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Tibor Glant

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-9733
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    Collapse Overview 
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    Additional Appointments:
    Professor, Department of Internal Medicine, Section of Rheumatology

    Overview:
    Originally as a physician (working in internal medicine/rheumatology and then in histopathology as well), after spending three years in full-time research (Joint Diseases Laboratories, Shriners Hospital, Montreal, Canada and NIH/NIDR Bethesda), I have fundamentally changed my career converting my clinical experience and training to biomedical science. My major research interest during the past 25 years has been autoimmunity and autoimmune regulation of T and B cells in rheumatoid arthritis (RA) and ankylosing spondylitis (AS), and its corresponding animal models. I have generated monoclonal antibodies (mAbs) to cartilage antigenic components, and used these mAbs for immuno-electron microscopic localization of cartilage matrix molecules in aging and diseased cartilages. During the production of mAbs, serendipitously, I “discovered” cartilage proteoglycan (PG) aggrecan-induced arthritis (PGIA) in genetically susceptible (arthritis-prone) BALB/c mice.
    During the past 15 years, I/we have acquired extensive experience in genetics, breeding and genotyping mice as well as generating various constructs (>20) for transgenic and gene-deficient mice, including a few PG epitope-specific TCR-Tg mice. I am personally experienced essentially in all immunology and molecular biology methods, and most recently, those methods which are detecting epigenome alterations. The first (and only) genome-wide association study (GWAS) for arthritis susceptibility in mice (funded by the NIH between 1999 and 2009) identified numerous quantitative trait loci (QTLs) in F2 generations of various genetic combinations, of which 8 QTLs overlap with those RA risk loci described so far in human GWASs.
    I have had a long-standing interest and commitment to training of medical students for histopathology, and later on scientists and physician-scientists. In addition to mentoring pre- and postdoctoral trainees in my laboratory and faculty members, I was PI of numerous NIH grants; I was always funded since I moved to the USA.

    My Scopus ID is 56247794000.
    My NIH COMMONS name is TGLANT.

    Education:
    MD, Medical University of Debrecen, Hungary (Medicine)
    PhD, Medical University of Debrecen, Hungary (Immunology/Biochemistry)
    D.M.Sc, Hungarian Academy of Sciences, Budapest(Medical Sciences)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tseng HW, Glant TT, Brown MA, Kenna TJ, Thomas GP, Pettit AR. Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis. BMC Musculoskelet Disord. 2017 May 30; 18(1):228. PMID: 28558827.
      View in: PubMed
    2. Markovics A, Ocskó T, Katz RS, Buzás EI, Glant TT, Mikecz K. Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. PLoS One. 2016; 11(7):e0160284. PMID: 27466816; PMCID: PMC4965111.
    3. Boldizsar F, Tarjanyi O, Olasz K, Hegyi A, Mikecz K, Glant TT, Rauch TA. FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. Cardiovasc Pathol. 2016 Sep-Oct; 25(5):353-61. PMID: 27288745.
      View in: PubMed
    4. Nesterovitch AB, Arbieva Z, Toth DM, Tharp MD, Glant TT. A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice. J Dermatol Sci. 2016 Jul; 83(1):17-25. PMID: 27020408.
      View in: PubMed
    5. Glant TT, Ocsko T, Markovics A, Szekanecz Z, Katz RS, Rauch TA, Mikecz K. Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage. PLoS One. 2016; 11(3):e0150784. PMID: 26943656; PMCID: PMC4778950.
    6. de Wolf C, van der Zee R, den Braber I, Glant T, Maillère B, Favry E, van Lummel M, Koning F, Hoek A, Ludwig I, van Eden W, Broere F. An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA-Restricted T Cell Responses. Arthritis Rheumatol. 2016 Mar; 68(3):639-47. PMID: 26414917.
      View in: PubMed
    7. Tseng HW, Pitt ME, Glant TT, McRae AF, Kenna TJ, Brown MA, Pettit AR, Thomas GP. Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: sequential not parallel processes. Arthritis Res Ther. 2016 Jan 29; 18:35. PMID: 26831337; PMCID: PMC4734853.
    8. Kugyelka R, Kohl Z, Olasz K, Mikecz K, Rauch TA, Glant TT, Boldizsar F. Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis. Mediators Inflamm. 2016; 2016:6145810. PMID: 26903711; PMCID: PMC4745575.
    9. Haynes KR, Tseng HW, Kneissel M, Glant TT, Brown MA, Thomas GP. Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression. BMC Musculoskelet Disord. 2015 Nov 26; 16:368. PMID: 26612313; PMCID: PMC4662039.
    10. Rosenthal KS, Mikecz K, Steiner HL, Glant TT, Finnegan A, Carambula RE, Zimmerman DH. Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis. Expert Rev Vaccines. 2015 Jun; 14(6):891-908. PMID: 25787143; PMCID: PMC4786169.
    11. Kurkó J, Vida A, Ocskó T, Tryniszewska B, Rauch TA, Glant TT, Szekanecz Z, Mikecz K. Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow. PLoS One. 2014; 9(11):e111815. PMID: 25369029; PMCID: PMC4219784.
    12. Kurkó J, Vida A, Glant TT, Scanzello CR, Katz RS, Nair A, Szekanecz Z, Mikecz K. Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study. BMC Musculoskelet Disord. 2014 Aug 19; 15:281. PMID: 25138129; PMCID: PMC4152562.
    13. Glant TT, Mikecz K, Rauch TA. Epigenetics in the pathogenesis of rheumatoid arthritis. BMC Med. 2014 Feb 26; 12:35. PMID: 24568138; PMCID: PMC3936819.
    14. Delemarre EM, Roord ST, van den Broek T, Zonneveld-Huijssoon E, de Jager W, Rozemuller H, Martens AC, Broere F, Wulffraat NM, Glant TT, Prakken BJ, van Wijk F. Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the Teff cell compartment. Arthritis Rheumatol. 2014 Feb; 66(2):350-6. PMID: 24504807; PMCID: PMC4131556.
    15. Hanyecz A, Olasz K, Tarjanyi O, Nemeth P, Mikecz K, Glant TT, Boldizsar F. Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis. Biomed Res Int. 2014; 2014:942148. PMID: 24605340; PMCID: PMC3925549.
    16. Kobezda T, Ghassemi-Nejad S, Mikecz K, Glant TT, Szekanecz Z. Of mice and men: how animal models advance our understanding of T-cell function in RA. Nat Rev Rheumatol. 2014 Mar; 10(3):160-70. PMID: 24394350; PMCID: PMC3953227.
