 T-Lymphocytes, Cytotoxic
"T-Lymphocytes, Cytotoxic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
| Descriptor ID |
D013602
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| MeSH Number(s) |
A11.118.637.555.283.875 A11.118.637.555.567.550.500.200 A11.118.637.555.567.569.220.200 A11.118.637.555.567.569.500.200 A15.145.229.637.555.283.875 A15.145.229.637.555.567.550.500.200 A15.145.229.637.555.567.569.220.200 A15.145.229.637.555.567.569.500.200 A15.382.490.555.283.875 A15.382.490.555.567.550.500.200 A15.382.490.555.567.569.220.200 A15.382.490.555.567.569.500.200
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| Concept/Terms |
T-Lymphocytes, Cytotoxic- T-Lymphocytes, Cytotoxic
- Cytotoxic T-Lymphocyte
- T Lymphocytes, Cytotoxic
- T-Lymphocyte, Cytotoxic
- Cell-Mediated Lympholytic Cells
- Cell Mediated Lympholytic Cells
- Cell, Cell-Mediated Lympholytic
- Cell-Mediated Lympholytic Cell
- Cells, Cell-Mediated Lympholytic
- Lympholytic Cell, Cell-Mediated
- Lympholytic Cells, Cell-Mediated
- Cytotoxic T-Lymphocytes
- Cytotoxic T Lymphocytes
TC2 Cells- TC2 Cells
- Cell, TC2
- Cells, TC2
- TC2 Cell
TC1 Cells- TC1 Cells
- Cell, TC1
- Cells, TC1
- TC1 Cell
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Below are MeSH descriptors whose meaning is more general than "T-Lymphocytes, Cytotoxic".
- Anatomy [A]
- Cells [A11]
- Blood Cells [A11.118]
- Leukocytes [A11.118.637]
- Leukocytes, Mononuclear [A11.118.637.555]
- Cytokine-Induced Killer Cells [A11.118.637.555.283]
- T-Lymphocytes, Cytotoxic [A11.118.637.555.283.875]
- Lymphocytes [A11.118.637.555.567]
- Lymphocyte Subsets [A11.118.637.555.567.550]
- T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
- T-Lymphocytes, Cytotoxic [A11.118.637.555.567.550.500.200]
- T-Lymphocytes [A11.118.637.555.567.569]
- CD8-Positive T-Lymphocytes [A11.118.637.555.567.569.220]
- T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.220.200]
- T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
- T-Lymphocytes, Cytotoxic [A11.118.637.555.567.569.500.200]
- Hemic and Immune Systems [A15]
- Blood [A15.145]
- Blood Cells [A15.145.229]
- Leukocytes [A15.145.229.637]
- Leukocytes, Mononuclear [A15.145.229.637.555]
- Cytokine-Induced Killer Cells [A15.145.229.637.555.283]
- T-Lymphocytes, Cytotoxic [A15.145.229.637.555.283.875]
- Lymphocytes [A15.145.229.637.555.567]
- Lymphocyte Subsets [A15.145.229.637.555.567.550]
- T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
- T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.550.500.200]
- T-Lymphocytes [A15.145.229.637.555.567.569]
- CD8-Positive T-Lymphocytes [A15.145.229.637.555.567.569.220]
- T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.220.200]
- T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
- T-Lymphocytes, Cytotoxic [A15.145.229.637.555.567.569.500.200]
- Immune System [A15.382]
- Leukocytes [A15.382.490]
- Leukocytes, Mononuclear [A15.382.490.555]
- Cytokine-Induced Killer Cells [A15.382.490.555.283]
- T-Lymphocytes, Cytotoxic [A15.382.490.555.283.875]
- Lymphocytes [A15.382.490.555.567]
- Lymphocyte Subsets [A15.382.490.555.567.550]
- T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
- T-Lymphocytes, Cytotoxic [A15.382.490.555.567.550.500.200]
- T-Lymphocytes [A15.382.490.555.567.569]
- CD8-Positive T-Lymphocytes [A15.382.490.555.567.569.220]
- T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.220.200]
- T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
- T-Lymphocytes, Cytotoxic [A15.382.490.555.567.569.500.200]
Below are MeSH descriptors whose meaning is more specific than "T-Lymphocytes, Cytotoxic".
This graph shows the total number of publications written about "T-Lymphocytes, Cytotoxic" by people in this website by year, and whether "T-Lymphocytes, Cytotoxic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1984 | 1 | 0 | 1 | | 1989 | 2 | 0 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 2 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 4 | 2 | 6 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 3 | 4 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "T-Lymphocytes, Cytotoxic" by people in Profiles.
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Tasaki S, Suzuki K, Nishikawa A, Kassai Y, Takiguchi M, Kurisu R, Okuzono Y, Miyazaki T, Takeshita M, Yoshimoto K, Yasuoka H, Yamaoka K, Ikeura K, Tsunoda K, Morita R, Yoshimura A, Toyoshiba H, Takeuchi T. Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome. Ann Rheum Dis. 2017 Aug; 76(8):1458-1466.
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Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A, Yu D. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016 10; 17(10):1187-96.
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Siewe B, Wallace J, Rygielski S, Stapleton JT, Martin J, Deeks SG, Landay A. Regulatory B cells inhibit cytotoxic T lymphocyte (CTL) activity and elimination of infected CD4 T cells after in vitro reactivation of HIV latent reservoirs. PLoS One. 2014; 9(4):e92934.
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Akpek G, Mikulski M, Kleinberg M, Badros A, Yanovich S, Rapoport AP. Cellular therapy with sequential unmanipulated donor lymphocyte infusions in drug-resistant cytomegalovirus (CMV) encephalitis. Blood. 2011 May 26; 117(21):5772-4.
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Atchison E, Eklund J, Martone B, Wang L, Gidron A, Macvicar G, Rademaker A, Goolsby C, Marszalek L, Kozlowski J, Smith N, Kuzel TM. A pilot study of denileukin diftitox (DD) in combination with high-dose interleukin-2 (IL-2) for patients with metastatic renal cell carcinoma (RCC). J Immunother. 2010 Sep; 33(7):716-22.
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Getts MT, Richards MH, Miller SD. A critical role for virus-specific CD8(+) CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice. Virology. 2010 Jun 20; 402(1):102-11.
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Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ. Determinants of survival in progressive multifocal leukoencephalopathy. Neurology. 2009 Nov 10; 73(19):1551-8.
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Gehring S, Gregory SH, Wintermeyer P, San Martin M, Aloman C, Wands JR. Generation and characterization of an immunogenic dendritic cell population. J Immunol Methods. 2008 Mar 20; 332(1-2):18-30.
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Bluman EM, Coulie PG, Xiaojuan S, Machan J, Lin C, Meitner PA, Block JA, Terek RM. Lysis of human chondrosarcoma cells by cytolytic T lymphocytes recognizing a MAGE-A3 antigen presented by HLA-A1 molecules. J Orthop Res. 2007 May; 25(5):678-84.
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Aloman C, Gehring S, Wintermeyer P, Kuzushita N, Wands JR. Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction. Gastroenterology. 2007 Feb; 132(2):698-708.
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