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Katalin Mikecz

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Address1611 W. Harrison St.
Chicago IL 60612
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    My research focuses on rheumatoid arthritis (RA), a joint disease that causes chronic pain and disability. We described a new mouse model of RA 30 years ago, and fully characterized it with respect to its pathogenesis, immunology, and genetics. My group was the first to report on the non-invasive imaging of the trafficking of white blood cells in the inflamed joints of live mice (with RA-like arthritis) using two-photon microscopy. My current research interest is in the immune recognition of a cartilage molecule termed proteoglycan (or aggrecan) by lymphocytes from mice with arthritis and from RA patients. Our ultimate goals are to identify therapeutic targets and to find a cure for RA.

    My ORCID is 0000-0003-1506-4296
    My Scopus ID is 7006756303
    My NIH COMMONS name is KMIKECZ

    Education:
    MD: Medical University of Debrecen, Hungary (1982)
    PhD: Medical University of Debrecen & Hungarian Academy of Sciences, Budapest, Hungary (1989)


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2017 Jan; 56(1):109-120. PMID: 27598620.
      View in: PubMed
    2. Markovics A, Ocskó T, Katz RS, Buzás EI, Glant TT, Mikecz K. Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. PLoS One. 2016; 11(7):e0160284. PMID: 27466816; PMCID: PMC4965111.
    3. Boldizsar F, Tarjanyi O, Olasz K, Hegyi A, Mikecz K, Glant TT, Rauch TA. FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. Cardiovasc Pathol. 2016 Sep-Oct; 25(5):353-61. PMID: 27288745.
      View in: PubMed
    4. Glant TT, Ocsko T, Markovics A, Szekanecz Z, Katz RS, Rauch TA, Mikecz K. Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage. PLoS One. 2016; 11(3):e0150784. PMID: 26943656; PMCID: PMC4778950.
    5. Kugyelka R, Kohl Z, Olasz K, Mikecz K, Rauch TA, Glant TT, Boldizsar F. Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis. Mediators Inflamm. 2016; 2016:6145810. PMID: 26903711; PMCID: PMC4745575.
    6. Rosenthal KS, Mikecz K, Steiner HL, Glant TT, Finnegan A, Carambula RE, Zimmerman DH. Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis. Expert Rev Vaccines. 2015 Jun; 14(6):891-908. PMID: 25787143; PMCID: PMC4786169.
    7. Kurkó J, Vida A, Ocskó T, Tryniszewska B, Rauch TA, Glant TT, Szekanecz Z, Mikecz K. Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow. PLoS One. 2014; 9(11):e111815. PMID: 25369029; PMCID: PMC4219784.
    8. Kurkó J, Vida A, Glant TT, Scanzello CR, Katz RS, Nair A, Szekanecz Z, Mikecz K. Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study. BMC Musculoskelet Disord. 2014 Aug 19; 15:281. PMID: 25138129; PMCID: PMC4152562.
    9. Glant TT, Mikecz K, Rauch TA. Epigenetics in the pathogenesis of rheumatoid arthritis. BMC Med. 2014 Feb 26; 12:35. PMID: 24568138; PMCID: PMC3936819.
    10. Hanyecz A, Olasz K, Tarjanyi O, Nemeth P, Mikecz K, Glant TT, Boldizsar F. Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis. Biomed Res Int. 2014; 2014:942148. PMID: 24605340; PMCID: PMC3925549.
    11. Kobezda T, Ghassemi-Nejad S, Mikecz K, Glant TT, Szekanecz Z. Of mice and men: how animal models advance our understanding of T-cell function in RA. Nat Rev Rheumatol. 2014 Mar; 10(3):160-70. PMID: 24394350; PMCID: PMC3953227.
    12. Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Genetics of rheumatoid arthritis - a comprehensive review. Clin Rev Allergy Immunol. 2013 Oct; 45(2):170-9. PMID: 23288628; PMCID: PMC3655138.
