Last Name

Lothar Blatter

InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
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    My Scopus ID is 7006641795.

    Research Areas:
    Calcium regulation and signaling in the heart and the cardiovascular system, characterization of ion transporters and channels, electrophysiology, excitation-contraction coupling, mitochondrial calcium signaling and energetics, excitation-transcription coupling, and changes in calcium signaling in arrhythmia, hypertrophy and heart failure.

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    MD, University of Bern, Switzerland
    Dr Med, University of Bern, Switzerland

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kanaporis G, Kalik ZM, Blatter LA. Action potential shortening rescues atrial calcium alternans. J Physiol. 2019 Feb; 597(3):723-740. PMID: 30412286.
      View in: PubMed
    2. Duan L, Perez RE, Chen L, Blatter LA, Maki CG. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. J Mol Cell Biol. 2018 Aug 01; 10(4):331-340. PMID: 29190376.
      View in: PubMed
    3. Blatter LA. The intricacies of atrial calcium cycling during excitation-contraction coupling. J Gen Physiol. 2017 Sep 04; 149(9):857-865. PMID: 28798277.
      View in: PubMed
    4. Kanaporis G, Blatter LA. Alternans in atria: Mechanisms and clinical relevance. Medicina (Kaunas). 2017; 53(3):139-149. PMID: 28666575.
      View in: PubMed
    5. Kanaporis G, Blatter LA. AP and Ca2+ alternans: An inseparable couple. Channels (Austin). 2017 09 03; 11(5):368-369. PMID: 28498780.
      View in: PubMed
    6. Kanaporis G, Blatter LA. Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current. J Mol Cell Cardiol. 2017 04; 105:49-58. PMID: 28257761.
      View in: PubMed
    7. Maxwell JT, Blatter LA. A novel mechanism of tandem activation of ryanodine receptors by cytosolic and SR luminal Ca2+ during excitation-contraction coupling in atrial myocytes. J Physiol. 2017 06 15; 595(12):3835-3845. PMID: 28028837.
      View in: PubMed
    8. Bovo E, Huke S, Blatter LA, Zima AV. The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes. J Mol Cell Cardiol. 2017 03; 104:9-16. PMID: 28131630.
      View in: PubMed
    9. Blatter LA. Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells. Adv Exp Med Biol. 2017; 993:343-361. PMID: 28900923.
      View in: PubMed
    10. Hohendanner F, DeSantiago J, Heinzel FR, Blatter LA. Dyssynchronous calcium removal in heart failure-induced atrial remodeling. Am J Physiol Heart Circ Physiol. 2016 12 01; 311(6):H1352-H1359. PMID: 27694214.
      View in: PubMed
    11. Kanaporis G, Blatter LA. Ca(2+)-activated chloride channel activity during Ca(2+) alternans in ventricular myocytes. Channels (Austin). 2016 Nov; 10(6):507-17. PMID: 27356267.
      View in: PubMed
    12. Kanaporis G, Blatter LA. Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes. J Physiol. 2016 Feb 01; 594(3):699-714. PMID: 26662365; PMCID: PMC4930065 [Available on 02/01/17].
    13. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. 2015 Sep 15; 6(27):23135-56. PMID: 26337205; PMCID: PMC4695109.
    14. Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17; 117(3):234-8. PMID: 26185209.
      View in: PubMed
    15. Seidlmayer LK, Juettner VV, Kettlewell S, Pavlov EV, Blatter LA, Dedkova EN. Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate. Cardiovasc Res. 2015 May 01; 106(2):237-48. PMID: 25742913; PMCID: PMC4415062.
    16. Hammer KP, Hohendanner F, Blatter LA, Pieske BM, Heinzel FR. Variations in local calcium signaling in adjacent cardiac myocytes of the intact mouse heart detected with two-dimensional confocal microscopy. Front Physiol. 2014; 5:517. PMID: 25628569; PMCID: PMC4290493.
    17. Hohendanner F, Maxwell JT, Blatter LA. Cytosolic and nuclear calcium signaling in atrial myocytes: IP3-mediated calcium release and the role of mitochondria. Channels (Austin). 2015; 9(3):129-38. PMID: 25891132; PMCID: PMC4594594.
