Trimethoprim
"Trimethoprim" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
| Descriptor ID |
D014295
|
| MeSH Number(s) |
D03.383.742.906
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Trimethoprim".
Below are MeSH descriptors whose meaning is more specific than "Trimethoprim".
This graph shows the total number of publications written about "Trimethoprim" by people in this website by year, and whether "Trimethoprim" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 |
| 1987 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trimethoprim" by people in Profiles.
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Segreti J, Kessler HA, Kapell KS, Trenholme GM. In vitro activity of A-56268 (TE-031) and four other antimicrobial agents against Chlamydia trachomatis. Antimicrob Agents Chemother. 1987 Jan; 31(1):100-1.
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Mitsuyasu RT, Corwin HL, Harris AA, Trenholme GM, Levi S, Karkusis PH. Failure of trimethoprim-sulfamethoxazole in the therapy of recurrent Pneumocystis carinii pneumonia. Am Rev Respir Dis. 1982 Jun; 125(6):762-5.