    13. Glant TT, Besenyei T, Kádár A, Kurkó J, Tryniszewska B, Gál J, Soós G, Szekanecz Z, Hoffmann G, Block JA, Katz RS, Mikecz K, Rauch TA. Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models. Arthritis Rheum. 2013 Jul; 65(7):1725-35. PMID: 23653330; PMCID: PMC4102319.
    14. Szekanecz Z, Meskó B, Poliska S, Váncsa A, Szamosi S, Végh E, Simkovics E, Laki J, Kurkó J, Besenyei T, Mikecz K, Glant TT, Nagy L. Pharmacogenetics and pharmacogenomics in rheumatology. Immunol Res. 2013 Jul; 56(2-3):325-33. PMID: 23564183; PMCID: PMC4139282.
    15. Bell R, Li J, Shewman EF, Galante JO, Cole BJ, Bach BR, Troy KL, Mikecz K, Sandy JD, Plaas AH, Wang VM. ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy. J Orthop Res. 2013 Oct; 31(10):1540-8. PMID: 23754494.
      View in: PubMed
    16. Misják P, Bosze S, Horváti K, Pásztói M, Pálóczi K, Holub MC, Szakács F, Aradi B, György B, Szabó TG, Nagy G, Glant TT, Mikecz K, Falus A, Buzás EI. The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis. Immunol Lett. 2013 Apr; 152(1):25-31. PMID: 23578666.
      View in: PubMed
    17. Besenyei T, Kadar A, Tryniszewska B, Kurko J, Rauch TA, Glant TT, Mikecz K, Szekanecz Z. Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models. Clin Dev Immunol. 2012; 2012:284751. PMID: 23251214; PMCID: PMC3521484.
    18. Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A. Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013 Jan 04; 288(1):205-14. PMID: 23166324; PMCID: PMC3537015.
    19. Bell R, Li J, Gorski DJ, Bartels AK, Shewman EF, Wysocki RW, Cole BJ, Bach BR, Mikecz K, Sandy JD, Plaas AH, Wang VM. Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model. J Biomech. 2013 Feb 01; 46(3):498-505. PMID: 23159096.
      View in: PubMed
    20. Swaidani S, Cheng G, Lauer ME, Sharma M, Mikecz K, Hascall VC, Aronica MA. TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma. J Biol Chem. 2013 Jan 04; 288(1):412-22. PMID: 23118230; PMCID: PMC3537038.
    21. Egelston C, Kurkó J, Besenyei T, Tryniszewska B, Rauch TA, Glant TT, Mikecz K. Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis. Arthritis Rheum. 2012 Oct; 64(10):3179-88. PMID: 22492217; PMCID: PMC3402579.
    22. Kobezda T, Ghassemi-Nejad S, Glant TT, Mikecz K. In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis. Cell Immunol. 2012 Jul-Aug; 278(1-2):158-65. PMID: 23023071; PMCID: PMC3489964.
    23. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Ranjan KC, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul; 113(7):2532-42. PMID: 22415882; PMCID: PMC3349778.
    24. Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, Glant TT, Malfait AM, Crow MK, Spear GT, Finnegan A, Scanzello CR. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012 Jul; 64(7):2268-77. PMID: 22492243; PMCID: PMC3386375.
    25. Kis-Toth K, Radacs M, Olasz K, van Eden W, Mikecz K, Glant TT. Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice. Int Immunol. 2012 Aug; 24(8):507-17. PMID: 22518822; PMCID: PMC3406935.
    26. Glant TT, Adarichev VA, Boldizsar F, Besenyei T, Laszlo A, Mikecz K, Rauch TA. Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis. Genes Immun. 2012 Jun; 13(4):336-45. PMID: 22402741; PMCID: PMC3524972.
    27. Olasz K, Boldizsar F, Kis-Toth K, Tarjanyi O, Hegyi A, van Eden W, Rauch TA, Mikecz K, Glant TT. T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice. Clin Exp Immunol. 2012 Feb; 167(2):346-55. PMID: 22236012; PMCID: PMC3278702.
    28. Yan D, Chen D, Cool SM, van Wijnen AJ, Mikecz K, Murphy G, Im HJ. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther. 2011 Aug 11; 13(4):R130. PMID: 21835001; PMCID: PMC3239372.