    17. Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Genetics of rheumatoid arthritis - a comprehensive review. Clin Rev Allergy Immunol. 2013 Oct; 45(2):170-9. PMID: 23288628; PMCID: PMC3655138.
    18. Glant TT, Besenyei T, Kádár A, Kurkó J, Tryniszewska B, Gál J, Soós G, Szekanecz Z, Hoffmann G, Block JA, Katz RS, Mikecz K, Rauch TA. Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models. Arthritis Rheum. 2013 Jul; 65(7):1725-35. PMID: 23653330; PMCID: PMC4102319.
    19. Szekanecz Z, Meskó B, Poliska S, Váncsa A, Szamosi S, Végh E, Simkovics E, Laki J, Kurkó J, Besenyei T, Mikecz K, Glant TT, Nagy L. Pharmacogenetics and pharmacogenomics in rheumatology. Immunol Res. 2013 Jul; 56(2-3):325-33. PMID: 23564183; PMCID: PMC4139282.
    20. Rodeghero R, Cao Y, Olalekan SA, Iwakua Y, Glant TT, Finnegan A. Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J Immunol. 2013 Jun 01; 190(11):5423-35. PMID: 23630349; PMCID: PMC3690552.
    21. Misják P, Bosze S, Horváti K, Pásztói M, Pálóczi K, Holub MC, Szakács F, Aradi B, György B, Szabó TG, Nagy G, Glant TT, Mikecz K, Falus A, Buzás EI. The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis. Immunol Lett. 2013 Apr; 152(1):25-31. PMID: 23578666.
      View in: PubMed
    22. Besenyei T, Kadar A, Tryniszewska B, Kurko J, Rauch TA, Glant TT, Mikecz K, Szekanecz Z. Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models. Clin Dev Immunol. 2012; 2012:284751. PMID: 23251214; PMCID: PMC3521484.
    23. Haynes KR, Pettit AR, Duan R, Tseng HW, Glant TT, Brown MA, Thomas GP. Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors. Arthritis Res Ther. 2012 Nov 22; 14(6):R253. PMID: 23171658; PMCID: PMC3674607.
    24. Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A. Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013 Jan 04; 288(1):205-14. PMID: 23166324; PMCID: PMC3537015.
    25. Egelston C, Kurkó J, Besenyei T, Tryniszewska B, Rauch TA, Glant TT, Mikecz K. Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis. Arthritis Rheum. 2012 Oct; 64(10):3179-88. PMID: 22492217; PMCID: PMC3402579.
    26. Kobezda T, Ghassemi-Nejad S, Glant TT, Mikecz K. In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis. Cell Immunol. 2012 Jul-Aug; 278(1-2):158-65. PMID: 23023071; PMCID: PMC3489964.
    27. Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, Glant TT, Malfait AM, Crow MK, Spear GT, Finnegan A, Scanzello CR. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012 Jul; 64(7):2268-77. PMID: 22492243; PMCID: PMC3386375.
    28. Kis-Toth K, Radacs M, Olasz K, van Eden W, Mikecz K, Glant TT. Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice. Int Immunol. 2012 Aug; 24(8):507-17. PMID: 22518822; PMCID: PMC3406935.
    29. Glant TT, Adarichev VA, Boldizsar F, Besenyei T, Laszlo A, Mikecz K, Rauch TA. Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis. Genes Immun. 2012 Jun; 13(4):336-45. PMID: 22402741; PMCID: PMC3524972.
    30. Kezic JM, Davey MP, Glant TT, Rosenbaum JT, Rosenzweig HL. Interferon-? regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis. Arthritis Rheum. 2012 Mar; 64(3):762-71. PMID: 21987263; PMCID: PMC3271189.
    31. Olasz K, Boldizsar F, Kis-Toth K, Tarjanyi O, Hegyi A, van Eden W, Rauch TA, Mikecz K, Glant TT. T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice. Clin Exp Immunol. 2012 Feb; 167(2):346-55. PMID: 22236012; PMCID: PMC3278702.
    32. Kezic JM, Glant TT, Rosenbaum JT, Rosenzweig HL. Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis. Arthritis Res Ther. 2012 Jan 23; 14(1):R18. PMID: 22269151; PMCID: PMC3392808.
    33. Hamel KM, Cao Y, Ashaye S, Wang Y, Dunn R, Kehry MR, Glant TT, Finnegan A. B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis. J Immunol. 2011 Nov 01; 187(9):4900-6. PMID: 21948985; PMCID: PMC3242639.
    34. Nesterovitch AB, Hoffman MD, Simon M, Petukhov PA, Tharp MD, Glant TT. Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum. Clin Exp Dermatol. 2011 Dec; 36(8):889-95. PMID: 21790734.
      View in: PubMed
    35. Nagyeri G, Radacs M, Ghassemi-Nejad S, Tryniszewska B, Olasz K, Hutas G, Gyorfy Z, Hascall VC, Glant TT, Mikecz K. TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin. J Biol Chem. 2011 Jul 01; 286(26):23559-69. PMID: 21566135; PMCID: PMC3123119.
    36. Glant TT, Radacs M, Nagyeri G, Olasz K, Laszlo A, Boldizsar F, Hegyi A, Finnegan A, Mikecz K. Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis. Arthritis Rheum. 2011 May; 63(5):1312-21. PMID: 21305522; PMCID: PMC3086933.
    37. Nesterovitch AB, Szanto S, Gonda A, Bardos T, Kis-Toth K, Adarichev VA, Olasz K, Ghassemi-Najad S, Hoffman MD, Tharp MD, Mikecz K, Glant TT. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011 Apr; 178(4):1701-14. PMID: 21435452; PMCID: PMC3078426.
    38. Nesterovitch AB, Gyorfy Z, Hoffman MD, Moore EC, Elbuluk N, Tryniszewska B, Rauch TA, Simon M, Kang S, Fisher GJ, Mikecz K, Tharp MD, Glant TT. Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses. Am J Pathol. 2011 Apr; 178(4):1434-41. PMID: 21406173; PMCID: PMC3078441.
    39. Ghassemi-Nejad S, Kobezda T, Rauch TA, Matesz C, Glant TT, Mikecz K. Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis. Osteoarthritis Cartilage. 2011 Apr; 19(4):458-65. PMID: 21262368; PMCID: PMC3065523.
    40. Boldizsar F, Kis-Toth K, Tarjanyi O, Olasz K, Hegyi A, Mikecz K, Glant TT. Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice. Arthritis Rheum. 2010 Oct; 62(10):2984-94. PMID: 20564001; PMCID: PMC2952044.
