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Nozomu Inoue

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Address1611 W. Harrison St.
Chicago IL 60612
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    Collapse Overview 
    Collapse overview
    My areas of research interest are spine biomechanics and image-based biomechanics using three dimensional patient-specific computer models created by clinical CT/MRI of the spine, shoulder, elbow, wrist, hip, knee and foot & ankle.

    My ORCID is 0000-0002-6418-713X
    My Scopus ID is 35572384200
    My NIH COMMONS name is NINOUE

    Education
    MD, Kyoto Prefectural University of Medicine, Japan (1981)
    PhD, Kyoto Prefectural University of Medicine, Japan (1987)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pang H, Bow C, Cheung JPY, Zehra U, Borthakur A, Karppinen J, Inoue N, Wang HQ, Luk KDK, Cheung KMC, Samartzis D. The UTE Disc Sign on MRI: A Novel Imaging Biomarker Associated With Degenerative Spine Changes, Low Back Pain, and Disability. Spine (Phila Pa 1976). 2018 04 01; 43(7):503-511. PMID: 28767621.
      View in: PubMed
    2. Louie PK, Espinoza Orías AA, Fogg LF, LaBelle M, An HS, Andersson GBJ, Inoue N. Changes in Lumbar Endplate Area and Concavity Associated With Disc Degeneration. Spine (Phila Pa 1976). 2018 Mar 27. PMID: 29596278.
      View in: PubMed
    3. Miyazaki S, Diwan AD, Kato K, Cheng K, Bae WC, Sun Y, Yamada J, Muehleman C, Lenz ME, Inoue N, Sah RL, Kawakami M, Masuda K. ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model. Eur Spine J. 2018 Apr; 27(4):739-751. PMID: 29460012.
      View in: PubMed
    4. Yanke AB, Urita A, Shin JJ, Cvetanovich GL, Moran EK, Bach BR, Cole BJ, Inoue N, Verma NN. Topographic Analysis of the Distal Femoral Condyle Articular Cartilage Surface: Adequacy of the Graft from Opposite Condyles of the Same or Different Size for the Osteochondral Allograft Transplantation. Cartilage. 2018 Jan 01; 1947603517752056. PMID: 29334769.
      View in: PubMed
    5. Yang SH, Espinoza Orías AA, Pan CC, Senoo I, Andersson GBJ, An HS, Inoue N. Spatial geometric and magnetic resonance signal intensity changes with advancing stages of nucleus pulposus degeneration. BMC Musculoskelet Disord. 2017 Nov 21; 18(1):473. PMID: 29162082.
      View in: PubMed
    6. Hong JT, Tomoyuki T, Jain A, Orías AAE, Inoue N, An HS. Which salvage fixation technique is best for the failed initial screw fixation at the cervicothoracic junction? A biomechanical comparison study. Eur Spine J. 2017 Sep; 26(9):2417-2424. PMID: 28752245.
      View in: PubMed
    7. Basques BA, Espinoza Orías AA, Shifflett GD, Fice MP, Andersson GB, An HS, Inoue N. The Kinematics and Spondylosis of the Lumbar Spine Vary Depending on the Levels of Motion Segments in Individuals With Low Back Pain. Spine (Phila Pa 1976). 2017 Jul 01; 42(13):E767-E774. PMID: 27831966.
      View in: PubMed
    8. Forsythe B, Collins MJ, Arns TA, Zuke WA, Khair M, Verma NN, Cole BJ, Bach BR, Inoue N. Optimization of Anteromedial Portal Femoral Tunnel Drilling With Flexible and Straight Reamers in Anterior Cruciate Ligament Reconstruction: A Cadaveric 3-Dimensional Computed Tomography Analysis. Arthroscopy. 2017 May; 33(5):1036-1043. PMID: 28117107.
      View in: PubMed
    9. Fukui D, Kawakami M, Cheng K, Murata K, Yamada K, Sato R, Yoshida M, Yamada H, Inoue N, Masuda K. Three-dimensional micro-computed tomography analysis for spinal instability after lumbar facetectomy in the rat. Eur Spine J. 2017 08; 26(8):2014-2020. PMID: 28012080.
