Profiles

Keywords
Last Name
Institution

Igor J. Koralnik

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentNeurological Sciences
Address
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    My Scopus ID is 7003930241.
    My NIH COMMONS name is IKORALNI.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Sierra Morales F, Illingworth C, Lin K, Rivera Agosto I, Powell C, Sloane JA, Koralnik IJ. PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy. J Neurovirol. 2017 Oct; 23(5):789-792. PMID: 28831749.
      View in: PubMed
    2. Sierra Morales F, Wright RB, Novo JE, Arvanitis LD, Stefoski D, Koralnik IJ. Glioblastoma in natalizumab-treated multiple sclerosis patients. Ann Clin Transl Neurol. 2017 Jul; 4(7):512-516. PMID: 28695151.
      View in: PubMed
    3. Bialasiewicz S, Hart G, Oliver K, Agnihotri SP, Koralnik IJ, Viscidi R, Nissen MD, Sloots TP, Burke MT, Isbel NM, Burke J. A Difficult Decision: Atypical JC Polyomavirus Encephalopathy in a Kidney Transplant Recipient. Transplantation. 2017 Jun; 101(6):1461-1467. PMID: 27367472.
      View in: PubMed
    4. Siddiqi OK, Brown M, Cooper C, Atadzhanov M, Lakhi S, Koralnik IJ. Developing a successful global neurology program. Ann Neurol. 2017 Feb; 81(2):167-170. PMID: 28019673.
      View in: PubMed
    5. Siddiqi OK, Elafros MA, Bositis CM, Koralnik IJ, Theodore WH, Okulicz JF, Kalungwana L, Potchen MJ, Sikazwe I, Birbeck GL. New-onset seizure in HIV-infected adult Zambians: A search for causes and consequences. Neurology. 2017 Jan 31; 88(5):477-482. PMID: 28003499.
      View in: PubMed
    6. Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA, Anders RA, Sosman JA, Moslehi JJ. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. N Engl J Med. 2016 Nov 03; 375(18):1749-1755. PMID: 27806233.
      View in: PubMed
    7. Baharnoori M, Lyons J, Dastagir A, Koralnik I, Stankiewicz JM. Nonfatal PML in a patient with multiple sclerosis treated with dimethyl fumarate. Neurol Neuroimmunol Neuroinflamm. 2016 Oct; 3(5):e274. PMID: 27606353; PMCID: PMC4996537.
    8. Miskin DP, Saadi A, Chikoya L, Sloane JA, Koralnik IJ, Siddiqi OK. Challenges in the diagnosis and treatment of CNS demyelinating disorders in Zambia. Mult Scler J Exp Transl Clin. 2016 Jan-Dec; 2:2055217316657117. PMID: 28607733.
      View in: PubMed
    9. Wüthrich C, Batson S, Anderson MP, White LR, Koralnik IJ. JC Virus Infects Neurons and Glial Cells in the Hippocampus. J Neuropathol Exp Neurol. 2016 Jun 12. PMID: 27297673.
      View in: PubMed
    10. Xue Y, Ratushny V, Koralnik IJ, Schlaug G, Wu PA. Allergic Dermatitis Caused by Endovascular Coiling of Brain Aneurysm. Dermatitis. 2016 May-Jun; 27(3):149-50. PMID: 27172313.
      View in: PubMed
    11. Miskin DP, Ngo LH, Koralnik IJ. Diagnostic delay in progressive multifocal leukoencephalopathy. Ann Clin Transl Neurol. 2016 May; 3(5):386-91. PMID: 27231708; PMCID: PMC4863751.
    12. Miskin DP, Chalkias SG, Dang X, Bord E, Batson S, Koralnik IJ. Interleukin-7 treatment of PML in a patient with idiopathic lymphocytopenia. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2):e213. PMID: 27144212; PMCID: PMC4841501.
    13. Crossley KM, Agnihotri S, Chaganti J, Rodriguez ML, McNally LP, Venna N, Turbett SE, Gutman M, Morey A, Koralnik IJ, Brew BJ. Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals. J Neurovirol. 2016 Aug; 22(4):541-5. PMID: 26727910; PMCID: PMC4925684.
    14. Miskin DP, Herman ST, Ngo LH, Koralnik IJ. Predictors and characteristics of seizures in survivors of progressive multifocal leukoencephalopathy. J Neurovirol. 2016 Aug; 22(4):464-71. PMID: 26676826; PMCID: PMC4937716 [Available on 08/01/17].
    15. Chalkias SG, Gheuens S, Bord E, Batson S, Koralnik IJ. Brief Report: Role of Thymic Reconstitution in the Outcome of AIDS-Related PML. J Acquir Immune Defic Syndr. 2015 Dec 01; 70(4):357-61. PMID: 26181821; PMCID: PMC4624521 [Available on 12/01/16].
    16. Kaliyaperumal S, Wüthrich C, Westmoreland SV, Koralnik IJ. Simian Virus 40 Infection in the Spinal Cord of Simian Immunodeficiency Virus-Immunosuppressed Rhesus Macaques. J Neuropathol Exp Neurol. 2015 Nov; 74(11):1071-6. PMID: 26469249; PMCID: PMC4610247 [Available on 11/01/16].
