 Isotretinoin
"Isotretinoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.
| Descriptor ID |
D015474
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| MeSH Number(s) |
D02.455.326.271.665.202.495.325 D02.455.426.392.368.367.379.249.700.325 D02.455.849.131.495.325 D23.767.261.700.325
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| Concept/Terms |
Isotretinoin- Isotretinoin
- 13-cis-Retinoic Acid
- 13 cis Retinoic Acid
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Below are MeSH descriptors whose meaning is more general than "Isotretinoin".
Below are MeSH descriptors whose meaning is more specific than "Isotretinoin".
This graph shows the total number of publications written about "Isotretinoin" by people in this website by year, and whether "Isotretinoin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1992 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isotretinoin" by people in Profiles.
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Avis I, Mart?nez A, Tauler J, Zudaire E, Mayburd A, Abu-Ghazaleh R, Ondrey F, Mulshine JL. Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. Cancer Res. 2005 May 15; 65(10):4181-90.
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Wang DL, Marko M, Dahl AR, Engelke KS, Placke ME, Imondi AR, Mulshine JL, De Luca LM. Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors. Clin Cancer Res. 2000 Sep; 6(9):3636-45.
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Dahl AR, Grossi IM, Houchens DP, Scovell LJ, Placke ME, Imondi AR, Stoner GD, De Luca LM, Wang D, Mulshine JL. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug; 6(8):3015-24.
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Avis I, Mathias A, Unsworth EJ, Miller MJ, Cuttitta F, Mulshine JL, Jakowlew SB. Analysis of small cell lung cancer cell growth inhibition by 13-cis-retinoic acid: importance of bioavailability. Cell Growth Differ. 1995 May; 6(5):485-92.
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Mulshine JL, Johnson BE, Gazdar AF, Shaw GL, Kramer BS, Mitsudomi T, Minna JD, Pass H, Phelps R, Ghosh B, et al. Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance. Lung Cancer. 1994 Mar; 10 Suppl 1:S73-81.
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Scully C, Boyle P. Vitamin A related compounds in the chemoprevention of potentially malignant oral lesions and carcinoma. Eur J Cancer B Oral Oncol. 1992 Oct; 28B(2):87-9.
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Mulshine JL, Birrer M, Treston AM, Scott F, Quinn K, Avis I, Cuttitta F. Growth factors and other targets for rational application as intervention agents. Adv Exp Med Biol. 1992; 320:81-8.
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Couch MJ, Pauli BU, Weinstein RS, Coon JS. Induction of reversible changes in cell-surface glycoconjugates and lung colonization potential by 13-cis retinoic acid. J Cell Biochem. 1988 Jun; 37(2):213-23.
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Green SG, Piette WW. Successful treatment of hypertrophic lupus erythematosus with isotretinoin. J Am Acad Dermatol. 1987 Aug; 17(2 Pt 2):364-8.
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