Arachidonate 5-Lipoxygenase
"Arachidonate 5-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
| Descriptor ID |
D001094
|
| MeSH Number(s) |
D08.811.682.690.416.583.500.055 D12.776.556.579.374.568.500.020
|
| Concept/Terms |
Arachidonate 5-Lipoxygenase- Arachidonate 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonate
- Arachidonate 5 Lipoxygenase
- Arachidonic Acid 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 5 Lipoxygenase
- LTA4 Synthase
- Synthase, LTA4
- Leukotriene A4 Synthase
- Synthase, Leukotriene A4
- Leukotriene A4 Synthetase
- Synthetase, Leukotriene A4
- 5-Lipoxygenase
- 5 Lipoxygenase
- Leukotriene A Synthase
- Synthase, Leukotriene A
|
Below are MeSH descriptors whose meaning is more general than "Arachidonate 5-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 5-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Arachidonate 5-Lipoxygenase" by people in Profiles.
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Human cytomegalovirus infection enhances 5-lipoxygenase and cycloxygenase-2 expression in colorectal cancer. Int J Oncol. 2023 11; 63(5).
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Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia. Alzheimers Res Ther. 2022 10 11; 14(1):152.
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Metabolic mechanisms in the pathogenesis of osteoarthritis. A review. J Knee Surg. 2006 Jul; 19(3):191-7.
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Increased cytosol Ca(2+) and type 1 programmed cell death in Bcl-2-positive U937 but not in Bcl-2-negative PC-3 and Panc-1 cells induced by the 5-lipoxygenase inhibitor MK 886. Prostaglandins Leukot Essent Fatty Acids. 2002 Apr; 66(4):443-52.
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Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. Cancer Res. 1999 May 01; 59(9):2223-8.
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Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling. J Clin Invest. 1996 Feb 01; 97(3):806-13.