    17. Bartsch T, Rempe T, Wrede A, Leypoldt F, Brück W, Adams O, Rohr A, Jansen O, Wüthrich C, Deuschl G, Koralnik IJ. Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate. Ann Neurol. 2015 Oct; 78(4):501-14. PMID: 26150206; PMCID: PMC4926166 [Available on 10/01/16].
    18. Sikazwe I, Elafros MA, Bositis CM, Siddiqi OK, Koralnik IJ, Kalungwana L, Theodore WH, Okulicz JF, Potchen MJ, Birbeck GL. HIV and new onset seizures: slipping through the cracks in HIV care and treatment. HIV Med. 2016 Feb; 17(2):118-23. PMID: 26200721.
      View in: PubMed
    19. Dang X, Chalkias S, Koralnik IJ. JC virus-iLOV fluorescent strains enable the detection of early and late viral protein expression. J Virol Methods. 2015 Oct; 223:25-9. PMID: 26205551; PMCID: PMC4554885 [Available on 10/01/16].
    20. Miskin DP, Koralnik IJ. Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area. Curr Opin Neurol. 2015 Jun; 28(3):288-94. PMID: 25887767; PMCID: PMC4414882.
    21. Agnihotri SP, Koralnik IJ. Training for a neurology career in a rare disease: The role of cyberconsults. Ann Neurol. 2015 May; 77(5):738-40. PMID: 25707384; PMCID: PMC4405469.
    22. Siddiqi OK, Elafros MA, Sikazwe I, Birbeck GL, Kalungwana L, Potchen MJ, Bositis CM, Koralnik IJ, Theodore WH. Acute EEG findings in HIV-infected Zambian adults with new-onset seizure. Neurology. 2015 Mar 31; 84(13):1317-22. PMID: 25740861; PMCID: PMC4388747.
    23. Satyanarayana G, Hammond SP, Broge TA, Mackenzie MR, Viscidi R, Politikos I, Koralnik IJ, Cutler CS, Ballen K, Boussiotis V, Marty FM, Tan CS. BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. Transpl Immunol. 2015 Mar; 32(2):116-20. PMID: 25536223; PMCID: PMC4368450.
    24. Koralnik IJ. Finger pointing to JC virus: a tale of two indexes. Ann Neurol. 2014 Dec; 76(6):789-91. PMID: 25380145; PMCID: PMC4427895.
    25. Potchen MJ, Siddiqi OK, Elafros MA, Koralnik IJ, Theodore WH, Sikazwe I, Kalungwana L, Bositis CM, Birbeck GL. Neuroimaging abnormalities and seizure recurrence in a prospective cohort study of zambians with human immunodeficiency virus and first seizure. Neurol Int. 2014 Oct 23; 6(4):5547. PMID: 25568738; PMCID: PMC4274408.
    26. Kalungwana L, Elafros MA, Siddiqi OK, Bositis CM, Sikazwe I, Koralnik IJ, Theodore WH, Birbeck GL. Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset seizure. Am J Trop Med Hyg. 2014 Dec; 91(6):1254-8. PMID: 25311691; PMCID: PMC4257655.
    27. Ellis LC, Koralnik IJ. JC virus nucleotides 376-396 are critical for VP1 capsid protein expression. J Neurovirol. 2015 Dec; 21(6):671-8. PMID: 25142442; PMCID: PMC4336641 [Available on 12/01/16].
    28. Agnihotri SP, Dang X, Carter JL, Fife TD, Bord E, Batson S, Koralnik IJ. JCV GCN in a natalizumab-treated MS patient is associated with mutations of the VP1 capsid gene. Neurology. 2014 Aug 19; 83(8):727-32. PMID: 25037207; PMCID: PMC4150135.
    29. Agnihotri SP, Wuthrich C, Dang X, Nauen D, Karimi R, Viscidi R, Bord E, Batson S, Troncoso J, Koralnik IJ. A fatal case of JC virus meningitis presenting with hydrocephalus in a human immunodeficiency virus-seronegative patient. Ann Neurol. 2014 Jul; 76(1):140-7. PMID: 24895208; PMCID: PMC4112354.
    30. Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34. PMID: 24687904; PMCID: PMC4425205.
    31. Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014 May; 75(5):659-69. PMID: 24752885; PMCID: PMC4426496.
    32. Dang L, Dang X, Koralnik IJ, Todd PK. JC polyomavirus granule cell neuronopathy in a patient treated with rituximab. JAMA Neurol. 2014 Apr; 71(4):487-9. PMID: 24515530; PMCID: PMC4086309.
    33. Schwenk H, Ramirez-Avila L, Sheu SH, Wuthrich C, Waugh J, Was A, Degirolami U, Burchett S, Koralnik IJ, Ahmed A. Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review. Pediatr Infect Dis J. 2014 Apr; 33(4):e99-105. PMID: 24632669; PMCID: PMC4020507.
