"Perforin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
| Descriptor ID |
D054353
|
| MeSH Number(s) |
D12.776.543.695.875
|
| Concept/Terms |
Perforin- Perforin
- Lymphocyte Pore-Forming Protein
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
- Perforin 1
- Cytolysin
|
Below are MeSH descriptors whose meaning is more general than "Perforin".
Below are MeSH descriptors whose meaning is more specific than "Perforin".
This graph shows the total number of publications written about "Perforin" by people in this website by year, and whether "Perforin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Perforin" by people in Profiles.
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Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death. ASN Neuro. 2013 Feb 06; 5(1):e00105.
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Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. J Immunol. 2006 Jul 15; 177(2):1028-39.
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Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. AIDS. 1999 Jul 30; 13(11):1295-303.
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Natural killer cell cytotoxicity and the multidrug resistance gene. Transplant Proc. 1993 Feb; 25(1 Pt 1):96-7.