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Sasha H. Shafikhani

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Hematology, Oncology and Cell Therapy
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-1368
Fax312-942-2808
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 6602255261.
    My NIH COMMONS name is SHAFIKHANI.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Roy R, Mahmud F, Zayas J, Kuzel TM, Reiser J, Shafikhani SH. Reduced Bioactive Microbial Products (Pathogen-Associated Molecular Patterns) Contribute to Dysregulated Immune Responses and Impaired Healing in Infected Wounds in Mice with Diabetes. J Invest Dermatol. 2023 Aug 22. PMID: 37619833.
      View in: PubMed
    2. Mony MP, Harmon KA, Hess R, Dorafshar AH, Shafikhani SH. An Updated Review of Hypertrophic Scarring. Cells. 2023 02 21; 12(5). PMID: 36899815.
      View in: PubMed
    3. Wood SJ, Kuzel TM, Shafikhani SH. Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics. Cells. 2023 01 03; 12(1). PMID: 36611992.
      View in: PubMed
    4. Wood SJ, Goldufsky JW, Seu MY, Dorafshar AH, Shafikhani SH. Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses. Cells. 2023 01 03; 12(1). PMID: 36611990.
      View in: PubMed
    5. Mohamed MF, Al-Khudari S, Cassini-Vieira P, Erra A, Bagabas R, Houser T, Stenson K, Bhayani M, Jelinek MJ, Bishehsari F, Kuzel TM, Shafikhani SH. Presence of CrkI-containing microvesicles in squamous cell carcinomas could have ramifications on tumor biology and cancer therapeutics. Sci Rep. 2022 03 21; 12(1):4803. PMID: 35314778.
      View in: PubMed
    6. Mohamed MF, Gupta K, Goldufsky JW, Roy R, Callaghan LT, Wetzel DM, Kuzel TM, Reiser J, Shafikhani SH. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022 03 11; 13(1):1295. PMID: 35277504.
      View in: PubMed
    7. Roy R, Zayas J, Singh SK, Delgado K, Wood SJ, Mohamed MF, Frausto DM, Albalawi YA, Price TP, Estupinian R, Giurini EF, Kuzel TM, Zloza A, Reiser J, Shafikhani SH. Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound. Elife. 2022 02 03; 11. PMID: 35112667.
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    8. Mahmud F, Roy R, Mohamed MF, Aboonabi A, Moric M, Ghoreishi K, Bayat M, Kuzel TM, Reiser J, Shafikhani SH. Therapeutic evaluation of immunomodulators in reducing surgical wound infection. FASEB J. 2022 01; 36(1):e22090. PMID: 34907595.
      View in: PubMed
    9. Roy R, Zayas J, Mohamed MF, Aboonabi A, Delgado K, Wallace J, Bayat M, Kuzel TM, Reiser J, Shafikhani SH. IL-10 Dysregulation Underlies Chemokine Insufficiency, Delayed Macrophage Response, and Impaired Healing in Diabetic Wounds. J Invest Dermatol. 2022 03; 142(3 Pt A):692-704.e14. PMID: 34517005.
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    10. Ahmadi H, Bayat M, Amini A, Mostafavinia A, Ebrahimpour-Malekshah R, Gazor R, Asadi R, Gachkar L, Rezaei F, Shafikhani SH, Ghoreishi SK, Chien S. Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats. Lasers Med Sci. 2022 Apr; 37(3):1593-1604. PMID: 34476655.
      View in: PubMed
    11. Mohamed MF, Wood SJ, Roy R, Reiser J, Kuzel TM, Shafikhani SH. Pseudomonas aeruginosa ExoT induces G1 cell cycle arrest in melanoma cells. Cell Microbiol. 2021 08; 23(8):e13339. PMID: 33821556.
