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Anna Plaas

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Rheumatology
Address1611 W. Harrison St.
Chicago IL 60610
Phone312-942-7194
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    My Scopus ID is 7003904296.
    My NIH COMMONS name is APLAAS.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Plaas AHK, Moran MM, Sandy JD, Hascall VC. Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now. Adv Exp Med Biol. 2023; 1402:3-29. PMID: 37052843.
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    2. Chan DD, Mashiatulla M, Li J, Ross RD, Pendyala M, Patwa A, Grinstaff MW, Plaas A, Sumner DR, Chan DD, Mashiatulla M, Li J, Ross RD, Pendyala M, Patwa A, Grinstaff MW, Plaas A, Sumner DR. Contrast-enhanced micro-computed tomography of compartment and time-dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis. Anat Rec (Hoboken). 2023 01; 306(1):92-109. PMID: 35751529; PMCID: PMC10084428.
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    3. Moran MM, Wilson BM, Li J, Engen PA, Naqib A, Green SJ, Virdi AS, Plaas A, Forsyth CB, Keshavarzian A, Sumner DR, Moran MM, Wilson BM, Li J, Engen PA, Naqib A, Green SJ, Virdi AS, Plaas A, Forsyth CB, Keshavarzian A, Sumner DR. The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats. FASEB J. 2020 11; 34(11):14302-14317. PMID: 32931052; PMCID: PMC8025663.
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    4. Richardson C, Plaas A, Varga J. Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment. Curr Rheumatol Rep. 2020 08 27; 22(10):73. PMID: 32856128.
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    5. Xue J, Chen J, Shen Q, Chan D, Li J, Tanguay AP, Schmidt TA, Niazi F, Plaas A. Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican. Cells. 2020 07 13; 9(7). PMID: 32668663.
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    6. Virk MS, Luo W, Sikes KJ, Li J, Plaas A, Cole BJ. Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction. BMC Musculoskelet Disord. 2020 Mar 28; 21(1):194. PMID: 32222148.
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    7. McCorry MC, Kim J, Springer NL, Sandy J, Plaas A, Bonassar LJ. Regulation of proteoglycan production by varying glucose concentrations controls fiber formation in tissue engineered menisci. Acta Biomater. 2019 12; 100:173-183. PMID: 31546030.
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    8. Rezvani SN, Chen J, Li J, Midura R, Cali V, Sandy JD, Plaas A, Wang VM. In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy. J Orthop Res. 2020 01; 38(1):59-69. PMID: 31478241.
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    9. Richardson C, Plaas A, Block JA. Intra-articular Hyaluronan Therapy for Symptomatic Knee Osteoarthritis. Rheum Dis Clin North Am. 2019 08; 45(3):439-451. PMID: 31277754.
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    10. Shen Q, Li J, Chan D, Sandy JD, Takeuchi J, Ross RD, Plaas A. Effect of intra-articular hyaluronan injection on inflammation and bone remodeling in the epiphyses and metaphyses of the knee in a murine model of joint injury. Am J Transl Res. 2019; 11(6):3280-3300. PMID: 31312344.
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    11. Sikes KJ, Renner K, Li J, Grande-Allen KJ, Connell JP, Cali V, Midura RJ, Sandy JD, Plaas A, Wang VM. Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa. J Orthop Res. 2018 10; 36(10):2622-2632. PMID: 29672913.
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    12. Sikes KJ, Li J, Gao SG, Shen Q, Sandy JD, Plaas A, Wang VM. TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells. Connect Tissue Res. 2018 09; 59(5):458-471. PMID: 29447016.
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    13. Bittermann A, Gao S, Rezvani S, Li J, Sikes KJ, Sandy J, Wang V, Lee S, Holmes G, Lin J, Plaas A. Oral Ibuprofen Interferes with Cellular Healing Responses in a Murine Model of Achilles Tendinopathy. J Musculoskelet Disord Treat. 2018; 4(2). PMID: 30687812.
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    14. Chan DD, Li J, Luo W, Predescu DN, Cole BJ, Plaas A. Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury. J Orthop Res. 2018 01; 36(1):365-376. PMID: 28646530.
