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Joao Werneck-de-Castro

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Endocrinology
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    Collapse Overview 
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    My ORCID is 0000-0001-9242-7930.
    My Scopus ID is 8073214900.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Blandino-Rosano M, Louzada RA, Werneck-De-Castro JP, Lubaczeuski C, Alma?a J, R?egg MA, Hall MN, Leibowitz G, Bernal-Mizrachi E. Raptor levels are critical for ?-cell adaptation to a high-fat diet in male mice. Mol Metab. 2023 09; 75:101769. PMID: 37423392.
      View in: PubMed
    2. Martins Pe?anha FL, Jaafar R, Werneck-de-Castro JP, Apostolopolou CC, Bhushan A, Bernal-Mizrachi E. The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse ?-Cells. Diabetes. 2022 08 01; 71(8):1694-1705. PMID: 35594378.
      View in: PubMed
    3. Blandino-Rosano M, Scheys JO, Werneck-de-Castro JP, Louzada RA, Alma?a J, Leibowitz G, R?egg MA, Hall MN, Bernal-Mizrachi E. Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. Am J Physiol Endocrinol Metab. 2022 08 01; 323(2):E133-E144. PMID: 35723227.
      View in: PubMed
    4. Israeli T, Riahi Y, Garzon P, Louzada RA, Werneck-de-Castro JP, Blandino-Rosano M, Yeroslaviz-Stolper R, Kadosh L, Tornovsky-Babeay S, Hacker G, Israeli N, Agmon O, Tirosh B, Cerasi E, Bernal-Mizrachi E, Leibowitz G. Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating ?-Cell Autophagy. Diabetes. 2022 03 01; 71(3):453-469. PMID: 34862201.
      View in: PubMed
    5. Bouviere J, Fortunato RS, Dupuy C, Werneck-de-Castro JP, Carvalho DP, Louzada RA. Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle. Antioxidants (Basel). 2021 Mar 30; 10(4). PMID: 33808211.
      View in: PubMed
    6. Werneck-de-Castro JP, Pe?anha FLM, Silvestre DH, Bernal-Mizrachi E. The RNA-binding protein LARP1 is dispensable for pancreatic ?-cell function and mass. Sci Rep. 2021 01 22; 11(1):2079. PMID: 33483593.
      View in: PubMed
    7. Louzada RA, Bouviere J, Matta LP, Werneck-de-Castro JP, Dupuy C, Carvalho DP, Fortunato RS. Redox Signaling in Widespread Health Benefits of Exercise. Antioxid Redox Signal. 2020 Apr 23. PMID: 32174127.
      View in: PubMed
    8. Jara MA, Werneck-De-Castro JP, Lubaczeuski C, Johnson JD, Bernal-Mizrachi E. Pancreatic and duodenal homeobox-1 (PDX1) contributes to ?-cell mass expansion and proliferation induced by Akt/PKB pathway. Islets. 2020 03 03; 12(2):32-40. PMID: 32876522.
      View in: PubMed
    9. Werneck-de-Castro JP, Blandino-Rosano M, Hilfiker-Kleiner D, Bernal-Mizrachi E. Glucose stimulates microRNA-199 expression in murine pancreatic ?-cells. J Biol Chem. 2020 01 31; 295(5):1261-1270. PMID: 31882540.
      View in: PubMed
    10. Sadagurski M, Debarba LK, Werneck-de-Castro JP, Ali Awada A, Baker TA, Bernal-Mizrachi E. Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to a diet rich in high fat and branched-chain amino acids. Am J Physiol Endocrinol Metab. 2019 09 01; 317(3):E526-E534. PMID: 31361548.
      View in: PubMed
    11. Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Concei??o RR, Werneck-de-Castro JP, Ignacio DL, Egri P, N?meth D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. J Clin Invest. 2019 01 02; 129(1):230-245. PMID: 30352046.
      View in: PubMed
    12. Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, R?egg MA, Hall MN, Bernal-Mizrachi E. Loss of mTORC1 signalling impairs ?-cell homeostasis and insulin processing. Nat Commun. 2017 07 12; 8:16014. PMID: 28699639.
      View in: PubMed
    13. Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP. Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 04; 27(4):577-586. PMID: 27967605.
      View in: PubMed
    14. Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC. Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes. Endocrinology. 2015 Oct; 156(10):3842-52. PMID: 26214036.
      View in: PubMed
    15. Louzada RA, Santos MC, Cavalcanti-de-Albuquerque JP, Rangel IF, Ferreira AC, Galina A, Werneck-de-Castro JP, Carvalho DP. Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1020-9. PMID: 25294216.
      View in: PubMed
    16. Fonseca TL, Werneck-De-Castro JP, Castillo M, Bocco BM, Fernandes GW, McAninch EA, Ignacio DL, Moises CC, Ferreira AR, Ferreira A, Gereben B, Bianco AC. Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse. Diabetes. 2014 May; 63(5):1594-604. PMID: 24487027.
      View in: PubMed
    17. Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013 Apr; 123(4):1492-500. PMID: 23524969.
      View in: PubMed
    18. Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013 Jul; 1830(7):3956-64. PMID: 22967761.
      View in: PubMed
    19. Louzada RA, Oliveira PF, Cavalcanti-de-Albuquerque JP, Cunha-Carvalho L, Baldanza MR, Kasai-Brunswick TH, Goldenberg RC, Campos-de-Carvalho AC, Werneck-de-Castro JP. Granulocyte-colony stimulating factor treatment of chronic myocardial infarction. Cardiovasc Drugs Ther. 2010 Apr; 24(2):121-30. PMID: 20127160.
      View in: PubMed
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