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Nell Lurain

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
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    Collapse Overview 
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    My Scopus ID is 6701749578.
    My NIH COMMONS name is NLURAIN.

    Research Areas:
    Human cytomegalovirus.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/nell-s-lurain-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/virology-quality-assurance-program

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/43456625/?sort=date&direction=ascending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=6701749578

    Education:
    PhD, Loyola University of Chicago
    BA, Oberlin College


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Letendre S, Bharti A, Perez-Valero I, Hanson B, Franklin D, Woods SP, Gianella S, de Oliveira MF, Heaton RK, Grant I, Landay AL, Lurain N. Higher Anti-CMV IgG Concentrations are Associated with Worse Neurocognitive Performance During Suppressive Antiretroviral Therapy. Clin Infect Dis. 2018 Mar 01. PMID: 29506084.
      View in: PubMed
    2. Cohen T, Williams JD, Opperman TJ, Sanchez R, Lurain NS, Tortorella D. Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication. J Virol. 2016 Dec 01; 90(23):10715-10727. PMID: 27654292.
      View in: PubMed
    3. Hodowanec A, Williams B, Hanson B, Livak B, Keating S, Lurain N, Adeyemi OM. Soluble CD163 But Not Soluble CD14 Is Associated With Cytomegalovirus Immunoglobulin G Antibody Levels in Virologically Suppressed HIV+ Individuals. J Acquir Immune Defic Syndr. 2015 Dec 15; 70(5):e171-4. PMID: 26569178.
      View in: PubMed
    4. Lurain NS, Hanson BA, Hotton AL, Weber KM, Cohen MH, Landay AL. The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):134-43. PMID: 26422187; PMCID: PMC4761818 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    5. Makinde HM, Lurain N, Bitterman P, Martinson J, Plants J, Landay AL, Spear GT. Characterization of IL-22 and IL-17 Expressing Leukocytes in the Cervix. Am J Reprod Immunol. 2016 Jan; 75(1):42-50. PMID: 26459205.
      View in: PubMed
    6. Styczynski AR, Anwar KN, Sultana H, Ghanem A, Lurain N, Chua A, Ghassemi M, Novak RM. In vitro antiretroviral activity and in vivo toxicity of the potential topical microbicide copper phthalocyanine sulfate. Virol J. 2015 Aug 30; 12:132. PMID: 26319137; PMCID: PMC4552998.
      View in: PubMed, PubMed Central
    7. Gagermeier JP, Rusinak JD, Lurain NS, Alex CG, Dilling DF, Wigfield CH, Love RB. Subtherapeutic ganciclovir (GCV) levels and GCV-resistant cytomegalovirus in lung transplant recipients. Transpl Infect Dis. 2014 Dec; 16(6):941-50. PMID: 25491023.
      View in: PubMed
    8. Lurain NS, Hanson BA, Martinson J, Leurgans SE, Landay AL, Bennett DA, Schneider JA. Reply to Itzhaki and Klapper. J Infect Dis. 2014 Mar; 209(6):974. PMID: 24280368; PMCID: PMC3999841.
      View in: PubMed, PubMed Central
    9. Šedý JR, Bjordahl RL, Bekiaris V, Macauley MG, Ware BC, Norris PS, Lurain NS, Benedict CA, Ware CF. CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells. J Immunol. 2013 Jul 15; 191(2):828-36. PMID: 23761635; PMCID: PMC3702646.
      View in: PubMed, PubMed Central
    10. Lurain NS, Hanson BA, Martinson J, Leurgans SE, Landay AL, Bennett DA, Schneider JA. Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease. J Infect Dis. 2013 Aug 15; 208(4):564-72. PMID: 23661800; PMCID: PMC3719902.
      View in: PubMed, PubMed Central
    11. Kuniholm MH, Parrinello CM, Anastos K, Augenbraun M, Plankey M, Nowicki M, Peters M, Golub ET, Lurain N, Landay AL, Strickler HD, Kaplan RC. Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women. PLoS One. 2013; 8(4):e61973. PMID: 23613990; PMCID: PMC3629158.
      View in: PubMed, PubMed Central
    12. Parrinello CM, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt PW, Deeks SG, Hodis HN, Kaplan RC. Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. J Infect Dis. 2012 Jun 15; 205(12):1788-96. PMID: 22492856; PMCID: PMC3415890.
      View in: PubMed, PubMed Central
    13. Weisblum Y, Panet A, Zakay-Rones Z, Haimov-Kochman R, Goldman-Wohl D, Ariel I, Falk H, Natanson-Yaron S, Goldberg MD, Gilad R, Lurain NS, Greenfield C, Yagel S, Wolf DG. Modeling of human cytomegalovirus maternal-fetal transmission in a novel decidual organ culture. J Virol. 2011 Dec; 85(24):13204-13. PMID: 21976654; PMCID: PMC3233115.