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    15. Mashiatulla M, Moran MM, Chan D, Li J, Freedman JD, Snyder BD, Grinstaff MW, Plaas A, Sumner DR. Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced ?CT. J Orthop Res. 2017 12; 35(12):2740-2748. PMID: 28471533.
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    16. Luo W, Sandy J, Trella K, Gorski D, Gao S, Li J, Brounts S, Galante J, Plaas A. Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGF? Signaling Components in Adipose-Derived Stromal Fibroblasts. PLoS One. 2016; 11(11):e0167069. PMID: 27902739.
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    17. Trella KJ, Li J, Stylianou E, Wang VM, Frank JM, Galante J, Sandy JD, Plaas A, Wysocki R. Genome-wide analysis identifies differential promoter methylation of Leprel2, Foxf1, Mmp25, Igfbp6, and Peg12 in murine tendinopathy. J Orthop Res. 2017 05; 35(5):947-955. PMID: 27517731.
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    18. Sandy JD, Chan DD, Trevino RL, Wimmer MA, Plaas A. Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis. Osteoarthritis Cartilage. 2015 Nov; 23(11):1939-45. PMID: 26521740.
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    19. Chan DD, Xiao WF, Li J, de la Motte CA, Sandy JD, Plaas A. Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage. Osteoarthritis Cartilage. 2015 Nov; 23(11):1879-89. PMID: 26521733.
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    20. Gorski DJ, Xiao W, Li J, Luo W, Lauer M, Kisiday J, Plaas A, Sandy J. Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells. Matrix Biol. 2015 Sep; 47:66-84. PMID: 25840345.
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    21. Sayegh ET, Sandy JD, Virk MS, Romeo AA, Wysocki RW, Galante JO, Trella KJ, Plaas A, Wang VM. Recent Scientific Advances Towards the Development of Tendon Healing Strategies. Curr Tissue Eng. 2015; 4(2):128-143. PMID: 26753125.
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    22. Bell R, Li J, Shewman EF, Galante JO, Cole BJ, Bach BR, Troy KL, Mikecz K, Sandy JD, Plaas AH, Wang VM. ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy. J Orthop Res. 2013 Oct; 31(10):1540-8. PMID: 23754494.
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    23. Bell R, Li J, Gorski DJ, Bartels AK, Shewman EF, Wysocki RW, Cole BJ, Bach BR, Mikecz K, Sandy JD, Plaas AH, Wang VM. Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model. J Biomech. 2013 Feb 01; 46(3):498-505. PMID: 23159096.
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    24. Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A. Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism. Arthritis Res Ther. 2012 Jun 21; 14(3):R151. PMID: 22721434.
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    25. Kotwal N, Li J, Sandy J, Plaas A, Sumner DR. Initial application of EPIC-?CT to assess mouse articular cartilage morphology and composition: effects of aging and treadmill running. Osteoarthritis Cartilage. 2012 Aug; 20(8):887-95. PMID: 22609479.
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    26. Wang VM, Bell RM, Thakore R, Eyre DR, Galante JO, Li J, Sandy JD, Plaas A. Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5. J Orthop Res. 2012 Apr; 30(4):620-6. PMID: 21928430.
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    27. Aggarwal R, Sequeira W, Kokebie R, Mikolaitis RA, Fogg L, Finnegan A, Plaas A, Block JA, Jolly M. Serum free light chains as biomarkers for systemic lupus erythematosus disease activity. Arthritis Care Res (Hoboken). 2011 Jun; 63(6):891-8. PMID: 21312346.
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    28. Plaas A, Velasco J, Gorski DJ, Li J, Cole A, Christopherson K, Sandy JD. The relationship between fibrogenic TGF?1 signaling in the joint and cartilage degradation in post-injury osteoarthritis. Osteoarthritis Cartilage. 2011 Sep; 19(9):1081-90. PMID: 21624477.
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    29. Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor ?1 (TGF?1) signaling. J Biol Chem. 2011 Jul 22; 286(29):26016-27. PMID: 21566131.
