 Baclofen
"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
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| MeSH Number(s) |
D02.241.081.114.500.350.100
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| Concept/Terms |
Baclofen- Baclofen
- PCP-GABA
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- Baclophen
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
Baclospas- Baclospas
- Ashbourne Brand of Baclofen
- Baclofen Ashbourne Brand
Clofen- Clofen
- Alphapharm Brand of Baclofen
- Baclofen Alphapharm Brand
Apo-Baclofen- Apo-Baclofen
- Apo Baclofen
- ApoBaclofen
- Apotex Brand of Baclofen
- Baclofen Apotex Brand
PMS-Baclofen- PMS-Baclofen
- PMS Baclofen
- PMSBaclofen
- Pharmascience Brand of Baclofen
- Baclofen Pharmascience Brand
Ba-34,647- Ba-34,647
- Ba34,647
- CIBA-34,647-BA
- CIBA34,647BA
- Ba-34647
- Ba34647
Baclofen AWD- Baclofen AWD
- AWD, Baclofen
- ASTA Medica Brand of Baclofen
Lebic- Lebic
- Isis Brand of Baclofen
- Baclofen Isis Brand
Lioresal- Lioresal
- Novartis Brand of Baclofen
- Baclofen Novartis Brand
- Medtronic Brand of Baclofen
- Baclofen Medtronic Brand
- Ciba-Geigy Brand of Baclofen
- Baclofen Ciba-Geigy Brand
- Ciba Geigy Brand of Baclofen
- Liorésal
Nu-Baclo- Nu-Baclo
- Nu Baclo
- NuBaclo
- Nu-Pharm Brand of Baclofen
- Baclofen Nu-Pharm Brand
- Nu Pharm Brand of Baclofen
Baclofène-Irex- Baclofène-Irex
- Baclofène Irex
- BaclofèneIrex
- Irex Brand of Baclofen
- Baclofen Irex Brand
Atrofen- Atrofen
- Athena Brand of Baclofen
- Baclofen Athena Brand
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Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 2 | 1 | 3 | | 1985 | 1 | 0 | 1 | | 1987 | 1 | 0 | 1 | | 1989 | 1 | 0 | 1 | | 1992 | 1 | 1 | 2 | | 1993 | 2 | 0 | 2 | | 1997 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Baclofen" by people in Profiles.
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Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y, Nguyen DV, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, Hagerman RJ. Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial. Sci Transl Med. 2012 Sep 19; 4(152):152ra127.
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Hagerman R, Lauterborn J, Au J, Berry-Kravis E. Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ. 2012; 54:297-335.
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Voigt RM, Herrold AA, Napier TC. Baclofen facilitates the extinction of methamphetamine-induced conditioned place preference in rats. Behav Neurosci. 2011 Apr; 125(2):261-7.
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Diederich NJ, Comella CL, Matge G, Becker G, Schiltz F, Metz H. Sustained effect of high-dose intrathecal baclofen in primary generalized dystonia: a 2-year follow-up study. Mov Disord. 1997 Nov; 12(6):1100-2.
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Kroin JS, Bianchi GD, Penn RD. Intrathecal baclofen down-regulates GABAB receptors in the rat substantia gelatinosa. J Neurosurg. 1993 Oct; 79(4):544-9.
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Kroin JS, Ali A, York M, Penn RD. The distribution of medication along the spinal canal after chronic intrathecal administration. Neurosurgery. 1993 Aug; 33(2):226-30; discussion 230.
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Kroin JS. Intrathecal drug administration. Present use and future trends. Clin Pharmacokinet. 1992 May; 22(5):319-26.
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Kravitz HM, Corcos DM, Hansen G, Penn RD, Cartwright RD, Gianino J. Intrathecal baclofen. Effects on nocturnal leg muscle spasticity. Am J Phys Med Rehabil. 1992 Feb; 71(1):48-52.
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Penn RD, Savoy SM, Corcos D, Latash M, Gottlieb G, Parke B, Kroin JS. Intrathecal baclofen for severe spinal spasticity. N Engl J Med. 1989 Jun 08; 320(23):1517-21.
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Penn RD, Kroin JS. Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg. 1987 Feb; 66(2):181-5.
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