"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
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| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Picrotoxin" by people in Profiles.
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Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala. Eur J Neurosci. 2011 Jul; 34(2):177-89.
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Spontaneous synchronous synaptic calcium transients in cultured cortical neurons. J Neurosci. 1992 Dec; 12(12):4834-45.