 Receptor, trkA
"Receptor, trkA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
| Descriptor ID |
D020917
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.660 D12.776.543.750.060.496 D12.776.543.750.750.400.550.550
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| Concept/Terms |
Receptor, trkA- Receptor, trkA
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- gp140(c-TRK)
- Neurotrophic Tyrosine Kinase Receptor Type 1
- NTRK1 Receptor
- Receptor, NTRK1
- p140-trkA
- p140 trkA
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- Receptor, Neurotrophic Tyrosine Kinase Type 1
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- trk1 Transforming Tryrosine Kinase
- trkA Receptor
- c-trk Protein
- c trk Protein
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
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Below are MeSH descriptors whose meaning is more general than "Receptor, trkA".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkA".
This graph shows the total number of publications written about "Receptor, trkA" by people in this website by year, and whether "Receptor, trkA" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, trkA" by people in Profiles.
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O-Sullivan I, Kc R, Singh G, Das V, Ma K, Li X, Mwale F, Votta-Velis G, Bruce B, Natarajan Anbazhagan A, van Wijnen AJ, Im HJ. Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization. Int J Mol Sci. 2022 Oct 11; 23(20).
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Kc R, Li X, Kroin JS, Liu Z, Chen D, Xiao G, Levine B, Li J, Hamilton JL, van Wijnen AJ, Piel M, Shelly DA, Brass D, Kolb E, Im HJ. PKCd null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth. Ann Rheum Dis. 2016 Dec; 75(12):2133-2141.
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Kim JS, Ali MH, Wydra F, Li X, Hamilton JL, An HS, Cs-Szabo G, Andrews S, Moric M, Xiao G, Wang JH, Chen D, Cavanaugh JM, Im HJ. Characterization of degenerative human facet joints and facet joint capsular tissues. Osteoarthritis Cartilage. 2015 Dec; 23(12):2242-2251.
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Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, Kimura T, Masuda K. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine (Phila Pa 1976). 2007 Mar 15; 32(6):635-42.
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Mufson EJ, Ma SY, Cochran EJ, Bennett DA, Beckett LA, Jaffar S, Saragovi HU, Kordower JH. Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol. 2000 Nov 06; 427(1):19-30.
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