    34. Tan CS, Broge TA, Ngo L, Gheuens S, Viscidi R, Bord E, Rosenblatt J, Wong M, Avigan D, Koralnik IJ. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is associated with selective control of JC virus reactivation. Biol Blood Marrow Transplant. 2014 Jul; 20(7):992-9. PMID: 24680976; PMCID: PMC4057943.
    35. Siddiqi OK, Ghebremichael M, Dang X, Atadzhanov M, Kaonga P, Khoury MN, Koralnik IJ. Molecular diagnosis of central nervous system opportunistic infections in HIV-infected Zambian adults. Clin Infect Dis. 2014 Jun; 58(12):1771-7. PMID: 24668125; PMCID: PMC4036687.
    36. Ellis LC, Norton E, Dang X, Koralnik IJ. Agnogene deletion in a novel pathogenic JC virus isolate impairs VP1 expression and virion production. PLoS One. 2013; 8(11):e80840. PMID: 24265839; PMCID: PMC3827225.
    37. Wüthrich C, Popescu BF, Gheuens S, Marvi M, Ziman R, Denq SP, Tham M, Norton E, Parisi JE, Dang X, Lucchinetti CF, Koralnik IJ. Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. J Neuropathol Exp Neurol. 2013 Nov; 72(11):1043-51. PMID: 24128680; PMCID: PMC4465443.
    38. Dang X, Koralnik IJ. Gone over to the dark side: Natalizumab-associated JC virus infection of neurons in cerebellar gray matter. Ann Neurol. 2013 Oct; 74(4):503-5. PMID: 23913509; PMCID: PMC4426847.
    39. Kaliyaperumal S, Dang X, Wuethrich C, Knight HL, Pearson C, MacKey J, Mansfield KG, Koralnik IJ, Westmoreland SV. Frequent infection of neurons by SV40 virus in SIV-infected macaque monkeys with progressive multifocal leukoencephalopathy and meningoencephalitis. Am J Pathol. 2013 Dec; 183(6):1910-1917. PMID: 24095925.
      View in: PubMed
    40. Khoury MN, Mittleman MA, Koralnik IJ. ABO blood groups and risk for progressive multifocal leukoencephalopathy. JAMA Neurol. 2013 Oct; 70(10):1331-2. PMID: 24126810; PMCID: PMC4112352.
    41. Khoury MN, Gheuens S, Ngo L, Wang X, Alsop DC, Koralnik IJ. Hyperperfusion in progressive multifocal leukoencephalopathy is associated with disease progression and absence of immune reconstitution inflammatory syndrome. Brain. 2013 Nov; 136(Pt 11):3441-50. PMID: 24088807; PMCID: PMC3808691.
    42. Khoury MN, Tan CS, Peaslee M, Koralnik IJ. CSF viral escape in a patient with HIV-associated neurocognitive disorder. J Neurovirol. 2013 Aug; 19(4):402-5. PMID: 23737348; PMCID: PMC3759614.
    43. Lach B, Connolly B, Wüthrich C, Koralnik IJ. Inflammatory infratentorial progressive multifocal leukoencephalopathy in a patient with rheumatoid arthritis. Neuropathology. 2014 Feb; 34(1):39-44. PMID: 23683127; PMCID: PMC3783631.
    44. Tan CS, Broge TA, Seung E, Vrbanac V, Viscidi R, Gordon J, Tager AM, Koralnik IJ. Detection of JC virus-specific immune responses in a novel humanized mouse model. PLoS One. 2013; 8(5):e64313. PMID: 23700470; PMCID: PMC3658964.
    45. Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology. 2013 Apr 09; 80(15):1430-8. PMID: 23568998; PMCID: PMC3662270.
    46. Gheuens S, Buggy BP, Tlomak W, Wüthrich C, Koralnik IJ. A game of viral hide and seek: miliary PML masquerading as EBV encephalitis in an HIV+ patient. Clin Neurol Neurosurg. 2013 Sep; 115(9):1861-3. PMID: 23535451; PMCID: PMC3700558.
    47. Siddiqi OK, Koralnik IJ, Atadzhanov M, Birbeck GL. Emerging subspecialties in neurology: global health. Neurology. 2013 Feb 19; 80(8):e78-80. PMID: 23420898; PMCID: PMC3589295.
    48. Koralnik IJ, Clifford DB. Comment: avoiding detrimental effects of corticosteroids on JC virus T-cell responses--primum non nocere. Neurology. 2012 Dec 04; 79(23):2263. PMID: 23175725.
      View in: PubMed
    49. Marousi S, Travasarou M, Karageorgiou CE, Gheuens S, Koralnik IJ. Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 2012 Nov 20; 79(21):2160; author reply 2160. PMID: 23170016.
      View in: PubMed
    50. Gheuens S, Wüthrich C, Koralnik IJ. Progressive multifocal leukoencephalopathy: why gray and white matter. Annu Rev Pathol. 2013 Jan 24; 8:189-215. PMID: 23092189.
