Catechol O-Methyltransferase Inhibitors
"Catechol O-Methyltransferase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.
| Descriptor ID |
D065098
|
| MeSH Number(s) |
D27.505.519.389.237 D27.505.954.427.090.050.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Catechol O-Methyltransferase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Catechol O-Methyltransferase Inhibitors".
This graph shows the total number of publications written about "Catechol O-Methyltransferase Inhibitors" by people in this website by year, and whether "Catechol O-Methyltransferase Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 |
| 2000 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
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Below are the most recent publications written about "Catechol O-Methyltransferase Inhibitors" by people in Profiles.
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Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004. Mov Disord. 2005 May; 20(5):523-39.
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Role of COMT inhibitors and dopamine agonists in the treatment of motor fluctuations. Mov Disord. 2005; 20 Suppl 11:S30-7.
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Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol Pharmacol. 2000 Mar; 57(3):589-94.
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Influence of COMT inhibition on levodopa pharmacology and therapy. Neurology. 1998 May; 50(5 Suppl 5):S26-30.
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Highlights of the North American and European experiences. Neurology. 1998 May; 50(5 Suppl 5):S15-6.