    18. Hohendanner F, Walther S, Maxwell JT, Kettlewell S, Awad S, Smith GL, Lonchyna VA, Blatter LA. Inositol-1,4,5-trisphosphate induced Ca2+ release and excitation-contraction coupling in atrial myocytes from normal and failing hearts. J Physiol. 2015 Mar 15; 593(6):1459-77. PMID: 25416623; PMCID: PMC4376424.
    19. Kanaporis G, Blatter LA. The mechanisms of calcium cycling and action potential dynamics in cardiac alternans. Circ Res. 2015 Feb 27; 116(5):846-56. PMID: 25532796; PMCID: PMC4344847.
    20. Dedkova EN, Blatter LA. Role of ß-hydroxybutyrate, its polymer poly-ß-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol. 2014; 5:260. PMID: 25101001; PMCID: PMC4102118.
    21. Walther S, Pluteanu F, Renz S, Nikonova Y, Maxwell JT, Yang LZ, Schmidt K, Edwards JN, Wakula P, Groschner K, Maier LS, Spiess J, Blatter LA, Pieske B, Kockskämper J. Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H689-700. PMID: 25015964; PMCID: PMC4187402.
    22. Edwards JN, Blatter LA. Cardiac alternans and intracellular calcium cycling. Clin Exp Pharmacol Physiol. 2014 Jul; 41(7):524-32. PMID: 25040398; PMCID: PMC4122248.
    23. Hohendanner F, McCulloch AD, Blatter LA, Michailova AP. Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches. Front Pharmacol. 2014; 5:35. PMID: 24639654; PMCID: PMC3944219.
    24. Walther S, Awad S, Lonchyna VA, Blatter LA. NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2014 Mar; 306(6):H856-66. PMID: 24441548; PMCID: PMC3949047.
    25. Kapoor N, Maxwell JT, Mignery GA, Will D, Blatter LA, Banach K. Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes. PLoS One. 2014; 9(1):e83715. PMID: 24409283; PMCID: PMC3883750.
    26. Shkryl VM, Blatter LA. Ca(2+) release events in cardiac myocytes up close: insights from fast confocal imaging. PLoS One. 2013; 8(4):e61525. PMID: 23637847; PMCID: PMC3630194.
    27. Figueroa L, Shkryl VM, Blatter LA, Ríos E. Using two dyes with the same fluorophore to monitor cellular calcium concentration in an extended range. PLoS One. 2013; 8(2):e55778. PMID: 23409040; PMCID: PMC3567097.
    28. Dedkova EN, Seidlmayer LK, Blatter LA. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol. 2013 Jun; 59:41-54. PMID: 23388837; PMCID: PMC3670593.
    29. Zima AV, Pabbidi MR, Lipsius SL, Blatter LA. Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H983-93. PMID: 23376829; PMCID: PMC3625900.
    30. Dedkova EN, Blatter LA. Calcium signaling in cardiac mitochondria. J Mol Cell Cardiol. 2013 May; 58:125-33. PMID: 23306007; PMCID: PMC3627826.
    31. Seidlmayer LK, Blatter LA, Pavlov E, Dedkova EN. Inorganic polyphosphate--an unusual suspect of the mitochondrial permeability transition mystery. Channels (Austin). 2012 Nov-Dec; 6(6):463-7. PMID: 22990682; PMCID: PMC3536732.
    32. Maxwell JT, Blatter LA. Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes. J Physiol. 2012 Dec 01; 590(23):6037-45. PMID: 22988145; PMCID: PMC3530115.
    33. Domeier TL, Maxwell JT, Blatter LA. ß-Adrenergic stimulation increases the intra-sarcoplasmic reticulum Ca2+ threshold for Ca2+ wave generation. J Physiol. 2012 Dec 01; 590(23):6093-108. PMID: 22988136; PMCID: PMC3530119.
    34. Florea SM, Blatter LA. Regulation of cardiac alternans by ß-adrenergic signaling pathways. Am J Physiol Heart Circ Physiol. 2012 Oct 15; 303(8):H1047-56. PMID: 22904161; PMCID: PMC3469647.