    29. Nagyeri G, Radacs M, Ghassemi-Nejad S, Tryniszewska B, Olasz K, Hutas G, Gyorfy Z, Hascall VC, Glant TT, Mikecz K. TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin. J Biol Chem. 2011 Jul 01; 286(26):23559-69. PMID: 21566135; PMCID: PMC3123119.
    30. Glant TT, Radacs M, Nagyeri G, Olasz K, Laszlo A, Boldizsar F, Hegyi A, Finnegan A, Mikecz K. Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis. Arthritis Rheum. 2011 May; 63(5):1312-21. PMID: 21305522; PMCID: PMC3086933.
    31. Nesterovitch AB, Szanto S, Gonda A, Bardos T, Kis-Toth K, Adarichev VA, Olasz K, Ghassemi-Najad S, Hoffman MD, Tharp MD, Mikecz K, Glant TT. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011 Apr; 178(4):1701-14. PMID: 21435452; PMCID: PMC3078426.
    32. Nesterovitch AB, Gyorfy Z, Hoffman MD, Moore EC, Elbuluk N, Tryniszewska B, Rauch TA, Simon M, Kang S, Fisher GJ, Mikecz K, Tharp MD, Glant TT. Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses. Am J Pathol. 2011 Apr; 178(4):1434-41. PMID: 21406173; PMCID: PMC3078441.
    33. Ghassemi-Nejad S, Kobezda T, Rauch TA, Matesz C, Glant TT, Mikecz K. Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis. Osteoarthritis Cartilage. 2011 Apr; 19(4):458-65. PMID: 21262368; PMCID: PMC3065523.
    34. Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A. Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res. 2011 Apr; 29(4):516-22. PMID: 21337391.
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    35. Boldizsar F, Kis-Toth K, Tarjanyi O, Olasz K, Hegyi A, Mikecz K, Glant TT. Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice. Arthritis Rheum. 2010 Oct; 62(10):2984-94. PMID: 20564001; PMCID: PMC2952044.
    36. Wiranowska M, Ladd S, Moscinski LC, Hill B, Haller E, Mikecz K, Plaas A. Modulation of hyaluronan production by CD44 positive glioma cells. Int J Cancer. 2010 Aug 01; 127(3):532-42. PMID: 19957333; PMCID: PMC3962665.
    37. Boldizsar F, Mikecz K, Glant TT. Immunosenescence and its potential modulation: lessons from mouse models. Expert Rev Clin Immunol. 2010 May; 6(3):353-7. PMID: 20441421.
      View in: PubMed
    38. Angyal A, Egelston C, Kobezda T, Olasz K, László A, Glant TT, Mikecz K. Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints. Arthritis Res Ther. 2010; 12(2):R44. PMID: 20298547; PMCID: PMC2888192.
    39. Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Mikecz K, Glant TT, Iwakura Y, Finnegan A. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol. 2010 Feb 01; 184(3):1552-9. PMID: 20028652; PMCID: PMC2846113.
    40. Végvári A, Szabó Z, Szántó S, Glant TT, Mikecz K, Szekanecz Z. The genetic background of ankylosing spondylitis. Joint Bone Spine. 2009 Dec; 76(6):623-8. PMID: 19541528.
      View in: PubMed
    41. Tarjanyi O, Boldizsar F, Nemeth P, Mikecz K, Glant TT. Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. Immun Ageing. 2009 Jun 11; 6:8. PMID: 19519881; PMCID: PMC2704168.
    42. Panicker S, Borgia J, Fhied C, Mikecz K, Oegema TR. Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair. Osteoarthritis Cartilage. 2009 Aug; 17(8):1014-21. PMID: 19364543.
      View in: PubMed
    43. Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol. 2009 May; 21(5):511-22. PMID: 19254958; PMCID: PMC2675029.