      View in: PubMed
    12. Ebrahimpour-Malekshah R, Amini A, Zare F, Mostafavinia A, Davoody S, Deravi N, Rahmanian M, Hashemi SM, Habibi M, Ghoreishi SK, Chien S, Shafikhani S, Ahmadi H, Bayat S, Bayat M. Combined therapy of photobiomodulation and adipose-derived stem cells synergistically improve healing in an ischemic, infected and delayed healing wound model in rats with type 1 diabetes mellitus. BMJ Open Diabetes Res Care. 2020 02; 8(1). PMID: 32098898.
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    13. Kroin JS, Li J, Shafikhani S, Gupta KH, Moric M, Buvanendran A. Local Vancomycin Effectively Reduces Surgical Site Infection at Implant Site in Rodents. Reg Anesth Pain Med. 2018 Oct; 43(7):795-804. PMID: 29905629.
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    14. Kaminski A, Gupta KH, Goldufsky JW, Lee HW, Gupta V, Shafikhani SH. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018 09 19; 8(1):14047. PMID: 30232373.
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    15. Kouhkheil R, Fridoni M, Piryaei A, Taheri S, Chirani AS, Anarkooli IJ, Nejatbakhsh R, Shafikhani S, Schuger LA, Reddy VB, Ghoreishi SK, Jalalifirouzkouhi R, Chien S, Bayat M. The effect of combined pulsed wave low-level laser therapy and mesenchymal stem cell-conditioned medium on the healing of an infected wound with methicillin-resistant Staphylococcal aureus in diabetic rats. J Cell Biochem. 2018 07; 119(7):5788-5797. PMID: 29574990.
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    16. Soleimani H, Amini A, Taheri S, Sajadi E, Shafikhani S, Schuger LA, Reddy VB, Ghoreishi SK, Pouriran R, Chien S, Bayat M. The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats. J Photochem Photobiol B. 2018 Apr; 181:23-30. PMID: 29486459.
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    17. Gupta KH, Goldufsky JW, Wood SJ, Tardi NJ, Moorthy GS, Gilbert DZ, Zayas JP, Hahm E, Altintas MM, Reiser J, Shafikhani SH. Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles. Dev Cell. 2017 06 19; 41(6):674-684.e5. PMID: 28633020.
      View in: PubMed
    18. Kohlhapp FJ, Huelsmann EJ, Lacek AT, Schenkel JM, Lusciks J, Broucek JR, Goldufsky JW, Hughes T, Zayas JP, Dolubizno H, Sowell RT, K?hner R, Burd S, Kubasiak JC, Nabatiyan A, Marshall S, Bommareddy PK, Li S, Newman JH, Monken CE, Shafikhani SH, Marzo AL, Guevara-Patino JA, Lasfar A, Thomas PG, Lattime EC, Kaufman HL, Zloza A. Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Cell Rep. 2016 10 18; 17(4):957-965. PMID: 27760326.
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    19. Kroin JS, Li J, Goldufsky JW, Gupta KH, Moghtaderi M, Buvanendran A, Shafikhani SH. Perioperative high inspired oxygen fraction therapy reduces surgical site infection with Pseudomonas aeruginosa in rats. J Med Microbiol. 2016 Aug; 65(8):738-744. PMID: 27302326.
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    20. Wood SJ, Goldufsky JW, Bello D, Masood S, Shafikhani SH. Pseudomonas aeruginosa ExoT Induces Mitochondrial Apoptosis in Target Host Cells in a Manner That Depends on Its GTPase-activating Protein (GAP) Domain Activity. J Biol Chem. 2015 Nov 27; 290(48):29063-73. PMID: 26451042.
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    21. Goldufsky J, Wood SJ, Jayaraman V, Majdobeh O, Chen L, Qin S, Zhang C, DiPietro LA, Shafikhani SH. Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing. Wound Repair Regen. 2015 Jul-Aug; 23(4):557-64. PMID: 25912785.
