem RY, Boktour MR, Hanna HA, Husni R, Hanna EY, Keutgen X, Shukrallah B, Raad II. Sinus surgery combined with antifungal therapy is effective in the treatment of invasive Aspergillus sinusitis in neutropenic patients with cancer. Infection. 2008 Dec; 36(6):539-42. PMID: 18726553.
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    60. Raad II, Fang X, Keutgen XM, Jiang Y, Sherertz R, Hachem R. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr Opin Infect Dis. 2008 Aug; 21(4):385-92. PMID: 18594291.
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    61. Megerle K, Keutgen X, M?ller M, Germann G, Sauerbier M. Treatment of scaphoid non-unions of the proximal third with conventional bone grafting and mini-Herbert screws: an analysis of clinical and radiological results. J Hand Surg Eur Vol. 2008 Apr; 33(2):179-85. PMID: 18443060.
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    62. Keutgen X, Hachem R, Jiang Y, Pham-Williams T, Tarrand J, Raad I. A comparison of galactomannan-ELISA and a newly developed galactomannan-LATEX test in the serologic diagnosis of invasive aspergillosis in patients with hematologic malignancies. Eur J Clin Microbiol Infect Dis. 2007 Sep; 26(9):655-8. PMID: 17623114.
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