Last Name

Abde Abukhdeir

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 14055505300.
    My NIH COMMONS name is AABUKHD1.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bishehsari F, Zhang L, Barlass U, Preite NZ, Turturro S, Najor MS, Shetuni BB, Zayas JP, Mahdavinia M, Abukhdeir AM, Keshavarzian A. KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation. Int J Cancer. 2018 10 15; 143(8):1994-2007. PMID: 29756386.
      View in: PubMed
    2. Wang J, Shidfar A, Ivancic D, Ranjan M, Liu L, Choi MR, Parimi V, Gursel DB, Sullivan ME, Najor MS, Abukhdeir AM, Scholtens D, Khan SA. Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer. Int J Cancer. 2017 06 01; 140(11):2484-2497. PMID: 28263391.
      View in: PubMed
    3. Turturro SB, Najor MS, Ruby CE, Cobleigh MA, Abukhdeir AM. Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin. Breast Cancer Res Treat. 2016 Feb; 156(1):33-43. PMID: 26915040; PMCID: PMC4788696.
    4. Mohseni M, Cidado J, Croessmann S, Cravero K, Cimino-Mathews A, Wong HY, Scharpf R, Zabransky DJ, Abukhdeir AM, Garay JP, Wang GM, Beaver JA, Cochran RL, Blair BG, Rosen DM, Erlanger B, Argani P, Hurley PJ, Lauring J, Park BH. MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17606-11. PMID: 25422431; PMCID: PMC4267353.
    5. Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir AM, Gustin JP, Rosen DM, Denmeade SR, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran RL, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, Park BH. Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation. Cancer Res. 2013 Jun 01; 73(11):3248-61. PMID: 23580570; PMCID: PMC3674106.
    6. Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH. The growth response to androgen receptor signaling in ERa-negative human breast cells is dependent on p21 and mediated by MAPK activation. Breast Cancer Res. 2012 Feb 09; 14(1):R27. PMID: 22321971; PMCID: PMC3496145.
    7. Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17773-8. PMID: 21987798; PMCID: PMC3203756.
    8. Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM, Park BH. PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells. Cancer Biol Ther. 2011 Feb 01; 11(3):358-67. PMID: 21124076; PMCID: PMC3047087.
    9. Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. Oncogene. 2010 Apr 22; 29(16):2337-45. PMID: 20101210; PMCID: PMC3042798.
    10. Hansel DE, Nakayama M, Luo J, Abukhdeir AM, Park BH, Bieberich CJ, Hicks JL, Eisenberger M, Nelson WG, Mostwin JL, De Marzo AM. Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. Prostate. 2009 May 01; 69(6):603-9. PMID: 19125417; PMCID: PMC3170854.
    11. Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, Vitolo MI, Bachman KE, Park BH. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2835-40. PMID: 19196980; PMCID: PMC2636736.
    12. Abukhdeir AM, Park BH. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med. 2008 Jul 01; 10:e19. PMID: 18590585; PMCID: PMC2678956.
    13. Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, Konishi Y, Blair BG, Brenner K, Garrett-Mayer E, Carraway H, Bachman KE, Park BH. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):288-93. PMID: 18162533; PMCID: PMC2224203.
    14. Lauring J, Abukhdeir AM, Konishi H, Garay JP, Gustin JP, Wang Q, Arceci RJ, Matsui W, Park BH. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood. 2008 Jan 15; 111(2):856-64. PMID: 17942756; PMCID: PMC2200833.
    15. Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH. Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. Cancer Res. 2007 Sep 15; 67(18):8460-7. PMID: 17875684.
      View in: PubMed
    16. Karakas B, Weeraratna AT, Abukhdeir AM, Konishi H, Gustin JP, Vitolo MI, Bachman KE, Park BH. P21 gene knock down does not identify genetic effectors seen with gene knock out. Cancer Biol Ther. 2007 Jul; 6(7):1025-30. PMID: 17611398.
      View in: PubMed
    17. Konishi H, Lauring J, Garay JP, Karakas B, Abukhdeir AM, Gustin JP, Konishi Y, Park BH. A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting. Nat Protoc. 2007; 2(11):2865-74. PMID: 18007621.
      View in: PubMed
    18. Abukhdeir AM, Blair BG, Brenner K, Karakas B, Konishi H, Lim J, Sahasranaman V, Huang Y, Keen J, Davidson N, Vitolo MI, Bachman KE, Park BH. Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells. Breast Cancer Res Treat. 2006 Sep; 99(1):23-33. PMID: 16541319.
      View in: PubMed
    19. Layden BT, Abukhdeir AM, Malarkey C, Oriti LA, Salah W, Stigler C, Geraldes CF, Mota de Freitas D. Identification of Li(+) binding sites and the effect of Li(+) treatment on phospholipid composition in human neuroblastoma cells: a (7)Li and (31)P NMR study. Biochim Biophys Acta. 2005 Sep 25; 1741(3):339-49. PMID: 16115751.
      View in: PubMed
    20. Srinivasan C, Toon J, Amari L, Abukhdeir AM, Hamm H, Geraldes CF, Ho YK, Mota de Freitas D. Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation. J Inorg Biochem. 2004 May; 98(5):691-701. PMID: 15134914.
      View in: PubMed
    21. Layden BT, Minadeo N, Suhy J, Abukhdeir AM, Metreger T, Foley K, Borge G, Crayton JW, Bryant FB, de Freitas DM. Biochemical and psychiatric predictors of Li(+) response and toxicity in Li(+)-treated bipolar patients. Bipolar Disord. 2004 Feb; 6(1):53-61. PMID: 14996141.
      View in: PubMed
    22. Layden BT, Abukhdeir AM, Williams N, Fonseca CP, Carroll L, Castro MM, Geraldes CF, Bryant FB, Freitas DM. Effects of Li(+) transport and Li(+) immobilization on Li(+)/Mg(2+) competition in cells: implications for bipolar disorder. Biochem Pharmacol. 2003 Nov 15; 66(10):1915-24. PMID: 14599549.
      View in: PubMed
    23. Williams N, Layden BT, Suhy J, Metreger T, Foley K, Abukhdeir AM, Borge G, Crayton J, Bryant FB, Mota de Freitas D. Testing competing path models linking the biochemical variables in red blood cells from Li+-treated bipolar patients. Bipolar Disord. 2003 Oct; 5(5):320-9. PMID: 14525552.
      View in: PubMed
    24. Diven CF, Wang F, Abukhdeir AM, Salah W, Layden BT, Geraldes CF, Mota de Freitas D. Evaluation of [Co(gly)3]- as a 35Cl- NMR shift reagent for cellular studies. Inorg Chem. 2003 Apr 21; 42(8):2774-82. PMID: 12691588.
      View in: PubMed
    25. Abukhdeir AM, Layden BT, Minadeo N, Bryant FB, Stubbs EB, Mota de Freitas D. Effect of chronic Li+ treatment on free intracellular Mg2+ in human neuroblastoma SH-SY5Y cells. Bipolar Disord. 2003 Feb; 5(1):6-13. PMID: 12656932.
      View in: PubMed
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