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Sasha H. Shafikhani

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Hematology, Oncology and Cell Therapy
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-1368
Fax312-942-2808
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 6602255261.
    My NIH COMMONS name is SHAFIKHANI.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kroin JS, Li J, Shafikhani S, Gupta KH, Moric M, Buvanendran A. Local Vancomycin Effectively Reduces Surgical Site Infection at Implant Site in Rodents. Reg Anesth Pain Med. 2018 Oct; 43(7):795-804. PMID: 29905629.
      View in: PubMed
    2. Kaminski A, Gupta KH, Goldufsky JW, Lee HW, Gupta V, Shafikhani SH. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018 09 19; 8(1):14047. PMID: 30232373.
      View in: PubMed
    3. Kouhkheil R, Fridoni M, Piryaei A, Taheri S, Chirani AS, Anarkooli IJ, Nejatbakhsh R, Shafikhani S, Schuger LA, Reddy VB, Ghoreishi SK, Jalalifirouzkouhi R, Chien S, Bayat M. The effect of combined pulsed wave low-level laser therapy and mesenchymal stem cell-conditioned medium on the healing of an infected wound with methicillin-resistant Staphylococcal aureus in diabetic rats. J Cell Biochem. 2018 07; 119(7):5788-5797. PMID: 29574990.
      View in: PubMed
    4. Soleimani H, Amini A, Taheri S, Sajadi E, Shafikhani S, Schuger LA, Reddy VB, Ghoreishi SK, Pouriran R, Chien S, Bayat M. The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats. J Photochem Photobiol B. 2018 Apr; 181:23-30. PMID: 29486459.
      View in: PubMed
    5. Gupta KH, Goldufsky JW, Wood SJ, Tardi NJ, Moorthy GS, Gilbert DZ, Zayas JP, Hahm E, Altintas MM, Reiser J, Shafikhani SH. Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles. Dev Cell. 2017 06 19; 41(6):674-684.e5. PMID: 28633020.
      View in: PubMed
    6. Kohlhapp FJ, Huelsmann EJ, Lacek AT, Schenkel JM, Lusciks J, Broucek JR, Goldufsky JW, Hughes T, Zayas JP, Dolubizno H, Sowell RT, Kühner R, Burd S, Kubasiak JC, Nabatiyan A, Marshall S, Bommareddy PK, Li S, Newman JH, Monken CE, Shafikhani SH, Marzo AL, Guevara-Patino JA, Lasfar A, Thomas PG, Lattime EC, Kaufman HL, Zloza A. Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Cell Rep. 2016 10 18; 17(4):957-965. PMID: 27760326.
      View in: PubMed
    7. Kroin JS, Li J, Goldufsky JW, Gupta KH, Moghtaderi M, Buvanendran A, Shafikhani SH. Perioperative high inspired oxygen fraction therapy reduces surgical site infection with Pseudomonas aeruginosa in rats. J Med Microbiol. 2016 Aug; 65(8):738-44. PMID: 27302326.
      View in: PubMed
    8. Wood SJ, Goldufsky JW, Bello D, Masood S, Shafikhani SH. Pseudomonas aeruginosa ExoT Induces Mitochondrial Apoptosis in Target Host Cells in a Manner That Depends on Its GTPase-activating Protein (GAP) Domain Activity. J Biol Chem. 2015 Nov 27; 290(48):29063-73. PMID: 26451042.
      View in: PubMed
    9. Goldufsky J, Wood SJ, Jayaraman V, Majdobeh O, Chen L, Qin S, Zhang C, DiPietro LA, Shafikhani SH. Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing. Wound Repair Regen. 2015 Jul-Aug; 23(4):557-64. PMID: 25912785.
      View in: PubMed
    10. Kroin JS, Buvanendran A, Li J, Moric M, Im HJ, Tuman KJ, Shafikhani SH. Short-term glycemic control is effective in reducing surgical site infection in diabetic rats. Anesth Analg. 2015 Jun; 120(6):1289-96. PMID: 25695673.
      View in: PubMed
    11. Wood S, Goldufsky J, Shafikhani SH. Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. PLoS Pathog. 2015 May; 11(5):e1004934. PMID: 26020630.