    35. Seidlmayer LK, Gomez-Garcia MR, Blatter LA, Pavlov E, Dedkova EN. Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes. J Gen Physiol. 2012 May; 139(5):321-31. PMID: 22547663; PMCID: PMC3343371.
    36. Shkryl VM, Maxwell JT, Domeier TL, Blatter LA. Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes. Am J Physiol Heart Circ Physiol. 2012 Jun 01; 302(11):H2310-20. PMID: 22467301; PMCID: PMC3378301.
    37. Shkryl VM, Blatter LA, Ríos E. Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle. J Gen Physiol. 2012 Mar; 139(3):189-207. PMID: 22330954; PMCID: PMC3289960.
    38. Figueroa L, Shkryl VM, Zhou J, Manno C, Momotake A, Brum G, Blatter LA, Ellis-Davies GC, Ríos E. Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. J Physiol. 2012 Mar 15; 590(6):1389-411. PMID: 22310315; PMCID: PMC3382330.
    39. Shkryl VM, Maxwell JT, Blatter LA. A novel method for spatially complex diffraction-limited photoactivation and photobleaching in living cells. J Physiol. 2012 Mar 01; 590(5):1093-100. PMID: 22183727; PMCID: PMC3381818.
    40. Maxwell JT, Domeier TL, Blatter LA. Dantrolene prevents arrhythmogenic Ca2+ release in heart failure. Am J Physiol Heart Circ Physiol. 2012 Feb 15; 302(4):H953-63. PMID: 22180651; PMCID: PMC3322737.
    41. Bovo E, Mazurek SR, Blatter LA, Zima AV. Regulation of sarcoplasmic reticulum Ca²? leak by cytosolic Ca²? in rabbit ventricular myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6039-50. PMID: 21986204; PMCID: PMC3286684.
    42. Dedkova EN, Blatter LA. Measuring mitochondrial function in intact cardiac myocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):48-61. PMID: 21964191; PMCID: PMC3246130.
    43. Porta M, Zima AV, Nani A, Diaz-Sylvester PL, Copello JA, Ramos-Franco J, Blatter LA, Fill M. Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks. Biophys J. 2011 Feb 16; 100(4):931-8. PMID: 21320437; PMCID: PMC3037573.
    44. Picht E, Zima AV, Shannon TR, Duncan AM, Blatter LA, Bers DM. Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res. 2011 Apr 01; 108(7):847-56. PMID: 21311044; PMCID: PMC3084972.
    45. Florea SM, Blatter LA. The role of mitochondria for the regulation of cardiac alternans. Front Physiol. 2010; 1:141. PMID: 21423381; PMCID: PMC3059961.
    46. Zima AV, Bovo E, Bers DM, Blatter LA. Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol. 2010 Dec 01; 588(Pt 23):4743-57. PMID: 20962003; PMCID: PMC3010143.
    47. Rinne A, Blatter LA. Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1701-7. PMID: 20852052; PMCID: PMC2993207.
    48. Rinne A, Blatter LA. A fluorescence-based assay to monitor transcriptional activity of NFAT in living cells. J Physiol. 2010 Sep 01; 588(Pt 17):3211-6. PMID: 20624790; PMCID: PMC2976016.
    49. Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res. 2010 Sep 03; 107(5):659-66. PMID: 20616315; PMCID: PMC2933281.
    50. Domeier TL, Blatter LA, Zima AV. Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine receptor channels. Channels (Austin). 2010 Mar-Apr; 4(2):87-92. PMID: 20139707; PMCID: PMC2944407.
    51. Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2001-9. PMID: 20304816; PMCID: PMC2886636.
    52. Domeier TL, Blatter LA, Zima AV. Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure. J Physiol. 2009 Nov 01; 587(Pt 21):5197-209. PMID: 19736296; PMCID: PMC2790258.
    53. Rinne A, Banach K, Blatter LA. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. J Mol Cell Cardiol. 2009 Sep; 47(3):400-10. PMID: 19540841; PMCID: PMC2779755.
    54. Qin J, Zima AV, Porta M, Blatter LA, Fill M. Trifluoperazine: a rynodine receptor agonist. Pflugers Arch. 2009 Aug; 458(4):643-51. PMID: 19277699; PMCID: PMC2752966.