    44. Farkas B, Boldizsar F, Tarjanyi O, Laszlo A, Lin SM, Hutas G, Tryniszewska B, Mangold A, Nagyeri G, Rosenzweig HL, Finnegan A, Mikecz K, Glant TT. BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance. Arthritis Res Ther. 2009; 11(1):R21. PMID: 19220900; PMCID: PMC2688253.
    45. Hutás G, Bajnok E, Gál I, Finnegan A, Glant TT, Mikecz K. CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis. Blood. 2008 Dec 15; 112(13):4999-5006. PMID: 18815286; PMCID: PMC2597605.
    46. Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008 Aug; 58(8):2397-408. PMID: 18668542.
      View in: PubMed
    47. Adarichev VA, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant TT. Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation. Genes Immun. 2008 Oct; 9(7):591-601. PMID: 18650834; PMCID: PMC3951374.
    48. Glant TT, Szántó S, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Adarichev VA. Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation. J Immunol. 2008 Jul 15; 181(2):1307-14. PMID: 18606685.
      View in: PubMed
    49. Mahoney DJ, Mikecz K, Ali T, Mabilleau G, Benayahu D, Plaas A, Milner CM, Day AJ, Sabokbar A. TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. J Biol Chem. 2008 Sep 19; 283(38):25952-62. PMID: 18586671; PMCID: PMC2533787.
    50. Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD. Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage. 2007 Jul; 15(7):719-34. PMID: 17360199.
      View in: PubMed
    51. Szántó S, Koreny T, Mikecz K, Glant TT, Szekanecz Z, Varga J. Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice. Arthritis Res Ther. 2007; 9(3):R50. PMID: 17511858; PMCID: PMC2206348.
    52. Adarichev VA, Vermes C, Hanyecz A, Ludanyi K, Tunyogi-Csapo M, Finnegan A, Mikecz K, Glant TT. Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis. Autoimmunity. 2006 Dec; 39(8):663-73. PMID: 17178563.
      View in: PubMed
    53. Sarraj B, Ludányi K, Glant TT, Finnegan A, Mikecz K. Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis. J Immunol. 2006 Aug 01; 177(3):1932-40. PMID: 16849507.
      View in: PubMed
    54. Gál I, Bajnok E, Szántó S, Sarraj B, Glant TT, Mikecz K. Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis. Arthritis Rheum. 2005 Oct; 52(10):3269-78. PMID: 16206283.
      View in: PubMed
    55. Buzás EI, Végvári A, Murad YM, Finnegan A, Mikecz K, Glant TT. T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis. Cell Immunol. 2005 Jun; 235(2):98-108. PMID: 16185673.
      View in: PubMed
    56. Gonda A, Gál I, Szántó S, Sarraj B, Glant TT, Hunyadi J, Mikecz K. CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis. Exp Dermatol. 2005 Sep; 14(9):700-8. PMID: 16098130.
      View in: PubMed
    57. Végvári A, Szabó Z, Szántó S, Nesterovitch AB, Mikecz K, Glant TT, Adarichev VA. Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy. J Immunol. 2005 Aug 15; 175(4):2475-83. PMID: 16081819.
      View in: PubMed
    58. Szabó Z, Szántó S, Végvári A, Szekanecz Z, Mikecz K, Glant TT. Genetic control of experimental spondylarthropathy. Arthritis Rheum. 2005 Aug; 52(8):2452-60. PMID: 16059927.
      View in: PubMed
    59. Hallab NJ, Anderson S, Caicedo M, Brasher A, Mikecz K, Jacobs JJ. Effects of soluble metals on human peri-implant cells. J Biomed Mater Res A. 2005 Jul 01; 74(1):124-40. PMID: 15937919.
      View in: PubMed
    60. Bárdos T, Szabó Z, Czipri M, Vermes C, Tunyogi-Csapó M, Urban RM, Mikecz K, Glant TT. A longitudinal study on an autoimmune murine model of ankylosing spondylitis. Ann Rheum Dis. 2005 Jul; 64(7):981-7. PMID: 15640265; PMCID: PMC1755557.
    61. Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004 Dec 15; 173(12):7135-9. PMID: 15585834.