      View in: PubMed
    10. Kishimoto M, Akeda K, Sudo A, Espinoza Orías AA, Inoue N. In vivo measurement of vertebral endplate surface area along the whole-spine. J Orthop Res. 2016 08; 34(8):1418-30. PMID: 27346338.
      View in: PubMed
    11. Zhou J, Espinoza Orías AA, Kang X, He J, Zhang Z, Inoue N, An HS. CT-based morphometric analysis of the occipital condyle: focus on occipital condyle screw insertion. J Neurosurg Spine. 2016 Nov; 25(5):572-579. PMID: 27341056.
      View in: PubMed
    12. Espinoza Orías AA, Mammoser NM, Triano JJ, An HS, Andersson GB, Inoue N. Effects of Axial Torsion on Disc Height Distribution: An In Vivo Study. J Manipulative Physiol Ther. 2016 05; 39(4):294-303. PMID: 27059249.
      View in: PubMed
    13. Yoshioka N, Ikoma K, Kido M, Imai K, Maki M, Arai Y, Fujiwara H, Tokunaga D, Inoue N, Kubo T. Weight-bearing three-dimensional computed tomography analysis of the forefoot in patients with flatfoot deformity. J Orthop Sci. 2016 Mar; 21(2):154-8. PMID: 26786344.
      View in: PubMed
    14. Akeda K, Yamada T, Inoue N, Nishimura A, Sudo A. Risk factors for lumbar intervertebral disc height narrowing: a population-based longitudinal study in the elderly. BMC Musculoskelet Disord. 2015 Nov 09; 16:344. PMID: 26552449; PMCID: PMC4640385.
      View in: PubMed, PubMed Central
    15. Yanke AB, Khair MM, Stanley R, Walton D, Lee S, Bush-Joseph CA, Espinoza Orías A, Espinosa Orias AA, Inoue N, Nho SJ. Sex Differences in Patients With CAM Deformities With Femoroacetabular Impingement: 3-Dimensional Computed Tomographic Quantification. Arthroscopy. 2015 Dec; 31(12):2301-6. PMID: 26219994.
      View in: PubMed
    16. Imai K, Ikoma K, Kido M, Maki M, Fujiwara H, Arai Y, Oda R, Tokunaga D, Inoue N, Kubo T. Joint space width of the tibiotalar joint in the healthy foot. J Foot Ankle Res. 2015; 8:26. PMID: 26146520; PMCID: PMC4490633.
      View in: PubMed, PubMed Central
    17. Munns JJ, Lee JY, Espinoza Orías AA, Takatori R, Andersson GB, An HS, Inoue N. Ligamentum flavum hypertrophy in asymptomatic and chronic low back pain subjects. PLoS One. 2015; 10(5):e0128321. PMID: 26010138; PMCID: PMC4444243.
      View in: PubMed, PubMed Central
    18. Shih YR, Phadke A, Yamaguchi T, Kang H, Inoue N, Masuda K, Varghese S. Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. Acta Biomater. 2015 Jun; 19:1-9. PMID: 25805106.
      View in: PubMed
    19. Shin JJ, Haro M, Yanke AB, Mascarenhas R, Romeo AA, Cole BJ, Inoue N, Verma NN. Topographic analysis of the capitellum and distal femoral condyle: finding the best match for treating osteochondral defects of the humeral capitellum. Arthroscopy. 2015 May; 31(5):843-9. PMID: 25636985.
      View in: PubMed
    20. Kurakawa T, Kakutani K, Morita Y, Kato Y, Yurube T, Hirata H, Miyazaki S, Terashima Y, Maeno K, Takada T, Doita M, Kurosaka M, Inoue N, Masuda K, Nishida K. Functional impact of integrin a5ß1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system. Spine J. 2015 Mar 01; 15(3):417-26. PMID: 25546513.