      View in: PubMed
    51. Gheuens S, Ngo L, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Metabolic profile of PML lesions in patients with and without IRIS: an observational study. Neurology. 2012 Sep 04; 79(10):1041-8. PMID: 22914832; PMCID: PMC3430711.
    52. Tan CS, Bord E, Broge TA, Glotzbecker B, Mills H, Gheuens S, Rosenblatt J, Avigan D, Koralnik IJ. Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy. J Acquir Immune Defic Syndr. 2012 Jul 01; 60(3):244-8. PMID: 22549384; PMCID: PMC3400136.
    53. Dang X, Wüthrich C, Gordon J, Sawa H, Koralnik IJ. JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant. PLoS One. 2012; 7(4):e35793. PMID: 22536439; PMCID: PMC3334910.
    54. Gheuens S, Smith DR, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 2012 May 01; 78(18):1390-3. PMID: 22517104; PMCID: PMC3345789.
    55. Sethi NK, Torgovnick J, McArthur JC, Tan IL, Koralnik IJ. Progressive multifocal leukoencephalopathy in a patient without immunodeficiency. Neurology. 2012 Jan 03; 78(1):73; author response 73-4. PMID: 22201115.
      View in: PubMed
    56. Wüthrich C, Koralnik IJ. Frequent infection of cortical neurons by JC virus in patients with progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol. 2012 Jan; 71(1):54-65. PMID: 22157619; PMCID: PMC3246306.
    57. Dang X, Vidal JE, Oliveira AC, Simpson DM, Morgello S, Hecht JH, Ngo LH, Koralnik IJ. JC virus granule cell neuronopathy is associated with VP1 C terminus mutants. J Gen Virol. 2012 Jan; 93(Pt 1):175-83. PMID: 21940415; PMCID: PMC3352331.
    58. Gheuens S, Cheeseman SH, Koralnik IJ. Hidden in plain view: emergence of progressive multifocal leukoencephalopathy after treatment of CNS toxoplasmosis. Acta Neurol Belg. 2011 Sep; 111(3):217-9. PMID: 22141286; PMCID: PMC3249644.
    59. Viscidi RP, Khanna N, Tan CS, Li X, Jacobson L, Clifford DB, Nath A, Margolick JB, Shah KV, Hirsch HH, Koralnik IJ. JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals. Clin Infect Dis. 2011 Oct; 53(7):711-5. PMID: 21852452; PMCID: PMC3166351.
    60. McGuire JL, Fridman V, Wüthrich C, Koralnik IJ, Jacobs D. Progressive multifocal leukoencephalopathy associated with isolated CD8+ T-lymphocyte deficiency mimicking tumefactive MS. J Neurovirol. 2011 Oct; 17(5):500-3. PMID: 21786075; PMCID: PMC3204182.
    61. Aquino K, Koralnik IJ, Silvers D. Clinical Reasoning: An 83-year-old woman with progressive hemiataxia, tremor, and infratentorial lesions. Neurology. 2011 Jul 12; 77(2):e7-10. PMID: 21747070; PMCID: PMC3140070.
    62. Tan IL, Koralnik IJ, Rumbaugh JA, Burger PC, King-Rennie A, McArthur JC. Progressive multifocal leukoencephalopathy in a patient without immunodeficiency. Neurology. 2011 Jul 19; 77(3):297-9. PMID: 21734181; PMCID: PMC3136053.
    63. Gheuens S, Bord E, Kesari S, Simpson DM, Gandhi RT, Clifford DB, Berger JR, Ngo L, Koralnik IJ. Role of CD4+ and CD8+ T-cell responses against JC virus in the outcome of patients with progressive multifocal leukoencephalopathy (PML) and PML with immune reconstitution inflammatory syndrome. J Virol. 2011 Jul; 85(14):7256-63. PMID: 21543472; PMCID: PMC3126613.
    64. Dang X, Bialasiewicz S, Nissen MD, Sloots TP, Koralnik IJ, Tan CS. Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PLoS One. 2011 Mar 16; 6(3):e16736. PMID: 21436884; PMCID: PMC3059210.
    65. Lima MA, Bernal-Cano F, Clifford DB, Gandhi RT, Koralnik IJ. Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy. J Neurol Neurosurg Psychiatry. 2010 Nov; 81(11):1288-91. PMID: 20710013; PMCID: PMC3077967.
    66. Tan CS, Ellis LC, Wüthrich C, Ngo L, Broge TA, Saint-Aubyn J, Miller JS, Koralnik IJ. JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol. 2010 Sep; 84(18):9200-9. PMID: 20610709; PMCID: PMC2937633.
    67. Tan CS, Chen Y, Viscidi RP, Kinkel RP, Stein MC, Koralnik IJ. Discrepant findings in immune responses to JC virus in patients receiving natalizumab. Lancet Neurol. 2010 Jun; 9(6):565-6; author reply 566-7. PMID: 20494320; PMCID: PMC3817610.
    68. Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010 Apr; 9(4):425-37. PMID: 20298966; PMCID: PMC2880524.