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    62. Adarichev VA, Vermes C, Hanyecz A, Mikecz K, Bremer EG, Glant TT. Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation. Arthritis Res Ther. 2005; 7(2):R196-207. PMID: 15743466; PMCID: PMC1065315.
    63. Szántó S, Bárdos T, Gál I, Glant TT, Mikecz K. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice. Arthritis Rheum. 2004 Sep; 50(9):3012-22. PMID: 15457471.
      View in: PubMed
    64. Szántó S, Gál I, Gonda A, Glant TT, Mikecz K. Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis. J Immunol. 2004 Jun 01; 172(11):6723-34. PMID: 15153489.
      View in: PubMed
    65. Szántó S, Bárdos T, Szabó Z, David CS, Buzás EI, Mikecz K, Glant TT. Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum. 2004 Jun; 50(6):1984-95. PMID: 15188376.
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    66. Hanyecz A, Berlo SE, Szántó S, Broeren CP, Mikecz K, Glant TT. Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype. Arthritis Rheum. 2004 May; 50(5):1665-76. PMID: 15146438.
      View in: PubMed
    67. Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K. Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci. 2004 Apr; 327(4):188-95. PMID: 15084914.
      View in: PubMed
    68. Lesley J, Gál I, Mahoney DJ, Cordell MR, Rugg MS, Hyman R, Day AJ, Mikecz K. TSG-6 modulates the interaction between hyaluronan and cell surface CD44. J Biol Chem. 2004 Jun 11; 279(24):25745-54. PMID: 15060082.
      View in: PubMed
    69. Glant TT, Mikecz K. Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis. Methods Mol Med. 2004; 102:313-38. PMID: 15286393.
      View in: PubMed
    70. Hanyecz A, Bárdos T, Berlo SE, Buzás E, Nesterovitch AB, Mikecz K, Glant TT. Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan. Arthritis Rheum. 2003 Oct; 48(10):2959-73. PMID: 14558103.
      View in: PubMed
    71. Buzás EI, Hanyecz A, Murad Y, Hudecz F, Rajnavölgyi E, Mikecz K, Glant TT. Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones. J Immunol. 2003 Sep 15; 171(6):3025-33. PMID: 12960328.
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    72. Adarichev VA, Nesterovitch AB, Bárdos T, Biesczat D, Chandrasekaran R, Vermes C, Mikecz K, Finnegan A, Glant TT. Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun; 48(6):1708-20. PMID: 12794840.
      View in: PubMed
    73. Fülöp C, Szántó S, Mukhopadhyay D, Bárdos T, Kamath RV, Rugg MS, Day AJ, Salustri A, Hascall VC, Glant TT, Mikecz K. Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May; 130(10):2253-61. PMID: 12668637.
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    74. Zhang J, Bárdos T, Shao Q, Tschopp J, Mikecz K, Glant TT, Finnegan A. IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism. J Immunol. 2003 Apr 01; 170(7):3495-503. PMID: 12646610.
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    75. Adarichev VA, Valdez JC, Bárdos T, Finnegan A, Mikecz K, Glant TT. Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 01; 170(5):2283-92. PMID: 12594249.
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    76. Gal I, Lesley J, Ko W, Gonda A, Stoop R, Hyman R, Mikecz K. Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow. J Biol Chem. 2003 Mar 28; 278(13):11150-8. PMID: 12540844.
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    77. Bardos T, Czipri M, Vermes C, Finnegan A, Mikecz K, Zhang J. CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther. 2003; 5(2):R106-13. PMID: 12718754; PMCID: PMC165034.
    78. Glant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics. Crit Rev Immunol. 2003; 23(3):199-250. PMID: 14584879.
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    79. Finnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, Czipri M, Mikecz K, Zhang J. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol. 2002 Sep 15; 169(6):3345-52. PMID: 12218156.
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    80. Zhang J, Bárdos T, Li D, Gál I, Vermes C, Xu J, Mikecz K, Finnegan A, Lipkowitz S, Glant TT. Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol. 2002 Sep 01; 169(5):2236-40. PMID: 12193687.
