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Avik Roy

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentNeurological Sciences
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 14008929100.
    My NIH COMMONS name is AVIK_ROY.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gottschalk CG, Roy A, Jana M, Kundu M, Pahan K. Activation of Peroxisome Proliferator-Activated Receptor-a Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. Mol Neurobiol. 2019 May 24. PMID: 31127527.
      View in: PubMed
    2. Patel D, Jana A, Roy A, Pahan K. Cinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson's Disease Via Astrocytic GDNF. J Neuroimmune Pharmacol. 2019 Sep; 14(3):503-518. PMID: 31119595.
      View in: PubMed
    3. Mondal S, Rangasamy SB, Roy A, Dasarathy S, Kordower JH, Pahan K. Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys. J Immunol. 2019 May 01. PMID: 31043478.
      View in: PubMed
    4. Chakrabarti S, Chandra S, Roy A, Dasarathi S, Kundu M, Pahan K. Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARa: Implications for late-infantile Batten disease therapy. Neurobiol Dis. 2019 07; 127:362-373. PMID: 30928643.
      View in: PubMed
    5. Dodiya HB, Forsyth CB, Voigt RM, Engen PA, Patel J, Shaikh M, Green SJ, Naqib A, Roy A, Kordower JH, Pahan K, Shannon KM, Keshavarzian A. Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease. Neurobiol Dis. 2018 Dec 21. PMID: 30579705.
      View in: PubMed
    6. Chandra S, Roy A, Jana M, Pahan K. Cinnamic acid activates PPARa to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model. Neurobiol Dis. 2019 04; 124:379-395. PMID: 30578827.
      View in: PubMed
    7. Mondal S, Jana M, Dasarathi S, Roy A, Pahan K. Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells. Sci Signal. 2018 Nov 27; 11(558). PMID: 30482850.
      View in: PubMed
    8. Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K. Aspirin binds to PPARa to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):E7408-E7417. PMID: 30012602.
      View in: PubMed
    9. Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. J Clin Invest. 2018 Oct 01; 128(10):4297-4312. PMID: 29990310.
      View in: PubMed
    10. Chakrabarti S, Jana M, Roy A, Pahan K. Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid. Curr Alzheimer Res. 2018; 15(10):894-904. PMID: 29732971.
      View in: PubMed
    11. Kundu M, Roy A, Pahan K. Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-?. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11482-11487. PMID: 29073075.
      View in: PubMed
    12. Chandra G, Roy A, Rangasamy SB, Pahan K. Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson's Disease. J Immunol. 2017 06 01; 198(11):4312-4326. PMID: 28446566.
      View in: PubMed
    13. Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K. Identification and characterization of PPARa ligands in the hippocampus. Nat Chem Biol. 2016 Dec; 12(12):1075-1083. PMID: 27748752.
      View in: PubMed
    14. Kundu M, Mondal S, Roy A, Martinson JL, Pahan K. Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-ß. J Immunol. 2016 10 15; 197(8):3099-3110. PMID: 27605008.
      View in: PubMed
    15. Modi KK, Rangasamy SB, Dasarathi S, Roy A, Pahan K. Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement. J Neuroimmune Pharmacol. 2016 12; 11(4):693-707. PMID: 27342118.
      View in: PubMed
    16. Roy A. Targeting BPOZ-2 in Lewy body disease. Neural Regen Res. 2016 Jun; 11(6):910-1. PMID: 27482213.
      View in: PubMed
    17. Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K. Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease. J Biol Chem. 2016 07 15; 291(29):15267-81. PMID: 27226559.
      View in: PubMed
    18. Roy A, Rangasamy SB, Kundu M, Pahan K. BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease. Sci Rep. 2016 Feb 26; 6:22067. PMID: 26916519.
      View in: PubMed
    19. Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. HMG-CoA Reductase Inhibitors Bind to PPARa to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 04; 22(2):253-65. PMID: 26118928.
      View in: PubMed
    20. Modi KK, Roy A, Brahmachari S, Rangasamy SB, Pahan K. Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease. PLoS One. 2015; 10(6):e0130398. PMID: 26102198.
      View in: PubMed
    21. Roy A, Pahan K. PPARa signaling in the hippocampus: crosstalk between fat and memory. J Neuroimmune Pharmacol. 2015 Mar; 10(1):30-4. PMID: 25575492.
      View in: PubMed
    22. Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K. Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 47(2):385-402. PMID: 26401561.
