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Avik Roy

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentNeurological Sciences
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    Collapse Overview 
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    My Scopus ID is 14008929100.
    My NIH COMMONS name is AVIK_ROY.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K. Aspirin binds to PPARa to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):E7408-E7417. PMID: 30012602.
      View in: PubMed
    2. Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. J Clin Invest. 2018 Oct 01; 128(10):4297-4312. PMID: 29990310.
      View in: PubMed
    3. Chakrabarti S, Jana M, Roy A, Pahan K. Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid. Curr Alzheimer Res. 2018; 15(10):894-904. PMID: 29732971.
      View in: PubMed
    4. Kundu M, Roy A, Pahan K. Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-?. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11482-11487. PMID: 29073075.
      View in: PubMed
    5. Chandra G, Roy A, Rangasamy SB, Pahan K. Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson's Disease. J Immunol. 2017 06 01; 198(11):4312-4326. PMID: 28446566.
      View in: PubMed
    6. Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K. Identification and characterization of PPARa ligands in the hippocampus. Nat Chem Biol. 2016 Dec; 12(12):1075-1083. PMID: 27748752.
      View in: PubMed
    7. Kundu M, Mondal S, Roy A, Martinson JL, Pahan K. Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-ß. J Immunol. 2016 10 15; 197(8):3099-3110. PMID: 27605008.
      View in: PubMed
    8. Modi KK, Rangasamy SB, Dasarathi S, Roy A, Pahan K. Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement. J Neuroimmune Pharmacol. 2016 12; 11(4):693-707. PMID: 27342118.
      View in: PubMed
    9. Roy A. Targeting BPOZ-2 in Lewy body disease. Neural Regen Res. 2016 Jun; 11(6):910-1. PMID: 27482213; PMCID: PMC4962582.
    10. Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K. Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease. J Biol Chem. 2016 07 15; 291(29):15267-81. PMID: 27226559; PMCID: PMC4946939 [Available on 07/15/17].
    11. Roy A, Rangasamy SB, Kundu M, Pahan K. BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease. Sci Rep. 2016 Feb 26; 6:22067. PMID: 26916519; PMCID: PMC4768134.
    12. Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. HMG-CoA Reductase Inhibitors Bind to PPARa to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 04; 22(2):253-65. PMID: 26118928; PMCID: PMC4526399.
    13. Modi KK, Roy A, Brahmachari S, Rangasamy SB, Pahan K. Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease. PLoS One. 2015; 10(6):e0130398. PMID: 26102198; PMCID: PMC4478015.
    14. Roy A, Pahan K. PPARa signaling in the hippocampus: crosstalk between fat and memory. J Neuroimmune Pharmacol. 2015 Mar; 10(1):30-4. PMID: 25575492; PMCID: PMC4360966.
    15. Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K. Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 47(2):385-402. PMID: 26401561; PMCID: PMC4582676.
    16. Roy A, Modi KK, Khasnavis S, Ghosh S, Watson R, Pahan K. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. PLoS One. 2014; 9(7):e101883. PMID: 25007337; PMCID: PMC4090203.
    17. Khasnavis S, Roy A, Ghosh S, Watson R, Pahan K. Protection of dopaminergic neurons in a mouse model of Parkinson's disease by a physically-modified saline containing charge-stabilized nanobubbles. J Neuroimmune Pharmacol. 2014 Mar; 9(2):218-32. PMID: 24122363.
      View in: PubMed
    18. Roy A, Pahan K. Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease. FEBS Lett. 2013 Nov 01; 587(21):3567-74. PMID: 24076025; PMCID: PMC3929398.
    19. Roy A, Jana M, Corbett GT, Ramaswamy S, Kordower JH, Gonzalez FJ, Pahan K. Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a. Cell Rep. 2013 Aug 29; 4(4):724-37. PMID: 23972989; PMCID: PMC3804033.
    20. Roy A, Pahan K. Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis. J Clin Cell Immunol. 2013 Aug 12; 7:158. PMID: 24575330.
      View in: PubMed
    21. Khasnavis S, Ghosh A, Roy A, Pahan K. Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase. J Biol Chem. 2013 Jul 19; 288(29):20843-55. PMID: 23744073; PMCID: PMC3774356.
    22. Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. J Neuroimmune Pharmacol. 2013 Jun; 8(3):739-55. PMID: 23475543; PMCID: PMC3663914.
    23. Corbett GT, Roy A, Pahan K. Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem. 2013 Mar 22; 288(12):8299-312. PMID: 23404502; PMCID: PMC3605648.
    24. Khasnavis S, Jana A, Roy A, Mazumder M, Bhushan B, Wood T, Ghosh S, Watson R, Pahan K. Suppression of nuclear factor-?B activation and inflammation in microglia by physically modified saline. J Biol Chem. 2012 Aug 24; 287(35):29529-42. PMID: 22753407; PMCID: PMC3436140.
    25. Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One. 2012; 7(6):e38113. PMID: 22723850; PMCID: PMC3377667.
    26. Corbett GT, Roy A, Pahan K. Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense. J Immunol. 2012 Jul 15; 189(2):1002-13. PMID: 22706077; PMCID: PMC3523125.
    27. Mondal S, Roy A, Jana A, Ghosh S, Kordower JH, Pahan K. Testing NF-?B-based therapy in hemiparkinsonian monkeys. J Neuroimmune Pharmacol. 2012 Sep; 7(3):544-56. PMID: 22661311; PMCID: PMC3419771.
    28. Roy A, Pahan K. Prospects of statins in Parkinson disease. Neuroscientist. 2011 Jun; 17(3):244-55. PMID: 21252380; PMCID: PMC3132406.
    29. Ghosh A, Roy A, Matras J, Brahmachari S, Gendelman HE, Pahan K. Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci. 2009 Oct 28; 29(43):13543-56. PMID: 19864567; PMCID: PMC2862566.
    30. Mondal S, Roy A, Pahan K. Functional blocking monoclonal antibodies against IL-12p40 homodimer inhibit adoptive transfer of experimental allergic encephalomyelitis. J Immunol. 2009 Apr 15; 182(8):5013-23. PMID: 19342681; PMCID: PMC2721330.
    31. Roy A, Pahan K. Gemfibrozil, stretching arms beyond lipid lowering. Immunopharmacol Immunotoxicol. 2009; 31(3):339-51. PMID: 19694602; PMCID: PMC2772998.
    32. Roy A, Jana A, Yatish K, Freidt MB, Fung YK, Martinson JA, Pahan K. Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases. Free Radic Biol Med. 2008 Sep 01; 45(5):686-99. PMID: 18590811; PMCID: PMC2701551.
    33. Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18754-9. PMID: 18000063; PMCID: PMC2141849.
    34. Roy A, Liu X, Pahan K. Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin. J Biol Chem. 2007 Nov 02; 282(44):32222-32. PMID: 17823123; PMCID: PMC2637617.
    35. Dasgupta S, Roy A, Jana M, Hartley DM, Pahan K. Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Mol Pharmacol. 2007 Oct; 72(4):934-46. PMID: 17625103.
      View in: PubMed
    36. Roy A, Fung YK, Liu X, Pahan K. Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem. 2006 May 26; 281(21):14971-80. PMID: 16551637; PMCID: PMC1963414.
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