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    81. Bárdos T, Zhang J, Mikecz K, David CS, Glant TT. Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age. Arthritis Rheum. 2002 Sep; 46(9):2465-75. PMID: 12355495.
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    82. Stoop R, Gál I, Glant TT, McNeish JD, Mikecz K. Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions. Eur J Immunol. 2002 Sep; 32(9):2532-42. PMID: 12207337.
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    83. Glant TT, Kamath RV, Bárdos T, Gál I, Szántó S, Murad YM, Sandy JD, Mort JS, Roughley PJ, Mikecz K. Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. Arthritis Rheum. 2002 Aug; 46(8):2207-18. PMID: 12209527.
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    84. Bárdos T, Czipri M, Vermes C, Zhang J, Mikecz K, Glant TT. Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice. Clin Exp Immunol. 2002 Aug; 129(2):224-31. PMID: 12165077; PMCID: PMC1906433.
    85. Bárdos T, Mikecz K, Finnegan A, Zhang J, Glant TT. T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol. 2002 Jun 15; 168(12):6013-21. PMID: 12055209.
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    86. Adarichev VA, Bárdos T, Christodoulou S, T Phillips M, Mikecz K, Glant TT. Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis. Immunogenetics. 2002 Jun; 54(3):184-92. PMID: 12073147.
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    87. Lesley J, English NM, Gál I, Mikecz K, Day AJ, Hyman R. Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. J Biol Chem. 2002 Jul 19; 277(29):26600-8. PMID: 12011075.
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    88. Stoop R, Kotani H, McNeish JD, Otterness IG, Mikecz K. Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice. Arthritis Rheum. 2001 Dec; 44(12):2922-31. PMID: 11762953.
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    89. Bárdos T, Kamath RV, Mikecz K, Glant TT. Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis. Am J Pathol. 2001 Nov; 159(5):1711-21. PMID: 11696432; PMCID: PMC1867074.
    90. Kaplan C, Valdez JC, Chandrasekaran R, Eibel H, Mikecz K, Glant TT, Finnegan A. Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis. Arthritis Res. 2002; 4(1):54-8. PMID: 11879537; PMCID: PMC64852.
    91. Hallab NJ, Mikecz K, Vermes C, Skipor A, Jacobs JJ. Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation. J Biomed Mater Res. 2001 Sep 05; 56(3):427-36. PMID: 11372061.
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    92. Shi M, Dennis K, Peschon JJ, Chandrasekaran R, Mikecz K. Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton. J Immunol. 2001 Jul 01; 167(1):123-31. PMID: 11418640.
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    93. Hallab NJ, Mikecz K, Vermes C, Skipor A, Jacobs JJ. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation. Mol Cell Biochem. 2001 Jun; 222(1-2):127-36. PMID: 11678594.
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    94. Zhang J, Bárdos T, Mikecz K, Finnegan A, Glant TT. Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis. J Immunol. 2001 Apr 15; 166(8):4981-6. PMID: 11290777.
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    95. Glant TT, Bárdos T, Vermes C, Chandrasekaran R, Valdéz JC, Otto JM, Gerard D, Velins S, Lovász G, Zhang J, Mikecz K, Finnegan A. Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease. Arthritis Rheum. 2001 Mar; 44(3):682-92. PMID: 11263784.
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    96. Otto JM, Chandrasekeran R, Vermes C, Mikecz K, Finnegan A, Rickert SE, Enders JT, Glant TT. A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis. J Immunol. 2000 Nov 01; 165(9):5278-86. PMID: 11046062.
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    97. Mikecz K. Vitaxin applied molecular evolution. Curr Opin Investig Drugs. 2000 Oct; 1(2):199-203. PMID: 11249574.
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    98. Zhang J, Mikecz K, Finnegan A, Glant TT. Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway. J Immunol. 2000 Sep 15; 165(6):2970-4. PMID: 10975804.
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    99. Hallab NJ, Mikecz K, Jacobs JJ. A triple assay technique for the evaluation of metal-induced, delayed-type hypersensitivity responses in patients with or receiving total joint arthroplasty. J Biomed Mater Res. 2000 Sep; 53(5):480-9. PMID: 10984695.