    41. Carulli D, Pizzorusso T, Kwok JC, Putignano E, Poli A, Forostyak S, Andrews MR, Deepa SS, Glant TT, Fawcett JW. Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain. 2010 Aug; 133(Pt 8):2331-47. PMID: 20566484.
      View in: PubMed
    42. Boldizsar F, Mikecz K, Glant TT. Immunosenescence and its potential modulation: lessons from mouse models. Expert Rev Clin Immunol. 2010 May; 6(3):353-7. PMID: 20441421.
      View in: PubMed
    43. Angyal A, Egelston C, Kobezda T, Olasz K, László A, Glant TT, Mikecz K. Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints. Arthritis Res Ther. 2010; 12(2):R44. PMID: 20298547; PMCID: PMC2888192.
    44. de Jong H, Berlo SE, Hombrink P, Otten HG, van Eden W, Lafeber FP, Heurkens AH, Bijlsma JW, Glant TT, Prakken BJ. Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 2010 Jan; 69(1):255-62. PMID: 19213744.
      View in: PubMed
    45. Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Mikecz K, Glant TT, Iwakura Y, Finnegan A. IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol. 2010 Feb 01; 184(3):1552-9. PMID: 20028652; PMCID: PMC2846113.
    46. Végvári A, Szabó Z, Szántó S, Glant TT, Mikecz K, Szekanecz Z. The genetic background of ankylosing spondylitis. Joint Bone Spine. 2009 Dec; 76(6):623-8. PMID: 19541528.
      View in: PubMed
    47. Tarjanyi O, Boldizsar F, Nemeth P, Mikecz K, Glant TT. Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. Immun Ageing. 2009 Jun 11; 6:8. PMID: 19519881; PMCID: PMC2704168.
    48. Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol. 2009 May; 21(5):511-22. PMID: 19254958; PMCID: PMC2675029.
    49. Farkas B, Boldizsar F, Tarjanyi O, Laszlo A, Lin SM, Hutas G, Tryniszewska B, Mangold A, Nagyeri G, Rosenzweig HL, Finnegan A, Mikecz K, Glant TT. BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance. Arthritis Res Ther. 2009; 11(1):R21. PMID: 19220900; PMCID: PMC2688253.
    50. Wieten L, Berlo SE, Ten Brink CB, van Kooten PJ, Singh M, van der Zee R, Glant TT, Broere F, van Eden W. IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis. PLoS One. 2009; 4(1):e4186. PMID: 19142233; PMCID: PMC2617761.
    51. Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJ, Flavell RA, Kobayashi KS, Rosenbaum JT, Davey MP. Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis. J Leukoc Biol. 2009 Apr; 85(4):711-8. PMID: 19129483; PMCID: PMC2718807.
    52. Hutás G, Bajnok E, Gál I, Finnegan A, Glant TT, Mikecz K. CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis. Blood. 2008 Dec 15; 112(13):4999-5006. PMID: 18815286; PMCID: PMC2597605.
    53. Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008 Aug; 58(8):2397-408. PMID: 18668542.
      View in: PubMed
    54. Adarichev VA, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant TT. Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation. Genes Immun. 2008 Oct; 9(7):591-601. PMID: 18650834; PMCID: PMC3951374.
    55. Glant TT, Szántó S, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Adarichev VA. Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation. J Immunol. 2008 Jul 15; 181(2):1307-14. PMID: 18606685.
      View in: PubMed
    56. Rosenzweig HL, Martin TM, Planck SR, Jann MM, Smith JR, Glant TT, van Eden W, Davey MP, Rosenbaum JT. Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. Ophthalmic Res. 2008; 40(3-4):189-92. PMID: 18421237.
      View in: PubMed
    57. Cao Y, Doodes PD, Glant TT, Finnegan A. IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. J Immunol. 2008 Jan 15; 180(2):922-30. PMID: 18178832.
      View in: PubMed
    58. Tunyogi-Csapo M, Koreny T, Vermes C, Galante JO, Jacobs JJ, Glant TT. Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. J Orthop Res. 2007 Oct; 25(10):1378-88. PMID: 17557346.
      View in: PubMed
    59. Cao Y, Brombacher F, Tunyogi-Csapo M, Glant TT, Finnegan A. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum. 2007 Mar; 56(3):861-70. PMID: 17330244.
      View in: PubMed
    60. Szántó S, Koreny T, Mikecz K, Glant TT, Szekanecz Z, Varga J. Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice. Arthritis Res Ther. 2007; 9(3):R50. PMID: 17511858; PMCID: PMC2206348.
    61. O'Neill SK, Glant TT, Finnegan A. The role of B cells in animal models of rheumatoid arthritis. Front Biosci. 2007 Jan 01; 12:1722-36. PMID: 17127417.
      View in: PubMed
    62. Adarichev VA, Vermes C, Hanyecz A, Ludanyi K, Tunyogi-Csapo M, Finnegan A, Mikecz K, Glant TT. Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis. Autoimmunity. 2006 Dec; 39(8):663-73. PMID: 17178563.
      View in: PubMed
    63. Koreny T, Tunyogi-Csapó M, Gál I, Vermes C, Jacobs JJ, Glant TT. The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis. Arthritis Rheum. 2006 Oct; 54(10):3221-32. PMID: 17009257.
      View in: PubMed
    64. Sarraj B, Ludányi K, Glant TT, Finnegan A, Mikecz K. Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis. J Immunol. 2006 Aug 01; 177(3):1932-40. PMID: 16849507.
      View in: PubMed
    65. Berlo SE, Guichelaar T, Ten Brink CB, van Kooten PJ, Hauet-Broeren F, Ludanyi K, van Eden W, Broeren CP, Glant TT. Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice. Arthritis Rheum. 2006 Aug; 54(8):2423-33. PMID: 16869010.
      View in: PubMed
    66. Adarichev VA, Glant TT. Experimental spondyloarthropathies: animal models of ankylosing spondylitis. Curr Rheumatol Rep. 2006 Aug; 8(4):267-74. PMID: 16839505.
      View in: PubMed
    67. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris. J Biomed Mater Res A. 2006 Apr; 77(1):192-201. PMID: 16392133.
      View in: PubMed
    68. Murad YM, Szabó Z, Ludányi K, Glant TT. Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan. Clin Exp Immunol. 2005 Nov; 142(2):303-11. PMID: 16232217; PMCID: PMC1809506.
    69. Berlo SE, van Kooten PJ, Ten Brink CB, Hauet-Broere F, Oosterwegel MA, Glant TT, Van Eden W, Broeren CP. Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation. J Autoimmun. 2005 Nov; 25(3):172-80. PMID: 16257179.