    55. O'Rourke B, Blatter LA. Mitochondrial Ca2+ uptake: tortoise or hare? J Mol Cell Cardiol. 2009 Jun; 46(6):767-74. PMID: 19162034; PMCID: PMC4005816.
    56. Dedkova EN, Blatter LA. Characteristics and function of cardiac mitochondrial nitric oxide synthase. J Physiol. 2009 Feb 15; 587(Pt 4):851-72. PMID: 19103678; PMCID: PMC2669975.
    57. Zima AV, Qin J, Fill M, Blatter LA. Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2008-16. PMID: 18790837; PMCID: PMC2614574.
    58. Zima AV, Picht E, Bers DM, Blatter LA. Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res. 2008 Oct 10; 103(8):e105-15. PMID: 18787194; PMCID: PMC2678058.
    59. Wang YG, Zima AV, Ji X, Pabbidi R, Blatter LA, Lipsius SL. Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H851-9. PMID: 18567703; PMCID: PMC2519214.
    60. Kockskämper J, Zima AV, Roderick HL, Pieske B, Blatter LA, Bootman MD. Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol. 2008 Aug; 45(2):128-47. PMID: 18603259; PMCID: PMC2654363.
    61. Dedkova EN, Blatter LA. Mitochondrial Ca2+ and the heart. Cell Calcium. 2008 Jul; 44(1):77-91. PMID: 18178248.
      View in: PubMed
    62. Domeier TL, Zima AV, Maxwell JT, Huke S, Mignery GA, Blatter LA. IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H596-604. PMID: 18055509.
      View in: PubMed
    63. Zima AV, Picht E, Bers DM, Blatter LA. Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophys J. 2008 Mar 01; 94(5):1867-79. PMID: 18024505; PMCID: PMC2242770.
    64. Florea SM, Blatter LA. The effect of oxidative stress on Ca2+ release and capacitative Ca2+ entry in vascular endothelial cells. Cell Calcium. 2008 Apr; 43(4):405-15. PMID: 17767954.
      View in: PubMed
    65. Zima AV, Bare DJ, Mignery GA, Blatter LA. IP3-dependent nuclear Ca2+ signalling in the mammalian heart. J Physiol. 2007 Oct 15; 584(Pt 2):601-11. PMID: 17761776; PMCID: PMC2277156.
    66. Picht E, Zima AV, Blatter LA, Bers DM. SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1073-81. PMID: 17376815.
      View in: PubMed
    67. Aromolaran AS, Zima AV, Blatter LA. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C106-18. PMID: 17344311.
      View in: PubMed
    68. Copello JA, Zima AV, Diaz-Sylvester PL, Fill M, Blatter LA. Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2129-40. PMID: 17314267; PMCID: PMC2094215.
    69. Dedkova EN, Wang YG, Ji X, Blatter LA, Samarel AM, Lipsius SL. Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes. J Physiol. 2007 Apr 01; 580(Pt 1):327-45. PMID: 17234690; PMCID: PMC2075434.
    70. Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res. 2006 Sep 29; 99(7):740-8. PMID: 16946134.
      View in: PubMed
    71. Zima AV, Kockskämper J, Blatter LA. Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes. J Physiol. 2006 Nov 15; 577(Pt 1):281-93. PMID: 16945967; PMCID: PMC2000679.
    72. Jung C, Zima AV, Szentesi P, Jona I, Blatter LA, Niggli E. Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium. 2007 Feb; 41(2):187-94. PMID: 16920191.
      View in: PubMed
    73. Snopko RM, Aromolaran AS, Karko KL, Ramos-Franco J, Blatter LA, Mejía-Alvarez R. Cell culture modifies Ca2+ signaling during excitation-contraction coupling in neonate cardiac myocytes. Cell Calcium. 2007 Jan; 41(1):13-25. PMID: 16908061.
      View in: PubMed
    74. Sedova M, Dedkova EN, Blatter LA. Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C840-50. PMID: 16723510.
      View in: PubMed
    75. Sheehan KA, Zima AV, Blatter LA. Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. J Physiol. 2006 May 01; 572(Pt 3):799-809. PMID: 16484302; PMCID: PMC1780000.