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    22. Kroin JS, Buvanendran A, Li J, Moric M, Im HJ, Tuman KJ, Shafikhani SH. Short-term glycemic control is effective in reducing surgical site infection in diabetic rats. Anesth Analg. 2015 Jun; 120(6):1289-96. PMID: 25695673.
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    23. Wood S, Goldufsky J, Shafikhani SH. Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. PLoS Pathog. 2015 May; 11(5):e1004934. PMID: 26020630.
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    24. Goldufsky J, Wood S, Hajihossainlou B, Rehman T, Majdobeh O, Kaufman HL, Ruby CE, Shafikhani SH. Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines. J Med Microbiol. 2015 Feb; 64(Pt 2):164-73. PMID: 25627204.
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    25. Wood S, Jayaraman V, Huelsmann EJ, Bonish B, Burgad D, Sivaramakrishnan G, Qin S, DiPietro LA, Zloza A, Zhang C, Shafikhani SH. Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response. PLoS One. 2014; 9(3):e91574. PMID: 24618995.
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    26. Campbell J, Filardo G, Bruce B, Bajaj S, Friel N, Hakimiyan A, Wood S, Grumet R, Shafikhani S, Chubinskaya S, Cole BJ. Salvage of contaminated osteochondral allografts: the effects of chlorhexidine on human articular chondrocyte viability. Am J Sports Med. 2014 Apr; 42(4):973-8. PMID: 24518877.
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    27. Wood S, Pithadia R, Rehman T, Zhang L, Plichta J, Radek KA, Forsyth C, Keshavarzian A, Shafikhani SH. Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. PLoS One. 2013; 8(1):e54646. PMID: 23358457.
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    28. Mahmood F, Hakimiyan A, Jayaraman V, Wood S, Sivaramakrishnan G, Rehman T, Reuhs BL, Chubinskaya S, Shafikhani SH. A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system. J Med Microbiol. 2013 Apr; 62(Pt 4):531-539. PMID: 23288430.
      View in: PubMed
    29. Wood S, Sivaramakrishnan G, Engel J, Shafikhani SH. Cell migration regulates the kinetics of cytokinesis. Cell Cycle. 2011 Feb 15; 10(4):648-54. PMID: 21293189.
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    30. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76. PMID: 18787414.
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    31. Shafikhani SH, Morales C, Engel J. The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Cell Microbiol. 2008 Apr; 10(4):994-1007. PMID: 18053004.
      View in: PubMed
    32. Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, K?nig W, Engel J, Backert S. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol Med Microbiol. 2007 Jul; 50(2):190-205. PMID: 17428306.
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    33. Shafikhani SH, Engel J. Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15605-10. PMID: 17030800.
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    34. Shafikhani SH, Leighton T. AbrB and Spo0E control the proper timing of sporulation in Bacillus subtilis. Curr Microbiol. 2004 Apr; 48(4):262-9. PMID: 15057450.
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    35. Shafikhani SH, N??ez E, Leighton T. Hpr (ScoC) and the phosphorelay couple cell cycle and sporulation in Bacillus subtilis. FEMS Microbiol Lett. 2004 Feb 09; 231(1):99-110. PMID: 14769473.
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    36. Shafikhani SH, N??ez E, Leighton T. ScoC mediates catabolite repression of sporulation in Bacillus subtilis. Curr Microbiol. 2003 Oct; 47(4):327-36. PMID: 14629015.
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    37. Shafikhani SH, Partovi AA, Leighton T. Catabolite-induced repression of sporulation in Bacillus subtilis. Curr Microbiol. 2003 Oct; 47(4):300-8. PMID: 14629011.
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    38. Shafikhani S. Factors affecting PCR-mediated recombination. Environ Microbiol. 2002 Aug; 4(8):482-6. PMID: 12153589.
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    39. Shafikhani SH, Mandic-Mulec I, Strauch MA, Smith I, Leighton T. Postexponential regulation of sin operon expression in Bacillus subtilis. J Bacteriol. 2002 Jan; 184(2):564-71. PMID: 11751836.
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