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    100. Kim JH, Glant TT, Lesley J, Hyman R, Mikecz K. Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand. Exp Cell Res. 2000 May 01; 256(2):445-53. PMID: 10772817.
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    101. Holló K, Glant TT, Garzó M, Finnegan A, Mikecz K, Buzás E. Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis. Clin Exp Immunol. 2000 Apr; 120(1):167-73. PMID: 10759779; PMCID: PMC1905608.
    102. Hallab NJ, Jacobs JJ, Skipor A, Black J, Mikecz K, Galante JO. Systemic metal-protein binding associated with total joint replacement arthroplasty. J Biomed Mater Res. 2000 Mar 05; 49(3):353-61. PMID: 10602068.
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    103. Otto JM, Cs-Szabó G, Gallagher J, Velins S, Mikecz K, Buzás EI, Enders JT, Li Y, Olsen BR, Glant TT. Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Arthritis Rheum. 1999 Dec; 42(12):2524-31. PMID: 10615997.
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    104. Finnegan A, Mikecz K, Tao P, Glant TT. Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines. J Immunol. 1999 Nov 15; 163(10):5383-90. PMID: 10553063.
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    105. Mikecz K, Dennis K, Shi M, Kim JH. Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis. Arthritis Rheum. 1999 Apr; 42(4):659-68. PMID: 10211879.
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    106. Glant TT, Cs-Szabó G, Nagase H, Jacobs JJ, Mikecz K. Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage. Arthritis Rheum. 1998 Jun; 41(6):1007-18. PMID: 9627010.
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    107. Glant TT, Buzás EI, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K. Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol. 1998 Apr 15; 160(8):3812-9. PMID: 9558085.
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    108. Brennan FR, Mikecz K, Glant TT, Jobanputra P, Pinder S, Bavington C, Morrison P, Nuki G. CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro. Scand J Immunol. 1997 Feb; 45(2):213-20. PMID: 9042434.
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    109. Cole AA, Chubinskaya S, Schumacher B, Huch K, Szabo G, Yao J, Mikecz K, Hasty KA, Kuettner KE. Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase. J Biol Chem. 1996 May 03; 271(18):11023-6. PMID: 8631924.
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    110. Chubinskaya S, Huch K, Mikecz K, Cs-Szabo G, Hasty KA, Kuettner KE, Cole AA. Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints. Lab Invest. 1996 Jan; 74(1):232-40. PMID: 8569187.
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    111. Buzás EI, Mikecz K, Glant TT. Aggrecan: A Target Molecule of Autoimmune Reactions. Pathol Oncol Res. 1996; 2(4):219-228. PMID: 11173607.
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    112. Glant TT, Jacobs JJ, Mikecz K, Yao J, Chubinskaja S, Williams JM, Urban RL, Shanbhag AS, Lee SH, Sumner DR. Particulate-Induced, Prostaglandin- and Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements. Am J Ther. 1996 Jan; 3(1):27-41. PMID: 11856995.
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    113. Mikecz K, Glant TT. Immunoregulation of Proteoglycan-Induced Arthritis in Balb/c Mice. Am J Ther. 1996 Jan; 3(1):42-51. PMID: 11856996.
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    114. Buzás EI, Brennan FR, Mikecz K, Garzó M, Negroiu G, Holló K, Cs-Szabó G, Pintye E, Glant TT. A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice. J Immunol. 1995 Sep 01; 155(5):2679-87. PMID: 7544381.
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    115. Brennan FR, Mikecz K, Buzás EI, Ragasa D, Cs-Szabó G, Negroiu G, Glant TT. Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin Exp Immunol. 1995 Sep; 101(3):414-21. PMID: 7664487; PMCID: PMC1553246.
    116. Yao J, Glant TT, Lark MW, Mikecz K, Jacobs JJ, Hutchinson NI, Hoerrner LA, Kuettner KE, Galante JO. The potential role of fibroblasts in periprosthetic osteolysis: fibroblast response to titanium particles. J Bone Miner Res. 1995 Sep; 10(9):1417-27. PMID: 7502715.