      View in: PubMed
    21. Yamaguchi T, Goto S, Nishigaki Y, Espinoza Orías AA, Bae WC, Masuda K, Inoue N. Microstructural analysis of three-dimensional canal network in the rabbit lumbar vertebral endplate. J Orthop Res. 2015 Feb; 33(2):270-6. PMID: 25367593.
      View in: PubMed
    22. Kido M, Ikoma K, Hara Y, Imai K, Maki M, Ikeda T, Fujiwara H, Tokunaga D, Inoue N, Kubo T. Effect of therapeutic insoles on the medial longitudinal arch in patients with flatfoot deformity: a three-dimensional loading computed tomography study. Clin Biomech (Bristol, Avon). 2014 Dec; 29(10):1095-8. PMID: 25457972; PMCID: PMC4300106.
      View in: PubMed, PubMed Central
    23. Simon P, Gupta A, Pappou I, Hussey MM, Santoni BG, Inoue N, Frankle MA. Glenoid subchondral bone density distribution in male total shoulder arthroplasty subjects with eccentric and concentric wear. J Shoulder Elbow Surg. 2015 Mar; 24(3):416-24. PMID: 25240512.
      View in: PubMed
    24. Senoo I, Espinoza Orías AA, An HS, Andersson GB, Park DK, Triano JJ, Inoue N. In vivo 3-dimensional morphometric analysis of the lumbar foramen in healthy subjects. Spine (Phila Pa 1976). 2014 Jul 15; 39(16):E929-35. PMID: 24825158; PMCID: PMC4111842.
      View in: PubMed, PubMed Central
    25. Bayne CO, Stanley R, Simon P, Espinoza-Orias A, Salata MJ, Bush-Joseph CA, Inoue N, Nho SJ. Effect of capsulotomy on hip stability-a consideration during hip arthroscopy. Am J Orthop (Belle Mead NJ). 2014 Apr; 43(4):160-5. PMID: 24730000.
      View in: PubMed
    26. Yamaguchi T, Inoue N, Sah RL, Lee YP, Taborek AP, Williams GM, Moseley TA, Bae WC, Masuda K. Micro-computed tomography-based three-dimensional kinematic analysis during lateral bending for spinal fusion assessment in a rat posterolateral lumbar fusion model. Tissue Eng Part C Methods. 2014 Jul; 20(7):578-87. PMID: 24199634; PMCID: PMC4074752.
      View in: PubMed, PubMed Central
    27. Lundberg HJ, Swanson A, Knowlton C, Inoue N, Wimmer MA. Methods for locating the tibio-femoral contact pathway in total knee replacements using marker-based gait analysis and standard radiography. Iowa Orthop J. 2014; 34:94-101. PMID: 25328466; PMCID: PMC4127717.
      View in: PubMed, PubMed Central
    28. Gupta AK, Forsythe B, Lee AS, Harris JD, McCormick F, Abrams GD, Verma NN, Romeo AA, Inoue N, Cole BJ. Topographic analysis of the glenoid and proximal medial tibial articular surfaces: a search for the ideal match for glenoid resurfacing. Am J Sports Med. 2013 Aug; 41(8):1893-9. PMID: 23857887; PMCID: PMC4074354.
      View in: PubMed, PubMed Central
    29. Iwata T, Miyamoto K, Hioki A, Ohashi M, Inoue N, Shimizu K. In vivo measurement of lumbar foramen during axial loading using a compression device and computed tomography. J Spinal Disord Tech. 2013 Jul; 26(5):E177-82. PMID: 23381186.
      View in: PubMed
    30. Kido M, Ikoma K, Imai K, Tokunaga D, Inoue N, Kubo T. Load response of the medial longitudinal arch in patients with flatfoot deformity: in vivo 3D study. Clin Biomech (Bristol, Avon). 2013 Jun; 28(5):568-73. PMID: 23643289; PMCID: PMC4098854.
      View in: PubMed, PubMed Central
    31. Kang RW, Yanke AB, Espinoza Orias AA, Orias AE, Inoue N, Nho SJ. Emerging ideas: Novel 3-D quantification and classification of cam lesions in patients with femoroacetabular impingement. Clin Orthop Relat Res. 2013 Feb; 471(2):358-62. PMID: 23129477; PMCID: PMC3549194.