      View in: PubMed
    70. Gál I, Bajnok E, Szántó S, Sarraj B, Glant TT, Mikecz K. Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis. Arthritis Rheum. 2005 Oct; 52(10):3269-78. PMID: 16206283.
      View in: PubMed
    71. Buzás EI, Végvári A, Murad YM, Finnegan A, Mikecz K, Glant TT. T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis. Cell Immunol. 2005 Jun; 235(2):98-108. PMID: 16185673.
      View in: PubMed
    72. Gonda A, Gál I, Szántó S, Sarraj B, Glant TT, Hunyadi J, Mikecz K. CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis. Exp Dermatol. 2005 Sep; 14(9):700-8. PMID: 16098130.
      View in: PubMed
    73. Végvári A, Szabó Z, Szántó S, Nesterovitch AB, Mikecz K, Glant TT, Adarichev VA. Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy. J Immunol. 2005 Aug 15; 175(4):2475-83. PMID: 16081819.
      View in: PubMed
    74. Szabó Z, Szántó S, Végvári A, Szekanecz Z, Mikecz K, Glant TT. Genetic control of experimental spondylarthropathy. Arthritis Rheum. 2005 Aug; 52(8):2452-60. PMID: 16059927.
      View in: PubMed
    75. Fritz EA, Jacobs JJ, Glant TT, Roebuck KA. Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-kappaB. J Orthop Res. 2005 Nov; 23(6):1249-57. PMID: 15950427.
      View in: PubMed
    76. O'Neill SK, Shlomchik MJ, Glant TT, Cao Y, Doodes PD, Finnegan A. Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol. 2005 Mar 15; 174(6):3781-8. PMID: 15749919.
      View in: PubMed
    77. Hallab NJ, Anderson S, Stafford T, Glant T, Jacobs JJ. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res. 2005 Mar; 23(2):384-91. PMID: 15734252.
      View in: PubMed
    78. Bárdos T, Szabó Z, Czipri M, Vermes C, Tunyogi-Csapó M, Urban RM, Mikecz K, Glant TT. A longitudinal study on an autoimmune murine model of ankylosing spondylitis. Ann Rheum Dis. 2005 Jul; 64(7):981-7. PMID: 15640265; PMCID: PMC1755557.
    79. Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol. 2004 Dec 15; 173(12):7135-9. PMID: 15585834.
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    80. Adarichev VA, Vermes C, Hanyecz A, Mikecz K, Bremer EG, Glant TT. Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation. Arthritis Res Ther. 2005; 7(2):R196-207. PMID: 15743466; PMCID: PMC1065315.
    81. Szántó S, Bárdos T, Gál I, Glant TT, Mikecz K. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice. Arthritis Rheum. 2004 Sep; 50(9):3012-22. PMID: 15457471.
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    82. Vermes C, Chandrasekaran R, Dobai JG, Jacobs JJ, Andersson GB, An H, Hallab NJ, Galante JO, Glant TT. The combination of pamidronate and calcitriol reverses particle- and TNF-alpha-induced altered functions of bone-marrow-derived stromal cells with osteoblastic phenotype. J Bone Joint Surg Br. 2004 Jul; 86(5):759-70. PMID: 15274277.
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    83. Szántó S, Gál I, Gonda A, Glant TT, Mikecz K. Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis. J Immunol. 2004 Jun 01; 172(11):6723-34. PMID: 15153489.
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    84. Szántó S, Bárdos T, Szabó Z, David CS, Buzás EI, Mikecz K, Glant TT. Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum. 2004 Jun; 50(6):1984-95. PMID: 15188376.
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    85. Hanyecz A, Berlo SE, Szántó S, Broeren CP, Mikecz K, Glant TT. Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype. Arthritis Rheum. 2004 May; 50(5):1665-76. PMID: 15146438.
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    86. Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K. Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci. 2004 Apr; 327(4):188-95. PMID: 15084914.
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    87. Glant TT, Mikecz K. Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis. Methods Mol Med. 2004; 102:313-38. PMID: 15286393.
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    88. Hanyecz A, Bárdos T, Berlo SE, Buzás E, Nesterovitch AB, Mikecz K, Glant TT. Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan. Arthritis Rheum. 2003 Oct; 48(10):2959-73. PMID: 14558103.
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    89. Firneisz G, Zehavi I, Vermes C, Hanyecz A, Frieman JA, Glant TT. Identification and quantification of disease-related gene clusters. Bioinformatics. 2003 Sep 22; 19(14):1781-6. PMID: 14512349.
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    90. Buzás EI, Hanyecz A, Murad Y, Hudecz F, Rajnavölgyi E, Mikecz K, Glant TT. Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones. J Immunol. 2003 Sep 15; 171(6):3025-33. PMID: 12960328.
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    91. Ortutay Z, Polgár A, Gömör B, Géher P, Lakatos T, Glant TT, Gay RE, Gay S, Pállinger E, Farkas C, Farkas E, Tóthfalusi L, Kocsis K, Falus A, Buzás EI. Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion. Arthritis Rheum. 2003 Aug; 48(8):2163-72. PMID: 12905469.
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    92. Liu W, Burton-Wurster N, Glant TT, Tashman S, Sumner DR, Kamath RV, Lust G, Kimura JH, Cs-Szabo G. Spontaneous and experimental osteoarthritis in dog: similarities and differences in proteoglycan levels. J Orthop Res. 2003 Jul; 21(4):730-7. PMID: 12798075.
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    93. Adarichev VA, Nesterovitch AB, Bárdos T, Biesczat D, Chandrasekaran R, Vermes C, Mikecz K, Finnegan A, Glant TT. Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun; 48(6):1708-20. PMID: 12794840.
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    94. Czipri M, Otto JM, Cs-Szabó G, Kamath RV, Vermes C, Firneisz G, Kolman KJ, Watanabe H, Li Y, Roughley PJ, Yamada Y, Olsen BR, Glant TT. Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. J Biol Chem. 2003 Oct 03; 278(40):39214-23. PMID: 12732630.
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    95. Fülöp C, Szántó S, Mukhopadhyay D, Bárdos T, Kamath RV, Rugg MS, Day AJ, Salustri A, Hascall VC, Glant TT, Mikecz K. Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May; 130(10):2253-61. PMID: 12668637.
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    96. Zhang J, Bárdos T, Shao Q, Tschopp J, Mikecz K, Glant TT, Finnegan A. IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism. J Immunol. 2003 Apr 01; 170(7):3495-503. PMID: 12646610.
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    97. Burton-Wurster N, Liu W, Matthews GL, Lust G, Roughley PJ, Glant TT, Cs-Szabó G. TGF beta 1 and biglycan, decorin, and fibromodulin metabolism in canine cartilage. Osteoarthritis Cartilage. 2003 Mar; 11(3):167-76. PMID: 12623288.