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    117. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med. 1995 Jun; 1(6):558-63. PMID: 7585123.
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    118. Brennan FR, Negroiu G, Buzás EI, Fülöp C, Holló K, Mikecz K, Glant TT. Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin Exp Immunol. 1995 Apr; 100(1):104-10. PMID: 7697908; PMCID: PMC1534264.
    119. Brennan FR, Mikecz K, Buzás EI, Glant TT. Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma. Immunol Lett. 1995 Feb; 45(1-2):87-91. PMID: 7622193.
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    120. Glant TT, Fülöp C, Cs-Szabó G, Buzás E, Ragasa D, Mikecz K. Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis. Scand J Rheumatol Suppl. 1995; 101:43-9. PMID: 7538228.
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    121. Mikecz K, Brennan FR, Kim JH, Glant TT. The role of adhesion molecules in the development of autoimmune arthritis. Scand J Rheumatol Suppl. 1995; 101:99-106. PMID: 7747139.
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    122. Buzás EI, Mikecz K, Brennan FR, Glant TT. Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice. Cell Immunol. 1994 Oct 15; 158(2):292-304. PMID: 7923385.
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    123. Mikecz K, Glant TT. Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis. Arthritis Rheum. 1994 Sep; 37(9):1395-403. PMID: 7945505.
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    124. Williams JM, Zurawski J, Mikecz K, Glant TT. Functional assessment of joint use in experimental inflammatory murine arthritis. J Orthop Res. 1993 Mar; 11(2):172-80. PMID: 8483030.
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    125. Glant TT, Mikecz K, Bartlett RR, Deák F, Thonar EJ, Williams JM, Mattar T, Kuettner KE, Schleyerbach R. Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. Immunopharmacology. 1992 Mar-Apr; 23(2):105-16. PMID: 1601639.
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    126. Glant TT, Fülöp C, Mikecz K, Buzás E, Molnár G, Erhardt P. Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases. Biochem Soc Trans. 1990 Oct; 18(5):796-9. PMID: 2083679.
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    127. Dayer E, Mathai L, Glant TT, Mikecz K, Poole AR. Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis. Arthritis Rheum. 1990 Sep; 33(9):1394-405. PMID: 1698370.
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    128. Mikecz K, Glant TT, Buzás E, Poole AR. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice. Arthritis Rheum. 1990 Jun; 33(6):866-76. PMID: 2194463.
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    129. Mikecz K, Glant TT, Baron M, Poole AR. Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis. Cell Immunol. 1988 Mar; 112(1):55-63. PMID: 2449981.
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    130. Mikecz K, Glant TT, Buzás E, Poole AR. Cartilage proteoglycans as potential autoantigens in humans and in experimental animals. Agents Actions. 1988 Feb; 23(1-2):63-6. PMID: 3354391.
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    131. Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum. 1987 Mar; 30(3):306-18. PMID: 3566822.
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    132. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum. 1987 Feb; 30(2):201-12. PMID: 3827960.
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    133. Glant TT, Mikecz K, Roughley PJ, Buzás E, Poole AR. Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans. Biochem J. 1986 May 15; 236(1):71-5. PMID: 2431678; PMCID: PMC1146787.
    134. Glant TT, Mikecz K, Poole AR. Monoclonal antibodies to different protein-related epitopes of human articular cartilage proteoglycans. Biochem J. 1986 Feb 15; 234(1):31-41. PMID: 2423072; PMCID: PMC1146523.
    135. Glant T, Mikecz K. Antigenic profiles of human, bovine and canine articular chondrocytes. Cell Tissue Res. 1986; 244(2):359-69. PMID: 3521881.
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    136. Glant TT, Hadházy C, Mikecz K, Sipos A. Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. Histochemistry. 1985; 82(2):149-58. PMID: 3997552.
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    137. Mikecz K, Sonkoly I, Mészáros C, Szegedi G. Serum IgE level in systemic lupus erythematosus. Acta Med Hung. 1985; 42(1-2):59-65. PMID: 4034338.
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