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Jaime DeSantiago

TitleInstructor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 6603356235.
    My NIH COMMONS name is DESANTIAGO.

    Research Areas:
    Cardiac excitation-contraction coupling, arrhythmogenesis, atrial fibrillation, heart failure.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/jaime-desantiago-md-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-xun-ai-md

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=DeSantiago+J

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=6603356235

    Education:
    MD, Universidad Autonoma de Zacatecas, Mexico
    PhD, University of Health Sciences/The Chicago Medical School
    MS, Universidad Autonoma de San Luis Potosi, Mexico


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Varma D, Almeida JFQ, DeSantiago J, Blatter LA, Banach K. Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes. J Mol Cell Cardiol. 2022 02; 163:147-155. PMID: 34755642.
      View in: PubMed
    2. Yan J, Bare DJ, DeSantiago J, Zhao W, Mei Y, Chen Z, Ginsburg K, Solaro RJ, Wolska BM, Bers DM, Chen SRW, Ai X. JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca2+]SR Leak-Load Relationship. Circ Res. 2021 02 19; 128(4):455-470. PMID: 33334123.
      View in: PubMed
    3. DeSantiago J, Bare DJ, Varma D, Solaro RJ, Arora R, Banach K. Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity. Heart Rhythm. 2018 08; 15(8):1233-1241. PMID: 29625277.
      View in: PubMed
    4. Hohendanner F, DeSantiago J, Heinzel FR, Blatter LA. Dyssynchronous calcium removal in heart failure-induced atrial remodeling. Am J Physiol Heart Circ Physiol. 2016 12 01; 311(6):H1352-H1359. PMID: 27694214.
      View in: PubMed
    5. DeSantiago J, Bare DJ, Xiao L, Ke Y, Solaro RJ, Banach K. p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes. J Mol Cell Cardiol. 2014 Feb; 67:77-85. PMID: 24380729.
      View in: PubMed
    6. Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol. 2014 Jan; 66:27-40. PMID: 24161911.
      View in: PubMed
    7. DeSantiago J, Bare DJ, Banach K. Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity. Stem Cells Dev. 2013 Sep 15; 22(18):2497-507. PMID: 23614555.
      View in: PubMed
    8. DeSantiago J, Bare DJ, Ke Y, Sheehan KA, Solaro RJ, Banach K. Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol. 2013 Jul; 60:121-8. PMID: 23612118.
      View in: PubMed
    9. Neef S, Sag CM, Daut M, B?umer H, Grefe C, El-Armouche A, DeSantiago J, Pereira L, Bers DM, Backs J, Maier LS. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIId-KO mice. J Mol Cell Cardiol. 2013 Jun; 59:107-16. PMID: 23473775.
      View in: PubMed
    10. DeSantiago J, Bare DJ, Semenov I, Minshall RD, Geenen DL, Wolska BM, Banach K. Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells. J Mol Cell Cardiol. 2012 Jun; 52(6):1249-56. PMID: 22465692.
      View in: PubMed
    11. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM. SR-targeted CaMKII inhibition improves SR Ca?+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIdC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. PMID: 20971119.
      View in: PubMed
    12. Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res. 2010 Sep 03; 107(5):659-66. PMID: 20616315.
      View in: PubMed
    13. Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1263-73. PMID: 19700627.
      View in: PubMed
    14. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33. PMID: 19307602.
      View in: PubMed
    15. Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 06; 102(11):1389-97. PMID: 18467626.
      View in: PubMed
    16. Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM. CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol. 2007 Jan; 42(1):196-205. PMID: 17052727.
      View in: PubMed
    17. Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res. 2006 Sep 29; 99(7):740-8. PMID: 16946134.
      View in: PubMed
    18. Altamirano J, Li Y, DeSantiago J, Piacentino V, Houser SR, Bers DM. The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. J Physiol. 2006 Sep 15; 575(Pt 3):845-54. PMID: 16825310.
      View in: PubMed
    19. Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers DM, Dedman JR. Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H599-606. PMID: 16143658.
      View in: PubMed
    20. DeSantiago J, Maier LS, Bers DM. Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes. J Mol Cell Cardiol. 2004 Jan; 36(1):67-74. PMID: 14734049.
      View in: PubMed
    21. Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003 May 02; 92(8):904-11. PMID: 12676813.
      View in: PubMed
    22. DeSantiago J, Maier LS, Bers DM. Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol. 2002 Aug; 34(8):975-84. PMID: 12234767.
      View in: PubMed
    23. Li L, Desantiago J, Chu G, Kranias EG, Bers DM. Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. Am J Physiol Heart Circ Physiol. 2000 Mar; 278(3):H769-79. PMID: 10710345.
      View in: PubMed
    24. Rasgado-Flores H, Espinosa-Tanguma R, Tie J, DeSantiago J. Voltage dependence of Na-Ca exchange in barnacle muscle cells. I. Na-Na exchange activated by alpha-chymotrypsin. Ann N Y Acad Sci. 1996 Apr 15; 779:236-48. PMID: 8659831.
      View in: PubMed
    25. Pe?a-Rasgado C, Summers JC, McGruder KD, DeSantiago J, Rasgado-Flores H. Effect of isosmotic removal of extracellular Na+ on cell volume and membrane potential in muscle cells. Am J Physiol. 1994 Sep; 267(3 Pt 1):C759-67. PMID: 7943205.
      View in: PubMed
    26. Rasgado-Flores H, Gonzalez-Serratos H, DeSantiago J. Extracellular Mg(2+)-dependent Na+, K+, and Cl- efflux in squid giant axons. Am J Physiol. 1994 Apr; 266(4 Pt 1):C1112-7. PMID: 8178958.
      View in: PubMed
    27. Espinosa-Tanguma R, DeSantiago J, Rasgado-Flores H. Alpha-chymotrypsin deregulation of the sodium-calcium exchanger in barnacle muscle cells. Am J Physiol. 1993 Oct; 265(4 Pt 1):C1118-27. PMID: 8238302.
      View in: PubMed
    28. Rasgado-Flores H, DeSantiago J, Espinosa-Tanguma R. Stoichiometry and regulation of the Na-Ca exchanger in barnacle muscle cells. Ann N Y Acad Sci. 1991; 639:22-33. PMID: 1664702.
      View in: PubMed
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