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    98. Adarichev VA, Valdez JC, Bárdos T, Finnegan A, Mikecz K, Glant TT. Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 01; 170(5):2283-92. PMID: 12594249.
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    99. Glant TT. Short overview of potential gene therapy approaches in orthopedic spine surgery. Spine (Phila Pa 1976). 2003 Feb 01; 28(3):207-8. PMID: 12567019.
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    100. Glant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics. Crit Rev Immunol. 2003; 23(3):199-250. PMID: 14584879.
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    101. Finnegan A, Kaplan CD, Cao Y, Eibel H, Glant TT, Zhang J. Collagen-induced arthritis is exacerbated in IL-10-deficient mice. Arthritis Res Ther. 2003; 5(1):R18-24. PMID: 12716449; PMCID: PMC154422.
    102. Bárdos T, Zhang J, Mikecz K, David CS, Glant TT. Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age. Arthritis Rheum. 2002 Sep; 46(9):2465-75. PMID: 12355495.
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    103. Stoop R, Gál I, Glant TT, McNeish JD, Mikecz K. Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions. Eur J Immunol. 2002 Sep; 32(9):2532-42. PMID: 12207337.
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    104. Zhang J, Bárdos T, Li D, Gál I, Vermes C, Xu J, Mikecz K, Finnegan A, Lipkowitz S, Glant TT. Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol. 2002 Sep 01; 169(5):2236-40. PMID: 12193687.
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    105. Glant TT, Kamath RV, Bárdos T, Gál I, Szántó S, Murad YM, Sandy JD, Mort JS, Roughley PJ, Mikecz K. Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis. Arthritis Rheum. 2002 Aug; 46(8):2207-18. PMID: 12209527.
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    106. Bárdos T, Czipri M, Vermes C, Zhang J, Mikecz K, Glant TT. Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice. Clin Exp Immunol. 2002 Aug; 129(2):224-31. PMID: 12165077; PMCID: PMC1906433.
    107. Bárdos T, Mikecz K, Finnegan A, Zhang J, Glant TT. T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol. 2002 Jun 15; 168(12):6013-21. PMID: 12055209.
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    108. Hallab NJ, Vermes C, Messina C, Roebuck KA, Glant TT, Jacobs JJ. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002 Jun 05; 60(3):420-33. PMID: 11920666.
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    109. Adarichev VA, Bárdos T, Christodoulou S, T Phillips M, Mikecz K, Glant TT. Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis. Immunogenetics. 2002 Jun; 54(3):184-92. PMID: 12073147.
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    110. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts. J Orthop Res. 2002 May; 20(3):490-8. PMID: 12038622.
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    111. Vermes C, Jacobs JJ, Zhang J, Firneisz G, Roebuck KA, Glant TT. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. J Biol Chem. 2002 May 10; 277(19):16879-87. PMID: 11884403.
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    112. Glant TT. Point of view. Spine (Phila Pa 1976). 2002 Feb 15; 27(4):368. PMID: 11840101.
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    113. Firneisz G, Lakatos PL, Szalay F, Polli C, Glant TT, Ferenci P. Common mutations of ATP7B in Wilson disease patients from Hungary. Am J Med Genet. 2002 Feb 15; 108(1):23-8. PMID: 11857545.
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    114. Vermes C, Glant TT, Hallab NJ, Fritz EA, Roebuck KA, Jacobs JJ. The potential role of the osteoblast in the development of periprosthetic osteolysis: review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth factors. J Arthroplasty. 2001 Dec; 16(8 Suppl 1):95-100. PMID: 11742458.
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    115. Jacobs JJ, Roebuck KA, Archibeck M, Hallab NJ, Glant TT. Osteolysis: basic science. Clin Orthop Relat Res. 2001 Dec; (393):71-7. PMID: 11764373.
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    116. Bárdos T, Kamath RV, Mikecz K, Glant TT. Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis. Am J Pathol. 2001 Nov; 159(5):1711-21. PMID: 11696432; PMCID: PMC1867074.
    117. Kaplan C, Valdez JC, Chandrasekaran R, Eibel H, Mikecz K, Glant TT, Finnegan A. Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis. Arthritis Res. 2002; 4(1):54-8. PMID: 11879537; PMCID: PMC64852.
    118. Janssen U, Thomas G, Glant T, Phillips A. Expression of inter-alpha-trypsin inhibitor and tumor necrosis factor-stimulated gene 6 in renal proximal tubular epithelial cells. Kidney Int. 2001 Jul; 60(1):126-36. PMID: 11422744.
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    119. Zhang J, Bárdos T, Mikecz K, Finnegan A, Glant TT. Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis. J Immunol. 2001 Apr 15; 166(8):4981-6. PMID: 11290777.
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    120. Glant TT, Bárdos T, Vermes C, Chandrasekaran R, Valdéz JC, Otto JM, Gerard D, Velins S, Lovász G, Zhang J, Mikecz K, Finnegan A. Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease. Arthritis Rheum. 2001 Mar; 44(3):682-92. PMID: 11263784.
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    121. Roebuck KA, Vermes C, Carpenter LR, Fritz EA, Narayanan R, Glant TT. Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter. J Bone Miner Res. 2001 Mar; 16(3):501-10. PMID: 11277268.
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    122. Vermes C, Chandrasekaran R, Jacobs JJ, Galante JO, Roebuck KA, Glant TT. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb; 83-A(2):201-11. PMID: 11216681.
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    123. Archibeck MJ, Jacobs JJ, Roebuck KA, Glant TT. The basic science of periprosthetic osteolysis. Instr Course Lect. 2001; 50:185-95. PMID: 11372314.
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    124. Otto JM, Chandrasekeran R, Vermes C, Mikecz K, Finnegan A, Rickert SE, Enders JT, Glant TT. A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis. J Immunol. 2000 Nov 01; 165(9):5278-86. PMID: 11046062.
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    125. Zhang J, Mikecz K, Finnegan A, Glant TT. Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway. J Immunol. 2000 Sep 15; 165(6):2970-4. PMID: 10975804.
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    126. Vermes C, Roebuck KA, Chandrasekaran R, Dobai JG, Jacobs JJ, Glant TT. Particulate wear debris activates protein tyrosine kinases and nuclear factor kappaB, which down-regulates type I collagen synthesis in human osteoblasts. J Bone Miner Res. 2000 Sep; 15(9):1756-65. PMID: 10976995.
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    127. Kim JH, Glant TT, Lesley J, Hyman R, Mikecz K. Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand. Exp Cell Res. 2000 May 01; 256(2):445-53. PMID: 10772817.