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    30. Plaas A, Li J, Riesco J, Das R, Sandy JD, Harrison A. Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. Arthritis Res Ther. 2011 Mar 20; 13(2):R46. PMID: 21418601.
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    31. Plaas A, Sandy JD, Liu H, Diaz MA, Schenkman D, Magnus RP, Bolam-Bretl C, Kopesky PW, Wang VM, Galante JO. Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis. J Orthop Res. 2011 Jun; 29(6):900-6. PMID: 21246622.
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    32. Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum. 2010 Dec; 62(12):3686-94. PMID: 20722014.
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    33. Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A. Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res. 2011 Apr; 29(4):516-22. PMID: 21337391.
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    34. Lee HY, Kopesky PW, Plaas A, Sandy J, Kisiday J, Frisbie D, Grodzinsky AJ, Ortiz C. Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage. Osteoarthritis Cartilage. 2010 Nov; 18(11):1477-86. PMID: 20692354.
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    35. Wiranowska M, Ladd S, Moscinski LC, Hill B, Haller E, Mikecz K, Plaas A. Modulation of hyaluronan production by CD44 positive glioma cells. Int J Cancer. 2010 Aug 01; 127(3):532-42. PMID: 19957333.
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    36. Kopesky PW, Lee HY, Vanderploeg EJ, Kisiday JD, Frisbie DD, Plaas AH, Ortiz C, Grodzinsky AJ. Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes. Matrix Biol. 2010 Jun; 29(5):427-38. PMID: 20153827.
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    37. Jackson CG, Plaas AH, Sandy JD, Hua C, Kim-Rolands S, Barnhill JG, Harris CL, Clegg DO. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis Cartilage. 2010 Mar; 18(3):297-302. PMID: 19912983.
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    38. Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum. 2009 Oct; 60(10):2985-96. PMID: 19790045.
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    39. Block JA, Oegema TR, Sandy JD, Plaas A. The effects of oral glucosamine on joint health: is a change in research approach needed? Osteoarthritis Cartilage. 2010 Jan; 18(1):5-11. PMID: 19733270.
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    40. Lee JH, Fitzgerald JB, DiMicco MA, Cheng DM, Flannery CR, Sandy JD, Plaas AH, Grodzinsky AJ. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. Arch Biochem Biophys. 2009 Sep; 489(1-2):118-26. PMID: 19607802.
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    41. Schmidt TA, Plaas AH, Sandy JD. Disulfide-bonded multimers of proteoglycan 4 PRG4 are present in normal synovial fluids. Biochim Biophys Acta. 2009 May; 1790(5):375-84. PMID: 19332105.
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    42. Fosang AJ, Last K, Poon CJ, Plaas AH. Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan. Matrix Biol. 2009 Jan; 28(1):53-61. PMID: 19041721.
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    43. Scanzello CR, Plaas A, Crow MK. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol. 2008 Sep; 20(5):565-72. PMID: 18698179.
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    44. Sohaskey ML, Yu J, Diaz MA, Plaas AH, Harland RM. JAWS coordinates chondrogenesis and synovial joint positioning. Development. 2008 Jul; 135(13):2215-20. PMID: 18539921.
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    45. Mahoney DJ, Mikecz K, Ali T, Mabilleau G, Benayahu D, Plaas A, Milner CM, Day AJ, Sabokbar A. TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. J Biol Chem. 2008 Sep 19; 283(38):25952-62. PMID: 18586671.
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    46. Yoshihara Y, Plaas A, Osborn B, Margulis A, Nelson F, Stewart M, Rugg MS, Milner CM, Day AJ, Nemoto K, Sandy JD. Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin. Osteoarthritis Cartilage. 2008 Nov; 16(11):1343-55. PMID: 18524635.
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    47. Franco G, Jonoska N, Osborn B, Plaas A. Knee joint injury and repair modeled by membrane systems. Biosystems. 2008 Mar; 91(3):473-88. PMID: 17913339.
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    48. Jong A, Wu CH, Chen HM, Luo F, Kwon-Chung KJ, Chang YC, Lamunyon CW, Plaas A, Huang SH. Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell. 2007 Aug; 6(8):1486-96. PMID: 17545316.