    76. Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res. 2006 Jul 15; 71(2):310-21. PMID: 16581043.
      View in: PubMed
    77. Shannon TR, Bers DM, Blatter LA, Niggli E. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium. 2005 Nov; 38(5):497-505. PMID: 16122794.
      View in: PubMed
    78. Remus TP, Zima AV, Bossuyt J, Bare DJ, Martin JL, Blatter LA, Bers DM, Mignery GA. Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem. 2006 Jan 06; 281(1):608-16. PMID: 16249182.
      View in: PubMed
    79. Aromolaran AA, Blatter LA. Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1426-36. PMID: 16093279.
      View in: PubMed
    80. Wang YG, Dedkova EN, Ji X, Blatter LA, Lipsius SL. Phenylephrine acts via IP3-dependent intracellular NO release to stimulate L-type Ca2+ current in cat atrial myocytes. J Physiol. 2005 Aug 15; 567(Pt 1):143-57. PMID: 15946966; PMCID: PMC1474159.
    81. Li X, Zima AV, Sheikh F, Blatter LA, Chen J. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res. 2005 Jun 24; 96(12):1274-81. PMID: 15933266.
      View in: PubMed
    82. Dedkova EN, Blatter LA. Modulation of mitochondrial Ca2+ by nitric oxide in cultured bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C836-45. PMID: 15901603.
      View in: PubMed
    83. Kockskämper J, Zima AV, Blatter LA. Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes. J Physiol. 2005 May 01; 564(Pt 3):697-714. PMID: 15695247; PMCID: PMC1464475.
    84. Despa S, Kockskämper J, Blatter LA, Bers DM. Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy. Biophys J. 2004 Aug; 87(2):1360-8. PMID: 15298938; PMCID: PMC1304474.
    85. Kockskämper J, Ahmmed GU, Zima AV, Sheehan KA, Glitsch HG, Blatter LA. Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C527-38. PMID: 15084477.
      View in: PubMed
    86. Zima AV, Blatter LA. Inositol-1,4,5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias. J Physiol. 2004 Mar 16; 555(Pt 3):607-15. PMID: 14754996; PMCID: PMC1664857.
    87. Zima AV, Copello JA, Blatter LA. Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. J Physiol. 2004 Mar 16; 555(Pt 3):727-41. PMID: 14724208; PMCID: PMC1664876.
    88. Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Res. 2004 Mar 05; 94(4):478-86. PMID: 14699012.
      View in: PubMed
    89. Dedkova EN, Ji X, Wang YG, Blatter LA, Lipsius SL. Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawal in cat atrial myocytes. Circ Res. 2003 Dec 12; 93(12):1233-40. PMID: 14615286.
      View in: PubMed
    90. Dedkova EN, Ji X, Lipsius SL, Blatter LA. Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C406-15. PMID: 14512291.
      View in: PubMed
    91. Zima AV, Copello JA, Blatter LA. Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. FEBS Lett. 2003 Jul 17; 547(1-3):32-6. PMID: 12860382.
      View in: PubMed
    92. Zima AV, Kockskämper J, Mejia-Alvarez R, Blatter LA. Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. J Physiol. 2003 Aug 01; 550(Pt 3):765-83. PMID: 12824454; PMCID: PMC2343083.
    93. Wang YG, Dedkova EN, Fiening JP, Ojamaa K, Blatter LA, Lipsius SL. Acute exposure to thyroid hormone increases Na+ current and intracellular Ca2+ in cat atrial myocytes. J Physiol. 2003 Jan 15; 546(Pt 2):491-9. PMID: 12527735; PMCID: PMC2342523.
    94. Sheehan KA, Blatter LA. Regulation of junctional and non-junctional sarcoplasmic reticulum calcium release in excitation-contraction coupling in cat atrial myocytes. J Physiol. 2003 Jan 01; 546(Pt 1):119-35. PMID: 12509483; PMCID: PMC2342474.
    95. Blatter LA, Kockskämper J, Sheehan KA, Zima AV, Hüser J, Lipsius SL. Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes. J Physiol. 2003 Jan 01; 546(Pt 1):19-31. PMID: 12509476; PMCID: PMC2342467.
