"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
|
| MeSH Number(s) |
D02.241.081.114.500.350.100
|
| Concept/Terms |
Baclofen- Baclofen
- Baclophen
- PCP-GABA
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Ba-34,647- Ba-34,647
- Ba34,647
- Ba-34647
- Ba34647
- CIBA-34,647-BA
- CIBA34,647BA
|
Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
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Below are the most recent publications written about "Baclofen" by people in Profiles.
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Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci Transl Med. 2012 Sep 19; 4(152):152ra127.
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Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ. 2012; 54:297-335.
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Baclofen facilitates the extinction of methamphetamine-induced conditioned place preference in rats. Behav Neurosci. 2011 Apr; 125(2):261-7.
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Sustained effect of high-dose intrathecal baclofen in primary generalized dystonia: a 2-year follow-up study. Mov Disord. 1997 Nov; 12(6):1100-2.
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Intrathecal baclofen down-regulates GABAB receptors in the rat substantia gelatinosa. J Neurosurg. 1993 Oct; 79(4):544-9.
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The distribution of medication along the spinal canal after chronic intrathecal administration. Neurosurgery. 1993 Aug; 33(2):226-30; discussion 230.
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Intrathecal drug administration. Present use and future trends. Clin Pharmacokinet. 1992 May; 22(5):319-26.
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Intrathecal baclofen. Effects on nocturnal leg muscle spasticity. Am J Phys Med Rehabil. 1992 Feb; 71(1):48-52.
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Intrathecal baclofen for severe spinal spasticity. N Engl J Med. 1989 Jun 08; 320(23):1517-21.
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Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg. 1987 Feb; 66(2):181-5.