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    49. Brown MP, Trumble TN, Plaas AH, Sandy JD, Romano M, Hernandez J, Merritt KA. Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Osteoarthritis Cartilage. 2007 Nov; 15(11):1318-25. PMID: 17543547.
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    50. Wang SX, Laverty S, Dumitriu M, Plaas A, Grynpas MD. The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum. 2007 May; 56(5):1537-48. PMID: 17469133.
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    51. Tester NJ, Plaas AH, Howland DR. Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans. J Neurosci Res. 2007 Apr; 85(5):1110-8. PMID: 17265470.
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    52. Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD. Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage. 2007 Jul; 15(7):719-34. PMID: 17360199.
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    53. Hood E, Gonzalez M, Plaas A, Strom J, VanAuker M. Immuno-targeting of nonionic surfactant vesicles to inflammation. Int J Pharm. 2007 Jul 18; 339(1-2):222-30. PMID: 17448616.
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    54. Osborn B, Bai Y, Plaas AH, Sandy JD. Image analysis of aggrecan degradation in articular cartilage with formalin-fixed samples. Methods Mol Med. 2007; 135:167-82. PMID: 17951658.
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    55. Kenagy RD, Plaas AH, Wight TN. Versican degradation and vascular disease. Trends Cardiovasc Med. 2006 Aug; 16(6):209-15. PMID: 16839865.
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    56. Kaji T, Yamamoto C, Oh-i M, Fujiwara Y, Yamazaki Y, Morita T, Plaas AH, Wight TN. The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells. Biochim Biophys Acta. 2006 Sep; 1760(9):1465-74. PMID: 16914267.
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    57. Rodriguez E, Roland SK, Plaas A, Roughley PJ. The glycosaminoglycan attachment regions of human aggrecan. J Biol Chem. 2006 Jul 07; 281(27):18444-50. PMID: 16679517.
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    58. Stewart MC, Fosang AJ, Bai Y, Osborn B, Plaas A, Sandy JD. ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. Osteoarthritis Cartilage. 2006 Apr; 14(4):392-402. PMID: 16406703.
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    59. Seog J, Dean D, Rolauffs B, Wu T, Genzer J, Plaas AH, Grodzinsky AJ, Ortiz C. Nanomechanics of opposing glycosaminoglycan macromolecules. J Biomech. 2005 Sep; 38(9):1789-97. PMID: 16023465.
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    60. Mouw JK, Case ND, Guldberg RE, Plaas AH, Levenston ME. Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering. Osteoarthritis Cartilage. 2005 Sep; 13(9):828-36. PMID: 16006153.
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    61. Poon CJ, Plaas AH, Keene DR, McQuillan DJ, Last K, Fosang AJ. N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity. J Biol Chem. 2005 Jun 24; 280(25):23615-21. PMID: 15849197.
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    62. Laverty S, Sandy JD, Celeste C, Vachon P, Marier JF, Plaas AH. Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum. 2005 Jan; 52(1):181-91. PMID: 15641100.
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    63. Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD. ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. J Biol Chem. 2004 Mar 12; 279(11):10042-51. PMID: 14701864.
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    64. Ng L, Grodzinsky AJ, Patwari P, Sandy J, Plaas A, Ortiz C. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. J Struct Biol. 2003 Sep; 143(3):242-57. PMID: 14572479.
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    65. Sauerland K, Plaas AH, Raiss RX, Steinmeyer J. The sulfation pattern of chondroitin sulfate from articular cartilage explants in response to mechanical loading. Biochim Biophys Acta. 2003 Jul 30; 1638(3):241-8. PMID: 12878325.
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    66. Derwin KA, Soslowsky LJ, Kimura JH, Plaas AH. Proteoglycans and glycosaminoglycan fine structure in the mouse tail tendon fascicle. J Orthop Res. 2001 Mar; 19(2):269-77. PMID: 11347701.
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    67. Plaas AH, West L, Midura RJ, Hascall VC. Disaccharide composition of hyaluronan and chondroitin/dermatan sulfate. Analysis with fluorophore-assisted carbohydrate electrophoresis. Methods Mol Biol. 2001; 171:117-28. PMID: 11450222.