    96. Kockskämper J, Blatter LA. Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytes. J Physiol. 2002 11 15; 545(1):65-79. PMID: 12433950.
      View in: PubMed
    97. Dedkova EN, Wang YG, Blatter LA, Lipsius SL. Nitric oxide signalling by selective beta(2)-adrenoceptor stimulation prevents ACh-induced inhibition of beta(2)-stimulated Ca(2+) current in cat atrial myocytes. J Physiol. 2002 Aug 01; 542(Pt 3):711-23. PMID: 12154173; PMCID: PMC2290448.
    98. Dedkova EN, Blatter LA. Nitric oxide inhibits capacitative Ca2+ entry and enhances endoplasmic reticulum Ca2+ uptake in bovine vascular endothelial cells. J Physiol. 2002 Feb 15; 539(Pt 1):77-91. PMID: 11850503; PMCID: PMC2290138.
    99. Wang YG, Dedkova EN, Steinberg SF, Blatter LA, Lipsius SL. Beta 2-adrenergic receptor signaling acts via NO release to mediate ACh-induced activation of ATP-sensitive K+ current in cat atrial myocytes. J Gen Physiol. 2002 Jan; 119(1):69-82. PMID: 11773239; PMCID: PMC2233856.
    100. Kockskämper J, Sheehan KA, Bare DJ, Lipsius SL, Mignery GA, Blatter LA. Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes. Biophys J. 2001 Nov; 81(5):2590-605. PMID: 11606273; PMCID: PMC1301727.
    101. Lipsius SL, Hüser J, Blatter LA. Intracellular Ca2+ release sparks atrial pacemaker activity. News Physiol Sci. 2001 Jun; 16:101-6. PMID: 11443225.
      View in: PubMed
    102. Wang YG, Benedict WJ, Hüser J, Samarel AM, Blatter LA, Lipsius SL. Brief rapid pacing depresses contractile function via Ca(2+)/PKC-dependent signaling in cat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H90-8. PMID: 11123222.
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    103. Sedova M, Blatter LA. Intracellular sodium modulates mitochondrial calcium signaling in vascular endothelial cells. J Biol Chem. 2000 Nov 10; 275(45):35402-7. PMID: 10958797.
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    104. Hüser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol. 2000 May 01; 524 Pt 3:795-806. PMID: 10790159; PMCID: PMC2269904.
    105. Hüser J, Blatter LA, Lipsius SL. Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol. 2000 Apr 15; 524 Pt 2:415-22. PMID: 10766922; PMCID: PMC2269880.
    106. Sedova M, Klishin A, Huser J, Blatter LA. Capacitative Ca2+ entry is graded with degree of intracellular Ca2+ store depletion in bovine vascular endothelial cells. J Physiol. 2000 Mar 15; 523 Pt 3:549-59. PMID: 10718737; PMCID: PMC2269830.
    107. Hüser J, Blatter LA, Sheu SS. Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients? J Bioenerg Biomembr. 2000 Feb; 32(1):27-33. PMID: 11768759.
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    108. Hüser J, Blatter LA. Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore. Biochem J. 1999 Oct 15; 343 Pt 2:311-7. PMID: 10510294; PMCID: PMC1220555.
    109. Sedova M, Blatter LA. Dynamic regulation of [Ca2+]i by plasma membrane Ca(2+)-ATPase and Na+/Ca2+ exchange during capacitative Ca2+ entry in bovine vascular endothelial cells. Cell Calcium. 1999 May; 25(5):333-43. PMID: 10463097.
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    110. Blatter LA. Cell volume measurements by fluorescence confocal microscopy: theoretical and practical aspects. Methods Enzymol. 1999; 307:274-95. PMID: 10506979.
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    111. Hüser J, Holda JR, Kockskamper J, Blatter LA. Focal agonist stimulation results in spatially restricted Ca2+ release and capacitative Ca2+ entry in bovine vascular endothelial cells. J Physiol. 1999 Jan 01; 514 ( Pt 1):101-9. PMID: 9831719; PMCID: PMC2269050.
    112. Holda JR, Klishin A, Sedova M, Hüser J, Blatter LA. Capacitative Calcium Entry. News Physiol Sci. 1998 Aug; 13:157-163. PMID: 11390782.