      View in: PubMed, PubMed Central
    32. Takigawa T, Simon P, Espinoza Orías AA, Hong JT, Ito Y, Inoue N, An HS. Biomechanical comparison of occiput-C1-C2 fixation techniques: C0-C1 transarticular screw and direct occiput condyle screw. Spine (Phila Pa 1976). 2012 May 20; 37(12):E696-701. PMID: 22158063.
      View in: PubMed
    33. Simon P, Espinoza Orías AA, Andersson GB, An HS, Inoue N. In vivo topographic analysis of lumbar facet joint space width distribution in healthy and symptomatic subjects. Spine (Phila Pa 1976). 2012 May 20; 37(12):1058-64. PMID: 22433501; PMCID: PMC3685171.
      View in: PubMed, PubMed Central
    34. Chan EF, Harjanto R, Asahara H, Inoue N, Masuda K, Bugbee WD, Firestein GS, Hosalkar HS, Lotz MK, Sah RL. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am. 2012 Apr; 43(2):173-85, v. PMID: 22480467; PMCID: PMC3321216.
      View in: PubMed, PubMed Central
    35. Watanabe S, Inoue N, Yamaguchi T, Hirano Y, Espinoza Orías AA, Nishida S, Hirose Y, Mizuno J. Three-dimensional kinematic analysis of the cervical spine after anterior cervical decompression and fusion at an adjacent level: a preliminary report. Eur Spine J. 2012 May; 21(5):946-55. PMID: 22124708; PMCID: PMC3337902.
      View in: PubMed, PubMed Central
    36. Kido M, Ikoma K, Imai K, Maki M, Takatori R, Tokunaga D, Inoue N, Kubo T. Load response of the tarsal bones in patients with flatfoot deformity: in vivo 3D study. Foot Ankle Int. 2011 Nov; 32(11):1017-22. PMID: 22338949.
      View in: PubMed
    37. Inoue N, Espinoza Orías AA. Biomechanics of intervertebral disk degeneration. Orthop Clin North Am. 2011 Oct; 42(4):487-99, vii. PMID: 21944586; PMCID: PMC3183968.
      View in: PubMed, PubMed Central
    38. Bhatia A, Albazzaz M, Espinoza Orías AA, Inoue N, Miller LM, Acerbo A, George A, Sumner DR. Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo. J Mech Behav Biomed Mater. 2012 Jan; 5(1):1-8. PMID: 22100074; PMCID: PMC3222863.
      View in: PubMed, PubMed Central
    39. Hong JT, Takigawa T, Udayakunmar R, Shin HK, Simon P, Espinoza Orías AA, Inoue N, An HS. Biomechanical effect of the C2 laminar decortication on the stability of C2 intralaminar screw construct and biomechanical comparison of C2 intralaminar screw and C2 pars screw. Neurosurgery. 2011 Sep; 69(1 Suppl Operative):ons1-6; discussion ons6-7. PMID: 21415794.
      View in: PubMed
    40. Imai K, Ikoma K, Maki M, Kido M, Tsuji Y, Takatori R, Tokunaga D, Inoue N, Kubo T. Features of hindfoot 3D kinetics in flat foot in ankle-joint maximal dorsiflexion and plantarflexion. J Orthop Sci. 2011 Sep; 16(5):638-43. PMID: 21674204.
      View in: PubMed
    41. Hioki A, Miyamoto K, Shimizu K, Inoue N. Test-retest repeatability of lumbar sagittal alignment and disc height measurements with or without axial loading: a computed tomography study. J Spinal Disord Tech. 2011 Apr; 24(2):93-8. PMID: 21430497.
      View in: PubMed
    42. Hong JT, Tomoyuki T, Udayakumar R, Espinoza Orías AA, Inoue N, An HS. Biomechanical comparison of three different types of C7 fixation techniques. Spine (Phila Pa 1976). 2011 Mar 01; 36(5):393-8. PMID: 21325933.