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    128. Holló K, Glant TT, Garzó M, Finnegan A, Mikecz K, Buzás E. Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis. Clin Exp Immunol. 2000 Apr; 120(1):167-73. PMID: 10759779; PMCID: PMC1905608.
    129. Otto JM, Cs-Szabó G, Gallagher J, Velins S, Mikecz K, Buzás EI, Enders JT, Li Y, Olsen BR, Glant TT. Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Arthritis Rheum. 1999 Dec; 42(12):2524-31. PMID: 10615997.
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    130. Finnegan A, Mikecz K, Tao P, Glant TT. Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines. J Immunol. 1999 Nov 15; 163(10):5383-90. PMID: 10553063.
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    131. Roebuck KA, Jacobs JJ, Glant TT. New horizons in orthopaedic research: elucidation of cellular signal transduction pathways. J Bone Joint Surg Am. 1999 May; 81(5):599-602. PMID: 10360688.
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    132. Glant TT, Cs-Szabó G, Nagase H, Jacobs JJ, Mikecz K. Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage. Arthritis Rheum. 1998 Jun; 41(6):1007-18. PMID: 9627010.
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    133. Glant TT, Buzás EI, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K. Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol. 1998 Apr 15; 160(8):3812-9. PMID: 9558085.
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    134. Fülöp C, Kamath RV, Li Y, Otto JM, Salustri A, Olsen BR, Glant TT, Hascall VC. Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes. Gene. 1997 Nov 20; 202(1-2):95-102. PMID: 9427551.
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    135. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT. Effects of particles on fibroblast proliferation and bone resorption in vitro. Clin Orthop Relat Res. 1997 Sep; (342):205-17. PMID: 9308543.
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    136. Cs-Szabó G, Melching LI, Roughley PJ, Glant TT. Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples. Arthritis Rheum. 1997 Jun; 40(6):1037-45. PMID: 9182913.
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    137. Brennan FR, Mikecz K, Glant TT, Jobanputra P, Pinder S, Bavington C, Morrison P, Nuki G. CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro. Scand J Immunol. 1997 Feb; 45(2):213-20. PMID: 9042434.
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    138. Yao J, Cs-Szabó G, Jacobs JJ, Kuettner KE, Glant TT. Suppression of osteoblast function by titanium particles. J Bone Joint Surg Am. 1997 Jan; 79(1):107-12. PMID: 9010191.
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    139. Lee SH, Brennan FR, Jacobs JJ, Urban RM, Ragasa DR, Glant TT. Human monocyte/macrophage response to cobalt-chromium corrosion products and titanium particles in patients with total joint replacements. J Orthop Res. 1997 Jan; 15(1):40-9. PMID: 9066525.
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    140. Fülöp C, Cs-Szabó G, Glant TT. Species-specific alternative splicing of the epidermal growth factor-like domain 1 of cartilage aggrecan. Biochem J. 1996 Nov 01; 319 ( Pt 3):935-40. PMID: 8921002; PMCID: PMC1217878.
    141. Buzás EI, Mikecz K, Glant TT. Aggrecan: A Target Molecule of Autoimmune Reactions. Pathol Oncol Res. 1996; 2(4):219-228. PMID: 11173607.
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    142. Glant TT, Jacobs JJ, Mikecz K, Yao J, Chubinskaja S, Williams JM, Urban RL, Shanbhag AS, Lee SH, Sumner DR. Particulate-Induced, Prostaglandin- and Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements. Am J Ther. 1996 Jan; 3(1):27-41. PMID: 11856995.
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    143. Mikecz K, Glant TT. Immunoregulation of Proteoglycan-Induced Arthritis in Balb/c Mice. Am J Ther. 1996 Jan; 3(1):42-51. PMID: 11856996.
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    144. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT. Human monocyte response to particulate biomaterials generated in vivo and in vitro. J Orthop Res. 1995 Sep; 13(5):792-801. PMID: 7472759.
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    145. Brennan FR, Mikecz K, Buzás EI, Ragasa D, Cs-Szabó G, Negroiu G, Glant TT. Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin Exp Immunol. 1995 Sep; 101(3):414-21. PMID: 7664487; PMCID: PMC1553246.
    146. Buzás EI, Brennan FR, Mikecz K, Garzó M, Negroiu G, Holló K, Cs-Szabó G, Pintye E, Glant TT. A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice. J Immunol. 1995 Sep 01; 155(5):2679-87. PMID: 7544381.
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    147. Yao J, Glant TT, Lark MW, Mikecz K, Jacobs JJ, Hutchinson NI, Hoerrner LA, Kuettner KE, Galante JO. The potential role of fibroblasts in periprosthetic osteolysis: fibroblast response to titanium particles. J Bone Miner Res. 1995 Sep; 10(9):1417-27. PMID: 7502715.
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    148. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT. Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty. J Arthroplasty. 1995 Aug; 10(4):498-506. PMID: 8523010.
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    149. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med. 1995 Jun; 1(6):558-63. PMID: 7585123.
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    150. Cs-Szabó G, Roughley PJ, Plaas AH, Glant TT. Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage. Arthritis Rheum. 1995 May; 38(5):660-8. PMID: 7538297.
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    151. Singer II, Kawka DW, Bayne EK, Donatelli SA, Weidner JR, Williams HR, Ayala JM, Mumford RA, Lark MW, Glant TT, et al. VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis. J Clin Invest. 1995 May; 95(5):2178-86. PMID: 7537757; PMCID: PMC295822.
    152. Brennan FR, Negroiu G, Buzás EI, Fülöp C, Holló K, Mikecz K, Glant TT. Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin Exp Immunol. 1995 Apr; 100(1):104-10. PMID: 7697908; PMCID: PMC1534264.
    153. Brennan FR, Mikecz K, Buzás EI, Glant TT. Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma. Immunol Lett. 1995 Feb; 45(1-2):87-91. PMID: 7622193.
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    154. Mikecz K, Brennan FR, Kim JH, Glant TT. The role of adhesion molecules in the development of autoimmune arthritis. Scand J Rheumatol Suppl. 1995; 101:99-106. PMID: 7747139.
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    155. Glant TT, Fülöp C, Cs-Szabó G, Buzás E, Ragasa D, Mikecz K. Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis. Scand J Rheumatol Suppl. 1995; 101:43-9. PMID: 7538228.
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    156. Buzás EI, Mikecz K, Brennan FR, Glant TT. Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice. Cell Immunol. 1994 Oct 15; 158(2):292-304. PMID: 7923385.