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    113. Blatter LA, Niggli E. Confocal near-membrane detection of calcium in cardiac myocytes. Cell Calcium. 1998 May; 23(5):269-79. PMID: 9681190.
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    114. Hüser J, Bers DM, Blatter LA. Subcellular properties of [Ca2+]i transients in phospholamban-deficient mouse ventricular cells. Am J Physiol. 1998 May; 274(5 Pt 2):H1800-11. PMID: 9612393.
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    115. Hüser J, Rechenmacher CE, Blatter LA. Imaging the permeability pore transition in single mitochondria. Biophys J. 1998 Apr; 74(4):2129-37. PMID: 9545072; PMCID: PMC1299554.
    116. Klishin A, Sedova M, Blatter LA. Time-dependent modulation of capacitative Ca2+ entry signals by plasma membrane Ca2+ pump in endothelium. Am J Physiol. 1998 Apr; 274(4 Pt 1):C1117-28. PMID: 9575809.
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    117. Hüser J, Blatter LA. Elementary events of agonist-induced Ca2+ release in vascular endothelial cells. Am J Physiol. 1997 Nov; 273(5 Pt 1):C1775-82. PMID: 9374666.
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    118. Wang YG, Hüser J, Blatter LA, Lipsius SL. Withdrawal of acetylcholine elicits Ca2+-induced delayed afterdepolarizations in cat atrial myocytes. Circulation. 1997 Aug 19; 96(4):1275-81. PMID: 9286959.
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    119. Blatter LA, Hüser J, Ríos E. Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):4176-81. PMID: 9108125; PMCID: PMC20594.
    120. Holda JR, Blatter LA. Capacitative calcium entry is inhibited in vascular endothelial cells by disruption of cytoskeletal microfilaments. FEBS Lett. 1997 Feb 17; 403(2):191-6. PMID: 9042964.
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    121. Satoh H, Blatter LA, Bers DM. Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes. Am J Physiol. 1997 Feb; 272(2 Pt 2):H657-68. PMID: 9124422.
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    122. Satoh H, Hayashi H, Blatter LA, Bers DM. BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes. Heart Vessels. 1997; Suppl 12:58-61. PMID: 9476545.
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    123. McCall E, Li L, Satoh H, Shannon TR, Blatter LA, Bers DM. Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. Circ Res. 1996 Dec; 79(6):1110-21. PMID: 8943949.
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    124. Hüser J, Lipsius SL, Blatter LA. Calcium gradients during excitation-contraction coupling in cat atrial myocytes. J Physiol. 1996 Aug 01; 494 ( Pt 3):641-51. PMID: 8865063; PMCID: PMC1160666.
    125. Holda JR, Oberti C, Perez-Reyes E, Blatter LA. Characterization of an oxytocin-induced rise in [Ca2+]i in single human myometrium smooth muscle cells. Cell Calcium. 1996 Jul; 20(1):43-51. PMID: 8864570.
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    126. Satoh H, Delbridge LM, Blatter LA, Bers DM. Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects. Biophys J. 1996 Mar; 70(3):1494-504. PMID: 8785306; PMCID: PMC1225076.
    127. Tsugorka A, Ríos E, Blatter LA. Imaging elementary events of calcium release in skeletal muscle cells. Science. 1995 Sep 22; 269(5231):1723-6. PMID: 7569901.
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    128. Blatter LA, Taha Z, Mesaros S, Shacklock PS, Wier WG, Malinski T. Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells. Circ Res. 1995 May; 76(5):922-4. PMID: 7729011.
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    129. Blatter LA. Depletion and filling of intracellular calcium stores in vascular smooth muscle. Am J Physiol. 1995 Feb; 268(2 Pt 1):C503-12. PMID: 7864090.
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    130. Murphy TH, Blatter LA, Bhat RV, Fiore RS, Wier WG, Baraban JM. Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission. J Neurosci. 1994 Mar; 14(3 Pt 1):1320-31. PMID: 8120627.
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    131. Blatter LA, Wier WG. Nitric oxide decreases [Ca2+]i in vascular smooth muscle by inhibition of the calcium current. Cell Calcium. 1994 Feb; 15(2):122-31. PMID: 8149412.