      View in: PubMed
    43. Hong JT, Takigawa T, Sugisaki K, Espinoza Orías AA, Inoue N, An HS. Biomechanical and morphometric evaluation of occipital condyle for occipitocervical segmental fixation. Neurol Med Chir (Tokyo). 2011; 51(10):701-6. PMID: 22027245.
      View in: PubMed
    44. Takatori R, Tokunaga D, Hase H, Mikami Y, Ikeda T, Harada T, Imai K, Ito H, Nishimura T, An HS, Inoue N, Kubo T. Three-dimensional morphology and kinematics of the craniovertebral junction in rheumatoid arthritis. Spine (Phila Pa 1976). 2010 Nov 01; 35(23):E1278-84. PMID: 20736886.
      View in: PubMed
    45. Takigawa T, Espinoza Orías AA, An HS, Gohgi S, Udayakumar RK, Sugisaki K, Natarajan RN, Wimmer MA, Inoue N. Spinal kinematics and facet load transmission after total disc replacement. Spine (Phila Pa 1976). 2010 Oct 15; 35(22):E1160-6. PMID: 20881657.
      View in: PubMed
    46. Nakajima M, Inoue M, Hojo T, Inoue N, Tanaka K, Takatori R, Itoi M. Effect of electroacupuncture on the healing process of tibia fracture in a rat model: a randomised controlled trial. Acupunct Med. 2010 Sep; 28(3):140-3. PMID: 20615854.
      View in: PubMed
    47. Otsuka Y, An HS, Ochia RS, Andersson GB, Espinoza Orías AA, Inoue N. In vivo measurement of lumbar facet joint area in asymptomatic and chronic low back pain subjects. Spine (Phila Pa 1976). 2010 Apr 15; 35(8):924-8. PMID: 20354471; PMCID: PMC2855783.
      View in: PubMed, PubMed Central
    48. Sugisaki K, An HS, Espinoza Orías AA, Rhim R, Andersson GB, Inoue N. In vivo three-dimensional morphometric analysis of the lumbar pedicle isthmus. Spine (Phila Pa 1976). 2009 Nov 15; 34(24):2599-604. PMID: 19910763; PMCID: PMC2810254.
      View in: PubMed, PubMed Central
    49. Imai K, Tokunaga D, Takatori R, Ikoma K, Maki M, Ohkawa H, Ogura A, Tsuji Y, Inoue N, Kubo T. In vivo three-dimensional analysis of hindfoot kinematics. Foot Ankle Int. 2009 Nov; 30(11):1094-100. PMID: 19912721.
      View in: PubMed
    50. Fukuroku J, Inoue N, Rafiee B, Sim FH, Frassica FJ, Chao EY. Extracortical bone-bridging fixation with use of cortical allograft and recombinant human osteogenic protein-1. J Bone Joint Surg Am. 2007 Jul; 89(7):1486-96. PMID: 17606787.
      View in: PubMed
    51. Urban RM, Turner TM, Hall DJ, Inoue N, Gitelis S. Increased bone formation using calcium sulfate-calcium phosphate composite graft. Clin Orthop Relat Res. 2007 Jun; 459:110-7. PMID: 17415007.
      View in: PubMed
    52. Ochia RS, Inoue N, Takatori R, Andersson GB, An HS. In vivo measurements of lumbar segmental motion during axial rotation in asymptomatic and chronic low back pain male subjects. Spine (Phila Pa 1976). 2007 Jun 01; 32(13):1394-9. PMID: 17545906.
      View in: PubMed
    53. Miyamoto K, Masuda K, Kim JG, Inoue N, Akeda K, Andersson GB, An HS. Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J. 2006 Nov-Dec; 6(6):692-703. PMID: 17088200.
      View in: PubMed
    54. An HS, Masuda K, Inoue N. Intervertebral disc degeneration: biological and biomechanical factors. J Orthop Sci. 2006 Oct; 11(5):541-52. PMID: 17013747; PMCID: PMC2778630.