      View in: PubMed, PubMed Central
    14. Jacobson M, Lurain N, Hunt P. Cytomegalovirus viraemia in the modern antiretroviral era(*). HIV Med. 2011 Aug; 12(7):387-8. PMID: 21729228.
      View in: PubMed
    15. Caliendo AM, Valsamakis A, Bremer JW, Ferreira-Gonzalez A, Granger S, Sabatini L, Tsongalis GJ, Wang YF, Yen-Lieberman B, Young S, Lurain NS. Multilaboratory evaluation of real-time PCR tests for hepatitis B virus DNA quantification. J Clin Microbiol. 2011 Aug; 49(8):2854-8. PMID: 21697326; PMCID: PMC3147738.
      View in: PubMed, PubMed Central
    16. Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Parrinello CM, Hunt P, Deeks SG, Hodis HN. T cell activation predicts carotid artery stiffness among HIV-infected women. Atherosclerosis. 2011 Jul; 217(1):207-13. PMID: 21492857; PMCID: PMC3139014.
      View in: PubMed, PubMed Central
    17. Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt P, Karim R, Kern DM, Hodis HN, Deeks SG. T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis. 2011 Feb 15; 203(4):452-63. PMID: 21220772; PMCID: PMC3071219.
      View in: PubMed, PubMed Central
    18. Lurain NS, Chou S. Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev. 2010 Oct; 23(4):689-712. PMID: 20930070; PMCID: PMC2952978.
      View in: PubMed, PubMed Central
    19. Avery RK, Mossad SB, Poggio E, Lard M, Budev M, Bolwell B, Waldman WJ, Braun W, Mawhorter SD, Fatica R, Krishnamurthi V, Young JB, Shrestha R, Stephany B, Lurain N, Yen-Lieberman B. Utility of leflunomide in the treatment of complex cytomegalovirus syndromes. Transplantation. 2010 Aug 27; 90(4):419-26. PMID: 20683281.
      View in: PubMed
    20. Richardson-Harman N, Lackman-Smith C, Fletcher PS, Anton PA, Bremer JW, Dezzutti CS, Elliott J, Grivel JC, Guenthner P, Gupta P, Jones M, Lurain NS, Margolis LB, Mohan S, Ratner D, Reichelderfer P, Roberts P, Shattock RJ, Cummins JE. Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis. J Clin Microbiol. 2009 Nov; 47(11):3530-9. PMID: 19726602; PMCID: PMC2772583.
      View in: PubMed, PubMed Central
    21. Bradley AJ, Lurain NS, Ghazal P, Trivedi U, Cunningham C, Baluchova K, Gatherer D, Wilkinson GW, Dargan DJ, Davison AJ. High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169. J Gen Virol. 2009 Oct; 90(Pt 10):2375-80. PMID: 19553388; PMCID: PMC2885757.
      View in: PubMed, PubMed Central
    22. Shapira MY, Resnick IB, Chou S, Neumann AU, Lurain NS, Stamminger T, Caplan O, Saleh N, Efferth T, Marschall M, Wolf DG. Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. Clin Infect Dis. 2008 May 01; 46(9):1455-7. PMID: 18419454.
      View in: PubMed
    23. Weinberg A, Lurain N. Introduction to the special issue dedicated to the 11th International CMV and Beta Herpesvirus Workshop. J Clin Virol. 2008 Mar; 41(3):173. PMID: 18243782.
      View in: PubMed
    24. Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res Hum Retroviruses. 2008 Mar; 24(3):453-62. PMID: 18327985.
      View in: PubMed
    25. Harwani SC, Lurain NS, Zariffard MR, Spear GT. Differential inhibition of human cytomegalovirus (HCMV) by toll-like receptor ligands mediated by interferon-beta in human foreskin fibroblasts and cervical tissue. Virol J. 2007 Dec 05; 4:133. PMID: 18053251; PMCID: PMC2222636.
      View in: PubMed, PubMed Central
    26. Fox-Canale AM, Hope TJ, Martinson J, Lurain JR, Rademaker AW, Bremer JW, Landay A, Spear GT, Lurain NS. Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue. Virology. 2007 Dec 05; 369(1):55-68. PMID: 17716703; PMCID: PMC2174066.
      View in: PubMed, PubMed Central
    27. Caliendo AM, Ingersoll J, Fox-Canale AM, Pargman S, Bythwood T, Hayden MK, Bremer JW, Lurain NS. Evaluation of real-time PCR laboratory-developed tests using analyte-specific reagents for cytomegalovirus quantification. J Clin Microbiol. 2007 Jun; 45(6):1723-7. PMID: 17409210; PMCID: PMC1933050.