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    157. Mikecz K, Glant TT. Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis. Arthritis Rheum. 1994 Sep; 37(9):1395-403. PMID: 7945505.
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    158. Glant TT, Jacobs JJ. Response of three murine macrophage populations to particulate debris: bone resorption in organ cultures. J Orthop Res. 1994 Sep; 12(5):720-31. PMID: 7931789.
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    159. Walcz E, Deák F, Erhardt P, Coulter SN, Fülöp C, Horvath P, Doege KJ, Glant TT. Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan. Genomics. 1994 Jul 15; 22(2):364-71. PMID: 7806222.
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    160. Yamaga KM, Kimura LH, Plymyer MR, Glant TT, Lance EM. Differentiation antigens of human articular chondrocytes and their tissue distribution as assessed by monoclonal antibodies. J Autoimmun. 1994 Apr; 7(2):203-17. PMID: 8037839.
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    161. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT. Macrophage/particle interactions: effect of size, composition and surface area. J Biomed Mater Res. 1994 Jan; 28(1):81-90. PMID: 8126033.
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    162. Shanbhag AS, Jacobs JJ, Glant TT, Gilbert JL, Black J, Galante JO. Composition and morphology of wear debris in failed uncemented total hip replacement. J Bone Joint Surg Br. 1994 Jan; 76(1):60-7. PMID: 8300684.
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    163. Buzás EI, Holló K, Rubliczky L, Garzó M, Nyirkos P, Glant TT. Effect of pregnancy on proteoglycan-induced progressive polyarthritis in BALB/c mice: remission of disease activity. Clin Exp Immunol. 1993 Nov; 94(2):252-60. PMID: 8222315; PMCID: PMC1534222.
    164. Glant TT, Jacobs JJ, Molnár G, Shanbhag AS, Valyon M, Galante JO. Bone resorption activity of particulate-stimulated macrophages. J Bone Miner Res. 1993 Sep; 8(9):1071-9. PMID: 8237476.
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    165. Fülöp C, Walcz E, Valyon M, Glant TT. Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module. J Biol Chem. 1993 Aug 15; 268(23):17377-83. PMID: 8349621.
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    166. Cs-Szabó G, Fülöp C, Hadházy C, Elödi P, Glant TT. Substrate specificity of 'elastomucoproteinase': an enzyme which can degrade cartilage aggrecan. Biochim Biophys Acta. 1993 Mar 26; 1162(3):266-74. PMID: 8457590.
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    167. Williams JM, Zurawski J, Mikecz K, Glant TT. Functional assessment of joint use in experimental inflammatory murine arthritis. J Orthop Res. 1993 Mar; 11(2):172-80. PMID: 8483030.
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    168. Sárközi AM, Hámori G, Fülöp C, Búzás E, Brózik M, Merétey K, Glant TT. [Serum keratan sulfate studies and their significance in the evaluation of cartilage degradation in degenerative and inflammatory joint diseases]. Orv Hetil. 1993 Feb 28; 134(9):461-7. PMID: 8446416.
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    169. Thonar EJ, Glant T. Serum keratan sulfate--a marker of predisposition to polyarticular osteoarthritis. Clin Biochem. 1992 Jun; 25(3):175-80. PMID: 1633632.
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    170. Glant TT, Mikecz K, Bartlett RR, Deák F, Thonar EJ, Williams JM, Mattar T, Kuettner KE, Schleyerbach R. Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. Immunopharmacology. 1992 Mar-Apr; 23(2):105-16. PMID: 1601639.
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    171. Poole CA, Glant TT, Schofield JR. Chondrons from articular cartilage. (IV). Immunolocalization of proteoglycan epitopes in isolated canine tibial chondrons. J Histochem Cytochem. 1991 Sep; 39(9):1175-87. PMID: 1717545.
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    172. Thonar EJ, Manicourt DM, Williams J, Lenz ME, Sweet MB, Schnitzer TJ, Otten L, Glant T, Kuettner KE. Circulating keratan sulfate: a marker of cartilage proteoglycan catabolism in osteoarthritis. J Rheumatol Suppl. 1991 Feb; 27:24-6. PMID: 2027120.
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    173. Glant TT, Fülöp C, Mikecz K, Buzás E, Molnár G, Erhardt P. Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases. Biochem Soc Trans. 1990 Oct; 18(5):796-9. PMID: 2083679.
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    174. Dayer E, Mathai L, Glant TT, Mikecz K, Poole AR. Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis. Arthritis Rheum. 1990 Sep; 33(9):1394-405. PMID: 1698370.
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    175. Mikecz K, Glant TT, Buzás E, Poole AR. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice. Arthritis Rheum. 1990 Jun; 33(6):866-76. PMID: 2194463.
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    176. Kopper L, Timar J, Kovalszky I, Fulop C, Glant T. Epitopes of cartilage core proteins and GAG pattern in human non-Hodgkin lymphoma xenografts. In Vivo. 1990 Mar-Apr; 4(2):149-52. PMID: 1717029.
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    177. Kopper L, Bankfalvi A, Mihalik R, Glant TT, Timar J. Proteoglycan-targeted antibodies as markers on non-Hodgkin lymphoma xenografts. Cancer Immunol Immunother. 1990; 32(2):137-42. PMID: 2289206.
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    178. Kopper L, Bánkfalvi A, Mihalik R, Timár J, Glant T. Pheno- and genotypic characteristics of human non-Hodgkin lymphoma xenografts. Acta Histochem Suppl. 1990; 39:455-9. PMID: 2080286.
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    179. Gitelis S, Kimura J, Block J, Glant T. Clonal analysis of human chondrosarcoma. Chir Organi Mov. 1990; 75(1 Suppl):11-3. PMID: 2249502.
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    180. Mikecz K, Glant TT, Baron M, Poole AR. Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis. Cell Immunol. 1988 Mar; 112(1):55-63. PMID: 2449981.
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    181. Mikecz K, Glant TT, Buzás E, Poole AR. Cartilage proteoglycans as potential autoantigens in humans and in experimental animals. Agents Actions. 1988 Feb; 23(1-2):63-6. PMID: 3354391.
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    182. Webber C, Glant TT, Roughley PJ, Poole AR. The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages. Biochem J. 1987 Dec 15; 248(3):735-40. PMID: 3435482; PMCID: PMC1148611.
    183. Roughley PJ, White RJ, Glant TT. The structure and abundance of cartilage proteoglycans during early development of the human fetus. Pediatr Res. 1987 Oct; 22(4):409-13. PMID: 3120142.
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    184. Hascall VC, Glant TT. Proteoglycan epitopes as potential markers of normal and pathologic cartilage metabolism. Arthritis Rheum. 1987 May; 30(5):586-8. PMID: 2439091.