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    68. Kawashima H, Hirose M, Hirose J, Nagakubo D, Plaas AH, Miyasaka M. Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44. J Biol Chem. 2000 Nov 10; 275(45):35448-56. PMID: 10950950.
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    69. Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol. 2000 Aug; 157(2):423-33. PMID: 10934147.
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    70. Plaas AH, Wong-Palms S, Koob T, Hernandez D, Marchuk L, Frank CB. Proteoglycan metabolism during repair of the ruptured medial collateral ligament in skeletally mature rabbits. Arch Biochem Biophys. 2000 Feb 01; 374(1):35-41. PMID: 10640393.
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    71. West LA, Roughley P, Nelson FR, Plaas AH. Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. Biochem J. 1999 Aug 15; 342 ( Pt 1):223-9. PMID: 10432320.
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    72. Brown MP, West LA, Merritt KA, Plaas AH. Changes in sulfation patterns of chondroitin sulfate in equine articular cartilage and synovial fluid in response to aging and osteoarthritis. Am J Vet Res. 1998 Jun; 59(6):786-91. PMID: 9622753.
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    73. Plaas AH, West LA, Wong-Palms S, Nelson FR. Glycosaminoglycan sulfation in human osteoarthritis. Disease-related alterations at the non-reducing termini of chondroitin and dermatan sulfate. J Biol Chem. 1998 May 15; 273(20):12642-9. PMID: 9575226.
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    74. Lauder RM, Huckerby TN, Nieduszynski IA, Plaas AH. Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage. Biochem J. 1998 Mar 01; 330 ( Pt 2):753-7. PMID: 9480886.
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    75. Plaas AH, Wong-Palms S, Roughley PJ, Midura RJ, Hascall VC. Chemical and immunological assay of the nonreducing terminal residues of chondroitin sulfate from human aggrecan. J Biol Chem. 1997 Aug 15; 272(33):20603-10. PMID: 9252375.
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    76. Bonassar LJ, Sandy JD, Lark MW, Plaas AH, Frank EH, Grodzinsky AJ. Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors. Arch Biochem Biophys. 1997 Aug 15; 344(2):404-12. PMID: 9264555.
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    77. Plaas AH, Hascall VC, Midura RJ. Ion exchange HPLC microanalysis of chondroitin sulfate: quantitative derivatization of chondroitin lyase digestion products with 2-aminopyridine. Glycobiology. 1996 Dec; 6(8):823-9. PMID: 9023544.
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    78. Berenson MC, Blevins FT, Plaas AH, Vogel KG. Proteoglycans of human rotator cuff tendons. J Orthop Res. 1996 Jul; 14(4):518-25. PMID: 8764859.
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    79. Kim YJ, Grodzinsky AJ, Plaas AH. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan. Arch Biochem Biophys. 1996 Apr 15; 328(2):331-40. PMID: 8645012.
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    80. Sandy JD, Plaas AH, Koob TJ. Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring. Acta Orthop Scand Suppl. 1995 Oct; 266:26-32. PMID: 8553857.
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    81. Wong-Palms S, Plaas AH. Glycosaminoglycan addition to proteoglycans by articular chondrocytes--evidence for core protein-specific pathways. Arch Biochem Biophys. 1995 Jun 01; 319(2):383-92. PMID: 7786019.
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    82. Cs-Szab? G, Roughley PJ, Plaas AH, Glant TT. Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage. Arthritis Rheum. 1995 May; 38(5):660-8. PMID: 7538297.
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    83. Deutsch AJ, Midura RJ, Plaas AH. Structure of chondroitin sulfate on aggrecan isolated from bovine tibial and costochondral growth plates. J Orthop Res. 1995 Mar; 13(2):230-9. PMID: 7722760.
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    84. Hascall VC, Midura RJ, Sorrell JM, Plaas AH. Immunology of chondroitin/dermatan sulfate. Adv Exp Med Biol. 1995; 376:205-16. PMID: 8597249.