      View in: PubMed, PubMed Central
    55. Ochia RS, Inoue N, Renner SM, Lorenz EP, Lim TH, Andersson GB, An HS. Three-dimensional in vivo measurement of lumbar spine segmental motion. Spine (Phila Pa 1976). 2006 Aug 15; 31(18):2073-8. PMID: 16915091.
      View in: PubMed
    56. Miyamoto K, Masuda K, Inoue N, Okuma M, Muehleman C, An HS. Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model: a biomechanical, biochemical, and histologic study. Spine (Phila Pa 1976). 2006 Feb 15; 31(4):E91-7. PMID: 16481942.
      View in: PubMed
    57. Higuera CA, Inoue N, Lim JS, Zhang R, Dimaano N, Frassica FJ, Chao EY. Tendon reattachment to a metallic implant using an allogenic bone plate augmented with rhOP-1 vs. autogenous cancellous bone and marrow in a canine model. J Orthop Res. 2005 Sep; 23(5):1091-9. PMID: 16140192.
      View in: PubMed
    58. Virolainen P, Inoue N, Nagao M, Frassica FJ, Chao EY. The effect of multidrug chemotherapy on bone graft augmented prosthesis fixation. J Orthop Res. 2005 Jul; 23(4):795-801. PMID: 16022992.
      View in: PubMed
    59. Jones KB, Inoue N, Tis JE, McCarthy EF, McHale KA, Chao EY. Quantification of the microstructural anisotropy of distraction osteogenesis in the rabbit tibia. Iowa Orthop J. 2005; 25:118-22. PMID: 16089083; PMCID: PMC1888786.
      View in: PubMed, PubMed Central
    60. Chao EY, Inoue N, Koo TK, Kim YH. Biomechanical considerations of fracture treatment and bone quality maintenance in elderly patients and patients with osteoporosis. Clin Orthop Relat Res. 2004 Aug; (425):12-25. PMID: 15292783.
      View in: PubMed
    61. Elshahat A, Shermak MA, Inoue N, Chao EY, Manson P. The use of Novabone and Norian in cranioplasty: a comparative study. J Craniofac Surg. 2004 May; 15(3):483-9. PMID: 15111816.
      View in: PubMed
    62. Lietman SA, Hobbs W, Inoue N, Reddi AH. Effects of selected growth factors on porcine meniscus in chemically defined medium. Orthopedics. 2003 Aug; 26(8):799-803. PMID: 12938945.
      View in: PubMed
    63. Matsuura M, Lounici S, Inoue N, Walulik S, Chao EY. Assessment of external fixator reusability using load- and cycle-dependent tests. Clin Orthop Relat Res. 2003 Jan; (406):275-81. PMID: 12579028.
      View in: PubMed
    64. Cullinane DM, Lietman SA, Inoue N, Deitz LW, Chao EY. The effect of recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation on allografts in a canine intercalary bone defect. J Orthop Res. 2002 Nov; 20(6):1240-5. PMID: 12472235.
      View in: PubMed
    65. Inoue N, Ohnishi I, Chen D, Deitz LW, Schwardt JD, Chao EY. Effect of pulsed electromagnetic fields (PEMF) on late-phase osteotomy gap healing in a canine tibial model. J Orthop Res. 2002 Sep; 20(5):1106-14. PMID: 12382979.
      View in: PubMed
    66. Kim YH, Inoue N, Chao EY. Kinematic simulation of fracture reduction and bone deformity correction under unilateral external fixation. J Biomech. 2002 Aug; 35(8):1047-58. PMID: 12126664.
      View in: PubMed
    67. Tis JE, Meffert CR, Inoue N, McCarthy EF, Machen MS, McHale KA, Chao EY. The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis. J Orthop Res. 2002 Jul; 20(4):793-800. PMID: 12168669.
      View in: PubMed
    68. Machen MS, Tis JE, Inoue N, Meffert RH, Chao EY, McHale KA. The effect of low intensity pulsed ultrasound on regenerate bone in a less-than-rigid biomechanical environment. Biomed Mater Eng. 2002; 12(3):239-47. PMID: 12446939.
      View in: PubMed
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