 Killer Cells, Natural
"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
| Descriptor ID |
D007694
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| MeSH Number(s) |
A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
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| Concept/Terms |
Killer Cells, Natural- Killer Cells, Natural
- NK Cells
- Cell, NK
- Cells, NK
- NK Cell
- Natural Killer Cells
- Cell, Natural Killer
- Cells, Natural Killer
- Killer Cell, Natural
- Natural Killer Cell
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Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".
Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".
This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1983 | 0 | 2 | 2 | | 1984 | 0 | 2 | 2 | | 1985 | 0 | 1 | 1 | | 1986 | 0 | 2 | 2 | | 1987 | 4 | 2 | 6 | | 1988 | 1 | 2 | 3 | | 1989 | 0 | 1 | 1 | | 1991 | 1 | 1 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 1 | 2 | | 1995 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 2 | 1 | 3 | | 2006 | 2 | 3 | 5 | | 2007 | 4 | 3 | 7 | | 2008 | 4 | 0 | 4 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 1 | 3 | | 2012 | 2 | 3 | 5 | | 2013 | 3 | 2 | 5 | | 2014 | 4 | 0 | 4 | | 2016 | 3 | 0 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.
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Long A, Dominguez D, Qin L, Chen S, Fan J, Zhang M, Fang D, Zhang Y, Kuzel TM, Zhang B. Type 2 Innate Lymphoid Cells Impede IL-33-Mediated Tumor Suppression. J Immunol. 2018 12 01; 201(11):3456-3464.
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Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Anti-a4ß7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. 2018 10 03; 10(461).
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Judge CJ, Kostadinova L, Sherman KE, Butt AA, Falck-Ytter Y, Funderburg NT, Landay AL, Lederman MM, Sieg SF, Sandberg JK, Anthony DD. CD56bright NK IL-7Ra expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections. J Leukoc Biol. 2017 07; 102(1):171-184.
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Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E. CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017 02; 33(2):93-100.
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Boudreau JE, Mulrooney TJ, Le Luduec JB, Barker E, Hsu KC. KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol. 2016 Apr 15; 196(8):3398-410.
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Davis ZB, Cogswell A, Scott H, Mertsching A, Boucau J, Wambua D, Le Gall S, Planelles V, Campbell KS, Barker E. A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells. PLoS Pathog. 2016 Feb; 12(2):e1005421.
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de Kivit S, Lempsink LJ, Plants J, Martinson J, Keshavarzian A, Landay AL. Modulation of TIM-3 expression on NK and T cell subsets in HIV immunological non-responders. Clin Immunol. 2015 Jan; 156(1):28-35.
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Dillon SM, Lee EJ, Bramante JM, Barker E, Wilson CC. The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression. J Acquir Immune Defic Syndr. 2014 Mar 01; 65(3):259-67.
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Mata MM, Mahmood F, Sowell RT, Baum LL. Effects of cryopreservation on effector cells for antibody dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cell activity in (51)Cr-release and CD107a assays. J Immunol Methods. 2014 Apr; 406:1-9.
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Qin L, Thompson LF, Kuzel TM, Zhang B. Requirement of NK cells for selective A2A receptor blockade to suppress CD73+ tumor metastasis. Immunotherapy. 2014; 6(1):19-21.
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