Metabolic Detoxication, Phase I
"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
| Descriptor ID |
D050216
|
| MeSH Number(s) |
G03.171.450.500 G03.787.225.450.500 G07.690.725.225.450.500
|
| Concept/Terms |
Metabolic Detoxication, Phase I- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Oxidative
- Detoxication, Oxidative Metabolic
- Detoxications, Oxidative Metabolic
- Metabolic Detoxications, Oxidative
- Oxidative Metabolic Detoxication
- Oxidative Metabolic Detoxications
- Phase I Detoxification
- Detoxification, Phase I
- Detoxifications, Phase I
- Metabolic Detoxification, Phase I
|
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