Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.

Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum. 2004 Jun; 50(6):1984-95.

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subject areas

Aggrecans
Amino Acid Sequence
Animals
Antigens
Arthritis
Cartilage
Epitopes, T-Lymphocyte
Extracellular Matrix Proteins
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DR4 Antigen
Humans
Immunization
Joints
Lectins, C-Type
Mice
Mice, Inbred BALB C
Mice, Transgenic
Molecular Sequence Data
Proteoglycans