      View in: PubMed, PubMed Central
    28. Caliendo AM, Valsamakis A, Zhou Y, Yen-Lieberman B, Andersen J, Young S, Ferreira-Gonzalez A, Tsongalis GJ, Pyles R, Bremer JW, Lurain NS. Multilaboratory comparison of hepatitis C virus viral load assays. J Clin Microbiol. 2006 May; 44(5):1726-32. PMID: 16672399; PMCID: PMC1479213.
      View in: PubMed, PubMed Central
    29. Lurain NS, Fox AM, Lichy HM, Bhorade SM, Ware CF, Huang DD, Kwan SP, Garrity ER, Chou S. Analysis of the human cytomegalovirus genomic region from UL146 through UL147A reveals sequence hypervariability, genotypic stability, and overlapping transcripts. Virol J. 2006 Jan 12; 3:4. PMID: 16409621; PMCID: PMC1360065.
      View in: PubMed, PubMed Central
    30. Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13218-23. PMID: 16131544; PMCID: PMC1201609.
      View in: PubMed, PubMed Central
    31. Zariffard MR, Novak RM, Lurain N, Sha BE, Graham P, Spear GT. Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis. J Infect Dis. 2005 Jun 01; 191(11):1913-21. PMID: 15871126.
      View in: PubMed
    32. Blackman SC, Lurain NS, Witte DP, Filipovich AH, Groen P, Schleiss MR. Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency. J Pediatr Hematol Oncol. 2004 Sep; 26(9):601-5. PMID: 15342989.
      View in: PubMed
    33. Lurain NS, Robert ES, Xu J, Camarca M, Landay A, Kovacs AA, Reichelderfer PS. HIV type 1 and cytomegalovirus coinfection in the female genital tract. J Infect Dis. 2004 Aug 01; 190(3):619-23. PMID: 15243940; PMCID: PMC3119023.
      View in: PubMed, PubMed Central
    34. Baldanti F, Lurain N, Gerna G. Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs. Hum Immunol. 2004 May; 65(5):403-9. PMID: 15172438.
      View in: PubMed
    35. Caliendo AM, Yen-Lieberman B, Baptista J, Andersen J, Crumpacker C, Schuurman R, Spector SA, Bremer J, Lurain NS. Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA. J Clin Microbiol. 2003 Aug; 41(8):3509-13. PMID: 12904347; PMCID: PMC179805.
      View in: PubMed, PubMed Central
    36. Chou S, Lurain NS, Thompson KD, Miner RC, Drew WL. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J Infect Dis. 2003 Jul 01; 188(1):32-9. PMID: 12825168.
      View in: PubMed
    37. Weinberg A, Jabs DA, Chou S, Martin BK, Lurain NS, Forman MS, Crumpacker C. Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. J Infect Dis. 2003 Mar 01; 187(5):777-84. PMID: 12599051.
      View in: PubMed
    38. Bhorade SM, Lurain NS, Jordan A, Leischner J, Villanueva J, Durazo R, Creech S, Vigneswaran WT, Garrity ER. Emergence of ganciclovir-resistant cytomegalovirus in lung transplant recipients. J Heart Lung Transplant. 2002 Dec; 21(12):1274-82. PMID: 12490272.
      View in: PubMed
    39. Isada CM, Yen-Lieberman B, Lurain NS, Schilz R, Kohn D, Longworth DL, Taege AJ, Mossad SB, Maurer J, Flechner SM, Mawhorter SD, Braun W, Gordon SM, Schmitt SK, Goldman M, Long J, Haug M, Avery RK. Clinical characteristics of 13 solid organ transplant recipients with ganciclovir-resistant cytomegalovirus infection. Transpl Infect Dis. 2002 Dec; 4(4):189-94. PMID: 12535261.
      View in: PubMed
    40. Lurain NS, Bhorade SM, Pursell KJ, Avery RK, Yeldandi VV, Isada CM, Robert ES, Kohn DJ, Arens MQ, Garrity ER, Taege AJ, Mullen MG, Todd KM, Bremer JW, Yen-Lieberman B. Analysis and characterization of antiviral drug-resistant cytomegalovirus isolates from solid organ transplant recipients. J Infect Dis. 2002 Sep 15; 186(6):760-8. PMID: 12198609.
      View in: PubMed
    41. Wolf DG, Lurain NS, Zuckerman T, Hoffman R, Satinger J, Honigman A, Saleh N, Robert ES, Rowe JM, Kra-Oz Z. Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients. Blood. 2003 Jan 15; 101(2):463-5. PMID: 12393485.