    69. Gheuens S, Fellay J, Goldstein DB, Koralnik IJ. Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy. J Neurovirol. 2010 Feb; 16(1):41-7. PMID: 20105104; PMCID: PMC2854537.
    70. Siddiqi OK, Atadzhanov M, Birbeck GL, Koralnik IJ. The spectrum of neurological disorders in a Zambian tertiary care hospital. J Neurol Sci. 2010 Mar 15; 290(1-2):1-5. PMID: 20070986; PMCID: PMC2854137.
    71. Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ. Determinants of survival in progressive multifocal leukoencephalopathy. Neurology. 2009 Nov 10; 73(19):1551-8. PMID: 19901246; PMCID: PMC2777072.
    72. Gheuens S, Pierone G, Peeters P, Koralnik IJ. Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry. 2010 Mar; 81(3):247-54. PMID: 19828476; PMCID: PMC2889486.
    73. Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW. Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis. 2009 Oct; 9(10):625-36. PMID: 19778765; PMCID: PMC2919371.
    74. Chen Y, Bord E, Tompkins T, Miller J, Tan CS, Kinkel RP, Stein MC, Viscidi RP, Ngo LH, Koralnik IJ. Asymptomatic reactivation of JC virus in patients treated with natalizumab. N Engl J Med. 2009 Sep 10; 361(11):1067-74. PMID: 19741227; PMCID: PMC3077718.
    75. Wüthrich C, Dang X, Westmoreland S, McKay J, Maheshwari A, Anderson MP, Ropper AH, Viscidi RP, Koralnik IJ. Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons. Ann Neurol. 2009 Jun; 65(6):742-8. PMID: 19557867; PMCID: PMC2865689.
    76. Tan CS, Dezube BJ, Bhargava P, Autissier P, Wüthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation. J Infect Dis. 2009 Mar 15; 199(6):881-8. PMID: 19434914; PMCID: PMC2893283.
    77. Wüthrich C, Cheng YM, Joseph JT, Kesari S, Beckwith C, Stopa E, Bell JE, Koralnik IJ. Frequent infection of cerebellar granule cell neurons by polyomavirus JC in progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol. 2009 Jan; 68(1):15-25. PMID: 19104450; PMCID: PMC2637912.
    78. Marzocchetti A, Lima M, Tompkins T, Kavanagh DG, Gandhi RT, O'Neill DW, Bhardwaj N, Koralnik IJ. Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy. Virology. 2009 Jan 20; 383(2):173-7. PMID: 19062062; PMCID: PMC2692892.
    79. Marzocchetti A, Wuthrich C, Tan CS, Tompkins T, Bernal-Cano F, Bhargava P, Ropper AH, Koralnik IJ. Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy. J Neurovirol. 2008 Oct; 14(5):455-8. PMID: 18989816; PMCID: PMC2643300.
    80. Dang X, Wüthrich C, Axthelm MK, Koralnik IJ. Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeys. J Neuropathol Exp Neurol. 2008 Aug; 67(8):784-92. PMID: 18648324; PMCID: PMC2745603.
    81. Kesari S, Akar S, Saad A, Drappatz J, Koralnik IJ, DeAngelo DJ. Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia. J Clin Oncol. 2008 Aug 01; 26(22):3804-7. PMID: 18669471.
      View in: PubMed
    82. Chen Y, Trofe J, Gordon J, Autissier P, Woodle ES, Koralnik IJ. BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy. J Clin Virol. 2008 Jun; 42(2):198-202. PMID: 18295538; PMCID: PMC2678795.
    83. Bernal-Cano F, Joseph JT, Koralnik IJ. Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired immunodeficiency syndrome patient. J Neurovirol. 2007 Oct; 13(5):474-6. PMID: 17994433.
      View in: PubMed
    84. Yang W, Beaudoin EL, Lu L, Du Pasquier RA, Kuroda MJ, Willemsen RA, Koralnik IJ, Junghans RP. Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int Immunol. 2007 Sep; 19(9):1083-93. PMID: 17660502.
      View in: PubMed
    85. Verma S, Cikurel K, Koralnik IJ, Morgello S, Cunningham-Rundles C, Weinstein ZR, Bergmann C, Simpson DM. Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera. J Infect Dis. 2007 Sep 01; 196(5):709-11. PMID: 17674313.
      View in: PubMed
    86. Lima MA, Katz-Brull R, Lenkinski RE, Nunez R, Feinrider D, Koralnik IJ. Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient. Eur J Neurol. 2007 Jun; 14(6):598-602. PMID: 17539934.
      View in: PubMed
    87. Lima MA, Marzocchetti A, Autissier P, Tompkins T, Chen Y, Gordon J, Clifford DB, Gandhi RT, Venna N, Berger JR, Koralnik IJ. Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. J Virol. 2007 Apr; 81(7):3361-8. PMID: 17229701; PMCID: PMC1866063.
    88. Dang X, Koralnik IJ. A granule cell neuron-associated JC virus variant has a unique deletion in the VP1 gene. J Gen Virol. 2006 Sep; 87(Pt 9):2533-7. PMID: 16894191.