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    132. Murphy TH, Baraban JM, Wier WG, Blatter LA. Visualization of quantal synaptic transmission by dendritic calcium imaging. Science. 1994 Jan 28; 263(5146):529-32. PMID: 7904774.
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    133. Murphy TH, Blatter LA, Wier WG, Baraban JM. Rapid communication between neurons and astrocytes in primary cortical cultures. J Neurosci. 1993 Jun; 13(6):2672-9. PMID: 8501531.
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    134. Murphy TH, Blatter LA, Wier WG, Baraban JM. Spontaneous synchronous synaptic calcium transients in cultured cortical neurons. J Neurosci. 1992 Dec; 12(12):4834-45. PMID: 1361198.
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    135. Blatter LA, Wier WG. Agonist-induced [Ca2+]i waves and Ca(2+)-induced Ca2+ release in mammalian vascular smooth muscle cells. Am J Physiol. 1992 Aug; 263(2 Pt 2):H576-86. PMID: 1510155.
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    136. Blatter LA, Blinks JR. Simultaneous measurement of Ca2+ in muscle with Ca electrodes and aequorin. Diffusible cytoplasmic constituent reduces Ca(2+)-independent luminescence of aequorin. J Gen Physiol. 1991 Dec; 98(6):1141-60. PMID: 1783896; PMCID: PMC2229069.
    137. Wier WG, Blatter LA. Ca(2+)-oscillations and Ca(2+)-waves in mammalian cardiac and vascular smooth muscle cells. Cell Calcium. 1991 Feb-Mar; 12(2-3):241-54. PMID: 2059996.
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    138. Blatter LA. Estimation of intracellular free magnesium using ion-selective microelectrodes: evidence for an Na/Mg exchange mechanism in skeletal muscle. Magnes Trace Elem. 1991-1992; 10(2-4):67-79. PMID: 1844563.
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    139. Blatter LA, McGuigan JA. Intracellular pH regulation in ferret ventricular muscle. The role of Na-H exchange and the influence of metabolic substrates. Circ Res. 1991 Jan; 68(1):150-61. PMID: 1845852.
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    140. Blatter LA, Wier WG. Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2. Biophys J. 1990 Dec; 58(6):1491-9. PMID: 2275965; PMCID: PMC1281101.
    141. Blatter LA. Intracellular free magnesium in frog skeletal muscle studied with a new type of magnesium-selective microelectrode: interactions between magnesium and sodium in the regulation of [Mg]i. Pflugers Arch. 1990 May; 416(3):238-46. PMID: 2381762.
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    142. Fry CH, Hall SK, Blatter LA, McGuigan JA. Analysis and presentation of intracellular measurements obtained with ion-selective microelectrodes. Exp Physiol. 1990 Mar; 75(2):187-98. PMID: 2340160.
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    143. Blatter LA, McGuigan JA. Estimation of the upper limit of the free magnesium concentration measured with Mg-sensitive microelectrodes in ferret ventricular muscle: (1) use of the Nicolsky-Eisenman equation and (2) in calibrating solutions of the appropriate concentration. Magnesium. 1988; 7(3):154-65. PMID: 3185015.
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    144. McGuigan JA, Blatter LA. Sodium/calcium exchange in ventricular muscle. Experientia. 1987 Dec 01; 43(11-12):1140-5. PMID: 2446907.
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    145. Blatter LA, McGuigan JA, Reverdin EC. Sodium/calcium exchange and calcium buffering in mammalian ventricular muscle. Jpn Heart J. 1986 Nov; 27 Suppl 1:93-107. PMID: 2434687.
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    146. Blatter LA, McGuigan JA. Free intracellular magnesium concentration in ferret ventricular muscle measured with ion selective micro-electrodes. Q J Exp Physiol. 1986 Jul; 71(3):467-73. PMID: 3763808.
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    147. Blatter LA, Cloetta B. [Incidence and prevalence of disabled rheumatic patients. A socio-epidemiological study on the services of the disability insurance system in the canton of Berne]. Schweiz Med Wochenschr. 1985 Jun 01; 115(22):768-75. PMID: 3874426.
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