      View in: PubMed
    23. Roy A, Modi KK, Khasnavis S, Ghosh S, Watson R, Pahan K. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. PLoS One. 2014; 9(7):e101883. PMID: 25007337.
      View in: PubMed
    24. Khasnavis S, Roy A, Ghosh S, Watson R, Pahan K. Protection of dopaminergic neurons in a mouse model of Parkinson's disease by a physically-modified saline containing charge-stabilized nanobubbles. J Neuroimmune Pharmacol. 2014 Mar; 9(2):218-32. PMID: 24122363.
      View in: PubMed
    25. Roy A, Pahan K. Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease. FEBS Lett. 2013 Nov 01; 587(21):3567-74. PMID: 24076025.
      View in: PubMed
    26. Roy A, Jana M, Corbett GT, Ramaswamy S, Kordower JH, Gonzalez FJ, Pahan K. Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a. Cell Rep. 2013 Aug 29; 4(4):724-37. PMID: 23972989.
      View in: PubMed
    27. Roy A, Pahan K. Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis. J Clin Cell Immunol. 2013 Aug 12; 7:158. PMID: 24575330.
      View in: PubMed
    28. Khasnavis S, Ghosh A, Roy A, Pahan K. Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase. J Biol Chem. 2013 Jul 19; 288(29):20843-55. PMID: 23744073.
      View in: PubMed
    29. Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. J Neuroimmune Pharmacol. 2013 Jun; 8(3):739-55. PMID: 23475543.
      View in: PubMed
    30. Corbett GT, Roy A, Pahan K. Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem. 2013 Mar 22; 288(12):8299-312. PMID: 23404502.
      View in: PubMed
    31. Khasnavis S, Jana A, Roy A, Mazumder M, Bhushan B, Wood T, Ghosh S, Watson R, Pahan K. Suppression of nuclear factor-?B activation and inflammation in microglia by physically modified saline. J Biol Chem. 2012 Aug 24; 287(35):29529-42. PMID: 22753407.
      View in: PubMed
    32. Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. PLoS One. 2012; 7(6):e38113. PMID: 22723850.
      View in: PubMed
    33. Corbett GT, Roy A, Pahan K. Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense. J Immunol. 2012 Jul 15; 189(2):1002-13. PMID: 22706077.
      View in: PubMed
    34. Mondal S, Roy A, Jana A, Ghosh S, Kordower JH, Pahan K. Testing NF-?B-based therapy in hemiparkinsonian monkeys. J Neuroimmune Pharmacol. 2012 Sep; 7(3):544-56. PMID: 22661311.
      View in: PubMed
    35. Roy A, Pahan K. Prospects of statins in Parkinson disease. Neuroscientist. 2011 Jun; 17(3):244-55. PMID: 21252380.
      View in: PubMed
    36. Ghosh A, Roy A, Matras J, Brahmachari S, Gendelman HE, Pahan K. Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci. 2009 Oct 28; 29(43):13543-56. PMID: 19864567.
      View in: PubMed
    37. Mondal S, Roy A, Pahan K. Functional blocking monoclonal antibodies against IL-12p40 homodimer inhibit adoptive transfer of experimental allergic encephalomyelitis. J Immunol. 2009 Apr 15; 182(8):5013-23. PMID: 19342681.
      View in: PubMed
    38. Roy A, Pahan K. Gemfibrozil, stretching arms beyond lipid lowering. Immunopharmacol Immunotoxicol. 2009; 31(3):339-51. PMID: 19694602.
      View in: PubMed
    39. Roy A, Jana A, Yatish K, Freidt MB, Fung YK, Martinson JA, Pahan K. Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases. Free Radic Biol Med. 2008 Sep 01; 45(5):686-99. PMID: 18590811.
      View in: PubMed
    40. Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18754-9. PMID: 18000063.
      View in: PubMed
    41. Roy A, Liu X, Pahan K. Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin. J Biol Chem. 2007 Nov 02; 282(44):32222-32. PMID: 17823123.
      View in: PubMed
    42. Dasgupta S, Roy A, Jana M, Hartley DM, Pahan K. Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Mol Pharmacol. 2007 Oct; 72(4):934-46. PMID: 17625103.
      View in: PubMed
    43. Roy A, Fung YK, Liu X, Pahan K. Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem. 2006 May 26; 281(21):14971-80. PMID: 16551637.
      View in: PubMed
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