      View in: PubMed
    89. Vulliemoz S, Lurati-Ruiz F, Borruat FX, Delavelle J, Koralnik IJ, Kuntzer T, Bogousslavsky J, Picard F, Landis T, Du Pasquier RA. Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis. J Neurol Neurosurg Psychiatry. 2006 Sep; 77(9):1079-82. PMID: 16914758; PMCID: PMC2077730.
    90. Koralnik IJ. Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name? Ann Neurol. 2006 Aug; 60(2):162-73. PMID: 16862584.
      View in: PubMed
    91. Du Pasquier RA, Stein MC, Lima MA, Dang X, Jean-Jacques J, Zheng Y, Letvin NL, Koralnik IJ. JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients. J Neuroimmunol. 2006 Jul; 176(1-2):181-6. PMID: 16750575.
      View in: PubMed
    92. Chen Y, Trofe J, Gordon J, Du Pasquier RA, Roy-Chaudhury P, Kuroda MJ, Woodle ES, Khalili K, Koralnik IJ. Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy. J Virol. 2006 Apr; 80(7):3495-505. PMID: 16537617; PMCID: PMC1440396.
    93. Wüthrich C, Kesari S, Kim WK, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol. 2006 Apr; 12(2):116-28. PMID: 16798673.
      View in: PubMed
    94. Lima MA, Drislane FW, Koralnik IJ. Seizures and their outcome in progressive multifocal leukoencephalopathy. Neurology. 2006 Jan 24; 66(2):262-4. PMID: 16434670.
      View in: PubMed
    95. Du Pasquier RA, Autissier P, Zheng Y, Jean-Jacques J, Koralnik IJ. Presence of JC virus-specific CTL in the cerebrospinal fluid of PML patients: rationale for immune-based therapeutic strategies. AIDS. 2005 Dec 02; 19(18):2069-76. PMID: 16284455.
      View in: PubMed
    96. Lima MA, Auriel E, Wüthrich C, Borenstein NM, Koralnik IJ. Progressive multifocal leukoencephalopathy as a complication of hepatitis C virus treatment in an HIV-negative patient. Clin Infect Dis. 2005 Aug 01; 41(3):417-9. PMID: 16007550.
      View in: PubMed
    97. Berger JR, Koralnik IJ. Progressive multifocal leukoencephalopathy and natalizumab--unforeseen consequences. N Engl J Med. 2005 Jul 28; 353(4):414-6. PMID: 15947082.
      View in: PubMed
    98. Koralnik IJ, Wüthrich C, Dang X, Rottnek M, Gurtman A, Simpson D, Morgello S. JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy. Ann Neurol. 2005 Apr; 57(4):576-80. PMID: 15786466.
      View in: PubMed
    99. Dang X, Axthelm MK, Letvin NL, Koralnik IJ. Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys. J Virol. 2005 Feb; 79(3):1361-6. PMID: 15650162; PMCID: PMC544112.
    100. Lima MA, Hanto DW, Curry MP, Wong MT, Dang X, Koralnik IJ. Atypical radiological presentation of progressive multifocal leukoencephalopathy following liver transplantation. J Neurovirol. 2005 Feb; 11(1):46-50. PMID: 15804958.
      View in: PubMed
    101. Lima MA, Koralnik IJ. New features of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy and natalizumab. J Neurovirol. 2005; 11 Suppl 3:52-7. PMID: 16540456.
      View in: PubMed
    102. Kim WK, Corey S, Chesney G, Knight H, Klumpp S, Wüthrich C, Letvin N, Koralnik I, Lackner A, Veasey R, Williams K. Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with central nervous system vessels and virus. J Neurovirol. 2004 Oct; 10(5):315-25. PMID: 15385254.
      View in: PubMed
    103. Katz-Brull R, Lenkinski RE, Du Pasquier RA, Koralnik IJ. Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology. 2004 Sep 14; 63(5):897-900. PMID: 15365144.
      View in: PubMed
    104. Du Pasquier RA, Schmitz JE, Jean-Jacques J, Zheng Y, Gordon J, Khalili K, Letvin NL, Koralnik IJ. Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J Virol. 2004 Sep; 78(18):10206-10. PMID: 15331755; PMCID: PMC514969.
    105. Chen Y, Sharp PM, Fowkes M, Kocher O, Joseph JT, Koralnik IJ. Analysis of 15 novel full-length BK virus sequences from three individuals: evidence of a high intra-strain genetic diversity. J Gen Virol. 2004 Sep; 85(Pt 9):2651-63. PMID: 15302959.
      View in: PubMed
    106. Axthelm MK, Koralnik IJ, Dang X, Wüthrich C, Rohne D, Stillman IE, Letvin NL. Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys. J Neuropathol Exp Neurol. 2004 Jul; 63(7):750-8. PMID: 15290900.
      View in: PubMed
    107. Du Pasquier RA, Kuroda MJ, Zheng Y, Jean-Jacques J, Letvin NL, Koralnik IJ. A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain. 2004 Sep; 127(Pt 9):1970-8. PMID: 15215217.