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    85. Kim YJ, Sah RL, Grodzinsky AJ, Plaas AH, Sandy JD. Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys. 1994 May 15; 311(1):1-12. PMID: 8185305.
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    86. Plaas AH, Wong-Palms S. Biosynthetic mechanisms for the addition of polylactosamine to chondrocyte fibromodulin. J Biol Chem. 1993 Dec 15; 268(35):26634-44. PMID: 8253794.
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    87. Plaas AH, Sandy JD. A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate. Matrix. 1993 Mar; 13(2):135-47. PMID: 8492742.
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    88. Sah RL, Doong JY, Grodzinsky AJ, Plaas AH, Sandy JD. Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. Arch Biochem Biophys. 1991 Apr; 286(1):20-9. PMID: 1897947.
      Citations:    
    89. Plaas AH, Neame PJ, Nivens CM, Reiss L. Identification of the keratan sulfate attachment sites on bovine fibromodulin. J Biol Chem. 1990 Nov 25; 265(33):20634-40. PMID: 2243109.
      Citations:    
    90. Sah RL, Grodzinsky AJ, Plaas AH, Sandy JD. Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants. Biochem J. 1990 May 01; 267(3):803-8. PMID: 2339990.
      Citations:    
    91. Plaas AH, Ison AL, Ackland J. Synthesis of small proteoglycans substituted with keratan sulfate by rabbit articular chondrocytes. J Biol Chem. 1989 Aug 25; 264(24):14447-54. PMID: 2527236.
      Citations:    
    92. Sandy JD, Plaas AH. Studies on the hyaluronate binding properties of newly synthesized proteoglycans purified from articular chondrocyte cultures. Arch Biochem Biophys. 1989 Jun; 271(2):300-14. PMID: 2499259.
      Citations:    
    93. Sah RL, Kim YJ, Doong JY, Grodzinsky AJ, Plaas AH, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res. 1989; 7(5):619-36. PMID: 2760736.
      Citations:    
    94. Plaas AH, Sandy JD, Kimura JH. Biosynthesis of cartilage proteoglycan and link protein by articular chondrocytes from immature and mature rabbits. J Biol Chem. 1988 Jun 05; 263(16):7560-6. PMID: 3372500.
      Citations:    
    95. Sandy JD, Flannery CR, Plaas AH. Structural studies on proteoglycan catabolism in rabbit articular cartilage explant cultures. Biochim Biophys Acta. 1987 Dec 10; 931(3):255-61. PMID: 3676346.
      Citations:    
    96. Sandy JD, Barrach HJ, Flannery CR, Plaas AH. The biosynthetic response of the mature chondrocyte in early osteoarthritis. J Rheumatol. 1987 May; 14 Spec No:16-9. PMID: 3625671.
      Citations:    
    97. Plaas AH, Sandy JD. The affinity of newly synthesized proteoglycan for hyaluronic acid can be enhanced by exposure to mild alkali. Biochem J. 1986 Feb 15; 234(1):221-3. PMID: 3707543.
      Citations:    
    98. Sandy JD, Plaas AH. Age-related changes in the kinetics of release of proteoglycans from normal rabbit cartilage explants. J Orthop Res. 1986; 4(3):263-72. PMID: 3090213.
      Citations:    
    99. Sandy JD, Plaas AH. A sensitive assay for active link protein from cartilage. Biochem J. 1985 Dec 01; 232(2):613-6. PMID: 4091812.
      Citations:    
    100. Plaas AH, Sandy JD. Age-related decrease in the link-stability of proteoglycan aggregates formed by articular chondrocytes. Biochem J. 1984 May 15; 220(1):337-40. PMID: 6743270.
      Citations:    
    101. Sandy JD, Adams ME, Billingham ME, Plaas A, Muir H. In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis. Arthritis Rheum. 1984 Apr; 27(4):388-97. PMID: 6712755.
      Citations:    
    102. Plaas AH, Sandy JD, Muir H. Proteoglycan aggregate formation by articular chondrocytes. Decrease in link-protein synthesis during culture. Biochem J. 1983 Sep 15; 214(3):855-64. PMID: 6626160.
      Citations:    
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