      View in: PubMed
    42. Lurain NS, Weinberg A, Crumpacker CS, Chou S. Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing. Antimicrob Agents Chemother. 2001 Oct; 45(10):2775-80. PMID: 11557468; PMCID: PMC90730.
      View in: PubMed, PubMed Central
    43. Caliendo AM, Schuurman R, Yen-Lieberman B, Spector SA, Andersen J, Manjiry R, Crumpacker C, Lurain NS, Erice A. Comparison of quantitative and qualitative PCR assays for cytomegalovirus DNA in plasma. J Clin Microbiol. 2001 Apr; 39(4):1334-8. PMID: 11283052; PMCID: PMC87935.
      View in: PubMed, PubMed Central
    44. Lurain NS, Kapell KS, Huang DD, Short JA, Paintsil J, Winkfield E, Benedict CA, Ware CF, Bremer JW. Human cytomegalovirus UL144 open reading frame: sequence hypervariability in low-passage clinical isolates. J Virol. 1999 Dec; 73(12):10040-50. PMID: 10559318; PMCID: PMC113055.
      View in: PubMed, PubMed Central
    45. Waldman WJ, Knight DA, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation. 1999 Sep 27; 68(6):814-25. PMID: 10515382.
      View in: PubMed
    46. Benedict CA, Butrovich KD, Lurain NS, Corbeil J, Rooney I, Schneider P, Tschopp J, Ware CF. Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus. J Immunol. 1999 Jun 15; 162(12):6967-70. PMID: 10358135.
      View in: PubMed
    47. Chou S, Lurain NS, Weinberg A, Cai GY, Sharma PL, Crumpacker CS. Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories. Antimicrob Agents Chemother. 1999 Jun; 43(6):1500-2. PMID: 10348781; PMCID: PMC89307.
      View in: PubMed, PubMed Central
    48. Waldman WJ, Knight DA, Blinder L, Shen J, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology. 1999; 42(5-6):412-8. PMID: 10702725.
      View in: PubMed
    49. McSharry JJ, Lurain NS, Drusano GL, Landay AL, Notka M, O'Gorman MR, Weinberg A, Shapiro HM, Reichelderfer PS, Crumpacker CS. Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates. Antimicrob Agents Chemother. 1998 Sep; 42(9):2326-31. PMID: 9736557; PMCID: PMC105827.
      View in: PubMed, PubMed Central
    50. McSharry JM, Lurain NS, Drusano GL, Landay A, Manischewitz J, Nokta M, O'Gorman M, Shapiro HM, Weinberg A, Reichelderfer P, Crumpacker C. Flow cytometric determination of ganciclovir susceptibilities of human cytomegalovirus clinical isolates. J Clin Microbiol. 1998 Apr; 36(4):958-64. PMID: 9542916; PMCID: PMC104668.
      View in: PubMed, PubMed Central
    51. Lurain NS, Ammons HC, Kapell KS, Yeldandi VV, Garrity ER, O'Keefe JP. Molecular analysis of human cytomegalovirus strains from two lung transplant recipients with the same donor. Transplantation. 1996 Aug 27; 62(4):497-502. PMID: 8781616.
      View in: PubMed
    52. Spear GT, Lurain NS, Parker CJ, Ghassemi M, Payne GH, Saifuddin M. Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV). J Immunol. 1995 Nov 01; 155(9):4376-81. PMID: 7594597.
      View in: PubMed
    53. Lurain NS, Spafford LE, Thompson KD. Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J Virol. 1994 Jul; 68(7):4427-31. PMID: 8207815; PMCID: PMC236367.
      View in: PubMed, PubMed Central
    54. Lurain NS, Thompson KD, Holmes EW, Read GS. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol. 1992 Dec; 66(12):7146-52. PMID: 1331515; PMCID: PMC240402.
      View in: PubMed, PubMed Central
    55. Tatarowicz WA, Lurain NS, Thompson KD. A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors. J Infect Dis. 1992 Oct; 166(4):904-7. PMID: 1326585.
      View in: PubMed
    56. Tatarowicz WA, Lurain NS, Thompson KD. In situ ELISA for the evaluation of antiviral compounds effective against human cytomegalovirus. J Virol Methods. 1991 Nov-Dec; 35(2):207-15. PMID: 1667788.
      View in: PubMed
    57. Lurain NS, Thompson KD, Farrand SK. Rapid detection of cytomegalovirus in clinical specimens by using biotinylated DNA probes and analysis of cross-reactivity with herpes simplex virus. J Clin Microbiol. 1986 Nov; 24(5):724-30. PMID: 3021812; PMCID: PMC269017.
      View in: PubMed, PubMed Central
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