      View in: PubMed
    108. Trofe J, Gordon J, Roy-Chaudhury P, Koralnik IJ, Atwood WJ, Alloway RR, Khalili K, Woodle ES. Polyomavirus nephropathy in kidney transplantation. Prog Transplant. 2004 Jun; 14(2):130-40; quiz 141-2. PMID: 15264457.
      View in: PubMed
    109. Koralnik IJ. New insights into progressive multifocal leukoencephalopathy. Curr Opin Neurol. 2004 Jun; 17(3):365-70. PMID: 15167073.
      View in: PubMed
    110. Trofe J, Gordon J, Roy-Chaudhury P, Koralnik I, Atwood W, Eash S, Alloway RR, Khalili K, Alexander JW, Woodle ES. Basic and clinical research in polyomavirus nephropathy. Exp Clin Transplant. 2004 Jun; 2(1):162-73. PMID: 15859923.
      View in: PubMed
    111. Koralnik IJ, Schellingerhout D, Frosch MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-2004. A 66-year-old man with progressive neurologic deficits. N Engl J Med. 2004 Apr 29; 350(18):1882-93. PMID: 15115835.
      View in: PubMed
    112. Du Pasquier RA, Kuroda MJ, Schmitz JE, Zheng Y, Martin K, Peyerl FW, Lifton M, Gorgone D, Autissier P, Letvin NL, Koralnik IJ. Low frequency of cytotoxic T lymphocytes against the novel HLA-A*0201-restricted JC virus epitope VP1(p36) in patients with proven or possible progressive multifocal leukoencephalopathy. J Virol. 2003 Nov; 77(22):11918-26. PMID: 14581528; PMCID: PMC254255.
    113. Du Pasquier RA, Corey S, Margolin DH, Williams K, Pfister LA, De Girolami U, Mac Key JJ, Wüthrich C, Joseph JT, Koralnik IJ. Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology. 2003 Sep 23; 61(6):775-82. PMID: 14504320.
      View in: PubMed
    114. Kempf W, Kadin ME, Dvorak AM, Lord CC, Burg G, Letvin NL, Koralnik IJ. Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis. 2003 Feb; 24(2):301-6. PMID: 12584181.
      View in: PubMed
    115. Du Pasquier RA, Koralnik IJ. Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial? J Neurovirol. 2003; 9 Suppl 1:25-31. PMID: 12709868.
      View in: PubMed
    116. Cinque P, Koralnik IJ, Clifford DB. The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: defining a consensus terminology. J Neurovirol. 2003; 9 Suppl 1:88-92. PMID: 12709878.
      View in: PubMed
    117. Koralnik IJ. Overview of the cellular immunity against JC virus in progressive multifocal leukoencephalopathy. J Neurovirol. 2002 Dec; 8 Suppl 2:59-65. PMID: 12491153.
      View in: PubMed
    118. Barouch DH, Faquin WC, Chen Y, Koralnik IJ, Robbins GK, Davis BT. BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient. Clin Infect Dis. 2002 Aug 01; 35(3):326-9. PMID: 12115100.
      View in: PubMed
    119. Kim JY, Koralnik IJ, LeFave M, Segal RA, Pfister LA, Pomeroy SL. Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences. Neuro Oncol. 2002 07; 4(3):165-70. PMID: 12084346; PMCID: PMC1920639.
    120. Koralnik IJ, Du Pasquier RA, Kuroda MJ, Schmitz JE, Dang X, Zheng Y, Lifton M, Letvin NL. Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope. J Immunol. 2002 Jan 01; 168(1):499-504. PMID: 11751998.
      View in: PubMed
    121. Petrogiannis-Haliotis T, Sakoulas G, Kirby J, Koralnik IJ, Dvorak AM, Monahan-Earley R, DE Girolami PC, DE Girolami U, Upton M, Major EO, Pfister LA, Joseph JT. BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med. 2001 Oct 25; 345(17):1250-5. PMID: 11680445.
      View in: PubMed
    122. Schifitto G, Yiannoutsos C, Simpson DM, Adornato BT, Singer EJ, Hollander H, Marra CM, Rubin M, Cohen BA, Tucker T, Koralnik IJ, Katzenstein D, Haidich B, Smith ME, Shriver S, Millar L, Clifford DB, McArthur JC. Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology. 2001 Oct 09; 57(7):1313-6. PMID: 11591856.
      View in: PubMed
    123. Du Pasquier RA, Clark KW, Smith PS, Joseph JT, Mazullo JM, De Girolami U, Letvin NL, Koralnik IJ. JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy. J Neurovirol. 2001 Aug; 7(4):318-22. PMID: 11517410.
      View in: PubMed
    124. Pfister LA, Letvin NL, Koralnik IJ. JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy. J Virol. 2001 Jun; 75(12):5672-6. PMID: 11356975; PMCID: PMC114280.
