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This is a "connection" page, showing publications co-authored by Nadim Hallab and Joshua Jacobs.
Nadim Hallab
Connection Strength
7.077
Joshua Jacobs
  1. Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris. Front Endocrinol (Lausanne). 2017; 8:5.
    View in: PubMed
    Score: 0.581
  2. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res. 2013 Feb; 31(2):173-82.
    View in: PubMed
    Score: 0.428
  3. In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation. J Biomed Mater Res A. 2010 Feb; 92(2):667-82.
    View in: PubMed
    Score: 0.358
  4. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009; 67(2):182-8.
    View in: PubMed
    Score: 0.332
  5. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res. 2008 Feb 13; 3:6.
    View in: PubMed
    Score: 0.313
  6. Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity? J Bone Joint Surg Am. 2006 Jun; 88(6):1171-2.
    View in: PubMed
    Score: 0.278
  7. Effects of soluble metals on human peri-implant cells. J Biomed Mater Res A. 2005 Jul 01; 74(1):124-40.
    View in: PubMed
    Score: 0.261
  8. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res. 2005 Mar; 23(2):384-91.
    View in: PubMed
    Score: 0.255
  9. Immune responses correlate with serum-metal in metal-on-metal hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):88-93.
    View in: PubMed
    Score: 0.250
  10. Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements. J Orthop Res. 2004 Mar; 22(2):250-9.
    View in: PubMed
    Score: 0.238
  11. Establishing clinically meaningful ranges of metal hypersensitivity in orthopaedic patients using COVID-19 vaccine-induced adaptive immune responses from fully vaccinated adults. J Orthop. 2024 Feb; 48:89-95.
    View in: PubMed
    Score: 0.233
  12. Spinal implant debris-induced osteolysis. Spine (Phila Pa 1976). 2003 Oct 15; 28(20):S125-38.
    View in: PubMed
    Score: 0.232
  13. Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation. J Biomed Mater Res A. 2003 Jun 01; 65(3):311-8.
    View in: PubMed
    Score: 0.226
  14. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002 Jun 05; 60(3):420-33.
    View in: PubMed
    Score: 0.211
  15. COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively. J Orthop Surg Res. 2021 Jun 30; 16(1):415.
    View in: PubMed
    Score: 0.198
  16. Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner. PLoS One. 2021; 16(5):e0251885.
    View in: PubMed
    Score: 0.196
  17. Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity? Clin Orthop Relat Res. 2020 04; 478(4):752-766.
    View in: PubMed
    Score: 0.181
  18. Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336.
    View in: PubMed
    Score: 0.167
  19. CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model. Open Orthop J. 2018; 12:115-124.
    View in: PubMed
    Score: 0.158
  20. Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences. J Bone Joint Surg Am. 2017 Apr 19; 99(8):621-628.
    View in: PubMed
    Score: 0.148
  21. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation. PLoS One. 2016; 11(7):e0160141.
    View in: PubMed
    Score: 0.140
  22. TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles. J Orthop Res. 2017 05; 35(5):1007-1017.
    View in: PubMed
    Score: 0.140
  23. The pathology of orthopedic implant failure is mediated by innate immune system cytokines. Mediators Inflamm. 2014; 2014:185150.
    View in: PubMed
    Score: 0.120
  24. Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences. J Long Term Eff Med Implants. 2014; 24(1):77-88.
    View in: PubMed
    Score: 0.118
  25. Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2013 Oct; 42(10):E84-7.
    View in: PubMed
    Score: 0.115
  26. Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42.
    View in: PubMed
    Score: 0.113
  27. Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure. PLoS One. 2013; 8(6):e67127.
    View in: PubMed
    Score: 0.113
  28. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am. 2013 Mar 20; 95(6):512-8.
    View in: PubMed
    Score: 0.111
  29. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Orthopedics. 2012 May; 35(5):386-91.
    View in: PubMed
    Score: 0.105
  30. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res A. 2010 Jun 15; 93(4):1312-21.
    View in: PubMed
    Score: 0.092
  31. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54.
    View in: PubMed
    Score: 0.086
  32. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009 Feb; 17(2):69-76.
    View in: PubMed
    Score: 0.084
  33. Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+. J Biomed Mater Res A. 2008 Sep 15; 86(4):905-13.
    View in: PubMed
    Score: 0.081
  34. Wear particles. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:99-102.
    View in: PubMed
    Score: 0.069
  35. The biology of alternative bearing surfaces in total joint arthroplasty. Instr Course Lect. 2005; 54:481-93.
    View in: PubMed
    Score: 0.063
  36. Can metal levels be used to monitor metal-on-metal hip arthroplasties? J Arthroplasty. 2004 Dec; 19(8 Suppl 3):59-65.
    View in: PubMed
    Score: 0.063
  37. Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res. 2003 Dec; (417):139-47.
    View in: PubMed
    Score: 0.058
  38. Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels - An in-vitro study. J Mech Behav Biomed Mater. 2021 06; 118:104443.
    View in: PubMed
    Score: 0.048
  39. In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH. Med Eng Phys. 2018 02; 52:1-9.
    View in: PubMed
    Score: 0.039
  40. Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation. J Mech Behav Biomed Mater. 2016 09; 62:570-587.
    View in: PubMed
    Score: 0.035
  41. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010 Aug; 468(8):2017-23.
    View in: PubMed
    Score: 0.023
  42. Stem diameter and rotational stability in revision total hip arthroplasty: a biomechanical analysis. J Orthop Surg Res. 2006 Oct 02; 1:5.
    View in: PubMed
    Score: 0.018
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.