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    185. Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum. 1987 Mar; 30(3):306-18. PMID: 3566822.
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    186. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum. 1987 Feb; 30(2):201-12. PMID: 3827960.
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    187. Glant TT, Mikecz K, Roughley PJ, Buzás E, Poole AR. Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans. Biochem J. 1986 May 15; 236(1):71-5. PMID: 2431678; PMCID: PMC1146787.
    188. Glant TT, Mikecz K, Poole AR. Monoclonal antibodies to different protein-related epitopes of human articular cartilage proteoglycans. Biochem J. 1986 Feb 15; 234(1):31-41. PMID: 2423072; PMCID: PMC1146523.
    189. Glant T, Mikecz K. Antigenic profiles of human, bovine and canine articular chondrocytes. Cell Tissue Res. 1986; 244(2):359-69. PMID: 3521881.
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    190. Glant TT, Hadházy C, Mikecz K, Sipos A. Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. Histochemistry. 1985; 82(2):149-58. PMID: 3997552.
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    191. Glant T, Lévai G. Localization of antigenic components in proteoglycan aggregate of bovine nasal cartilage. Histochemistry. 1983; 77(2):217-32. PMID: 6341327.
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    192. Glant TT. Concanavalin A-binding link protein in the proteoglycan aggregate of hyaline cartilage. Biochem Biophys Res Commun. 1982 May 14; 106(1):158-63. PMID: 7103979.
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    193. Glant T. Induction of cartilage degradation in experimental arthritis produced by allogeneic and xenogeneic proteoglycan antigens. Connect Tissue Res. 1982; 9(3):137-44. PMID: 6213366.
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    194. Glant T, Oláh I. Experimental arthritis produced by proteoglycan antigens in rabbits. Scand J Rheumatol. 1980; 9(4):271-9. PMID: 7455641.
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    195. Hadházy C, László MB, Glant T, Oláh EH. Studies on cartilage formation. XXII. Investigations of certain oxidative metabolic processes in regenerating articular cartilage. Acta Biol Acad Sci Hung. 1980; 31(1-3):121-31. PMID: 6261495.
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    196. Glant T, Csongor J, Szücs T. Immunopathologic role of proteoglycan antigens in rheumatoid joint disease. Scand J Immunol. 1980; 11(3):247-52. PMID: 9537052.
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    197. Mándi B, Holub M, Rossmann P, Csaba B, Glant T, Olveti E. Detection of thymosin 5 in calf and mouse thymus and in nude mouse dysgenetic thymus. Folia Biol (Praha). 1979; 25(1):49-55. PMID: 371994.
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    198. Oláh EH, Hadházy C, Glant T. Studies on cartilage formation XXL Activity of enzymes belonging to the pentose-phosphate cycle in the regenerating articular surface. Acta Biol Acad Sci Hung. 1979; 30(3):235-43. PMID: 550662.
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    199. Glant T, Hadas E, Nagy M. Cell-mediated and humoral immune responses to cartilage antigenic components. Scand J Immunol. 1979; 9(1):39-44. PMID: 105405.
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    200. Schmidt H, Glant T, Módis L. [The participation of phenol-(DOPA-)oxidase containing cells (POZ) with the delayed hypersensitivity. (Preliminary report) (author's transl)]. Acta Histochem. 1978; 63(2):271-5. PMID: 107710.
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    201. Glant T, Lévai G, Hadházy C. The localization of proteoglycans and glycoproteins in the hyaline cartilage. Histochemistry. 1977 Sep 22; 53(4):291-9. PMID: 332674.
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    202. Glant T, Hadházy C, Csernyánszky H. Species-common antigen of connective tissues. Acta Biol Acad Sci Hung. 1975; 26(3-4):197-208. PMID: 62479.
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    203. Glant T, Hadházy C, Bordán L, Harmati S. Antigenicity of bone tissue. I. Immunological and immunohistochemical study of non-collagenous proteins of the bovine cortical bone. Acta Morphol Acad Sci Hung. 1975; 23(2):111-22. PMID: 779406.
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    204. Mándi B, Hadházy C, Réthy A, Kiss EK, Glant T. Studies on cartilage formation. XVI. Chemical and histochemical assay of lipids in the regenerating articular cartilage. Acta Biol Acad Sci Hung. 1975; 26(3-4):115-33. PMID: 1234399.
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    205. Mándi B, Szegedi G, Pálóczi K, Glant T. The mechanism of thymosin action. Short communication. Acta Biol Acad Sci Hung. 1975; 26(3-4):233-5. PMID: 1234405.
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    206. Mándi B, Petkó M, Szöor G, Glant T. Connective tissue alterations following neonatal thymectomy. VI. Calcium histochemical, growth-dynamical and thermoanalytical investigations on bone tissue of thymectomized rats. Acta Morphol Acad Sci Hung. 1975; 23(1):59-69. PMID: 1211260.
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    207. Hadházy C, Glant T, Mándi B, Harmati S, Bordán L, Balogh K. Studies on cartilage formation. XX. Histochemical investigation of some enzymes of glycogen metabolsim in regenerative articular surfaces. Acta Morphol Acad Sci Hung. 1975; 23(3):183-93. PMID: 188310.
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    208. Csákó G, Csernyánszky H, Glant T. The role of basic substances of high molecular weight in the generalized Shwartzman reaction (GSR). Arzneimittelforschung. 1974 Oct; 24(10):1585-8. PMID: 4373012.
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    209. Mandi B, Glant T. Thymosin-producing cells of the thymus. Nat New Biol. 1973 Nov 07; 246(149):25. PMID: 4202328.
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    210. Hadhàzy C, Glant T, Màndi B, Tóth Z, Vereckei L, Boross A. Studies on cartilage formation. XV. Enzyme histochemical investigation on Krebs cycle, terminal oxidation and hexose monophosphate shunt. Acta Morphol Acad Sci Hung. 1973; 21(1):13-25. PMID: 4355444.
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    211. Hadházy C, Glant T, Mándi B, Miltényi L. On the antigenicity of cartilage tissue. Acta Biol Acad Sci Hung. 1972; 23(3):277-88. PMID: 4122537.
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    212. Mándi B, Hadházy C, Mándi A, Glant T. Effect of postnatal thymectomy on enchondral ossification. Acta Morphol Acad Sci Hung. 1971; 19(3):259-68. PMID: 5148337.
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    213. Hadházy C, Glant T. Effect of vesical mucosa grafts on bone healing. Acta Chir Acad Sci Hung. 1968; 9(2):97-107. PMID: 5681801.
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