    125. Koralnik IJ, Du Pasquier RA, Letvin NL. JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy. J Virol. 2001 Apr; 75(7):3483-7. PMID: 11238876; PMCID: PMC114143.
    126. Kempf W, Kadin ME, Kutzner H, Lord CL, Burg G, Letvin NL, Koralnik IJ. Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. J Cutan Pathol. 2001 Jan; 28(1):29-33. PMID: 11168749.
      View in: PubMed
    127. Kempf W, Margolin DH, Dezube BJ, Kadin ME, Letvin NL, Koralnik IJ. Clinicopathological characterization of an HIV-2-infected individual with two clonally unrelated primary lymphomas. Am J Hematol. 2000 Dec; 65(4):302-6. PMID: 11074559.
      View in: PubMed
    128. Koralnik IJ, Schmitz JE, Lifton MA, Forman MA, Letvin NL. Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals. J Neurovirol. 1999 Aug; 5(4):430-5. PMID: 10463865.
      View in: PubMed
    129. Koralnik IJ, Boden D, Mai VX, Lord CI, Letvin NL. JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy. Neurology. 1999 Jan 15; 52(2):253-60. PMID: 9932940.
      View in: PubMed
    130. Burquier V, Koralnik IJ, Vibert D, Burkhard P, Beaumanoir A, Jallon P, Mayer E, Hirschel B. [Effect of antiretroviral treatment on early electroencephalographic and otoneurologic manifestations in HIV infection and prognostic importance of verified perturbations]. Neurophysiol Clin. 1997 Dec; 27(6):508-19. PMID: 9488974.
      View in: PubMed
    131. Cereseto A, Berneman Z, Koralnik I, Vaughn J, Franchini G, Klotman ME. Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines. Leukemia. 1997 Jun; 11(6):866-70. PMID: 9177442.
      View in: PubMed
    132. Lagreze WD, Warner JE, Zamani AA, Gouras GK, Koralnik IJ, Bienfang DC. Mesencephalic clefts with associated eye movement disorders. Arch Ophthalmol. 1996 Apr; 114(4):429-32. PMID: 8602780.
      View in: PubMed
    133. Koralnik IJ, Mulloy JC, Andresson T, Fullen J, Franchini G. Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein. J Gen Virol. 1995 Aug; 76 ( Pt 8):1909-16. PMID: 7636472.
      View in: PubMed
    134. Koralnik IJ, Boeri E, Saxinger WC, Monico AL, Fullen J, Gessain A, Guo HG, Gallo RC, Markham P, Kalyanaraman V, et al. Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission. J Virol. 1994 Apr; 68(4):2693-707. PMID: 7908063; PMCID: PMC236747.
    135. Gessain A, Koralnik IJ, Fullen J, Boeri E, Mora C, Blank A, Salazar-Grueso EF, Kaplan J, Saxinger WC, Davidson M, et al. Phylogenetic study of ten new HTLV-I strains from the Americas. AIDS Res Hum Retroviruses. 1994 Jan; 10(1):103-6. PMID: 7514013.
      View in: PubMed
    136. Franchini G, Mulloy JC, Koralnik IJ, Lo Monico A, Sparkowski JJ, Andresson T, Goldstein DJ, Schlegel R. The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase. J Virol. 1993 Dec; 67(12):7701-4. PMID: 8230493; PMCID: PMC238245.
    137. Koralnik IJ, Fullen J, Franchini G. The p12I, p13II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J Virol. 1993 Apr; 67(4):2360-6. PMID: 8445734; PMCID: PMC240398.
    138. Koralnik IJ, Hirschel B. EEG findings in asymptomatic HIV. Neurology. 1993 Mar; 43(3 Pt 1):635-6. PMID: 8451023.
      View in: PubMed
    139. Koralnik IJ, Lemp JF, Gallo RC, Franchini G. In vitro infection of human macrophages by human T-cell leukemia/lymphotropic virus type I (HTLV-I). AIDS Res Hum Retroviruses. 1992 Nov; 8(11):1845-9. PMID: 1489573.
      View in: PubMed
    140. Koralnik IJ, Gessain A, Klotman ME, Lo Monico A, Berneman ZN, Franchini G. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8813-7. PMID: 1528897; PMCID: PMC50011.
    141. Koralnik IJ, Hirschel B. [Neurological complication of human immunodeficiency virus infection]. Presse Med. 1991 Jun 22; 20(24):1129-35. PMID: 1649474.
      View in: PubMed
    142. Hausler R, Vibert D, Koralnik IJ, Hirschel B. Neuro-otological manifestations in different stages of HIV infection. Acta Otolaryngol Suppl. 1991; 481:515-21. PMID: 1927460.
      View in: PubMed
    143. Koralnik IJ, Beaumanoir A, Häusler R, Kohler A, Safran AB, Delacoux R, Vibert D, Mayer E, Burkhard P, Nahory A, et al. A controlled study of early neurologic abnormalities in men with asymptomatic human immunodeficiency virus infection. N Engl J Med. 1990 Sep 27; 323(13):864-70. PMID: 1975637.
      View in: PubMed
    Koralnik's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description