      View in: PubMed
    12. Goldufsky J, Wood S, Hajihossainlou B, Rehman T, Majdobeh O, Kaufman HL, Ruby CE, Shafikhani SH. Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines. J Med Microbiol. 2015 Feb; 64(Pt 2):164-73. PMID: 25627204.
      View in: PubMed
    13. Wood S, Jayaraman V, Huelsmann EJ, Bonish B, Burgad D, Sivaramakrishnan G, Qin S, DiPietro LA, Zloza A, Zhang C, Shafikhani SH. Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response. PLoS One. 2014; 9(3):e91574. PMID: 24618995.
      View in: PubMed
    14. Campbell J, Filardo G, Bruce B, Bajaj S, Friel N, Hakimiyan A, Wood S, Grumet R, Shafikhani S, Chubinskaya S, Cole BJ. Salvage of contaminated osteochondral allografts: the effects of chlorhexidine on human articular chondrocyte viability. Am J Sports Med. 2014 Apr; 42(4):973-8. PMID: 24518877.
      View in: PubMed
    15. Wood S, Pithadia R, Rehman T, Zhang L, Plichta J, Radek KA, Forsyth C, Keshavarzian A, Shafikhani SH. Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. PLoS One. 2013; 8(1):e54646. PMID: 23358457.
      View in: PubMed
    16. Mahmood F, Hakimiyan A, Jayaraman V, Wood S, Sivaramakrishnan G, Rehman T, Reuhs BL, Chubinskaya S, Shafikhani SH. A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system. J Med Microbiol. 2013 Apr; 62(Pt 4):531-9. PMID: 23288430.
      View in: PubMed
    17. Wood S, Sivaramakrishnan G, Engel J, Shafikhani SH. Cell migration regulates the kinetics of cytokinesis. Cell Cycle. 2011 Feb 15; 10(4):648-54. PMID: 21293189.
      View in: PubMed
    18. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76. PMID: 18787414.
      View in: PubMed
    19. Shafikhani SH, Morales C, Engel J. The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Cell Microbiol. 2008 Apr; 10(4):994-1007. PMID: 18053004.
      View in: PubMed
    20. Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, König W, Engel J, Backert S. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol Med Microbiol. 2007 Jul; 50(2):190-205. PMID: 17428306.
      View in: PubMed
    21. Shafikhani SH, Engel J. Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15605-10. PMID: 17030800.
      View in: PubMed
    22. Shafikhani SH, Leighton T. AbrB and Spo0E control the proper timing of sporulation in Bacillus subtilis. Curr Microbiol. 2004 Apr; 48(4):262-9. PMID: 15057450.
      View in: PubMed
    23. Shafikhani SH, Núñez E, Leighton T. Hpr (ScoC) and the phosphorelay couple cell cycle and sporulation in Bacillus subtilis. FEMS Microbiol Lett. 2004 Feb 09; 231(1):99-110. PMID: 14769473.
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    24. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN. The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun. 2004 Jan; 72(1):546-58. PMID: 14688136.
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    25. Shafikhani SH, Núñez E, Leighton T. ScoC mediates catabolite repression of sporulation in Bacillus subtilis. Curr Microbiol. 2003 Oct; 47(4):327-36. PMID: 14629015.
      View in: PubMed
    26. Shafikhani SH, Partovi AA, Leighton T. Catabolite-induced repression of sporulation in Bacillus subtilis. Curr Microbiol. 2003 Oct; 47(4):300-8. PMID: 14629011.
      View in: PubMed
    27. Shafikhani S. Factors affecting PCR-mediated recombination. Environ Microbiol. 2002 Aug; 4(8):482-6. PMID: 12153589.
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    28. Shafikhani SH, Mandic-Mulec I, Strauch MA, Smith I, Leighton T. Postexponential regulation of sin operon expression in Bacillus subtilis. J Bacteriol. 2002 Jan; 184(2):564-71. PMID: 11751836.
      View in: PubMed
    29. Shafikhani S, Siegel RA, Ferrari E, Schellenberger V. Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization. Biotechniques. 1997 Aug; 23(2):304-10. PMID: 9266088.
      View in: PubMed
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